MONTANOVA CAPITAL, LLC More: the full row for MONTANOVA CAPITAL, LLC 2,841,334 $37.1M 1.01% 0 13F-HR Timeline JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 2,734,836 $35.6M 0.02% +285,857 13F-HR/A Timeline Group JOHNSON & JOHNSON in group JOHNSON & JOHNSON More: the full row for JOHNSON & JOHNSON 1,979,173 $25.8M 3.96% 0 13F-HR Timeline Group FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 1,839,227 $24M 0.01% -40,140 13F-HR Timeline Group Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 1,685,635 $22M 0.04% -157,165 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 1,535,449 $20.1M 0.01% +704,762 13F-HR Timeline Group BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 1,420,838 $18.6M 0.11% 0 13F-HR Timeline Group VANGUARD GROUP INC group of 3 filers holding More: the full row for VANGUARD GROUP INC 1,378,362 $18M new Timeline RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 1,296,012 $16.9M 0.18% -883,699 13F-HR Timeline Group PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 1,255,592 $16.4M 0.32% -209,000 13F-HR/A Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 814,871 $10.6M <0.01% 0 13F-HR Timeline Group Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 807,874 $10.6M 1.51% +525,000 13F-HR Timeline Group GREAT POINT PARTNERS LLC More: the full row for GREAT POINT PARTNERS LLC 800,198 $10.5M 2.56% +198 13F-HR Timeline Longaeva Partners L.P. More: the full row for Longaeva Partners L.P. 732,088 $9.56M 0.46% +262,088 13F-HR Timeline SECTORAL ASSET MANAGEMENT INC More: the full row for SECTORAL ASSET MANAGEMENT INC 727,587 $9.5M 7.87% -73,200 13F-HR Timeline HHLR ADVISORS, LTD. in group HHLR ADVISORS, LTD. More: the full row for HHLR ADVISORS, LTD. 669,337 $8.74M 0.52% 0 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 669,123 $8.74M <0.01% +132,968 13F-HR Timeline Group RED TREE MANAGEMENT, LLC More: the full row for RED TREE MANAGEMENT, LLC 638,158 $8.33M 7.45% 0 13F-HR Timeline Versant Venture Management, LLC More: the full row for Versant Venture Management, LLC 542,628 $7.09M 5.01% 0 13F-HR Timeline Jones Hill Capital LP More: the full row for Jones Hill Capital LP 513,053 $6.7M 1.44% 13F-HR Timeline Boxer Capital Management, LLC in group Boxer Capital Management, LLC More: the full row for Boxer Capital Management, LLC 494,000 $6.45M 0.85% 0 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 371,636 $4.85M 0.01% +105,875 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 350,200 $4.57M <0.01% new 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 307,108 $4.01M <0.01% +201,514 13F-HR Timeline Group SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 301,729 $3.94M 0.46% -5,811 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 282,038 $3.69M <0.01% +68,169 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 276,661 $3.61M 0.22% -2,300 13F-HR Timeline Group Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 232,534 $3.04M <0.01% +189,456 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 230,409 $3.01M <0.01% +31,020 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 226,302 $2.96M <0.01% +45,498 13F-HR Timeline Group BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 222,329 $2.9M 0.07% +149,835 13F-HR Timeline SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 173,475 $2.27M 0.39% 0 13F-HR Timeline Group Casdin Capital, LLC More: the full row for Casdin Capital, LLC 148,333 $1.94M 0.15% 0 13F-HR Timeline Eversept Partners, LP More: the full row for Eversept Partners, LP 146,411 $1.91M 0.13% +8,918 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 144,009 $1.88M <0.01% +33,948 13F-HR Timeline Group Ishara Investments LP More: the full row for Ishara Investments LP 142,000 $1.85M 1.87% new 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 107,380 $1.4M <0.01% +79,435 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 101,278 $1.32M <0.01% +16,850 13F-HR Timeline Group Verdad Advisers, LP More: the full row for Verdad Advisers, LP 86,032 $1.12M 1.26% new 13F-HR Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 84,891 $1.11M <0.01% -674,336 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 70,801 $925K <0.01% -53,485 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 69,400 $906K <0.01% +12,300 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 65,928 $861K <0.01% +12,052 13F-HR Timeline Group DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 59,946 $782K <0.01% new 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 