Caligan Partners LP More: the full row for Caligan Partners LP 6,075,028 $27.6M 1.96% new 13F-HR Timeline ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 6,029,775 $27.4M 0.04% +4,924,779 13F-HR Timeline Group BIOS Capital Management, LP in group BIOS Capital Management, LP More: the full row for BIOS Capital Management, LP 3,683,429 $16.8M 31.7% 0 13F-HR Timeline Group VANGUARD GROUP INC group of 3 filers holding More: the full row for VANGUARD GROUP INC 2,754,013 $12.5M new Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 2,718,029 $12.4M 0.02% 0 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 2,630,432 $12M 0.01% +627,882 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 2,313,380 $10.5M 0.01% +2,155,732 13F-HR Timeline Group Boxer Capital Management, LLC in group Boxer Capital Management, LLC More: the full row for Boxer Capital Management, LLC 2,250,000 $10.2M 1.34% new 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 1,849,004 $8.41M 0.51% +1,809,004 13F-HR Timeline Group PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 1,835,842 $8.35M 0.16% -2,489,158 13F-HR/A Timeline Group Nantahala Capital Management, LLC in group Nantahala Capital Management,… More: the full row for Nantahala Capital Management, LLC 1,681,330 $7.65M 0.48% -3,100,000 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 1,354,030 $6.16M 0.02% new 13F-HR/A Timeline BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 1,189,113 $5.41M 0.12% new 13F-HR Timeline FARALLON CAPITAL MANAGEMENT, L.L.C. More: the full row for FARALLON CAPITAL MANAGEMENT, L.L.C. 1,000,000 $4.55M 0.03% new 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 823,383 $3.75M <0.01% +621,748 13F-HR Timeline Group Bleichroeder LP More: the full row for Bleichroeder LP 736,842 $3.35M 0.58% 0 13F-HR Timeline Mink Brook Asset Management LLC in group Mink Brook Asset Management L… More: the full row for Mink Brook Asset Management LLC 590,552 $2.69M 1.5% -1,075,079 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 538,347 $2.45M <0.01% +33,364 13F-HR Timeline Group Trails Edge Capital Partners, LP More: the full row for Trails Edge Capital Partners, LP 500,000 $2.27M 0.54% new 13F-HR Timeline Opaleye Management Inc. More: the full row for Opaleye Management Inc. 1,120,000 $2.25M 0.3% 0 13F-HR Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 388,491 $1.77M <0.01% new 13F-HR/A Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 326,809 $1.49M <0.01% new 13F-HR Timeline Group GREAT POINT PARTNERS LLC More: the full row for GREAT POINT PARTNERS LLC 324,340 $1.48M 0.36% new 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 257,649 $1.17M <0.01% +167,831 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 199,953 $910K <0.01% +26,700 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 158,103 $719K <0.01% new 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 147,740 $672K <0.01% +5,843 13F-HR Timeline Group Voleon Capital Management LP More: the full row for Voleon Capital Management LP 143,796 $654K 0.01% new 13F-HR Timeline Seven Fleet Capital Management LP More: the full row for Seven Fleet Capital Management LP 134,242 $611K 0.19% new 13F-HR/A Timeline Creative Planning in group Creative Planning More: the full row for Creative Planning 128,366 $584K <0.01% 0 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 120,900 $550K <0.01% -59,821 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 108,641 $494K <0.01% -42,671 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 94,415 $430K <0.01% +6,968 13F-HR Timeline Group Texas Capital Bank Wealth Management Se… More: the full row for Texas Capital Bank Wealth Management Services Inc 88,500 $403K 0.02% +10,500 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 82,480 $375K 0.01% +73,417 13F-HR Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 73,209 $333K <0.01% -53,100 13F-HR Timeline Stonepine Capital Management, LLC More: the full row for Stonepine Capital Management, LLC 68,688 $313K 0.27% new 13F-HR Timeline Regency Capital Management Inc.\DE More: the full row for Regency Capital Management Inc.