TCG Crossover Management, LLC More: the full row for TCG Crossover Management, LLC 6,056,596 $44.3M 4.33% 0 13F-HR Timeline Deep Track Capital, LP More: the full row for Deep Track Capital, LP 3,579,209 $26.2M 0.98% 0 13F-HR Timeline Cormorant Asset Management, LP More: the full row for Cormorant Asset Management, LP 2,130,000 $15.6M 0.86% 0 13F-HR Timeline GREAT POINT PARTNERS LLC More: the full row for GREAT POINT PARTNERS LLC 1,648,523 $12.1M 5.69% -480,250 13F-HR Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 1,513,393 $11.1M 2.28% +991,781 13F-HR Timeline Group FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 1,466,062 $10.7M <0.01% +141,710 13F-HR Timeline Group Nantahala Capital Management, LLC in group Nantahala Capital Management,… More: the full row for Nantahala Capital Management, LLC 1,436,047 $10.5M 0.74% +450,413 13F-HR Timeline Group Venrock Adviser, LLC More: the full row for Venrock Adviser, LLC 1,345,780 $9.85M 0.68% 0 13F-HR Timeline Commodore Capital LP in group Commodore Capital LP More: the full row for Commodore Capital LP 1,284,110 $9.4M 0.69% 0 13F-HR Timeline Group Blackstone Inc. in group Blackstone Inc. More: the full row for Blackstone Inc. 936,607 $6.86M 0.03% -585,827 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 931,179 $6.82M 0.01% +285,542 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 855,676 $6.26M 0.01% +389,247 13F-HR Timeline Group SAMSARA BIOCAPITAL, LLC More: the full row for SAMSARA BIOCAPITAL, LLC 850,000 $6.22M 0.85% 0 13F-HR Timeline Caligan Partners LP More: the full row for Caligan Partners LP 752,167 $5.51M 1.39% new 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 728,919 $5.34M <0.01% new 13F-HR Timeline Group Saturn V Capital Management LP More: the full row for Saturn V Capital Management LP 653,071 $4.78M 1.87% +5,052 13F-HR Timeline Allostery Investments LP More: the full row for Allostery Investments LP 591,253 $4.33M 8.5% 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 479,326 $3.51M <0.01% -25,426 13F-HR/A Timeline Group Aberdeen Group plc in group Aberdeen Group plc More: the full row for Aberdeen Group plc 424,181 $3.11M 0.01% +107,750 13F-HR Timeline Group BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 406,903 $2.98M 0.09% new 13F-HR Timeline Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 302,642 $2.22M 0.02% +45,225 13F-HR Timeline Group SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 285,120 $2.09M 0.47% -176,540 13F-HR Timeline Group KENNEDY CAPITAL MANAGEMENT LLC More: the full row for KENNEDY CAPITAL MANAGEMENT LLC 225,470 $1.65M 0.04% +1,656 13F-HR Timeline Springhill Fund Asset Management (HK) C… More: the full row for Springhill Fund Asset Management (HK) Co Ltd 207,600 $1.52M 2.47% 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 174,873 $1.28M <0.01% +174,182 13F-HR Timeline Group Soleus Capital Management, L.P. More: the full row for Soleus Capital Management, L.P. 125,000 $915K 0.07% 0 13F-HR Timeline Atika Capital Management LLC in group Atika Capital Management LLC More: the full row for Atika Capital Management LLC 103,929 $761K 0.1% -9,702 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 91,300 $668K <0.01% -451,600 13F-HR Timeline Group Shay Capital LLC More: the full row for Shay Capital LLC 50,029 $366K 0.09% new 13F-HR Timeline HighVista Strategies LLC More: the full row for HighVista Strategies LLC 49,064 $359K 0.13% 0 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 48,136 $352K <0.01% -33,594 13F-HR Timeline TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 19,736 $144K <0.01% new 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 19,244 $141K <0.01% +6,200 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 16,749 $123K <0.01% +1,177 13F-HR Timeline Group Stonepine Capital Management, LLC More: the full row for Stonepine Capital Management, LLC 15,000 $110K 0.09% new 13F-HR Timeline GUGGENHEIM CAPITAL LLC in group GUGGENHEIM CAPITAL LLC More: the full row for GUGGENHEIM CAPITAL LLC 12,512 $91.6K <0.01% new 13F-HR Timeline Group AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 11,668 $85.4K <0.01% new 13F-HR Timeline Group HighTower Advisors, LLC More: the full row for HighTower Advisors, LLC 10,000 $73.2K <0.01% 0 13F-HR Timeline Cubist Systematic Strategies, LLC More: the full row for Cubist Systematic Strategies, LLC 7,557 $55.3K <0.01% -8,896 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 5,536 $40.5K <0.01% +1,990 13F-HR Timeline Group R Squared Ltd More: the full row for R Squared Ltd 4,950 $36.2K 0.04% 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 3,976 $29.1K <0.01% new 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 1,095 $8.02K <0.01% new 13F-HR/A Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 706 $5.17K <0.01% +22 13F-HR/A Timeline Financial Management Professionals, Inc. More: the full row for Financial Management Professionals, Inc. 100 $732 <0.01% 0 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 25 $183 <0.01% -7 13F-HR/A Timeline Group PRINCIPAL SECURITIES, INC. in group PRINCIPAL FINANCIAL GROUP INC More: the full row for PRINCIPAL SECURITIES, INC. 10 $73 <0.01% 0 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 37 $0 0% new 13F-HR Timeline Group Value filed as zero, left out of ratios. CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.