Soleus Capital Management, L.P. More: the full row for Soleus Capital Management, L.P. 1,494,420 $32M 2.42% +150,755 13F-HR Timeline Velan Capital Investment Management LP More: the full row for Velan Capital Investment Management LP 1,433,828 $30.7M 26.45% 0 13F-HR Timeline Carlyle Group Inc. in group Carlyle Group Inc. More: the full row for Carlyle Group Inc. 1,066,189 $22.7M 0.55% 0 13F-HR Timeline Group QIMING U.S. VENTURES MANAGEMENT, LLC More: the full row for QIMING U.S. VENTURES MANAGEMENT, LLC 928,964 $19.9M 38.83% 0 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 808,086 $17.3M <0.01% +8,058 13F-HR Timeline Group BRAIDWELL LP More: the full row for BRAIDWELL LP 714,658 $15.3M 0.45% +231,358 13F-HR Timeline VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 709,484 $15.2M <0.01% +15,059 13F-HR Timeline Group Integral Health Asset Management, LLC More: the full row for Integral Health Asset Management, LLC 650,000 $13.9M 1.23% +300,000 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 604,792 $12.9M <0.01% +39,070 13F-HR/A Timeline Group SAMSARA BIOCAPITAL, LLC More: the full row for SAMSARA BIOCAPITAL, LLC 584,642 $12.5M 1.72% 0 13F-HR Timeline FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 579,636 $12.4M <0.01% 0 13F-HR Timeline Group Rock Springs Capital Management LP More: the full row for Rock Springs Capital Management LP 463,088 $9.9M 0.38% +4,000 13F-HR Timeline KINGDON CAPITAL MANAGEMENT, L.L.C. More: the full row for KINGDON CAPITAL MANAGEMENT, L.L.C. 447,000 $9.56M 1.63% -50,000 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 423,610 $9.06M 0.01% +282,046 13F-HR Timeline Group Opaleye Management Inc. More: the full row for Opaleye Management Inc. 400,000 $8.55M 1.5% +46,500 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 388,523 $8.31M <0.01% +350,162 13F-HR Timeline Group Boxer Capital Management, LLC in group Boxer Capital Management, LLC More: the full row for Boxer Capital Management, LLC 350,000 $7.48M 0.64% 13F-HR Timeline Group GREAT POINT PARTNERS LLC More: the full row for GREAT POINT PARTNERS LLC 322,380 $6.89M 3.25% 0 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 287,204 $6.14M <0.01% -38,677 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 257,687 $5.51M <0.01% +271 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 247,272 $5.29M 0.01% +35,746 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 245,676 $5.25M 0.04% -249,428 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 230,306 $4.92M <0.01% +15,423 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 210,305 $4.5M <0.01% +154,540 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 170,695 $3.65M <0.01% +39,436 13F-HR/A Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 164,315 $3.51M <0.01% +158,998 13F-HR Timeline Group SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 135,720 $2.9M 0.54% -53,550 13F-HR Timeline Group STEMPOINT CAPITAL LP More: the full row for STEMPOINT CAPITAL LP 135,244 $2.89M 0.73% new 13F-HR Timeline Ally Bridge Group (NY) LLC More: the full row for Ally Bridge Group (NY) LLC 122,424 $2.62M 2.24% -277,042 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 104,367 $2.23M <0.01% -2,573 13F-HR Timeline Group Nuveen Asset Management, LLC in group TIAA More: the full row for Nuveen Asset Management, LLC 83,417 $1.78M <0.01% 0 13F-HR Timeline Group T. Rowe Price Investment Management, In… More: the full row for T. Rowe Price Investment Management, Inc. 82,165 $1.76M <0.01% new 13F-HR Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 77,722 $1.66M <0.01% +11,397 13F-HR Timeline Group SCHRODER INVESTMENT MANAGEMENT GROUP More: the full row for SCHRODER INVESTMENT MANAGEMENT GROUP 59,034 $1.24M <0.01% new 13F-HR Timeline Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 55,107 $1.18M 0.34% -68 13F-HR Timeline Group Fernwood Investment Management, LLC More: the full row for Fernwood Investment Management, LLC 52,897 $1.13M 0.39% 0 13F-HR Timeline DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 37,705 $806K <0.01% +780 13F-HR Timeline Group Mariner, LLC in group Mariner, LLC More: the full row for Mariner, LLC 36,794 $787K <0.01% -5,412 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 32,337 $691K <0.01% -70 13F-HR Timeline Group Lion Point Capital, LP More: the full row for Lion Point Capital, LP 32,000 $684K 3.58% 0 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 31,250 $668K 0.01% new 13F-HR/A Timeline Group Palo Alto Investors LP More: the full row for Palo Alto