\DE 68,000 $309K 0.14% +22,000 13F-HR Timeline HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 67,663 $307K <0.01% new 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 67,015 $305K <0.01% +64,829 13F-HR Timeline Group Palogic Value Management, L.P. More: the full row for Palogic Value Management, L.P. 65,000 $296K 0.13% new 13F-HR Timeline Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 61,313 $279K <0.01% new 13F-HR Timeline Group BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 42,065 $191K <0.01% 0 13F-HR Timeline Empowered Funds, LLC More: the full row for Empowered Funds, LLC 42,065 $191K <0.01% 0 13F-HR/A Timeline MANGROVE PARTNERS IM, LLC More: the full row for MANGROVE PARTNERS IM, LLC 41,717 $190K 0.02% new 13F-HR Timeline OMERS ADMINISTRATION Corp More: the full row for OMERS ADMINISTRATION Corp 41,600 $189K <0.01% -46,300 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 39,522 $180K <0.01% +10,857 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 35,000 $159K <0.01% new 13F-HR Timeline Group CAPTRUST FINANCIAL ADVISORS More: the full row for CAPTRUST FINANCIAL ADVISORS 32,000 $146K <0.01% 0 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 28,741 $131K <0.01% new 13F-HR Timeline Group nVerses Capital, LLC More: the full row for nVerses Capital, LLC 28,564 $130K 0.12% new 13F-HR Timeline Miller Financial Services LLC More: the full row for Miller Financial Services LLC 22,000 $100K 0.11% +12,000 13F-HR Timeline RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 19,508 $88.8K <0.01% -1,000 13F-HR Timeline Group Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 17,919 $81.5K 0.03% new 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 16,704 $76K <0.01% -7,033 13F-HR Timeline Group JAMES INVESTMENT RESEARCH, INC. More: the full row for JAMES INVESTMENT RESEARCH, INC. 16,364 $74.5K 0.01% 0 13F-HR Timeline NewEdge Advisors, LLC More: the full row for NewEdge Advisors, LLC 16,364 $74.5K <0.01% 0 13F-HR/A Timeline Bedel Financial Consulting, Inc. More: the full row for Bedel Financial Consulting, Inc. 15,000 $68.2K 0.01% 0 13F-HR Timeline KESTRA PRIVATE WEALTH SERVICES, LLC in group Kestra Advisory Services, LLC More: the full row for KESTRA PRIVATE WEALTH SERVICES, LLC 12,800 $58.2K <0.01% -3,200 13F-HR Timeline Group BLAIR WILLIAM & CO/IL More: the full row for BLAIR WILLIAM & CO/IL 12,466 $56.7K <0.01% -15,000 13F-HR Timeline Stokes Family Office, LLC More: the full row for Stokes Family Office, LLC 12,120 $55.1K 0.01% 0 13F-HR Timeline SANDERS MORRIS HARRIS LLC More: the full row for SANDERS MORRIS HARRIS LLC 12,000 $54.6K 0.01% new 13F-HR Timeline First City Capital Management, Inc. More: the full row for First City Capital Management, Inc. 11,836 $53.9K 0.03% 0 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 10,594 $48.2K <0.01% new 13F-HR Timeline Annandale Capital, LLC More: the full row for Annandale Capital, LLC 10,000 $46K 0.01% 0 13F-HR Timeline Reliant Investment Partners, LLC More: the full row for Reliant Investment Partners, LLC 10,000 $45.5K 0.04% 0 13F-HR Timeline Hilton Head Capital Partners, LLC More: the full row for Hilton Head Capital Partners, LLC 4,472 $20.3K 0.01% 0 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 3,785 $17.2K <0.01% -238,086 13F-HR/A Timeline Group Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 2,300 $10.8K <0.01% new 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 2,200 $10K <0.01% -11,700 13F-HR Timeline Group NATIONAL BANK OF CANADA /FI/ in group NATIONAL BANK OF CANADA /FI/ More: the full row for NATIONAL BANK OF CANADA /FI/ 2,014 $9.14K <0.01% 0 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 1,900 $8.64K <0.01% 0 13F-HR Timeline Group INTERNATIONAL ASSETS INVESTMENT MANAGEM… More: the full row for INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC 521 $2.44K <0.01% 0 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 530 $2.41K <0.01% -2,044 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 8 $36 <0.01% new 13F-HR Timeline Group Allworth Financial LP More: the full row for Allworth Financial LP 5 $23 <0.01% 0 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 5 $0 0% -294 13F-HR Timeline Group Value filed as zero, left out of ratios.