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Prosight Management, LP

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13F filer, CIK 1617201, DALLAS, TX

Prosight Management, LP reported $609,819,841 across 46 holdings for the quarter ended 2026-03-31, in a 13F-HR filed 2026-05-15. Its ten largest share positions make up 65.04% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001420506-26-001036

Period
2026-03-31
Reported value
$610M
Holdings
46
Top 10 weight
65.04%
New
16
Sold out
8

Largest buys vs the previous quarter

SecurityShares changeApprox. value
BSXadded+585,547$36.7M
WGSadded+468,463$30.1M
ALNYadded+58,891$19.5M
ALKSnew+513,632$18.2M
STTKadded+2,622,937$16.9M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
ICLRexited-110,000-$20M
FOLDexited-1,150,000-$16.4M
SEMexited-1,035,086-$15.4M
ROIVreduced-447,162-$12.4M
AVTRexited-898,499-$10.3M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q1 2026

Share positions as resolved from 13F-HR 0001420506-26-001036, largest first. % of portfolio is the value over $609,819,841, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
NKTRNEKTAR THERAPEUTICSQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 554,633 shares; 2026Q1: 735,000 shares 735,000$52.9M8.67%+180,367Timeline
BSXBOSTON SCIENTIFIC CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 76,100 shares; 2025Q4: 210,000 shares; 2026Q1: 795,547 shares 795,547$49.9M8.19%+585,547Timeline
JANXJANUX THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 205,000 shares; 2024Q4: 329,768 shares; 2025Q1: 689,901 shares; 2025Q2: 853,904 shares; 2025Q3: 865,350 shares; 2025Q4: 2,392,523 shares; 2026Q1: 3,550,000 shares 3,550,000$49.3M8.09%+1,157,477Timeline
PRCTPROCEPT BIOROBOTICS CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 76,991 shares; 2025Q4: 1,380,000 shares; 2026Q1: 1,945,000 shares 1,945,000$48.6M7.98%+565,000Timeline
LKFTLAKEFRONT BIOTHERAPEUTICS NVQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 1,028,843 shares; 2024Q4: 1,025,000 shares; 2025Q1: 1,314,898 shares; 2025Q2: 1,773,649 shares; 2025Q3: 1,150,000 shares; 2025Q4: 1,074,112 shares; 2026Q1: 1,550,000 shares 1,550,000$46.5M7.63%+475,888Timeline
WGSGENEDX HOLDINGS CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 55,000 shares; 2026Q1: 523,463 shares 523,463$33.6M5.51%+468,463Timeline
STTKSHATTUCK LABS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 5,678,726 shares; 2024Q4: 6,638,935 shares; 2025Q1: 6,638,935 shares; 2025Q2: 6,638,935 shares; 2025Q3: 5,451,195 shares; 2025Q4: 2,381,502 shares; 2026Q1: 5,004,439 shares 5,004,439$32.2M5.28%+2,622,937Timeline
ADCTADC THERAPEUTICS SAQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 9,636,237 shares; 2024Q4: 9,515,000 shares; 2025Q1: 9,543,004 shares; 2025Q2: 10,467,771 shares; 2025Q3: 7,472,303 shares; 2025Q4: 8,477,338 shares; 2026Q1: 8,300,000 shares 8,300,000$31.1M5.1%-177,338Timeline
KURAKURA ONCOLOGY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 705,109 shares; 2024Q4: 1,325,000 shares; 2025Q1: 2,078,315 shares; 2025Q2: 3,181,184 shares; 2025Q3: 2,758,516 shares; 2025Q4: 2,529,600 shares; 2026Q1: 3,356,700 shares 3,356,700$27.3M4.48%+827,100Timeline
ALNYALNYLAM PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 17,109 shares; 2026Q1: 76,000 shares 76,000$25.1M4.12%+58,891Timeline
