EcoR1 Capital, LLC More: the full row for EcoR1 Capital, LLC 7,873,448 $104M 4.16% +78,452 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 3,030,236 $40.1M <0.01% -278,939 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 2,548,468 $33.7M <0.01% +368,279 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 1,843,740 $24.4M <0.01% +143,584 13F-HR Timeline Group Fairmount Funds Management LLC in group Fairmount Funds Management LLC More: the full row for Fairmount Funds Management LLC 1,816,466 $24.1M 2.39% new 13F-HR Timeline Group Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 1,573,719 $20.8M 0.86% -635,470 13F-HR Timeline TANG CAPITAL MANAGEMENT LLC in group TANG CAPITAL MANAGEMENT LLC More: the full row for TANG CAPITAL MANAGEMENT LLC 1,330,879 $17.6M 1.17% 0 13F-HR Timeline Group Boxer Capital Management, LLC in group Boxer Capital Management, LLC More: the full row for Boxer Capital Management, LLC 1,300,000 $17.2M 1.47% 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 1,285,755 $17M <0.01% +379,573 13F-HR Timeline Group Camber Capital Management LP More: the full row for Camber Capital Management LP 1,250,000 $16.6M 0.65% new 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 925,007 $12.2M <0.01% +1,890 13F-HR Timeline First Light Asset Management, LLC More: the full row for First Light Asset Management, LLC 868,882 $11.5M 1.1% -79,249 13F-HR Timeline Palo Alto Investors LP More: the full row for Palo Alto Investors LP 843,971 $11.2M 1.73% 0 13F-HR Timeline Sanofi More: the full row for Sanofi 821,917 $10.9M 6.24% 13F-HR Timeline TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 645,334 $8.54M +248,257 Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 486,597 $6.44M <0.01% +21,196 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 485,073 $6.42M 0.04% +25,094 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 419,106 $5.55M <0.01% +68,742 13F-HR Timeline Group Soleus Capital Management, L.P. More: the full row for Soleus Capital Management, L.P. 414,000 $5.48M 0.41% new 13F-HR Timeline 5AM Venture Management, LLC More: the full row for 5AM Venture Management, LLC 357,733 $4.74M 1.13% 0 13F-HR Timeline FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 354,370 $4.69M <0.01% 0 13F-HR Timeline Group VICTORY CAPITAL MANAGEMENT INC More: the full row for VICTORY CAPITAL MANAGEMENT INC 334,450 $4.43M <0.01% +97,200 13F-HR Timeline Assenagon Asset Management S.A. More: the full row for Assenagon Asset Management S.A. 331,758 $4.39M 0.01% -143,688 13F-HR Timeline JENNISON ASSOCIATES LLC More: the full row for JENNISON ASSOCIATES LLC 269,131 $3.56M <0.01% +4,242 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 219,986 $2.91M <0.01% +20,073 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 215,917 $2.86M <0.01% +38,535 13F-HR/A Timeline Group Ensign Peak Advisors, Inc More: the full row for Ensign Peak Advisors, Inc 215,454 $2.85M 0.01% +139,699 13F-HR Timeline D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 197,107 $2.61M <0.01% -27,030 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 193,200 $2.56M <0.01% -7,200 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 173,727 $2.3M <0.01% -31,818 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 166,054 $2.2M <0.01% +5,733 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 146,517 $1.94M <0.01% -185,049 13F-HR Timeline Group LMR Partners LLP in group LMR Partners LLP More: the full row for LMR Partners LLP 140,722 $1.86M 0.03% new 13F-HR Timeline Group Sofinnova Investments, Inc. More: the full row for Sofinnova Investments, Inc. 132,927 $1.76M 0.13% new 13F-HR Timeline Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 125,070 $1.66M <0.01% +72,042 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 114,939 $1.52M <0.01% +81,195 13F-HR Timeline Group Granahan Investment Management, LLC More: the full row for Granahan Investment Management, LLC 106,079 $1.4M 0.06% new 13F-HR Timeline MACQUARIE GROUP LTD in group MACQUARIE GROUP LTD More: the full row for MACQUARIE GROUP LTD 93,732 $1.24M <0.01% 0 13F-HR Timeline Group VOLORIDGE INVESTMENT MANAGEMENT, LLC More: the full row for VOLORIDGE INVESTMENT MANAGEMENT, LLC 87,513 $1.16M <0.01% -85,708 13F-HR Timeline JACOBS LEVY EQUITY MANAGEMENT, INC More: the full row for JACOBS LEVY EQUITY MANAGEMENT, INC 85,381 $1.13M <0.01% +39,307 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 83,567 $1.11M <0.01% +39,267 13F-HR/A Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 80,870 $1.07M <0.01% +36,365 13F-HR Timeline Group Rafferty Asset Management, LLC More: the full row for Rafferty Asset Management, LLC 70,883 $938K <0.01% +32,185 13F-HR Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 66,467 $880K <0.01% +528 13F-HR Timeline Group UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 66,085 $875K -3,437 Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 61,584 $815K +50,445 Timeline Trexquant Investment LP More: the full row for Trexquant Investment LP 60,720 $804K 0.01% -37,152 13F-HR Timeline Fisher Asset Management, LLC More: the full row for Fisher Asset Management, LLC 58,878 $780K <0.01% -3,070 13F-HR Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 57,169 $757K <0.01% -1,972 13F-HR Timeline Group Nuveen Asset Management, LLC in group TIAA More: the full row for Nuveen Asset Management, LLC 56,012 $742K <0.01% 0 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 53,777 $712K <0.01% +38,376 13F-HR Timeline Group FEDERATED HERMES, INC. in group FEDERATED HERMES, INC. More: the full row for FEDERATED HERMES, INC. 45,184 $598K <0.01% -272,059 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 44,613 $591K <0.01% -8,544 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 40,013 $530K 0.04% +19,727 13F-HR Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 36,452 $483K <0.01% -5,594 13F-HR Timeline Group FMB WEALTH MANAGEMENT More: the full row for FMB WEALTH MANAGEMENT 35,592 $471K 0.27% 0 13F-HR Timeline DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 31,608 $418K <0.01% -64,364 13F-HR Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 30,520 $404K <0.01% 0 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 30,077 $398K <0.01% +1,111 13F-HR/A Timeline Swiss National Bank More: the full row for Swiss National Bank 29,700 $393K <0.01% +3,200 13F-HR Timeline MARTINGALE ASSET MANAGEMENT L P More: the full row for MARTINGALE ASSET MANAGEMENT L P 28,995 $384K 0.01% 0 13F-HR Timeline Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 28,129 $372K 0.01% +16,838 13F-HR Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 27,301 $361K 0.07% -165,419 13F-HR Timeline Group STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 26,677 $353K <0.01% +6,804 13F-HR Timeline ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 24,604 $326K <0.01% +3,092 13F-HR Timeline Group Y-Intercept (Hong Kong) Ltd More: the full row for Y-Intercept (Hong Kong) Ltd 23,497 $311K 0.02% new 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 23,288 $308K <0.01% -28,002 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 23,126 $306K <0.01% -42,983 13F-HR Timeline Group Bridgefront Capital, LLC More: the full row for Bridgefront Capital, LLC 19,011 $252K 0.08% new 13F-HR Timeline Graham Capital Management, L.P. More: the full row for Graham Capital Management, L.P. 18,954 $251K 0.01% new 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 18,675 $247K <0.01% +1,155 13F-HR Timeline Group Altium Capital Management LLC More: the full row for Altium Capital Management LLC 18,326 $243K 0.08% new 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 17,949 $238K <0.01% -148,287 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 17,867 $237K <0.01% +6,113 13F-HR/A Timeline Group Nebula Research & Development LLC More: the full row for Nebula Research & Development LLC 17,422 $231K 0.03% new 13F-HR Timeline SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 16,307 $216K <0.01% +4,231 13F-HR Timeline Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 16,026 $212K +2,623 Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 14,590 $193K <0.01% +1,359 13F-HR/A Timeline TD Asset Management Inc More: the full row for TD Asset Management Inc 14,000 $185K <0.01% -48,000 13F-HR Timeline PROFUND ADVISORS LLC More: the full row for PROFUND ADVISORS LLC 13,496 $179K 0.01% +5,768 13F-HR Timeline Aristides Capital LLC More: the full row for Aristides Capital LLC 12,700 $168K 0.05% new 13F-HR Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 12,254 $162K <0.01% 0 13F-HR Timeline Group Jain Global LLC More: the full row for Jain Global LLC 12,134 $161K <0.01% 13F-HR Timeline AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 11,846 $157K <0.01% -36,746 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 11,120 $147K <0.01% -15,977 13F-HR Timeline Group Corebridge Financial, Inc. in group Corebridge Financial, Inc. More: the full row for Corebridge Financial, Inc. 10,747 $142K <0.01% +285 13F-HR Timeline Group TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 10,362 $137K <0.01% +382 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 7,924 $105K <0.01% 0 13F-HR/A Timeline Caption Management, LLC More: the full row for Caption Management, LLC 7,542 $99.9K <0.01% new 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 6,452 $85.4K 0.01% +644 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 5,698 $75.4K <0.01% +5,360 13F-HR Timeline Group PUBLIC EMPLOYEES RETIREMENT ASSOCIATION… More: the full row for PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO 4,876 $65K <0.01% 0 13F-HR Timeline VIRTUS ADVISERS, LLC in group Virtus Investment Advisers, L… More: the full row for VIRTUS ADVISERS, LLC 4,733 $62.7K 0.03% +936 13F-HR Timeline Group AlphaQuest LLC More: the full row for AlphaQuest LLC 4,461 $59.1K 0.01% +4,237 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 3,951 $52.3K <0.01% 13F-HR Timeline KLP KAPITALFORVALTNING AS More: the full row for KLP KAPITALFORVALTNING AS 3,000 $39.7K <0.01% 13F-HR Timeline Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 2,722 $36K <0.01% -138 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 2,697 $35.7K <0.01% +1,531 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 1,917 $25.4K <0.01% 0 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 1,222 $17K <0.01% -2,870 13F-HR Timeline Group NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 1,270 $16.8K <0.01% +76 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 774 $10.2K <0.01% +301 13F-HR Timeline Group CANADA LIFE ASSURANCE Co in group CANADA LIFE ASSURANCE Co More: the full row for CANADA LIFE ASSURANCE Co 750 $10K <0.01% 0 13F-HR Timeline Group AMALGAMATED BANK More: the full row for AMALGAMATED BANK 664 $9K <0.01% 0 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 639 $8.46K <0.01% 13F-HR Timeline SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 362 $4.79K <0.01% -302 13F-HR Timeline Brooklyn Investment Group More: the full row for Brooklyn Investment Group 339 $4.49K <0.01% new 13F-HR Timeline Amundi in group Amundi More: the full row for Amundi 290 $4.16K <0.01% +45 13F-HR Timeline Group WHITTIER TRUST CO More: the full row for WHITTIER TRUST CO 307 $4.06K <0.01% 0 13F-HR Timeline QUADRANT CAPITAL GROUP LLC More: the full row for QUADRANT CAPITAL GROUP LLC 285 $3.77K <0.01% -52 13F-HR Timeline Asset Dedication, LLC More: the full row for Asset Dedication, LLC 190 $2.52K <0.01% 0 13F-HR Timeline MATHER GROUP, LLC. More: the full row for MATHER GROUP, LLC. 130 $1.72K <0.01% 0 13F-HR Timeline Sherman Asset Management, Inc. More: the full row for Sherman Asset Management, Inc. 120 $1.59K <0.01% 13F-HR Timeline MassMutual Private Wealth & Trust, FSB More: the full row for MassMutual Private Wealth & Trust, FSB 114 $1.51K <0.01% +102 13F-HR Timeline Smartleaf Asset Management LLC More: the full row for Smartleaf Asset Management LLC 101 $1.33K <0.01% +12 13F-HR Timeline Versant Capital Management, Inc More: the full row for Versant Capital Management, Inc 90 $1.19K <0.01% new 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 88 $1.17K <0.01% -342 13F-HR/A Timeline Group Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 105 $1K <0.01% 0 13F-HR Timeline Group CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 38 $1K <0.01% -97 13F-HR Timeline Group Covestor Ltd More: the full row for Covestor Ltd 38 $1K <0.01% +28 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 66 $874 <0.01% 0 13F-HR Timeline Group Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 55 $728 <0.01% 0 13F-HR Timeline Lindbrook Capital, LLC More: the full row for Lindbrook Capital, LLC 42 $556 <0.01% -61 13F-HR Timeline Riggs Asset Managment Co. Inc. More: the full row for Riggs Asset Managment Co. Inc. 30 $397 <0.01% 0 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 20 $265 <0.01% 0 13F-HR Timeline WealthCollab, LLC More: the full row for WealthCollab, LLC 20 $265 <0.01% new 13F-HR Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 19 $252 <0.01% -3 13F-HR Timeline ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 10 $132 <0.01% -15 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 10 $132 <0.01% new 13F-HR Timeline Group SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 5 $66 <0.01% 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 5 $66 <0.01% 13F-HR/A Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 0 $26 <0.01% new 13F-HR Timeline Amount filed as zero, left out of ratios. CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.