T. Rowe Price Investment Management, In… More: the full row for T. Rowe Price Investment Management, Inc. 6,700,208 $198M 0.12% +200,373 13F-HR Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 6,617,055 $195M 0.04% -431,778 13F-HR Timeline Group RTW INVESTMENTS, LP More: the full row for RTW INVESTMENTS, LP 4,869,798 $144M 2.17% 0 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 4,817,699 $142M 0.01% -18,341 13F-HR Timeline Group PRIMECAP MANAGEMENT CO/CA/ More: the full row for PRIMECAP MANAGEMENT CO/CA/ 2,668,550 $78.7M 0.06% +196,530 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 2,187,530 $64.5M 0.01% +29,832 13F-HR Timeline TANG CAPITAL MANAGEMENT LLC in group TANG CAPITAL MANAGEMENT LLC More: the full row for TANG CAPITAL MANAGEMENT LLC 1,555,600 $45.9M 3.04% +450,000 13F-HR Timeline Group BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 1,515,318 $44.7M 0.48% 0 13F-HR Timeline Group GENERAL ATLANTIC, L.P. More: the full row for GENERAL ATLANTIC, L.P. 1,261,684 $37.2M 1.32% 0 13F-HR Timeline Kynam Capital Management, LP More: the full row for Kynam Capital Management, LP 1,225,576 $36.2M 2.38% new 13F-HR Timeline Bellevue Group AG in group Bellevue Group AG More: the full row for Bellevue Group AG 1,205,464 $35.6M 0.68% 0 13F-HR Timeline Group ARMISTICE CAPITAL, LLC More: the full row for ARMISTICE CAPITAL, LLC 1,200,000 $35.4M 0.82% -64,000 13F-HR Timeline TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 995,700 $29.4M -359,142 Timeline Fiera Capital Corp in group Fiera Capital Corp More: the full row for Fiera Capital Corp 779,964 $23M 0.07% -65,768 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 632,944 $18.7M 0.02% +616,912 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 573,362 $16.9M 0.01% -103,269 13F-HR Timeline Group Deep Track Capital, LP More: the full row for Deep Track Capital, LP 519,376 $15.3M 0.57% new 13F-HR Timeline PRINCIPAL FINANCIAL GROUP INC group of 2 filers holding More: the full row for PRINCIPAL FINANCIAL GROUP INC 502,953 $14.8M -43,437 Timeline MASSACHUSETTS FINANCIAL SERVICES CO /MA/ in group MASSACHUSETTS FINANCIAL SERVI… More: the full row for MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 459,045 $13.5M <0.01% -39,176 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 403,304 $11.9M 0.03% new 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 328,059 $9.68M 0.07% +53,378 13F-HR Timeline Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 325,300 $9.6M 0.06% +78,000 13F-HR Timeline Group TD Asset Management Inc More: the full row for TD Asset Management Inc 317,476 $9.37M 0.01% +4,524 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 272,780 $8.05M <0.01% -600,831 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 202,806 $5.98M 0.01% 0 13F-HR/A Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 193,115 $5.7M <0.01% new 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 189,577 $5.59M <0.01% -95,362 13F-HR Timeline Group Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 165,000 $4.87M 0.05% new 13F-HR/A Timeline Group BNP PARIBAS ASSET MANAGEMENT Holding S.… in group BNP PARIBAS ASSET MANAGEMENT … More: the full row for BNP PARIBAS ASSET MANAGEMENT Holding S.A. 161,292 $4.76M 0.01% -265,860 13F-HR Timeline Group UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 140,706 $4.15M +4,730 Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 136,875 $4.04M <0.01% +20,163 13F-HR Timeline Group Candriam S.C.A. More: the full row for Candriam S.C.A. 134,785 $3.98M 0.02% -5,221 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 130,641 $3.85M <0.01% -274,184 13F-HR/A Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 114,151 $3.37M <0.01% +6,760 13F-HR Timeline Group Polar Capital Holdings Plc in group Polar Capital Holdings Plc More: the full row for Polar Capital Holdings Plc 114,023 $3.36M 0.02% -387,732 13F-HR Timeline Group Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 108,762 $3.21M 0.13% 0 13F-HR Timeline Cubist Systematic Strategies, LLC More: the full row for Cubist Systematic Strategies, LLC 106,600 $3.14M 0.05% new 13F-HR Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 96,570 $2.85M <0.01% -179,630 