MGTXMEIRAGTX HLDGS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 4,900,570 shares; 2024Q4: 4,390,837 shares; 2025Q1: 3,691,546 shares; 2025Q2: 4,587,423 shares; 2025Q3: 4,089,509 shares; 2025Q4: 3,209,788 shares; 2026Q1: 2,629,971 shares 2,629,971$22.8M3.73%-579,817Timeline
ALKSALKERMES PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 513,632 shares 513,632$18.2M2.98%newTimeline
SNDXSYNDAX PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 554,103 shares; 2024Q4: 620,000 shares; 2025Q1: 609,252 shares; 2025Q2: 1,079,673 shares; 2025Q3: 1,003,400 shares; 2025Q4: 665,000 shares; 2026Q1: 770,000 shares 770,000$18M2.95%+105,000Timeline
VEEVVEEVA SYS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 90,133 shares; 2026Q1: 86,480 shares 86,480$15.2M2.49%-3,653Timeline
ZYMEZYMEWORKS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 917,599 shares; 2024Q4: 820,000 shares; 2025Q1: 957,229 shares; 2025Q2: 1,309,904 shares; 2025Q3: 749,611 shares; 2025Q4: 530,393 shares; 2026Q1: 539,049 shares 539,049$13.5M2.21%+8,656Timeline
CRNXCRINETICS PHARMACEUTICALS INQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 298,123 shares; 2025Q3: 328,684 shares; 2025Q4: 262,904 shares; 2026Q1: 350,000 shares 350,000$12.7M2.08%+87,096Timeline
ABVXABIVAX SAQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 17,000 shares; 2026Q1: 105,000 shares 105,000$11.7M1.92%+88,000Timeline
CONCONCENTRA GROUP HOLDINGS PARQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 312,105 shares; 2025Q3: 610,000 shares; 2025Q4: 891,030 shares; 2026Q1: 505,822 shares 505,822$10.8M1.78%-385,208Timeline
TERNTERNS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 95,000 shares; 2026Q1: 202,300 shares 202,300$10.7M1.75%+107,300Timeline
PHRPHREESIA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 977,152 shares; 2026Q1: 1,100,000 shares 1,100,000$9.22M1.51%+122,848Timeline
OKURONKURE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 63,754 shares; 2025Q1: 186,570 shares; 2025Q2: 159,692 shares; 2025Q3: 267,959 shares; 2025Q4: 816,909 shares; 2026Q1: 2,154,381 shares 2,154,381$8.92M1.46%+1,337,472Timeline
CRBPCORBUS PHARMACEUTICALS HLDGSQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 130,000 shares; 2024Q4: 270,000 shares; 2025Q1: 575,136 shares; 2025Q2: 579,893 shares; 2025Q3: 343,400 shares; 2025Q4: 683,872 shares; 2026Q1: 697,108 shares 697,108$6.55M1.07%+13,236Timeline
SDGRSCHRODINGER INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 700,000 shares; 2024Q4: 720,500 shares; 2025Q1: 385,000 shares; 2025Q2: not reported; 2025Q3: 34,830 shares; 2025Q4: not reported; 2026Q1: 510,578 shares 510,578$5.8M0.95%newTimeline
EBSEMERGENT BIOSOLUTIONS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 639,118 shares 639,118$5.3M0.87%newTimeline
ROIVROIVANT SCIENCES LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 1,721,512 shares; 2024Q4: 1,500,000 shares; 2025Q1: 1,826,163 shares; 2025Q2: 1,808,539 shares; 2025Q3: 1,335,500 shares; 2025Q4: 627,162 shares; 2026Q1: 180,000 shares 180,000$4.99M0.82%-447,162Timeline
KIDSORTHOPEDIATRICS CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 73,647 shares; 2025Q3: 308,707 shares; 2025Q4: 136,741 shares; 2026Q1: 302,399 shares 302,399$4.8M0.79%+165,658Timeline
IMVTIMMUNOVANT INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 370,000 shares; 2024Q4: 305,523 shares; 2025Q1: 360,000 shares; 2025Q2: 479,400 shares; 2025Q3: 698,472 shares; 2025Q4: 243,404 shares; 2026Q1: 175,825 shares 175,825$4.37M0.72%-67,579Timeline
ICUIICU MED INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 27,450 shares 27,450$3.55M0.58%newTimeline