59,844 $782K <0.01% new 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 55,609 $726K <0.01% new 13F-HR Timeline Group 683 Capital Management, LLC in group 683 Capital Management, LLC More: the full row for 683 Capital Management, LLC 55,000 $718K 0.07% -36,442 13F-HR Timeline Group ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 54,068 $703K <0.01% -10,637 13F-HR Timeline Group Strategies Wealth Advisors, LLC More: the full row for Strategies Wealth Advisors, LLC 50,000 $653K 0.07% 0 13F-HR Timeline BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 49,280 $644K 0.01% 0 13F-HR Timeline Trexquant Investment LP More: the full row for Trexquant Investment LP 47,746 $624K <0.01% -11,285 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 47,449 $620K <0.01% +38,180 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 43,958 $574K <0.01% -15,549 13F-HR Timeline Group Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 42,818 $559K <0.01% +16,880 13F-HR Timeline Group Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 42,178 $551K 0.01% +22,752 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 39,879 $521K <0.01% -24,349 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 37,916 $495K <0.01% 0 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 35,846 $468K 0.01% new 13F-HR Timeline Group AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 35,681 $466K <0.01% +16,159 13F-HR Timeline Group Seven Fleet Capital Management LP More: the full row for Seven Fleet Capital Management LP 27,054 $353K 0.11% new 13F-HR/A Timeline INDEPENDENT FINANCIAL GROUP, LLC More: the full row for INDEPENDENT FINANCIAL GROUP, LLC 27,021 $353K 0.01% 0 13F-HR/A Timeline Jain Global LLC More: the full row for Jain Global LLC 22,984 $300K <0.01% new 13F-HR Timeline HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 22,170 $289K <0.01% new 13F-HR Timeline CANADA PENSION PLAN INVESTMENT BOARD More: the full row for CANADA PENSION PLAN INVESTMENT BOARD 20,600 $269K <0.01% new 13F-HR Timeline RBF Capital, LLC More: the full row for RBF Capital, LLC 20,000 $261K 0.01% 0 13F-HR/A Timeline Quarry LP More: the full row for Quarry LP 16,000 $209K 0.04% new 13F-HR Timeline Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 14,956 $195K <0.01% new 13F-HR Timeline OMERS ADMINISTRATION Corp More: the full row for OMERS ADMINISTRATION Corp 14,200 $185K <0.01% -20,700 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 13,503 $176K 0.01% +9,739 13F-HR Timeline Cannon Global Investment Management, LLC More: the full row for Cannon Global Investment Management, LLC 13,000 $170K 0.41% new 13F-HR Timeline Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 12,799 $167K <0.01% -10,578 13F-HR Timeline Group ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 12,382 $162K <0.01% -38,646 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 11,300 $148K <0.01% 0 13F-HR Timeline Diametric Capital, LP More: the full row for Diametric Capital, LP 10,729 $140K 0.04% new 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 8,860 $116K <0.01% -3,464 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 5,794 $76K <0.01% +2,454 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 2,488 $31K <0.01% +696 13F-HR/A Timeline Group Mirae Asset Global Investments Co., Ltd. in group Mirae Asset Global Investment… More: the full row for Mirae Asset Global Investments Co., Ltd. 1,588 $20.7K <0.01% +466 13F-HR/A Timeline Group Federation des caisses Desjardins du Qu… More: the full row for Federation des caisses Desjardins du Quebec 1,280 $16.7K <0.01% -1,280 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 1,145 $15K <0.01% -35 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 731 $9.55K <0.01% +607 13F-HR Timeline Group GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 513 $6.7K <0.01% +59 13F-HR Timeline Torren Management, LLC More: the full row for Torren Management, LLC 254 $3.32K <0.01% -1,308 13F-HR Timeline Banque Transatlantique SA in group Banque Transatlantique SA More: the full row for Banque Transatlantique SA 220 $2.95K <0.01% 0 13F-HR Timeline Group US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 123 $1.61K <0.01% new 13F-HR Timeline Group Cornerstone Financial Management LLC More: the full row for Cornerstone Financial Management LLC 64 $836 <0.01% 0 13F-HR/A Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 6 $78 <0.01% new 13F-HR Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 1 $13 <0.01% new 13F-HR Timeline