RTW INVESTMENTS, LP More: the full row for RTW INVESTMENTS, LP 4,869,798 $147M 1.46% 0 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 4,829,154 $146M 0.01% +289,929 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 4,706,168 $142M 0.03% +12,525 13F-HR Timeline Group PRIMECAP MANAGEMENT CO/CA/ More: the full row for PRIMECAP MANAGEMENT CO/CA/ 3,693,241 $111M 0.09% -268,639 13F-HR Timeline Bellevue Group AG in group Bellevue Group AG More: the full row for Bellevue Group AG 2,796,803 $84.3M 2.01% 0 13F-HR Timeline Group Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 2,766,868 $83.4M 2.33% +2,181,868 13F-HR Timeline TANG CAPITAL MANAGEMENT LLC in group TANG CAPITAL MANAGEMENT LLC More: the full row for TANG CAPITAL MANAGEMENT LLC 2,649,368 $79.9M 4.06% +20,830 13F-HR Timeline Group Deep Track Capital, LP More: the full row for Deep Track Capital, LP 1,931,884 $58.2M 1.2% -72,094 13F-HR Timeline T. Rowe Price Investment Management, In… More: the full row for T. Rowe Price Investment Management, Inc. 1,891,600 $57M 0.04% -4,069,627 13F-HR Timeline Logos Global Management LP More: the full row for Logos Global Management LP 1,500,000 $45.2M 2.33% +650,000 13F-HR Timeline BVF INC/IL in group BVF INC/IL More: the full row for BVF INC/IL 1,294,463 $39M 1.24% -194,512 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 1,237,403 $37.3M 0.03% +325,806 13F-HR Timeline Group ARMISTICE CAPITAL, LLC More: the full row for ARMISTICE CAPITAL, LLC 1,188,000 $35.8M 1.18% +90,000 13F-HR Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 1,102,271 $33.2M 0.06% +598,120 13F-HR Timeline Group Fiera Capital Corp in group Fiera Capital Corp More: the full row for Fiera Capital Corp 1,080,099 $32.6M 0.11% +35,268 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 1,021,265 $30.8M 0.03% +661,972 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 919,332 $27.7M <0.01% -49,452 13F-HR Timeline Kynam Capital Management, LP More: the full row for Kynam Capital Management, LP 884,937 $26.7M 1.69% +28,475 13F-HR Timeline BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 734,397 $22.1M 0.13% -1,588,259 13F-HR Timeline Group Trails Edge Capital Partners, LP More: the full row for Trails Edge Capital Partners, LP 682,597 $20.6M 4.84% 0 13F-HR Timeline Caption Management, LLC More: the full row for Caption Management, LLC 661,786 $20M 0.95% +567,402 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 656,309 $19.8M <0.01% +327,210 13F-HR Timeline Group Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 633,174 $19.1M 0.11% +249,616 13F-HR Timeline Group JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 594,712 $17.9M 0.01% +140,308 13F-HR/A Timeline Group PRINCIPAL FINANCIAL GROUP INC in group PRINCIPAL FINANCIAL GROUP INC More: the full row for PRINCIPAL FINANCIAL GROUP INC 519,130 $15.7M 0.01% -139,306 13F-HR Timeline Group ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 501,091 $15.1M 0.02% +39,261 13F-HR Timeline Group Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 484,782 $14.6M 0.38% +100,000 13F-HR Timeline MASSACHUSETTS FINANCIAL SERVICES CO /MA/ in group MASSACHUSETTS FINANCIAL SERVI… More: the full row for MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 407,373 $12.3M <0.01% -31 13F-HR Timeline Group D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 335,191 $10.1M 0.01% +151,251 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 323,606 $9.76M <0.01% +36,481 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 316,762 $9.55M 0.04% +77 13F-HR/A Timeline Candriam S.C.A. More: the full row for Candriam S.C.A. 269,729 $8.13M 0.04% 0 13F-HR Timeline CANTOR FITZGERALD, L. P. in group CANTOR FITZGERALD, L. P. More: the full row for CANTOR FITZGERALD, L. P. 250,211 $7.54M 0.27% new 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 230,399 $6.95M <0.01% -3,869 