EcoR1 Capital, LLC More: the full row for EcoR1 Capital, LLC 7,880,094 $175M 10.37% 0 13F-HR Timeline First Light Asset Management, LLC More: the full row for First Light Asset Management, LLC 3,539,593 $78.6M 10.19% -1,094,009 13F-HR Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 2,474,874 $54.9M 0.13% +106,504 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 1,869,840 $41.5M <0.01% +1,365,204 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 1,786,934 $39.7M <0.01% -389,664 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 1,537,550 $34.1M <0.01% +20,225 13F-HR Timeline Group TANG CAPITAL MANAGEMENT LLC in group TANG CAPITAL MANAGEMENT LLC More: the full row for TANG CAPITAL MANAGEMENT LLC 1,330,879 $29.5M 1.49% -214,274 13F-HR Timeline Group UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 1,322,304 $29.4M +797,118 Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 1,076,799 $23.9M <0.01% -67,160 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 1,046,488 $23.2M 0.02% -24,759 13F-HR Timeline Group Sofinnova Investments, Inc. More: the full row for Sofinnova Investments, Inc. 1,032,362 $22.9M 1.56% -127,671 13F-HR Timeline Sanofi More: the full row for Sanofi 821,917 $18.2M 10.38% 0 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 821,031 $18.2M <0.01% -39,692 13F-HR Timeline Group Palo Alto Investors LP More: the full row for Palo Alto Investors LP 812,821 $18M 3.84% -207,892 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 673,171 $14.9M <0.01% -241,910 13F-HR Timeline VICTORY CAPITAL MANAGEMENT INC More: the full row for VICTORY CAPITAL MANAGEMENT INC 532,085 $11.8M 0.01% +125,655 13F-HR Timeline TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 521,769 $11.6M -12,189 Timeline Woodline Partners LP More: the full row for Woodline Partners LP 501,023 $11.1M 0.06% -290,000 13F-HR Timeline 683 Capital Management, LLC in group 683 Capital Management, LLC More: the full row for 683 Capital Management, LLC 500,000 $11.1M 1.13% +304,373 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 463,358 $10.3M <0.01% -27,809 13F-HR Timeline Group JACOBS LEVY EQUITY MANAGEMENT, INC More: the full row for JACOBS LEVY EQUITY MANAGEMENT, INC 368,447 $8.18M 0.03% +351,960 13F-HR Timeline FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 354,508 $7.87M <0.01% +117 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 323,534 $7.18M <0.01% +267,522 13F-HR Timeline Group Soleus Capital Management, L.P. More: the full row for Soleus Capital Management, L.P. 321,040 $7.13M 0.49% +218,988 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 279,835 $6.21M <0.01% -742 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 263,086 $5.84M 0.01% -75,614 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 247,625 $5.5M <0.01% +233,325 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 222,130 $4.93M +177,793 Timeline Ensign Peak Advisors, Inc More: the full row for Ensign Peak Advisors, Inc 215,454 $4.78M 0.01% 0 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 203,542 $4.52M <0.01% +185,735 13F-HR Timeline Group Trexquant Investment LP More: the full row for Trexquant Investment LP 199,242 $4.42M 0.05% +45,679 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 196,263 $4.36M <0.01% -16,623 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 157,135 $3.49M <0.01% +3,779 13F-HR Timeline Group ARROWSTREET CAPITAL, LIMITED PARTNERSHIP in group ARROWSTREET CAPITAL, LIMITED … More: the full row for ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 150,810 $3.35M <0.01% new 13F-HR Timeline Group HighMark Wealth Management LLC More: the full row for HighMark Wealth Management LLC 145,550 $3.23M 1.58% +53,550 13F-HR Timeline Granahan Investment Management, LLC More: the full row for Granahan Investment Management, LLC 131,655 $2.92M 0.12% -14,836 13F-HR Timeline Camber Capital Management LP More: the full row for Camber Capital Management LP 125,000 $2.77M 0.39% -625,000 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 118,286 $2.63M <0.01% -254,283 13F-HR Timeline Group D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 112,349 $2.49M <0.01% -17,305 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 109,388 $2.43M 0.01% new 13F-HR/A Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 99,999 $2.22M <0.01% +43,780 13F-HR/A Timeline Group MACQUARIE GROUP LTD in group MACQUARIE GROUP LTD More: the full row for MACQUARIE GROUP LTD 93,732 $2.08M <0.01% 0 13F-HR Timeline Group Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 92,852 $2.06M <0.01% +60,778 13F-HR Timeline Group SECTORAL ASSET MANAGEMENT INC More: the full row for SECTORAL ASSET MANAGEMENT INC 83,900 $1.86M 1.23% new 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 83,174 $1.85M <0.01% +61,838 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 80,213 $1.78M <0.01% +4,192 13F-HR Timeline Group VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 73,005 $1.62M <0.01% -23,967 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 72,119 $1.6M <0.01% -1,833,035 13F-HR Timeline Group GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 