T. Rowe Price Investment Management, In… More: the full row for T. Rowe Price Investment Management, Inc. 7,051,818 $209M 0.14% +351,610 13F-HR Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 6,131,720 $182M 0.03% -485,335 13F-HR Timeline Group RTW INVESTMENTS, LP More: the full row for RTW INVESTMENTS, LP 4,869,798 $144M 2.21% 0 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 4,840,496 $144M 0.01% +22,797 13F-HR Timeline Group PRIMECAP MANAGEMENT CO/CA/ More: the full row for PRIMECAP MANAGEMENT CO/CA/ 2,678,650 $79.5M 0.07% +10,100 13F-HR Timeline BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 2,322,656 $68.9M 0.76% +807,338 13F-HR Timeline Group TANG CAPITAL MANAGEMENT LLC in group TANG CAPITAL MANAGEMENT LLC More: the full row for TANG CAPITAL MANAGEMENT LLC 1,915,708 $56.8M 3.14% +360,108 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 1,887,940 $56M 0.01% -299,590 13F-HR Timeline Kynam Capital Management, LP More: the full row for Kynam Capital Management, LP 1,695,576 $50.3M 4.3% +470,000 13F-HR Timeline Deep Track Capital, LP More: the full row for Deep Track Capital, LP 1,411,402 $41.9M 1.36% +892,026 13F-HR Timeline GENERAL ATLANTIC, L.P. More: the full row for GENERAL ATLANTIC, L.P. 1,261,684 $37.4M 1.26% 0 13F-HR Timeline Bellevue Group AG in group Bellevue Group AG More: the full row for Bellevue Group AG 1,221,794 $36.3M 0.81% +16,330 13F-HR Timeline Group ARMISTICE CAPITAL, LLC More: the full row for ARMISTICE CAPITAL, LLC 978,000 $29M 0.78% -222,000 13F-HR Timeline TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 828,764 $24.6M -166,936 Timeline Fiera Capital Corp in group Fiera Capital Corp More: the full row for Fiera Capital Corp 805,150 $23.9M 0.09% +25,186 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 639,288 $19M 0.01% +6,344 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 628,292 $18.6M 0.05% +224,988 13F-HR/A Timeline Group PRINCIPAL FINANCIAL GROUP INC group of 2 filers holding More: the full row for PRINCIPAL FINANCIAL GROUP INC 478,960 $14.2M -23,993 Timeline MASSACHUSETTS FINANCIAL SERVICES CO /MA/ in group MASSACHUSETTS FINANCIAL SERVI… More: the full row for MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 460,751 $13.7M <0.01% +1,706 13F-HR Timeline Group Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 395,334 $11.7M 0.07% +70,034 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 328,245 $9.74M 0.06% +186 13F-HR Timeline Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 301,170 $8.94M 0.41% +192,408 13F-HR Timeline TD Asset Management Inc More: the full row for TD Asset Management Inc 295,854 $8.78M 0.01% -21,622 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 295,408 $8.76M <0.01% +105,831 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 285,270 $8.46M 0.01% -288,092 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 225,545 $6.69M <0.01% -47,235 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 202,806 $6.02M 0.01% 0 13F-HR/A Timeline UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 179,032 $5.31M +38,326 Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 173,861 $5.16M <0.01% +43,220 13F-HR Timeline Group BNP PARIBAS ASSET MANAGEMENT Holding S.… in group BNP PARIBAS ASSET MANAGEMENT … More: the full row for BNP PARIBAS ASSET MANAGEMENT Holding S.A. 161,292 $4.79M 0.01% 0 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 141,675 $4.2M <0.01% +4,800 13F-HR Timeline Group Candriam S.C.A. More: the full row for Candriam S.C.A. 134,785 $4M 0.03% 0 13F-HR Timeline Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 110,101 $3.27M 0.06% -54,899 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 107,090 $3.18M <0.01% +86,465 13F-HR/A Timeline Group CANTOR FITZGERALD, L. P. in group CANTOR FITZGERALD, L. P. More: the full row for CANTOR FITZGERALD, L. P. 100,000 $2.97M 0.11% new 13F-HR Timeline Group DIADEMA PARTNERS LP More: the full row for DIADEMA PARTNERS LP 96,984 $2.88M 2.3% new 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 94,919 $2.82M <0.01% -19,232 13F-HR Timeline Group AXA S.A. in group AXA S.A. More: the full row for AXA S.A. 94,762 $2.81M 0.01% -124 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 