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 211,140 $6.37M 0.01% 0 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 206,866 $6.24M <0.01% -27,871 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 204,368 $6.16M 0.01% +103,428 13F-HR Timeline Group MOORE CAPITAL MANAGEMENT, LP More: the full row for MOORE CAPITAL MANAGEMENT, LP 197,308 $5.95M 0.22% new 13F-HR Timeline DIADEMA PARTNERS LP More: the full row for DIADEMA PARTNERS LP 193,189 $5.82M 2.41% +122,889 13F-HR Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 180,340 $5.44M 0.01% +119,177 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 164,000 $4.94M 0.01% +23,100 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 156,143 $4.7M <0.01% +6,810 13F-HR Timeline Group TD Asset Management Inc More: the full row for TD Asset Management Inc 135,828 $4.1M <0.01% -156,936 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 119,497 $3.6M <0.01% +87,107 13F-HR Timeline Group Aberdeen Group plc in group Aberdeen Group plc More: the full row for Aberdeen Group plc 116,857 $3.52M 0.01% new 13F-HR Timeline Group J. Goldman & Co LP More: the full row for J. Goldman & Co LP 114,749 $3.46M 0.16% new 13F-HR Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 113,844 $3.43M 0.01% new 13F-HR Timeline Group LORD, ABBETT & CO. LLC More: the full row for LORD, ABBETT & CO. LLC 100,784 $3.04M 0.01% new 13F-HR Timeline Integral Health Asset Management, LLC More: the full row for Integral Health Asset Management, LLC 100,000 $3.02M 0.16% new 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 97,940 $2.95M <0.01% +4,384 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 96,106 $2.9M 0.05% +74,115 13F-HR Timeline Group BNP PARIBAS ASSET MANAGEMENT Holding S.… in group BNP PARIBAS ASSET MANAGEMENT … More: the full row for BNP PARIBAS ASSET MANAGEMENT Holding S.A. 94,936 $2.86M <0.01% -968 13F-HR Timeline Group Rhenman & Partners Asset Management AB More: the full row for Rhenman & Partners Asset Management AB 85,724 $2.58M 0.32% -67,554 13F-HR Timeline Catalio Capital Management, LP More: the full row for Catalio Capital Management, LP 84,352 $2.54M 0.53% new 13F-HR Timeline Eschler Asset Management LLP in group Eschler Asset Management LLP More: the full row for Eschler Asset Management LLP 80,000 $2.41M 2.4% 0 13F-HR Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 76,519 $2.31M <0.01% -8,650 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 75,473 $2.28M <0.01% -1,755 13F-HR/A Timeline Group STEMPOINT CAPITAL LP More: the full row for STEMPOINT CAPITAL LP 63,543 $1.92M 0.37% new 13F-HR/A Timeline HUSSMAN STRATEGIC ADVISORS, INC. More: the full row for HUSSMAN STRATEGIC ADVISORS, INC. 63,000 $1.9M 0.41% +21,000 13F-HR Timeline SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 61,260 $1.85M <0.01% +10,923 13F-HR Timeline Group HighVista Strategies LLC More: the full row for HighVista Strategies LLC 58,697 $1.77M 0.49% +25,699 13F-HR Timeline Elmind Capital, LP More: the full row for Elmind Capital, LP 58,248 $1.76M 0.5% 0 13F-HR Timeline ENVESTNET ASSET MANAGEMENT INC in group ENVESTNET ASSET MANAGEMENT INC More: the full row for ENVESTNET ASSET MANAGEMENT INC 56,825 $1.71M <0.01% +1,635 13F-HR Timeline Group Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 48,962 $1.48M 0.57% +21,030 13F-HR Timeline Hennion & Walsh Asset Management, Inc. More: the full row for Hennion & Walsh Asset Management, Inc. 47,127 $1.42M 0.05% -1,458 13F-HR Timeline Eagle Health Investments LP More: the full row for Eagle Health Investments LP 46,300 $1.4M 0.29% 0 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 44,714 $1.35M <0.01% +2,228 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 42,882 $1.29M <0.01% -144 13F-HR Timeline Group UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 42,319 $1.28M +35,101 Timeline SCHRODER INVESTMENT MANAGEMENT GROUP