69,799 $1.55M 0.11% new 13F-HR Timeline Aquatic Capital Management LLC More: the full row for Aquatic Capital Management LLC 65,810 $1.46M 0.03% new 13F-HR Timeline Moody Aldrich Partners LLC More: the full row for Moody Aldrich Partners LLC 60,094 $1.33M 0.26% -23,130 13F-HR Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 59,225 $1.31M <0.01% -1,982 13F-HR Timeline Group Fisher Asset Management, LLC More: the full row for Fisher Asset Management, LLC 58,899 $1.31M <0.01% +21 13F-HR Timeline DCF Advisers, LLC More: the full row for DCF Advisers, LLC 48,000 $1.07M 0.51% +13,150 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 44,668 $992K <0.01% new 13F-HR Timeline Group PDT Partners, LLC More: the full row for PDT Partners, LLC 44,465 $987K 0.06% -64 13F-HR Timeline OCONNOR, A Distinct Business Unit of UB… More: the full row for OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 38,528 $855K 0.02% -8,523 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. Bleakley Financial Group, LLC More: the full row for Bleakley Financial Group, LLC 37,551 $834K 0.02% new 13F-HR Timeline FMB WEALTH MANAGEMENT More: the full row for FMB WEALTH MANAGEMENT 35,592 $790K 0.38% 0 13F-HR Timeline Skandinaviska Enskilda Banken AB (publ) More: the full row for Skandinaviska Enskilda Banken AB (publ) 33,523 $744K <0.01% 0 13F-HR Timeline SummitTX Capital, L.P. More: the full row for SummitTX Capital, L.P. 33,434 $742K 0.03% -23,675 13F-HR Timeline PANAGORA ASSET MANAGEMENT INC More: the full row for PANAGORA ASSET MANAGEMENT INC 33,369 $741K <0.01% new 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 33,328 $740K <0.01% +21,951 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 30,705 $682K <0.01% -198 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 30,642 $680K 0.03% new 13F-HR Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 30,520 $678K <0.01% 0 13F-HR Timeline AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 27,722 $615K <0.01% -2,289 13F-HR Timeline Group Rafferty Asset Management, LLC More: the full row for Rafferty Asset Management, LLC 26,829 $596K <0.01% -4,351 13F-HR Timeline Swiss National Bank More: the full row for Swiss National Bank 26,400 $586K <0.01% -6,000 13F-HR Timeline Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 24,745 $549K 0.01% new 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 23,791 $528K <0.01% new 13F-HR Timeline Group ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 23,756 $527K 0.01% +1,812 13F-HR Timeline Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 22,953 $510K 0.01% +8,761 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 19,504 $433K <0.01% -859 13F-HR Timeline Group Assenagon Asset Management S.A. More: the full row for Assenagon Asset Management S.A. 16,959 $376K <0.01% -225,526 13F-HR Timeline Creative Planning in group Creative Planning More: the full row for Creative Planning 16,854 $374K <0.01% +3,571 13F-HR Timeline Group ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 15,863 $352K <0.01% -7,263 13F-HR Timeline Group Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 15,662 $348K 0.12% new 13F-HR Timeline Group Nebula Research & Development LLC More: the full row for Nebula Research & Development LLC 15,533 $345K 0.03% +28 13F-HR Timeline Allianz Asset Management GmbH in group Allianz SE More: the full row for Allianz Asset Management GmbH 15,200 $337K <0.01% new 13F-HR Timeline Group LOS ANGELES CAPITAL MANAGEMENT LLC More: the full row for LOS ANGELES CAPITAL MANAGEMENT LLC 15,027 $334K <0.01% new 13F-HR Timeline Exome Asset Management LLC More: the full row for Exome Asset Management LLC 15,000 $333K 0.27% -101,623 13F-HR/A Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 14,217 $316K <0.01% -373 13F-HR Timeline Cresset Asset Management, LLC More: the full row for Cresset Asset Management, LLC 13,033 $289K <0.01% -1,580 13F-HR/A Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 12,681 $282K <0.01% -3,115 13F-HR Timeline Group Corton Capital Inc. More: the full row for Corton Capital Inc. 12,004 $266K 0.31% +1,305 13F-HR Timeline NEOS Investment Management LLC More: the full row for NEOS Investment Management LLC 11,404 $253K <0.01% new 13F-HR Timeline Tema ETFs LLC More: the full row for Tema ETFs LLC 11,404 $253K 0.07% new 13F-HR Timeline INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 10,795 $240K <0.01% new 13F-HR Timeline TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 9,419 $209K <0.01% -775 13F-HR Timeline FEDERATED HERMES, INC. in group FEDERATED HERMES, INC. More: the full row for FEDERATED HERMES, INC. 8,274 $184K <0.01% 0 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 7,924 $176K <0.01% 0 13F-HR/A Timeline Glenmede Investment Management, LP More: the full row for Glenmede Investment Management, LP 7,546 $168K <0.01% 13F-HR Timeline Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 6,498 $144K <0.01% +4,436 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 5,901 $131K 0.01% -250 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 5,898 $131K <0.01% +4,145 13F-HR Timeline Group SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 