WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 27,091,700 $42M 0.01% +1,746,020 13F-HR Timeline Group Blackstone Inc. in group Blackstone Inc. More: the full row for Blackstone Inc. 20,485,611 $31.8M 0.14% 0 13F-HR Timeline Group Deep Track Capital, LP More: the full row for Deep Track Capital, LP 17,849,482 $27.7M 0.9% +3,630,579 13F-HR Timeline Syncona Portfolio Ltd in group Syncona Portfolio Ltd More: the full row for Syncona Portfolio Ltd 16,640,720 $25.8M 97.81% 0 13F-HR Timeline Group ARMISTICE CAPITAL, LLC More: the full row for ARMISTICE CAPITAL, LLC 11,000,000 $17.1M 0.46% +1,800,000 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 10,162,348 $15.8M <0.01% -5,469,922 13F-HR Timeline Group Avoro Capital Advisors LLC More: the full row for Avoro Capital Advisors LLC 9,910,642 $15.4M 0.24% 0 13F-HR Timeline Tetragon Partners GP Ltd in group Tetragon Partners GP Ltd More: the full row for Tetragon Partners GP Ltd 8,600,000 $13.3M 4.28% +350,000 13F-HR Timeline Group Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 4,623,324 $7.17M 0.33% 0 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 3,944,834 $6.11M <0.01% -183,116 13F-HR Timeline Group SCHRODER INVESTMENT MANAGEMENT GROUP More: the full row for SCHRODER INVESTMENT MANAGEMENT GROUP 3,608,490 $5.99M 0.01% +743,858 13F-HR Timeline Laurion Capital Management LP More: the full row for Laurion Capital Management LP 3,369,248 $5.22M 0.4% +179,701 13F-HR Timeline Candriam S.C.A. More: the full row for Candriam S.C.A. 3,191,401 $4.95M 0.03% 0 13F-HR Timeline AXA S.A. in group AXA S.A. More: the full row for AXA S.A. 3,126,167 $4.85M 0.02% +1,301,482 13F-HR Timeline Group Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 3,045,000 $4.72M 0.74% -1,455,000 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 2,900,186 $4.5M <0.01% -39,055 13F-HR Timeline GREAT POINT PARTNERS LLC More: the full row for GREAT POINT PARTNERS LLC 2,728,910 $4.23M 2.3% -280,482 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 1,986,190 $3.08M <0.01% +332,949 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 1,584,125 $2.46M <0.01% +965,183 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 1,410,104 $2.19M <0.01% +338,571 13F-HR Timeline Group Perpetual Ltd in group Perpetual Ltd More: the full row for Perpetual Ltd 1,223,743 $1.9M 0.02% -55,877 13F-HR Timeline Group Alphabet Inc. in group Alphabet Inc. More: the full row for Alphabet Inc. 698,262 $1.08M 0.07% 0 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 619,913 $961K <0.01% -137,622 13F-HR Timeline Group DAFNA Capital Management LLC More: the full row for DAFNA Capital Management LLC 586,667 $909K 0.26% 0 13F-HR Timeline TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 560,143 $868K -680,024 Timeline Cetera Investment Advisers More: the full row for Cetera Investment Advisers 524,872 $814K <0.01% +168,650 13F-HR Timeline Atle Fund Management AB More: the full row for Atle Fund Management AB 479,644 $743K 0.33% 0 13F-HR Timeline Knott David M Jr More: the full row for Knott David M Jr 420,000 $651K 0.31% new 13F-HR Timeline Hennion & Walsh Asset Management, Inc. More: the full row for Hennion & Walsh Asset Management, Inc. 386,001 $598K 0.03% +126,021 13F-HR Timeline Eversept Partners, LP More: the full row for Eversept Partners, LP 343,947 $533K 0.06% +245,052 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 316,227 $490K <0.01% +115,995 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 309,576 $480K <0.01% -243,558 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 299,836 $463K <0.01% +2,100 13F-HR Timeline Group EDENTREE ASSET MANAGEMENT Ltd More: the full row for EDENTREE ASSET MANAGEMENT Ltd 300,000 $462K 0.16% new 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 261,146 $405K <0.01% -5,169 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 256,515 $398K <0.01% -15 13F-HR Timeline Group Privium Fund Management B.V. More: the full row for Privium Fund Management B.V. 251,674 $390K 0.1% +20,000 13F-HR Timeline Erste Asset Management GmbH in group Erste Asset Management GmbH More: the full row for Erste Asset Management GmbH 195,000 $324K <0.01% 0 13F-HR Timeline Group ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 199,709 $310K <0.01% -15,481 13F-HR Timeline Group BIT Capital GmbH More: the full row for BIT Capital GmbH 199,359 $309K 0.04% -437,620 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 188,908 $293K <0.01% -135,094 13F-HR Timeline Group Vident Advisory, LLC in group Vident Advisory, LLC More: the full row for Vident Advisory, LLC 155,504 $241K <0.01% new 13F-HR Timeline Group Vontobel Holding Ltd. in group Vontobel Holding Ltd. More: the full row for Vontobel Holding Ltd. 138,783 $215K <0.01% -8,636 13F-HR Timeline Group Aubrey Capital Management Ltd More: the full row for Aubrey Capital Management Ltd 119,998 $197K 0.08% +35,176 13F-HR Timeline NEOS Investment Management LLC More: the full row for NEOS Investment Management LLC 110,428 $171K <0.01% new 13F-HR Timeline Tema ETFs LLC More: the full row for Tema ETFs LLC 110,428 $171K 0.05% new 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 