WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 25,345,680 $59.6M 0.01% +1,125,454 13F-HR Timeline Group Blackstone Inc. in group Blackstone Inc. More: the full row for Blackstone Inc. 20,485,611 $48.1M 0.23% 0 13F-HR Timeline Group Syncona Portfolio Ltd in group Syncona Portfolio Ltd More: the full row for Syncona Portfolio Ltd 16,640,720 $39.1M 73.83% -1,913,904 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 15,632,270 $36.7M <0.01% -2,141,603 13F-HR Timeline Group Deep Track Capital, LP More: the full row for Deep Track Capital, LP 14,218,903 $33.4M 1.25% -1,053,269 13F-HR Timeline Avoro Capital Advisors LLC More: the full row for Avoro Capital Advisors LLC 9,910,642 $23.3M 0.33% -2,435,036 13F-HR Timeline ARMISTICE CAPITAL, LLC More: the full row for ARMISTICE CAPITAL, LLC 9,200,000 $21.6M 0.5% +2,328,000 13F-HR Timeline Tetragon Partners GP Ltd in group Tetragon Partners GP Ltd More: the full row for Tetragon Partners GP Ltd 8,250,000 $19.4M 6.26% +250,000 13F-HR/A Timeline Group Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 4,623,324 $10.9M 0.45% 0 13F-HR Timeline Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 4,500,000 $10.6M 1.65% 0 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 4,127,950 $9.7M <0.01% -297,796 13F-HR Timeline Group Candriam S.C.A. More: the full row for Candriam S.C.A. 3,191,401 $7.5M 0.04% new 13F-HR Timeline Laurion Capital Management LP More: the full row for Laurion Capital Management LP 3,189,547 $7.5M 0.47% 0 13F-HR Timeline GREAT POINT PARTNERS LLC More: the full row for GREAT POINT PARTNERS LLC 3,009,392 $7.07M 3.33% +197,437 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 2,939,241 $6.91M <0.01% -902,261 13F-HR Timeline SCHRODER INVESTMENT MANAGEMENT GROUP More: the full row for SCHRODER INVESTMENT MANAGEMENT GROUP 2,864,632 $6.33M 0.01% 0 13F-HR Timeline AXA S.A. in group AXA S.A. More: the full row for AXA S.A. 1,824,685 $4.29M 0.01% new 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 1,673,994 $3.93M <0.01% -156,527 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 1,653,241 $3.89M <0.01% +790,437 13F-HR Timeline Group Perpetual Ltd in group Perpetual Ltd More: the full row for Perpetual Ltd 1,279,620 $3.01M 0.04% -319,632 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 1,240,167 $2.91M +189,885 Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 1,071,533 $2.52M <0.01% -213,175 13F-HR Timeline Group Rock Springs Capital Management LP More: the full row for Rock Springs Capital Management LP 1,032,988 $2.43M 0.09% 0 13F-HR Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 757,535 $1.78M <0.01% 0 13F-HR Timeline Group Alphabet Inc. in group Alphabet Inc. More: the full row for Alphabet Inc. 698,262 $1.64M 0.1% 0 13F-HR Timeline Group BIT Capital GmbH More: the full row for BIT Capital GmbH 636,979 $1.5M 0.13% +379,050 13F-HR Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 618,942 $1.45M <0.01% +368,071 13F-HR Timeline DAFNA Capital Management LLC More: the full row for DAFNA Capital Management LLC 586,667 $1.38M 0.35% +100,000 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 553,134 $1.3M <0.01% -1,264,821 13F-HR/A Timeline Group HighVista Strategies LLC More: the full row for HighVista Strategies LLC 533,024 $1.25M 0.47% 0 13F-HR Timeline Atle Fund Management AB More: the full row for Atle Fund Management AB 479,644 $1.06M 0.5% +37,221 13F-HR Timeline Cetera Investment Advisers More: the full row for Cetera Investment Advisers 356,222 $837K <0.01% +224,222 13F-HR Timeline MAI Capital Management More: the full row for MAI Capital Management 328,326 $772K 0.01% -913 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 324,002 $761K <0.01% +20,994 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 297,736 $697K <0.01% +237,224 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 266,315 $626K <0.01% -119,558 13F-HR Timeline Group Hennion & Walsh