90,570 $2.69M <0.01% -6,000 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 83,670 $2.48M <0.01% +11,735 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 81,159 $2.41M <0.01% +3,894 13F-HR Timeline Group Cubist Systematic Strategies, LLC More: the full row for Cubist Systematic Strategies, LLC 68,629 $2.04M 0.03% -37,971 13F-HR Timeline ENVESTNET ASSET MANAGEMENT INC in group ENVESTNET ASSET MANAGEMENT INC More: the full row for ENVESTNET ASSET MANAGEMENT INC 67,259 $2M <0.01% +735 13F-HR Timeline Group SCHRODER INVESTMENT MANAGEMENT GROUP More: the full row for SCHRODER INVESTMENT MANAGEMENT GROUP 65,539 $1.94M <0.01% 0 13F-HR Timeline Hennion & Walsh Asset Management, Inc. More: the full row for Hennion & Walsh Asset Management, Inc. 62,555 $1.86M 0.08% +12,947 13F-HR Timeline TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 54,493 $1.62M 0.01% new 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 53,636 $1.59M <0.01% -22,034 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 52,662 $1.56M <0.01% -38,723 13F-HR/A Timeline Group Eagle Health Investments LP More: the full row for Eagle Health Investments LP 46,300 $1.37M 0.36% 0 13F-HR Timeline OCONNOR, A Distinct Business Unit of UB… More: the full row for OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 45,196 $1.34M 0.03% -78 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 44,011 $1.31M <0.01% +13,689 13F-HR/A Timeline Group BIT Capital GmbH More: the full row for BIT Capital GmbH 40,787 $1.21M 0.15% -27,053 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 40,321 $1.2M <0.01% -152,794 13F-HR Timeline Group Crossmark Global Holdings, Inc. More: the full row for Crossmark Global Holdings, Inc. 38,147 $1.13M 0.02% +127 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 37,124 $1.1M <0.01% +1,632 13F-HR Timeline Group ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 35,836 $1.06M 0.01% -4,618 13F-HR Timeline Group ASSETMARK, INC in group ASSETMARK, INC More: the full row for ASSETMARK, INC 33,710 $1M <0.01% +1,539 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 31,257 $927K <0.01% -4,782 13F-HR/A Timeline Group Caption Management, LLC More: the full row for Caption Management, LLC 29,393 $872K 0.04% new 13F-HR Timeline Rhenman & Partners Asset Management AB More: the full row for Rhenman & Partners Asset Management AB 28,278 $839K 0.1% -30,000 13F-HR Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 27,882 $827K <0.01% -728 13F-HR Timeline Group Orion Porfolio Solutions, LLC More: the full row for Orion Porfolio Solutions, LLC 22,934 $680K 0.01% +9,917 13F-HR Timeline Orion Portfolio Solutions, LLC More: the full row for Orion Portfolio Solutions, LLC 22,934 $680K 0.01% +9,917 13F-HR/A Timeline Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 22,330 $663K 0.58% new 13F-HR Timeline ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 18,443 $546K <0.01% -22,108 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 18,192 $540K 0.03% -704 13F-HR Timeline Group CAPSTONE INVESTMENT ADVISORS, LLC in group CAPSTONE INVESTMENT ADVISORS,… More: the full row for CAPSTONE INVESTMENT ADVISORS, LLC 17,200 $510K <0.01% 0 13F-HR Timeline Group STIFEL FINANCIAL CORP in group STIFEL FINANCIAL CORP More: the full row for STIFEL FINANCIAL CORP 16,890 $501K <0.01% +1,169 13F-HR Timeline Group NEOS Investment Management LLC More: the full row for NEOS Investment Management LLC 15,428 $458K 0.01% +4,234 13F-HR Timeline Tema ETFs LLC More: the full row for Tema ETFs LLC 15,428 $458K 0.14% +4,234 13F-HR Timeline DekaBank Deutsche Girozentrale More: the full row for DekaBank Deutsche Girozentrale 15,000 $434K <0.01% 0 13F-HR Timeline Virtus Investment Advisers, LLC group of 2 filers holding More: the full row for Virtus Investment Advisers, LLC 11,847 $352K +311 Timeline Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 11,669 $346K 0.01% -20,931 13F-HR/A Timeline Group DNB Asset Management AS in group DNB Asset Management AS More: the full row for DNB Asset Management AS 10,853 $322K <0.01% +555 13F-HR Timeline Group SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 10,736 $319K <0.01% new 13F-HR/A Timeline