TECXTECTONIC THERAPEUTIC INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 137,614 shares; 2024Q4: not reported; 2025Q1: 398,885 shares; 2025Q2: 442,056 shares; 2025Q3: 379,254 shares; 2025Q4: 235,000 shares; 2026Q1: 79,872 shares 79,872$2.47M0.4%-155,128Timeline
RCKTROCKET PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 159,369 shares; 2024Q4: 1,088,706 shares; 2025Q1: 1,480,000 shares; 2025Q2: 1,580,588 shares; 2025Q3: 1,267,965 shares; 2025Q4: 743,942 shares; 2026Q1: 683,856 shares 683,856$2.45M0.4%-60,086Timeline
UPBUPSTREAM BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 241,123 shares 241,123$2.17M0.36%newTimeline
PLRXPLIANT THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 334,263 shares; 2025Q2: 837,400 shares; 2025Q3: 20,487 shares; 2025Q4: 1,555,744 shares; 2026Q1: 1,667,600 shares 1,667,600$2.1M0.34%+111,856Timeline
OMEROMEROS CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 174,800 shares 174,800$1.85M0.3%newTimeline
ISRGINTUITIVE SURGICAL INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 14,000 shares; 2025Q2: not reported; 2025Q3: 48,711 shares; 2025Q4: not reported; 2026Q1: 4,000 shares 4,000$1.84M0.3%newTimeline
ANTXAN2 THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 515,754 shares 515,754$1.76M0.29%newTimeline
ACETADICET BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 250,244 shares; 2026Q1: 250,244 shares 250,244$1.7M0.28%0Timeline
RGNXREGENXBIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 200,000 shares 200,000$1.68M0.27%newTimeline
COYACOYA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 420,360 shares 420,360$1.66M0.27%newTimeline
VKTXVIKING THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 48,000 shares; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 45,000 shares 45,000$1.46M0.24%newTimeline
IRTCIRHYTHM HOLDINGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 10,000 shares 10,000$1.18M0.19%newTimeline
TBITRUEBLUE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 79,476 shares; 2025Q4: 442,554 shares; 2026Q1: 249,107 shares 249,107$974K0.16%-193,447Timeline
IMRXIMMUNEERING CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 190,000 shares; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 123,409 shares 123,409$650K0.11%newTimeline
PVLAPALVELLA THERAPEUTICS INC NEQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 5,000 shares 5,000$623K0.1%newTimeline
NVCRNOVOCURE LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 50,400 shares 50,400$549K0.09%newTimeline
RNTXREIN THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 372,157 shares; 2024Q4: 404,979 shares; 2025Q1: 430,000 shares; 2025Q2: 427,919 shares; 2025Q3: 567,898 shares; 2025Q4: 442,600 shares; 2026Q1: 411,600 shares 411,600$535K0.09%-31,000Timeline
TMDXTRANSMEDICS GROUP INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 5,000 shares 5,000$497K0.08%newTimeline

Sold out in Q1 2026

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
ICLRICON PUB LTD CO110,000$20Mshares
FOLDAMICUS THERAPEUTIC1,150,000$16.4Mshares
SEMSELECT MED HLDGS CORP1,035,086$15.4Mshares
AVTRAVANTOR INC898,499$10.3Mshares
LHLABCORP HOLDINGS INC34,532$8.66Mshares
CDNACAREDX INC250,000$4.71Mshares
BBIOBRIDGEBIO PHARMA INC30,000$2.29Mshares
TEMTEMPUS AI INC35,000$2.07Mshares

How Q1 2026 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001420506-26-001036 base2026-05-15acceptance time not in the bulk data set