13F-HR Timeline AXA S.A. in group AXA S.A. More: the full row for AXA S.A. 94,886 $2.8M 0.01% -154 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 91,385 $2.7M <0.01% -80,682 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 77,265 $2.28M <0.01% +594 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 75,670 $2.23M <0.01% +16,562 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 71,935 $2.12M <0.01% -11,120 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 69,954 $2.06M 0.01% -2,114 13F-HR Timeline Group BIT Capital GmbH More: the full row for BIT Capital GmbH 67,840 $2M 0.18% +43,840 13F-HR Timeline ENVESTNET ASSET MANAGEMENT INC in group ENVESTNET ASSET MANAGEMENT INC More: the full row for ENVESTNET ASSET MANAGEMENT INC 66,524 $1.96M <0.01% -6,456 13F-HR Timeline Group SCHRODER INVESTMENT MANAGEMENT GROUP More: the full row for SCHRODER INVESTMENT MANAGEMENT GROUP 65,539 $1.9M <0.01% 0 13F-HR Timeline Rhenman & Partners Asset Management AB More: the full row for Rhenman & Partners Asset Management AB 58,278 $1.72M 0.18% 0 13F-HR Timeline Hennion & Walsh Asset Management, Inc. More: the full row for Hennion & Walsh Asset Management, Inc. 49,608 $1.46M 0.07% +27,598 13F-HR Timeline Eagle Health Investments LP More: the full row for Eagle Health Investments LP 46,300 $1.37M 0.33% 0 13F-HR Timeline OCONNOR, A Distinct Business Unit of UB… More: the full row for OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 45,274 $1.34M 0.03% +10,162 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 40,551 $1.19M <0.01% +39,691 13F-HR Timeline Group ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 40,454 $1.19M 0.01% +2,104 13F-HR Timeline Group Crossmark Global Holdings, Inc. More: the full row for Crossmark Global Holdings, Inc. 38,020 $1.12M 0.02% +10,217 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 36,039 $1.06M <0.01% -190,302 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 35,492 $1.05M <0.01% +420 13F-HR Timeline Group Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 32,600 $962K 0.02% -28,022 13F-HR Timeline Group ASSETMARK, INC in group ASSETMARK, INC More: the full row for ASSETMARK, INC 32,171 $949K <0.01% +1,616 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 30,322 $895K <0.01% -14,648 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 28,610 $844K <0.01% -170,833 13F-HR Timeline Group Crestline Management, L.P. More: the full row for Crestline Management, L.P. 24,960 $736K 0.03% new 13F-HR Timeline Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 23,015 $679K <0.01% -168,526 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 20,625 $608K <0.01% +19,663 13F-HR/A Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 18,896 $557K 0.05% +3,437 13F-HR Timeline Group CAPSTONE INVESTMENT ADVISORS, LLC in group CAPSTONE INVESTMENT ADVISORS,… More: the full row for CAPSTONE INVESTMENT ADVISORS, LLC 17,200 $507K 0.01% -2,195 13F-HR Timeline Group STIFEL FINANCIAL CORP in group STIFEL FINANCIAL CORP More: the full row for STIFEL FINANCIAL CORP 15,721 $464K <0.01% -2,530 13F-HR Timeline Group DekaBank Deutsche Girozentrale More: the full row for DekaBank Deutsche Girozentrale 15,000 $427K <0.01% 0 13F-HR Timeline Orion Porfolio Solutions, LLC More: the full row for Orion Porfolio Solutions, LLC 13,017 $384K <0.01% -7,675 13F-HR Timeline Orion Portfolio Solutions, LLC More: the full row for Orion Portfolio Solutions, LLC 13,017 $384K <0.01% -7,675 13F-HR Timeline VIRTUS ADVISERS, LLC in group Virtus Investment Advisers, L… More: the full row for VIRTUS ADVISERS, LLC 11,536 $340K 0.14% +3,238 13F-HR Timeline Group NEOS Investment Management LLC More: the full row for NEOS Investment Management LLC 11,194 $330K 0.01% +1,102 13F-HR Timeline Tema ETFs LLC More: the full row for Tema ETFs LLC 11,194 $330K 0.14% 13F-HR Timeline Robertson Stephens Wealth Management, L… More: the full row for Robertson Stephens Wealth Management, LLC 11,030 $325K 0.01% 0 13F-HR Timeline Aigen Investment Management, LP More: the full row for Aigen Investment Management, LP 10,704 $316K 0.06% -5,767 13F-HR Timeline DNB Asset Management AS in group DNB Asset Management AS More: the full row for