Asset Management, Inc. More: the full row for Hennion & Walsh Asset Management, Inc. 259,980 $611K 0.03% new 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 256,530 $603K <0.01% -350,014 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 247,089 $581K <0.01% new 13F-HR Timeline Group Privium Fund Management B.V. More: the full row for Privium Fund Management B.V. 231,674 $544K 0.12% +46,035 13F-HR Timeline ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 215,190 $506K <0.01% new 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 200,232 $471K <0.01% +43,254 13F-HR Timeline Group EntryPoint Capital, LLC More: the full row for EntryPoint Capital, LLC 191,429 $450K 0.19% new 13F-HR Timeline Erste Asset Management GmbH in group Erste Asset Management GmbH More: the full row for Erste Asset Management GmbH 195,000 $441K 0.01% 0 13F-HR Timeline Group Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 158,685 $373K <0.01% -206,310 13F-HR Timeline Vontobel Holding Ltd. in group Vontobel Holding Ltd. More: the full row for Vontobel Holding Ltd. 147,419 $346K <0.01% -53,522 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 126,230 $297K <0.01% +66,218 13F-HR Timeline Group Leonteq Securities AG More: the full row for Leonteq Securities AG 100,000 $235K 0.02% +75,000 13F-HR Timeline Eversept Partners, LP More: the full row for Eversept Partners, LP 98,895 $232K 0.02% -307,663 13F-HR Timeline Mitsubishi UFJ Asset Management Co., Lt… in group Mitsubishi UFJ Trust & Bankin… More: the full row for Mitsubishi UFJ Asset Management Co., Ltd. 82,411 $221K <0.01% +14,432 13F-HR Timeline Group Clearstead Advisors, LLC More: the full row for Clearstead Advisors, LLC 91,107 $214K <0.01% -5,000 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 86,256 $203K <0.01% 0 13F-HR Timeline Group Aubrey Capital Management Ltd More: the full row for Aubrey Capital Management Ltd 84,822 $199K 0.08% new 13F-HR Timeline Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 75,940 $178K <0.01% -986,453 13F-HR Timeline Group Handelsbanken Fonder AB More: the full row for Handelsbanken Fonder AB 73,300 $172K <0.01% +17,300 13F-HR Timeline Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 72,396 $170K <0.01% new 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 70,891 $167K <0.01% +50,187 13F-HR Timeline Group Rathbones Group PLC More: the full row for Rathbones Group PLC 65,000 $153K <0.01% -2,300 13F-HR Timeline Bayesian Capital Management, LP More: the full row for Bayesian Capital Management, LP 65,000 $153K 0.02% +41,600 13F-HR Timeline SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 64,616 $152K <0.01% -2,713 13F-HR Timeline HighPoint Advisor Group LLC More: the full row for HighPoint Advisor Group LLC 78,620 $150K 0.01% new 13F-HR Timeline ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 56,273 $131K <0.01% new 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 46,598 $110K <0.01% -220,442 13F-HR Timeline Group WEALTH EFFECTS LLC More: the full row for WEALTH EFFECTS LLC 42,800 $101K 0.04% -8,200 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 42,345 $99.5K 0.01% +3,952 13F-HR Timeline EXCHANGE TRADED CONCEPTS, LLC More: the full row for EXCHANGE TRADED CONCEPTS, LLC 41,866 $98.4K <0.01% 0 13F-HR Timeline Bellevue Group AG in group Bellevue Group AG More: the full row for Bellevue Group AG 41,500 $97.5K <0.01% 0 13F-HR Timeline Group LPL Financial LLC More: the full row for LPL Financial LLC 36,725 $86.3K <0.01% +850 13F-HR Timeline OMERS ADMINISTRATION Corp More: the full row for OMERS ADMINISTRATION Corp 36,300 $85.3K <0.01% new 13F-HR Timeline TRUST CO OF TOLEDO NA /OH/ More: the full row for TRUST CO OF TOLEDO NA /OH/ 36,265 $85.2K 0.01% 0 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 32,462 $76.3K <0.01% -34,661 13F-HR Timeline Group Avanza Fonder AB More: the full row for Avanza Fonder AB 31,770 $74.7K <0.01% 