T. Rowe Price Investment Management, In… More: the full row for T. Rowe Price Investment Management, Inc. 7,063,896 $257M 0.16% -3,763 13F-HR Timeline RTW INVESTMENTS, LP More: the full row for RTW INVESTMENTS, LP 4,869,798 $177M 2.18% 0 13F-HR Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 4,780,889 $174M 0.03% +567,314 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 4,420,403 $161M 0.01% -435,369 13F-HR Timeline Group PRIMECAP MANAGEMENT CO/CA/ More: the full row for PRIMECAP MANAGEMENT CO/CA/ 3,754,560 $136M 0.1% -16,914 13F-HR Timeline Bellevue Group AG in group Bellevue Group AG More: the full row for Bellevue Group AG 2,796,803 $102M 2.11% +354,973 13F-HR Timeline Group BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 2,322,656 $84.4M 0.61% 0 13F-HR Timeline Group TANG CAPITAL MANAGEMENT LLC in group TANG CAPITAL MANAGEMENT LLC More: the full row for TANG CAPITAL MANAGEMENT LLC 2,305,608 $83.8M 3.22% +200,000 13F-HR Timeline Group Deep Track Capital, LP More: the full row for Deep Track Capital, LP 1,800,000 $65.4M 1.82% 0 13F-HR Timeline BVF INC/IL in group BVF INC/IL More: the full row for BVF INC/IL 1,574,288 $57.2M 2.32% +550,000 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 1,265,965 $46M 0.04% +989,463 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 1,016,771 $36.9M <0.01% +11,179 13F-HR Timeline Kynam Capital Management, LP More: the full row for Kynam Capital Management, LP 1,009,267 $36.7M 2.73% +33,000 13F-HR Timeline Logos Global Management LP More: the full row for Logos Global Management LP 850,000 $30.9M 3.05% +275,000 13F-HR Timeline ARMISTICE CAPITAL, LLC More: the full row for ARMISTICE CAPITAL, LLC 824,000 $29.9M 0.94% +146,000 13F-HR Timeline Fiera Capital Corp in group Fiera Capital Corp More: the full row for Fiera Capital Corp 795,157 $28.9M 0.09% -17,917 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 550,696 $20M -394,799 Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 535,831 $19.5M 0.04% -284,594 13F-HR Timeline Group Caption Management, LLC More: the full row for Caption Management, LLC 463,662 $16.8M 0.98% +284,159 13F-HR Timeline MASSACHUSETTS FINANCIAL SERVICES CO /MA/ in group MASSACHUSETTS FINANCIAL SERVI… More: the full row for MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 442,398 $16.1M <0.01% -3,369 13F-HR Timeline Group PRINCIPAL FINANCIAL GROUP INC group of 2 filers holding More: the full row for PRINCIPAL FINANCIAL GROUP INC 411,525 $15M -43,510 Timeline Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 384,782 $14M 0.42% 0 13F-HR Timeline Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 333,558 $12.1M 0.07% -12,394 13F-HR/A Timeline Group TD Asset Management Inc More: the full row for TD Asset Management Inc 288,860 $10.5M 0.01% +2,596 13F-HR Timeline Candriam S.C.A. More: the full row for Candriam S.C.A. 269,729 $9.8M 0.05% +134,950 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 269,204 $9.78M <0.01% +31,325 13F-HR/A Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 245,205 $8.91M <0.01% +23,826 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 225,310 $8.19M 0.01% -409,191 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 211,825 $7.7M <0.01% +18,625 13F-HR/A Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 211,140 $7.67M 0.01% +8,334 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 207,438 $7.54M 0.04% -39,060 13F-HR Timeline ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 199,497 $7.24M 0.01% +108,699 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 142,770 $5.19M 0.01% -79,282 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 125,756 $4.56M <0.01% +2,517 13F-HR Timeline Group DIADEMA PARTNERS LP More: the full row for DIADEMA PARTNERS LP 124,384 $4.52M 3.15% +20,000 13F-HR Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 123,242 $4.48M <0.01% -23,368 13F-HR Timeline Group SCHRODER INVESTMENT MANAGEMENT GROUP More: the full row for SCHRODER INVESTMENT MANAGEMENT GROUP 109,849 $3.99M <0.01% 0 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 107,043 $3.89M <0.01% +181 13F-HR/A Timeline Group Trexquant Investment LP More: the full row for Trexquant Investment LP 100,580 $3.65M 0.04% +81,291 13F-HR Timeline AXA Investment Managers S.A. More: the full row for AXA Investment Managers S.A. 95,172 $3.46M 0.01% 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 91,233 $3.31M <0.01% +9,091 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 83,681 $3.04M <0.01% +2,920 13F-HR Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 78,877 $2.87M <0.01% -3,861 13F-HR Timeline Group Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 71,030 $2.58M 0.03% +9,384 13F-HR/A Timeline Group Cubist Systematic Strategies, LLC