102,493 $159K <0.01% +91,222 13F-HR/A Timeline Group Clearstead Advisors, LLC More: the full row for Clearstead Advisors, LLC 91,107 $141K <0.01% 0 13F-HR Timeline Mitsubishi UFJ Asset Management Co., Lt… in group Mitsubishi UFJ Trust & Bankin… More: the full row for Mitsubishi UFJ Asset Management Co., Ltd. 89,949 $139K <0.01% +7,538 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 86,256 $134K <0.01% 0 13F-HR Timeline Group Leonteq Securities AG More: the full row for Leonteq Securities AG 75,000 $116K 0.01% -25,000 13F-HR Timeline Handelsbanken Fonder AB More: the full row for Handelsbanken Fonder AB 73,300 $114K <0.01% 0 13F-HR Timeline EXCHANGE TRADED CONCEPTS, LLC More: the full row for EXCHANGE TRADED CONCEPTS, LLC 69,993 $108K <0.01% +28,127 13F-HR Timeline SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 68,932 $107K <0.01% +4,316 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 67,055 $104K <0.01% -3,836 13F-HR Timeline Group HighPoint Advisor Group LLC More: the full row for HighPoint Advisor Group LLC 79,120 $104K 0.01% +500 13F-HR Timeline Rathbones Group PLC More: the full row for Rathbones Group PLC 65,000 $101K <0.01% 0 13F-HR Timeline Virtus Investment Advisers, LLC group of 2 filers holding More: the full row for Virtus Investment Advisers, LLC 61,027 $94.6K +34,598 Timeline Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 51,188 $79.3K <0.01% -107,497 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 50,411 $78.1K <0.01% -75,819 13F-HR/A Timeline Group China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 40,200 $62.3K 0.01% -2,145 13F-HR Timeline WEALTH EFFECTS LLC More: the full row for WEALTH EFFECTS LLC 36,300 $56.3K 0.02% -6,500 13F-HR Timeline TRUST CO OF TOLEDO NA /OH/ More: the full row for TRUST CO OF TOLEDO NA /OH/ 36,265 $56.2K 0.01% 0 13F-HR Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 34,645 $53.7K <0.01% -212,444 13F-HR/A Timeline Group MAI Capital Management More: the full row for MAI Capital Management 33,866 $52.5K <0.01% -294,460 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 33,659 $52.2K <0.01% +1,197 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 32,738 $50.7K <0.01% +11,381 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 32,595 $50.5K <0.01% -14,003 13F-HR Timeline Group LPL Financial LLC More: the full row for LPL Financial LLC 30,875 $47.9K <0.01% -5,850 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 27,130 $42.1K <0.01% -1,203 13F-HR Timeline Group HERBST GROUP, LLC More: the full row for HERBST GROUP, LLC 25,000 $38.8K 0.03% 0 13F-HR Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 22,927 $36K <0.01% -816 13F-HR Timeline Group OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 21,724 $33.7K <0.01% 0 13F-HR Timeline Group Avanza Fonder AB More: the full row for Avanza Fonder AB 21,276 $33.4K <0.01% -10,494 13F-HR Timeline Vanguard Personalized Indexing Manageme… in group VANGUARD GROUP INC More: the full row for Vanguard Personalized Indexing Management, LLC 18,611 $28.8K <0.01% new 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 15,068 $23.4K <0.01% +3,209 13F-HR/A Timeline Group DUMONT & BLAKE INVESTMENT ADVISORS LLC More: the full row for DUMONT & BLAKE INVESTMENT ADVISORS LLC 15,000 $23.2K 0.01% 0 13F-HR Timeline BLAIR WILLIAM & CO/IL More: the full row for BLAIR WILLIAM & CO/IL 12,794 $19.8K <0.01% 0 13F-HR Timeline Marex Group Ltd in group Marex Group Ltd More: the full row for Marex Group Ltd 12,500 $19.4K <0.01% 0 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 7,373 $11.4K <0.01% +1,033 13F-HR/A Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 6,857 $10.6K <0.01% +2,327 13F-HR/A Timeline Mirae Asset Global Investments Co., Ltd. in group Mirae Asset Global Investment… More: the full row for Mirae Asset Global Investments Co., Ltd. 5,790 $9.61K <0.01% -865 13F-HR Timeline Group EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 6,112 $9.47K <0.01% new 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 5,857 $9.08K <0.01% +1,127 13F-HR Timeline Group GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 5,113 $7.92K <0.01% +920 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 3,163 $4.9K <0.01% -167 13F-HR Timeline Group QUADRANT CAPITAL GROUP LLC More: the full row for QUADRANT CAPITAL GROUP LLC 3,024 $4.69K <0.01% 0 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 1,127 $1.75K <0.01% -45 13F-HR Timeline TrinityBridge Ltd More: the full row for TrinityBridge Ltd 500 $1K <0.01% 0 13F-HR Timeline CALDWELL SUTTER CAPITAL, INC. More: the full row for CALDWELL SUTTER CAPITAL, INC. 500 $775 <0.01% 0 13F-HR Timeline Byrne Asset Management LLC More: the full row for Byrne Asset Management LLC 250 $388 <0.01% 0 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 64 $99 <0.01% -2,038 13F-HR Timeline Group SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 60 $93 <0.01% +10 13F-HR Timeline HUNTINGTON NATIONAL BANK in group HUNTINGTON NATIONAL BANK More: the full row for HUNTINGTON NATIONAL BANK 1 $2 <0.01% 0 13F-HR Timeline Group CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.