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 28,333 $66.6K <0.01% -136,588 13F-HR Timeline Group VIRTUS ADVISERS, LLC in group Virtus Investment Advisers, L… More: the full row for VIRTUS ADVISERS, LLC 26,429 $62.1K 0.03% +6,081 13F-HR Timeline Group HERBST GROUP, LLC More: the full row for HERBST GROUP, LLC 25,000 $58.8K 0.04% 0 13F-HR Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 23,743 $56K <0.01% +8,479 13F-HR Timeline Group OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 21,724 $51.1K <0.01% +1,149 13F-HR/A Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 21,357 $50.2K <0.01% +2,609 13F-HR Timeline Group Arkadios Wealth Advisors More: the full row for Arkadios Wealth Advisors 20,000 $47K <0.01% new 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 18,057 $42K <0.01% +9,241 13F-HR Timeline EWA, LLC More: the full row for EWA, LLC 15,280 $35.9K 0.01% -1,427 13F-HR Timeline DUMONT & BLAKE INVESTMENT ADVISORS LLC More: the full row for DUMONT & BLAKE INVESTMENT ADVISORS LLC 15,000 $35.2K 0.01% new 13F-HR Timeline BLAIR WILLIAM & CO/IL More: the full row for BLAIR WILLIAM & CO/IL 12,794 $30.1K <0.01% -2,138 13F-HR Timeline Marex Group Ltd in group Marex Group Ltd More: the full row for Marex Group Ltd 12,500 $29.4K <0.01% -3,000 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 11,859 $27.9K <0.01% +10,866 13F-HR/A Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 11,271 $26.5K <0.01% new 13F-HR Timeline Group UNITED BANK More: the full row for UNITED BANK 10,850 $25.5K <0.01% 0 13F-HR Timeline Mirae Asset Global Investments Co., Ltd. in group Mirae Asset Global Investment… More: the full row for Mirae Asset Global Investments Co., Ltd. 6,655 $15K <0.01% -565 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 6,340 $14.9K <0.01% +233 13F-HR/A Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 4,730 $11.1K <0.01% +1,790 13F-HR Timeline Group R Squared Ltd More: the full row for R Squared Ltd 4,680 $11K 0.01% 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 4,530 $10.6K <0.01% +1,670 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 4,193 $9.85K <0.01% 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 3,330 $7.83K <0.01% -214 13F-HR Timeline Group QUADRANT CAPITAL GROUP LLC More: the full row for QUADRANT CAPITAL GROUP LLC 3,024 $7.11K <0.01% 0 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 2,102 $4.94K <0.01% +1,438 13F-HR Timeline Group Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 2,079 $4.89K <0.01% -485 13F-HR Timeline Lindbrook Capital, LLC More: the full row for Lindbrook Capital, LLC 1,935 $4.55K <0.01% 0 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 1,172 $2.75K <0.01% 13F-HR/A Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 682 $2K <0.01% new 13F-HR Timeline Group CALDWELL SUTTER CAPITAL, INC. More: the full row for CALDWELL SUTTER CAPITAL, INC. 500 $1.18K <0.01% new 13F-HR Timeline Truvestments Capital LLC More: the full row for Truvestments Capital LLC 500 $1.18K <0.01% new 13F-HR Timeline TrinityBridge Ltd More: the full row for TrinityBridge Ltd 500 $1K <0.01% 0 13F-HR Timeline Brooklyn Investment Group More: the full row for Brooklyn Investment Group 377 $886 <0.01% new 13F-HR Timeline Byrne Asset Management LLC More: the full row for Byrne Asset Management LLC 250 $588 <0.01% -1,150 13F-HR Timeline Cornerstone Planning Group LLC More: the full row for Cornerstone Planning Group LLC 100 $226 <0.01% 0 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 50 $118 <0.01% 13F-HR Timeline HUNTINGTON NATIONAL BANK in group HUNTINGTON NATIONAL BANK More: the full row for HUNTINGTON NATIONAL BANK 1 $2 <0.01% 0 13F-HR Timeline Group LAZARD ASSET MANAGEMENT LLC in group LAZARD ASSET MANAGEMENT LLC More: the full row for LAZARD ASSET MANAGEMENT LLC 178 $0 0% 0 13F-HR Timeline Group Value filed as zero, left out of ratios. CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.