More: the full row for SCHRODER INVESTMENT MANAGEMENT GROUP 42,920 $1.26M <0.01% -66,929 13F-HR Timeline ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 41,261 $1.24M 0.01% -226 13F-HR Timeline Group ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 40,279 $1.21M 0.01% new 13F-HR Timeline Eversept Partners, LP More: the full row for Eversept Partners, LP 39,238 $1.18M 0.08% new 13F-HR Timeline Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 38,498 $1.16M 0.02% -22,652 13F-HR Timeline Group Crossmark Global Holdings, Inc. More: the full row for Crossmark Global Holdings, Inc. 36,457 $1.1M 0.02% +51 13F-HR Timeline Y-Intercept (Hong Kong) Ltd More: the full row for Y-Intercept (Hong Kong) Ltd 34,927 $1.05M 0.02% -13,260 13F-HR Timeline COMMONWEALTH OF PENNSYLVANIA PUBLIC SCH… More: the full row for COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS 31,674 $955K <0.01% +23,494 13F-HR Timeline PUBLIC EMPLOYEES RETIREMENT SYSTEM OF O… More: the full row for PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO 31,253 $942K <0.01% +6,090 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 30,909 $932K <0.01% -72,344 13F-HR Timeline Group Tidal Investments LLC in group Tidal Investments LLC More: the full row for Tidal Investments LLC 30,651 $924K <0.01% new 13F-HR Timeline Group ASSETMARK, INC in group ASSETMARK, INC More: the full row for ASSETMARK, INC 28,387 $856K <0.01% -3,289 13F-HR Timeline Group State of New Jersey Common Pension Fund… in group State of New Jersey Common Pe… More: the full row for State of New Jersey Common Pension Fund D 27,663 $834K <0.01% 0 13F-HR Timeline Group Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 22,940 $692K 0.19% +4,371 13F-HR Timeline Group HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 22,861 $689K <0.01% -9,735 13F-HR Timeline Trexquant Investment LP More: the full row for Trexquant Investment LP 20,685 $624K <0.01% new 13F-HR Timeline Orion Porfolio Solutions, LLC More: the full row for Orion Porfolio Solutions, LLC 20,524 $619K 0.01% -1,476 13F-HR Timeline VOLORIDGE INVESTMENT MANAGEMENT, LLC More: the full row for VOLORIDGE INVESTMENT MANAGEMENT, LLC 19,492 $588K <0.01% -8,672 13F-HR Timeline Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 19,254 $581K 0.01% -19,354 13F-HR Timeline Group Bridgewater Associates, LP More: the full row for Bridgewater Associates, LP 18,930 $571K <0.01% +8,978 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 16,936 $511K <0.01% -3,246 13F-HR Timeline Group Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 16,420 $482K <0.01% new 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 15,434 $465K <0.01% +46 13F-HR Timeline Group PSP Research LLC More: the full row for PSP Research LLC 15,141 $457K 0.32% +717 13F-HR Timeline Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 13,892 $419K 0.01% new 13F-HR Timeline STIFEL FINANCIAL CORP in group STIFEL FINANCIAL CORP More: the full row for STIFEL FINANCIAL CORP 11,222 $338K <0.01% -439 13F-HR Timeline Group China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 10,783 $325K 0.02% -4,326 13F-HR Timeline TrinityBridge Ltd More: the full row for TrinityBridge Ltd 10,100 $304K 0.01% new 13F-HR Timeline Entropy Technologies, LP More: the full row for Entropy Technologies, LP 10,020 $302K 0.01% new 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 8,622 $260K -54,173 Timeline Federation des caisses Desjardins du Qu… More: the full row for Federation des caisses Desjardins du Quebec 8,312 $251K <0.01% +2,834 13F-HR Timeline Alta Wealth Advisors LLC More: the full row for Alta Wealth Advisors LLC 8,255 $249K 0.08% new 13F-HR Timeline Snowden Capital Advisors LLC More: the full row for Snowden Capital Advisors LLC 7,430 $224K 0.01% +460 13F-HR Timeline SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 7,078 $213K <0.01% -1,581 