4,921 $109K <0.01% -7,213 13F-HR Timeline PUBLIC EMPLOYEES RETIREMENT ASSOCIATION… More: the full row for PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO 4,864 $108K <0.01% -12 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 4,178 $92.8K <0.01% -1,211 13F-HR Timeline Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 4,017 $89.2K 0.03% -6,909 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 3,699 $82.1K <0.01% -21,888 13F-HR Timeline Group KLP KAPITALFORVALTNING AS More: the full row for KLP KAPITALFORVALTNING AS 3,000 $66.6K <0.01% 0 13F-HR Timeline BIT Capital GmbH More: the full row for BIT Capital GmbH 2,706 $60.1K <0.01% -22,716 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 2,346 $52.1K <0.01% +2,326 13F-HR/A Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 2,164 $48K <0.01% +1,377 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 1,917 $42.6K <0.01% 0 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 1,296 $29K <0.01% -52 13F-HR/A Timeline Group Global Retirement Partners, LLC More: the full row for Global Retirement Partners, LLC 1,230 $27.3K <0.01% 13F-HR Timeline Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 1,135 $25.2K -14,096 Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 1,136 $25K <0.01% +307 13F-HR Timeline Group Brooklyn Investment Group More: the full row for Brooklyn Investment Group 1,082 $24K <0.01% -5,291 13F-HR/A Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 1,082 $24K <0.01% +1,040 13F-HR Timeline Group NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 1,050 $23.3K <0.01% -230 13F-HR Timeline Larson Financial Group LLC More: the full row for Larson Financial Group LLC 867 $19.2K <0.01% +724 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 779 $17.3K <0.01% 0 13F-HR Timeline CANADA LIFE ASSURANCE Co in group CANADA LIFE ASSURANCE Co More: the full row for CANADA LIFE ASSURANCE Co 750 $17K <0.01% 0 13F-HR Timeline Group AMALGAMATED BANK More: the full row for AMALGAMATED BANK 745 $17K <0.01% 0 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 677 $15K <0.01% -10 13F-HR Timeline Quarry LP More: the full row for Quarry LP 500 $11.1K <0.01% new 13F-HR Timeline SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 453 $10.1K <0.01% +292 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 361 $8.01K <0.01% +33 13F-HR Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 337 $7.48K <0.01% -1,540 13F-HR Timeline BNP PARIBAS ASSET MANAGEMENT Holding S.… in group BNP PARIBAS ASSET MANAGEMENT … More: the full row for BNP PARIBAS ASSET MANAGEMENT Holding S.A. 234 $5K <0.01% new 13F-HR Timeline Group ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 185 $4.11K <0.01% -10 13F-HR Timeline BESSEMER GROUP INC in group BESSEMER GROUP INC More: the full row for BESSEMER GROUP INC 136 $3K <0.01% +110 13F-HR Timeline Group Sherman Asset Management, Inc. More: the full row for Sherman Asset Management, Inc. 120 $2.66K <0.01% 0 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 115 $2.55K <0.01% +11 13F-HR Timeline Group Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 105 $2K <0.01% 0 13F-HR Timeline Group Versant Capital Management, Inc More: the full row for Versant Capital Management, Inc 90 $2K <0.01% 0 13F-HR Timeline Physician Wealth Advisors, Inc. More: the full row for Physician Wealth Advisors, Inc. 85 $1.89K <0.01% +31 13F-HR Timeline Riggs Asset Managment Co. Inc. More: the full row for Riggs Asset Managment Co. Inc. 69 $1.53K <0.01% +39 13F-HR Timeline Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 55 $1.22K <0.01% 0 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 50 $1.11K <0.01% +23 13F-HR/A Timeline Steward Partners Investment Advisory, L… More: the full row for Steward Partners Investment Advisory, LLC 43 $955 <0.01% new 13F-HR Timeline ASSETMARK, INC in group ASSETMARK, INC More: the full row for ASSETMARK, INC 36 $799 <0.01% new 13F-HR Timeline Group Essential Partners LLC More: the full row for Essential Partners LLC 33 $733 <0.01% 13F-HR Timeline Parkside Financial Bank & Trust More: the full row for Parkside Financial Bank & Trust 25 $555 <0.01% new 13F-HR Timeline Blue Trust, Inc. More: the full row for Blue Trust, Inc. 19 $422 <0.01% 0 13F-HR Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 0 $422 <0.01% new 13F-HR Timeline Amount filed as zero, left out of ratios. Smartleaf Asset Management LLC More: the full row for Smartleaf Asset Management LLC 14 $314 <0.01% -6 13F-HR Timeline PRINCIPAL SECURITIES, INC. in group PRINCIPAL FINANCIAL GROUP INC More: the full row for PRINCIPAL SECURITIES, INC. 14 $311 <0.01% new 13F-HR Timeline Group MassMutual Private Wealth & Trust, FSB More: the full row for MassMutual Private Wealth & Trust, FSB 12 $266 <0.01% 0 13F-HR Timeline True Wealth Design, LLC More: the full row for True Wealth Design, LLC 4 $89 <0.01% -63 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 1 $22 <0.01% -9 13F-HR Timeline Covestor Ltd More: the full row for Covestor Ltd 5 $0 0% -1 13F-HR Timeline Value filed as zero, left out of ratios. CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.