DNB Asset Management AS 10,298 $304K <0.01% -70 13F-HR Timeline Group SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 8,827 $260K <0.01% +27 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 8,393 $248K 0.02% +960 13F-HR Timeline Snowden Capital Advisors LLC More: the full row for Snowden Capital Advisors LLC 7,673 $226K 0.01% -138 13F-HR Timeline TD Waterhouse Canada Inc. More: the full row for TD Waterhouse Canada Inc. 7,367 $217K <0.01% +137 13F-HR Timeline EXCHANGE TRADED CONCEPTS, LLC More: the full row for EXCHANGE TRADED CONCEPTS, LLC 5,075 $150K <0.01% 0 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 3,648 $108K <0.01% -890 13F-HR Timeline Group IFP Advisors, Inc More: the full row for IFP Advisors, Inc 2,934 $86.6K <0.01% +96 13F-HR Timeline JTC Employer Solutions Trustee Ltd More: the full row for JTC Employer Solutions Trustee Ltd 2,658 $77K 0.01% 0 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 1,705 $50.3K <0.01% +328 13F-HR/A Timeline Group Aquatic Capital Management LLC More: the full row for Aquatic Capital Management LLC 1,400 $41.3K <0.01% -9,500 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 1,350 $39K <0.01% +479 13F-HR Timeline Mirae Asset Global Investments Co., Ltd. in group Mirae Asset Global Investment… More: the full row for Mirae Asset Global Investments Co., Ltd. 1,319 $38.5K <0.01% -79 13F-HR Timeline Group Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 1,006 $29.7K <0.01% +9 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 831 $24.5K <0.01% 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 686 $20.2K <0.01% -276 13F-HR Timeline Group Leonteq Securities AG More: the full row for Leonteq Securities AG 625 $18.4K <0.01% -25 13F-HR Timeline First Horizon Advisors, Inc. More: the full row for First Horizon Advisors, Inc. 607 $17.9K <0.01% 0 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 559 $16.5K <0.01% +136 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 415 $12.2K <0.01% 0 13F-HR/A Timeline CIBC Private Wealth Group LLC in group CIBC Bancorp USA Inc. More: the full row for CIBC Private Wealth Group LLC 350 $10.6K <0.01% -150 13F-HR Timeline Group R Squared Ltd More: the full row for R Squared Ltd 350 $10.3K 0.01% 13F-HR Timeline Clearstead Advisors, LLC More: the full row for Clearstead Advisors, LLC 348 $10.3K <0.01% 0 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 310 $9.14K <0.01% -3 13F-HR Timeline Group Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 201 $5.93K <0.01% -43 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 179 $5K <0.01% -932 13F-HR Timeline Group Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 138 $4K <0.01% 0 13F-HR Timeline Group Steward Partners Investment Advisory, L… More: the full row for Steward Partners Investment Advisory, LLC 112 $3.3K <0.01% +12 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 109 $3.22K <0.01% 13F-HR Timeline JONES FINANCIAL COMPANIES LLLP in group JONES FINANCIAL COMPANIES LLLP More: the full row for JONES FINANCIAL COMPANIES LLLP 78 $2.3K <0.01% new 13F-HR Timeline Group Elequin Capital, LP More: the full row for Elequin Capital, LP 73 $2.15K <0.01% +30 13F-HR Timeline WHITTIER TRUST CO OF NEVADA INC More: the full row for WHITTIER TRUST CO OF NEVADA INC 56 $1.65K <0.01% +1 13F-HR Timeline Continuum Advisory, LLC More: the full row for Continuum Advisory, LLC 47 $1.39K <0.01% -20 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 30 $885 <0.01% 0 13F-HR Timeline Group Bell Investment Advisors, Inc More: the full row for Bell Investment Advisors, Inc 14 $413 <0.01% 0 13F-HR Timeline Larson Financial Group LLC More: the full row for Larson Financial Group LLC 10 $295 <0.01% 0 13F-HR Timeline NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO in group NORTHWESTERN MUTUAL INVESTMEN… More: the full row for NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 7 $207 <0.01% new 13F-HR Timeline Group Blue Trust, Inc. More: the full row for Blue Trust, Inc. 6 $177 <0.01% -230 13F-HR/A Timeline J.Safra Asset Management Corp More: the full row for J.Safra Asset Management Corp 5 $145 <0.01% 0 13F-HR Timeline CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.