TCG Crossover Management, LLC More: the full row for TCG Crossover Management, LLC 6,056,596 $46.3M 5.29% 0 13F-HR Timeline Deep Track Capital, LP More: the full row for Deep Track Capital, LP 3,480,144 $26.6M 0.86% -99,065 13F-HR Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 3,071,340 $23.5M 3.82% +861,321 13F-HR Timeline Group Cormorant Asset Management, LP More: the full row for Cormorant Asset Management, LP 2,130,000 $16.3M 1.21% 0 13F-HR Timeline Caligan Partners LP More: the full row for Caligan Partners LP 1,674,400 $12.8M 2.49% +405,281 13F-HR Timeline Nantahala Capital Management, LLC in group Nantahala Capital Management,… More: the full row for Nantahala Capital Management, LLC 1,482,994 $11.3M 0.8% 0 13F-HR Timeline Group FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 1,371,050 $10.5M <0.01% 0 13F-HR Timeline Group Venrock Adviser, LLC More: the full row for Venrock Adviser, LLC 1,345,780 $10.3M 0.77% 0 13F-HR Timeline GREAT POINT PARTNERS LLC More: the full row for GREAT POINT PARTNERS LLC 1,291,617 $9.88M 6.42% -346,494 13F-HR Timeline Octagon Capital Advisors LP More: the full row for Octagon Capital Advisors LP 1,267,000 $9.69M 2.13% +37,000 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 1,252,257 $9.58M 0.01% -121,603 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 1,251,765 $9.58M 0.01% +264,351 13F-HR Timeline Group BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 870,438 $6.66M 0.2% +299,770 13F-HR Timeline Aberdeen Group plc in group Aberdeen Group plc More: the full row for Aberdeen Group plc 710,516 $5.44M 0.01% 0 13F-HR Timeline Group Saturn V Capital Management LP More: the full row for Saturn V Capital Management LP 622,479 $4.76M 1.93% +69,553 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 475,280 $3.64M <0.01% -21,873 13F-HR Timeline Group Ensign Peak Advisors, Inc More: the full row for Ensign Peak Advisors, Inc 455,684 $3.49M 0.01% 0 13F-HR Timeline KENNEDY CAPITAL MANAGEMENT LLC More: the full row for KENNEDY CAPITAL MANAGEMENT LLC 241,188 $1.85M 0.04% +15,997 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 183,800 $1.41M 0.01% -18,124 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 170,733 $1.31M <0.01% -13,506 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 167,887 $1.28M <0.01% +138,469 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 167,656 $1.28M <0.01% +5,102 13F-HR Timeline Group Allostery Investments LP More: the full row for Allostery Investments LP 167,350 $1.28M 16.31% -932,304 13F-HR Timeline Soleus Capital Management, L.P. More: the full row for Soleus Capital Management, L.P. 125,000 $956K 0.07% 0 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 113,391 $867K <0.01% +111,913 13F-HR/A Timeline Group Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 100,000 $765K 0.11% -100,000 13F-HR Timeline Paloma Partners Management Co in group Paloma Partners Management Co More: the full row for Paloma Partners Management Co 95,130 $728K 0.17% +56,681 13F-HR Timeline Group STEMPOINT CAPITAL LP More: the full row for STEMPOINT CAPITAL LP 87,748 $671K 0.22% new 13F-HR Timeline J. Goldman & Co LP More: the full row for J. Goldman & Co LP 67,500 $516K 0.02% new 13F-HR Timeline HighVista Strategies LLC More: the full row for HighVista Strategies LLC 51,156 $391K 0.14% +2,092 13F-HR Timeline NewEdge Advisors, LLC More: the full row for NewEdge Advisors, LLC 30,000 $230K <0.01% new 13F-HR Timeline Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 19,367 $148K <0.01% new 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 18,194 $139K 0.01% new 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 16,818 $129K <0.01% +69 13F-HR Timeline Group GUGGENHEIM CAPITAL LLC in group GUGGENHEIM CAPITAL LLC More: the full row for GUGGENHEIM CAPITAL LLC 16,097 $123K <0.01% +2,305 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 10,670 $81.6K <0.01% -776 13F-HR Timeline Group Hurley Capital, LLC More: the full row for Hurley Capital, LLC 3,015 $23.1K 0.02% 0 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 981 $7.5K <0.01% +243 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 645 $4.93K <0.01% -2,368 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 536 $4.1K <0.01% -10,170 13F-HR Timeline Group Financial Management Professionals, Inc. More: the full row for Financial Management Professionals, Inc. 100 $765 <0.01% 0 13F-HR Timeline PRINCIPAL SECURITIES, INC. in group PRINCIPAL FINANCIAL GROUP INC More: the full row for PRINCIPAL SECURITIES, INC. 36 $275 <0.01% +26 13F-HR Timeline Group EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 8 $61 <0.01% new 13F-HR Timeline Group CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.