More: the full row for Cubist Systematic Strategies, LLC 68,572 $2.49M 0.04% -74,185 13F-HR Timeline Hennion & Walsh Asset Management, Inc. More: the full row for Hennion & Walsh Asset Management, Inc. 62,662 $2.28M 0.08% -4,118 13F-HR Timeline ENVESTNET ASSET MANAGEMENT INC in group ENVESTNET ASSET MANAGEMENT INC More: the full row for ENVESTNET ASSET MANAGEMENT INC 60,435 $2.2M <0.01% -2,852 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 58,977 $2.14M <0.01% +14,021 13F-HR Timeline Group Eagle Health Investments LP More: the full row for Eagle Health Investments LP 46,300 $1.68M 0.44% 0 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 45,969 $1.67M <0.01% -6,032 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 45,657 $1.66M <0.01% -909 13F-HR Timeline Group Y-Intercept (Hong Kong) Ltd More: the full row for Y-Intercept (Hong Kong) Ltd 45,331 $1.65M 0.04% -6,332 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 42,198 $1.53M <0.01% -162,019 13F-HR Timeline Group UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 41,234 $1.5M +12,232 Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 40,270 $1.46M <0.01% -141,909 13F-HR Timeline Group Eschler Asset Management LLP in group Eschler Asset Management LLP More: the full row for Eschler Asset Management LLP 40,000 $1.45M 1.08% 0 13F-HR Timeline Group Crossmark Global Holdings, Inc. More: the full row for Crossmark Global Holdings, Inc. 36,348 $1.32M 0.02% +3 13F-HR Timeline SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 34,985 $1.27M <0.01% +3,651 13F-HR Timeline Group ASSETMARK, INC in group ASSETMARK, INC More: the full row for ASSETMARK, INC 34,069 $1.24M <0.01% -889 13F-HR Timeline Group Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 28,615 $1.04M 0.75% +4,577 13F-HR/A Timeline Rhenman & Partners Asset Management AB More: the full row for Rhenman & Partners Asset Management AB 28,278 $1.03M 0.11% 0 13F-HR Timeline State of New Jersey Common Pension Fund… in group State of New Jersey Common Pe… More: the full row for State of New Jersey Common Pension Fund D 25,886 $940K <0.01% +16,591 13F-HR Timeline Group PUBLIC EMPLOYEES RETIREMENT SYSTEM OF O… More: the full row for PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO 25,163 $914K <0.01% new 13F-HR Timeline ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 24,339 $884K <0.01% -2,737 13F-HR Timeline Group Orion Porfolio Solutions, LLC More: the full row for Orion Porfolio Solutions, LLC 23,276 $846K 0.01% -689 13F-HR Timeline NEOS Investment Management LLC More: the full row for NEOS Investment Management LLC 21,370 $776K 0.01% -836 13F-HR Timeline Tema ETFs LLC More: the full row for Tema ETFs LLC 21,370 $776K 0.06% -836 13F-HR Timeline TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 21,139 $768K <0.01% 0 13F-HR/A Timeline Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 20,864 $758K 0.01% +6,104 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 20,731 $753K +11,837 Timeline Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 19,922 $724K 0.01% new 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 19,737 $717K <0.01% -18,439 13F-HR Timeline Group Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 19,013 $690K 0.01% +4,038 13F-HR Timeline Group CAPSTONE INVESTMENT ADVISORS, LLC in group CAPSTONE INVESTMENT ADVISORS,… More: the full row for CAPSTONE INVESTMENT ADVISORS, LLC 17,200 $625K 0.01% 0 13F-HR Timeline Group STIFEL FINANCIAL CORP in group STIFEL FINANCIAL CORP More: the full row for STIFEL FINANCIAL CORP 13,986 $508K <0.01% -2,844 13F-HR Timeline Group DekaBank Deutsche Girozentrale More: the full row for DekaBank Deutsche Girozentrale 15,000 $508K <0.01% 0 13F-HR Timeline Graham Capital Management, L.P. More: the full row for Graham Capital Management, L.P. 13,125 $477K 0.02% -1,571 13F-HR Timeline Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 12,472 $453K 0.13% 0 13F-HR Timeline Group OXFORD ASSET MANAGEMENT LLP More: the full row for OXFORD ASSET MANAGEMENT LLP 11,354 $412K 0.14% -9,704 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 8,796 $319K <0.01% -6,248 13F-HR Timeline R Squared Ltd More: the full row for R Squared Ltd 8,243 $299K 0.13% new 13F-HR Timeline COMMONWEALTH OF PENNSYLVANIA PUBLIC SCH… More: the full row for COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS 8,180 $297K <0.01% new 13F-HR Timeline DNB Asset Management AS in group DNB Asset Management AS More: the full row for DNB Asset Management AS 8,116 $295K <0.01% +488 13F-HR Timeline Group SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 7,592 $276K <0.01% +4,325 13F-HR Timeline Snowden Capital Advisors LLC More: the full row for Snowden Capital Advisors LLC 7,548 $274K 0.01% -126 13F-HR Timeline