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 4,517 $136K <0.01% -2,383 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 3,521 $103K <0.01% -178 13F-HR/A Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 3,097 $93.4K <0.01% +225 13F-HR Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 2,749 $82.9K <0.01% 0 13F-HR Timeline JTC Employer Solutions Trustee Ltd More: the full row for JTC Employer Solutions Trustee Ltd 2,658 $80K 0.01% 0 13F-HR Timeline Mirae Asset Global Investments Co., Ltd. in group Mirae Asset Global Investment… More: the full row for Mirae Asset Global Investments Co., Ltd. 2,288 $69K <0.01% +168 13F-HR/A Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 2,022 $61K <0.01% 0 13F-HR Timeline Group OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 1,524 $45.9K <0.01% +123 13F-HR Timeline Group SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 1,451 $43.7K <0.01% new 13F-HR Timeline Aquatic Capital Management LLC More: the full row for Aquatic Capital Management LLC 1,122 $33.8K <0.01% -23,853 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 980 $29.5K <0.01% +123 13F-HR Timeline Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 917 $27.6K <0.01% +38 13F-HR/A Timeline Leonteq Securities AG More: the full row for Leonteq Securities AG 804 $24.2K <0.01% -69 13F-HR Timeline MAI Capital Management More: the full row for MAI Capital Management 742 $22.4K <0.01% 0 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 634 $19.1K <0.01% -242 13F-HR Timeline Arax Advisory Partners More: the full row for Arax Advisory Partners 544 $16.4K <0.01% -842 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 438 $13.2K <0.01% -1,435 13F-HR Timeline Group US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 264 $7.96K <0.01% 0 13F-HR Timeline Group J.Safra Asset Management Corp More: the full row for J.Safra Asset Management Corp 227 $6.84K <0.01% +152 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 183 $5.52K <0.01% new 13F-HR/A Timeline Group Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 107 $3.24K <0.01% -124 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 103 $3.1K <0.01% 0 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 100 $3.02K <0.01% 0 13F-HR Timeline Steward Partners Investment Advisory, L… More: the full row for Steward Partners Investment Advisory, LLC 100 $3.02K <0.01% 0 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 86 $2.59K <0.01% 0 13F-HR Timeline Larson Financial Group LLC More: the full row for Larson Financial Group LLC 63 $1.9K <0.01% +53 13F-HR Timeline WEBSTER BANK, N. A. More: the full row for WEBSTER BANK, N. A. 51 $1.54K <0.01% 0 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 42 $1.27K <0.01% -441 13F-HR Timeline BESSEMER GROUP INC in group BESSEMER GROUP INC More: the full row for BESSEMER GROUP INC 46 $1K <0.01% new 13F-HR Timeline Group CVA Family Office, LLC More: the full row for CVA Family Office, LLC 32 $965 <0.01% new 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 30 $905 <0.01% 0 13F-HR Timeline Group CoreCap Advisors, LLC More: the full row for CoreCap Advisors, LLC 27 $814 <0.01% 0 13F-HR Timeline Park Place Capital Corp More: the full row for Park Place Capital Corp 26 $784 <0.01% 0 13F-HR Timeline Cornerstone Financial Management LLC More: the full row for Cornerstone Financial Management LLC 17 $513 <0.01% 0 13F-HR/A Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 16 $482 <0.01% -75 13F-HR Timeline Group Elequin Capital, LP More: the full row for Elequin Capital, LP 10 $302 <0.01% -27 13F-HR Timeline Rockefeller Capital Management L.P. in group Rockefeller Capital Managemen… More: the full row for Rockefeller Capital Management L.P. 8 $241 <0.01% -1,351 13F-HR Timeline Group Godfrey Financial Associates, Inc. More: the full row for Godfrey Financial Associates, Inc. 6 $181 <0.01% 0 13F-HR Timeline