Group Checkpoint Capital L.P. More: the full row for Checkpoint Capital L.P. 9,011 $267K 0.15% new 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 7,947 $236K 0.02% -446 13F-HR Timeline OPPENHEIMER ASSET MANAGEMENT INC. in group OPPENHEIMER ASSET MANAGEMENT … More: the full row for OPPENHEIMER ASSET MANAGEMENT INC. 7,574 $225K <0.01% new 13F-HR Timeline Group Snowden Capital Advisors LLC More: the full row for Snowden Capital Advisors LLC 7,476 $222K 0.01% -197 13F-HR Timeline TD Waterhouse Canada Inc. More: the full row for TD Waterhouse Canada Inc. 7,411 $212K <0.01% +44 13F-HR Timeline EXCHANGE TRADED CONCEPTS, LLC More: the full row for EXCHANGE TRADED CONCEPTS, LLC 4,241 $126K <0.01% -834 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 3,205 $95.1K <0.01% -443 13F-HR Timeline Group IFP Advisors, Inc More: the full row for IFP Advisors, Inc 2,798 $83K <0.01% -136 13F-HR Timeline Aquatic Capital Management LLC More: the full row for Aquatic Capital Management LLC 2,709 $80.4K <0.01% +1,309 13F-HR Timeline JTC Employer Solutions Trustee Ltd More: the full row for JTC Employer Solutions Trustee Ltd 2,658 $79K 0.01% 0 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 2,086 $61.9K <0.01% +1,400 13F-HR Timeline Group OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 1,448 $43K <0.01% -257 13F-HR Timeline Group Leonteq Securities AG More: the full row for Leonteq Securities AG 1,327 $39.4K <0.01% +702 13F-HR Timeline Mirae Asset Global Investments Co., Ltd. in group Mirae Asset Global Investment… More: the full row for Mirae Asset Global Investments Co., Ltd. 1,326 $39.2K <0.01% +7 13F-HR Timeline Group GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 1,014 $30.1K <0.01% +183 13F-HR Timeline Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 1,006 $29.8K <0.01% 0 13F-HR Timeline COLDSTREAM CAPITAL MANAGEMENT INC More: the full row for COLDSTREAM CAPITAL MANAGEMENT INC 876 $26K <0.01% new 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 644 $19.1K <0.01% +85 13F-HR/A Timeline First Horizon Advisors, Inc. More: the full row for First Horizon Advisors, Inc. 607 $18K <0.01% 0 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 476 $14.1K <0.01% +61 13F-HR/A Timeline Clearstead Advisors, LLC More: the full row for Clearstead Advisors, LLC 348 $10.3K <0.01% 0 13F-HR Timeline Lowe Wealth Advisors, LLC More: the full row for Lowe Wealth Advisors, LLC 330 $9.79K <0.01% new 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 310 $9.2K <0.01% 0 13F-HR Timeline Group CIBC Private Wealth Group LLC in group CIBC Bancorp USA Inc. More: the full row for CIBC Private Wealth Group LLC 357 $8.76K <0.01% +7 13F-HR Timeline Group CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 168 $5K <0.01% -11 13F-HR Timeline Group Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 138 $4K <0.01% 0 13F-HR Timeline Group Steward Partners Investment Advisory, L… More: the full row for Steward Partners Investment Advisory, LLC 112 $3.32K <0.01% 0 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 109 $3.23K <0.01% 0 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 96 $2.85K <0.01% new 13F-HR Timeline Group JONES FINANCIAL COMPANIES LLLP in group JONES FINANCIAL COMPANIES LLLP More: the full row for JONES FINANCIAL COMPANIES LLLP 78 $2.31K <0.01% 0 13F-HR/A Timeline Group WHITTIER TRUST CO OF NEVADA INC More: the full row for WHITTIER TRUST CO OF NEVADA INC 56 $1.66K <0.01% 0 13F-HR Timeline Continuum Advisory, LLC More: the full row for Continuum Advisory, LLC 47 $1.39K <0.01% 0 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 30 $890 <0.01% 0 13F-HR Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 27 $801 <0.01% new 13F-HR Timeline Park Place Capital Corp More: the full row for Park Place Capital Corp 26 $771 <0.01% new 13F-HR Timeline Bell Investment Advisors, Inc More: the full row for Bell Investment Advisors, Inc 14 $416 <0.01% 0 13F-HR Timeline Larson Financial Group LLC More: the full row for Larson Financial Group LLC 10 $297 <0.01% 0 13F-HR Timeline Blue Trust, Inc. More: the full row for Blue Trust, Inc. 6 $178 <0.01% 0 13F-HR Timeline CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.