Investors LP 30,651 $655K 0.1% new 13F-HR Timeline Sowell Financial Services LLC More: the full row for Sowell Financial Services LLC 28,043 $600K 0.03% new 13F-HR Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 27,069 $579K <0.01% +3,310 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 25,078 $536K <0.01% +1,048 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 22,814 $488K <0.01% +2,294 13F-HR Timeline Group Allostery Investments LP More: the full row for Allostery Investments LP 22,000 $470K 0.92% 13F-HR Timeline Simplify Asset Management Inc. More: the full row for Simplify Asset Management Inc. 20,000 $428K 0.03% new 13F-HR Timeline Propel Bio Management, LLC More: the full row for Propel Bio Management, LLC 20,000 $428K 0.42% new 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 18,334 $392K <0.01% +2,188 13F-HR/A Timeline Group AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 17,979 $384K <0.01% +1,173 13F-HR Timeline Group Verition Fund Management LLC More: the full row for Verition Fund Management LLC 15,050 $322K <0.01% -10,303 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 14,761 $316K <0.01% +1,652 13F-HR/A Timeline BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 13,853 $296K 0.01% +1,617 13F-HR Timeline STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 13,724 $293K <0.01% new 13F-HR Timeline Tema ETFs LLC More: the full row for Tema ETFs LLC 12,435 $266K 0.11% 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 10,852 $232K <0.01% -2,502 13F-HR Timeline Group EntryPoint Capital, LLC More: the full row for EntryPoint Capital, LLC 10,431 $223K 0.09% new 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 9,060 $194K <0.01% +895 13F-HR Timeline Group Leonteq Securities AG More: the full row for Leonteq Securities AG 8,000 $171K 0.02% 0 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 7,415 $159K <0.01% +3,828 13F-HR Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 6,874 $147K <0.01% 0 13F-HR Timeline Group MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 6,516 $139K <0.01% +304 13F-HR Timeline Group Corebridge Financial, Inc. in group Corebridge Financial, Inc. More: the full row for Corebridge Financial, Inc. 5,628 $120K <0.01% -425 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 5,165 $110K <0.01% -11,226 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 4,600 $98.3K <0.01% 0 13F-HR/A Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 2,888 $61.7K <0.01% +376 13F-HR Timeline Group WOLFF WIESE MAGANA LLC More: the full row for WOLFF WIESE MAGANA LLC 2,887 $61.7K 0.04% -259 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 2,276 $48.7K <0.01% 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 1,555 $33.2K <0.01% +860 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 1,213 $25.9K <0.01% 0 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 1,109 $23.7K <0.01% 0 13F-HR Timeline Group Creative Planning in group Creative Planning More: the full row for Creative Planning 1,032 $22.1K <0.01% new 13F-HR Timeline Group OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 837 $17.9K <0.01% 0 13F-HR/A Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 820 $17.5K <0.01% 0 13F-HR/A Timeline R Squared Ltd More: the full row for R Squared Ltd 720 $15.4K 0.01% 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 511 $10.9K <0.01% -1 13F-HR Timeline Group GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 500 $10.7K <0.01% new 13F-HR/A Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 392 $8K <0.01% 0 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 232 $5K <0.01% -1,317 13F-HR Timeline Group Greenline Partners, LLC More: the full row for Greenline Partners, LLC 100 $2.14K <0.01% new 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 53 $1.13K <0.01% +48 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 16 $342 <0.01% new 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 12 $257 <0.01% 0 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 6 $128 <0.01% 13F-HR Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 0 $21 <0.01% new 13F-HR Timeline Amount filed as zero, left out of ratios. CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 20 $0 0% +5 13F-HR Timeline Group Value filed as zero, left out of ratios. LAZARD ASSET MANAGEMENT LLC in group LAZARD ASSET MANAGEMENT LLC More: the full row for LAZARD ASSET MANAGEMENT LLC 17 $0 0% 0 13F-HR Timeline Group Value filed as zero, left out of ratios. CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.