EntryPoint Capital, LLC More: the full row for EntryPoint Capital, LLC 7,321 $266K 0.1% new 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 7,021 $255K 0.02% -961 13F-HR Timeline OPPENHEIMER ASSET MANAGEMENT INC. in group OPPENHEIMER ASSET MANAGEMENT … More: the full row for OPPENHEIMER ASSET MANAGEMENT INC. 6,934 $252K <0.01% -101 13F-HR Timeline Group LAZARD ASSET MANAGEMENT LLC in group LAZARD ASSET MANAGEMENT LLC More: the full row for LAZARD ASSET MANAGEMENT LLC 6,839 $248K <0.01% -82,048 13F-HR Timeline Group Robertson Stephens Wealth Management, L… More: the full row for Robertson Stephens Wealth Management, LLC 6,030 $219K 0.01% new 13F-HR Timeline JT Stratford LLC More: the full row for JT Stratford LLC 5,782 $210K 0.03% new 13F-HR Timeline Point72 Asia (Singapore) Pte. Ltd. More: the full row for Point72 Asia (Singapore) Pte. Ltd. 4,121 $150K 0.02% new 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 3,205 $116K <0.01% +542 13F-HR/A Timeline Group OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 3,295 $114K <0.01% +147 13F-HR Timeline Group IFP Advisors, Inc More: the full row for IFP Advisors, Inc 2,776 $101K <0.01% -6 13F-HR/A Timeline JTC Employer Solutions Trustee Ltd More: the full row for JTC Employer Solutions Trustee Ltd 2,658 $96K 0.01% 0 13F-HR Timeline Federation des caisses Desjardins du Qu… More: the full row for Federation des caisses Desjardins du Quebec 2,090 $75.9K <0.01% new 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 2,022 $73.5K <0.01% new 13F-HR Timeline Group BIT Capital GmbH More: the full row for BIT Capital GmbH 1,771 $64.3K <0.01% -405 13F-HR Timeline Mirae Asset Global Investments Co., Ltd. in group Mirae Asset Global Investment… More: the full row for Mirae Asset Global Investments Co., Ltd. 1,548 $56.2K <0.01% +13 13F-HR Timeline Group State of Tennessee, Department of Treas… More: the full row for State of Tennessee, Department of Treasury 1,227 $44.6K <0.01% -2,987 13F-HR Timeline Leonteq Securities AG More: the full row for Leonteq Securities AG 970 $35.2K <0.01% -301 13F-HR Timeline Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 915 $33.2K <0.01% -91 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 914 $33.2K <0.01% +311 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 862 $31.3K <0.01% -152 13F-HR Timeline HARBOUR INVESTMENTS, INC. More: the full row for HARBOUR INVESTMENTS, INC. 645 $23.4K <0.01% new 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 540 $19.6K <0.01% +94 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 500 $18.2K <0.01% -238 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 371 $13.5K <0.01% new 13F-HR Timeline Group CIBC Private Wealth Group LLC in group CIBC Bancorp USA Inc. More: the full row for CIBC Private Wealth Group LLC 350 $12.7K <0.01% -16 13F-HR Timeline Group Arax Advisory Partners More: the full row for Arax Advisory Partners 344 $12.5K <0.01% +42 13F-HR Timeline Lowe Wealth Advisors, LLC More: the full row for Lowe Wealth Advisors, LLC 330 $12K <0.01% 0 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 264 $9.59K <0.01% 0 13F-HR Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 250 $9.08K 0.01% -1,045 13F-HR Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 138 $5K <0.01% 0 13F-HR Timeline Group SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 103 $3.74K <0.01% -3 13F-HR Timeline Steward Partners Investment Advisory, L… More: the full row for Steward Partners Investment Advisory, LLC 100 $3.63K <0.01% 0 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 86 $3.12K <0.01% new 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 91 $3K <0.01% -21 13F-HR Timeline Group Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 77 $2.8K <0.01% new 13F-HR Timeline J.Safra Asset Management Corp More: the full row for J.Safra Asset Management Corp 75 $2.73K <0.01% 0 13F-HR Timeline Cape Investment Advisory, Inc. More: the full row for Cape Investment Advisory, Inc. 57 $2.07K <0.01% 0 13F-HR Timeline WEBSTER BANK, N. A. More: the full row for WEBSTER BANK, N. A. 51 $1.85K <0.01% 0 13F-HR Timeline Bell Investment Advisors, Inc More: the full row for Bell Investment Advisors, Inc 39 $1.42K <0.01% 0 13F-HR Timeline CVA Family Office, LLC More: the full row for CVA Family Office, LLC 34 $1.24K <0.01% new 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 30 $1.09K <0.01% 0 13F-HR Timeline Group Park Place Capital Corp More: the full row for Park Place Capital Corp 26 $945 <0.01% 0 13F-HR Timeline UMB Bank, n.a. More: the full row for UMB Bank, n.a. 17 $618 <0.01% new 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. Larson Financial Group LLC More: the full row for Larson Financial Group LLC 10 $363 <0.01% 0 13F-HR Timeline