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Prosight Management, LP

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13F filer, CIK 1617201, DALLAS, TX

Prosight Management, LP reported $483,927,204 across 38 holdings for the quarter ended 2025-12-31, in a 13F-HR filed 2026-02-13. Its ten largest share positions make up 57.22% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001420506-26-000422

Period
2025-12-31
Reported value
$484M
Holdings
38
Top 10 weight
57.22%
New
11
Sold out
15

Largest buys vs the previous quarter

SecurityShares changeApprox. value
PRCTadded+1,303,009$41M
NKTRnew+554,633$23.4M
JANXadded+1,527,173$21.1M
VEEVnew+90,133$20.1M
PHRnew+977,152$16.5M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
ISRGexited-48,711-$21.8M
BBIOreduced-234,500-$17.9M
ROIVreduced-708,338-$15.4M
DXCMexited-195,217-$13.1M
IMVTreduced-455,068-$11.6M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q4 2025

Share positions as resolved from 13F-HR 0001420506-26-000422, largest first. % of portfolio is the value over $483,927,204, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
PRCTPROCEPT BIOROBOTICS CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 76,991 shares; 2025Q4: 1,380,000 shares 1,380,000$43.4M8.97%+1,303,009Timeline
LKFTLAKEFRONT BIOTHERAPEUTICS NVQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,028,843 shares; 2024Q4: 1,025,000 shares; 2025Q1: 1,314,898 shares; 2025Q2: 1,773,649 shares; 2025Q3: 1,150,000 shares; 2025Q4: 1,074,112 shares 1,074,112$35.1M7.26%-75,888Timeline
JANXJANUX THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 205,000 shares; 2024Q4: 329,768 shares; 2025Q1: 689,901 shares; 2025Q2: 853,904 shares; 2025Q3: 865,350 shares; 2025Q4: 2,392,523 shares 2,392,523$33M6.82%+1,527,173Timeline
ADCTADC THERAPEUTICS SAQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 9,636,237 shares; 2024Q4: 9,515,000 shares; 2025Q1: 9,543,004 shares; 2025Q2: 10,467,771 shares; 2025Q3: 7,472,303 shares; 2025Q4: 8,477,338 shares 8,477,338$29.9M6.18%+1,005,035Timeline
KURAKURA ONCOLOGY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 705,109 shares; 2024Q4: 1,325,000 shares; 2025Q1: 2,078,315 shares; 2025Q2: 3,181,184 shares; 2025Q3: 2,758,516 shares; 2025Q4: 2,529,600 shares 2,529,600$26.3M5.43%-228,916Timeline
MGTXMEIRAGTX HLDGS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 4,900,570 shares; 2024Q4: 4,390,837 shares; 2025Q1: 3,691,546 shares; 2025Q2: 4,587,423 shares; 2025Q3: 4,089,509 shares; 2025Q4: 3,209,788 shares 3,209,788$25.5M5.27%-879,721Timeline
NKTRNEKTAR THERAPEUTICSQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 554,633 shares 554,633$23.4M4.85%newTimeline
VEEVVEEVA SYS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 90,133 shares 90,133$20.1M4.16%newTimeline
ICLRICON PUB LTD COQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 85,000 shares; 2025Q1: 60,099 shares; 2025Q2: 98,558 shares; 2025Q3: 109,500 shares; 2025Q4: 110,000 shares 110,000$20M4.14%+500Timeline
BSXBOSTON SCIENTIFIC CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 76,100 shares; 2025Q4: 210,000 shares 210,000$20M4.14%+133,900Timeline
CONCONCENTRA GROUP HOLDINGS PARQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 312,105 shares; 2025Q3: 610,000 shares; 2025Q4: 891,030 shares 891,030$17.5M3.62%+281,030Timeline
PHRPHREESIA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 977,152 shares 977,152$16.5M3.42%newTimeline
FOLDAMICUS THERAPEUTICQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 920,000 shares; 2025Q1: 1,379,383 shares; 2025Q2: 3,480,044 shares; 2025Q3: 1,709,533 shares; 2025Q4: 1,150,000 shares 1,150,000$16.4M3.38%-559,533Timeline
SEMSELECT MED HLDGS CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 26,065 shares; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 353,820 shares; 2025Q3: 874,915 shares; 2025Q4: 1,035,086 shares 1,035,086$15.4M3.18%+160,171Timeline
SNDXSYNDAX PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 554,103 shares; 2024Q4: 620,000 shares; 2025Q1: 609,252 shares; 2025Q2: 1,079,673 shares; 2025Q3: 1,003,400 shares; 2025Q4: 665,000 shares 665,000$14M2.89%-338,400Timeline
ZYMEZYMEWORKS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 917,599 shares; 2024Q4: 820,000 shares; 2025Q1: 957,229 shares; 2025Q2: 1,309,904 shares; 2025Q3: 749,611 shares; 2025Q4: 530,393 shares 530,393$14M2.89%-219,218Timeline
ROIVROIVANT SCIENCES LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,721,512 shares; 2024Q4: 1,500,000 shares; 2025Q1: 1,826,163 shares; 2025Q2: 1,808,539 shares; 2025Q3: 1,335,500 shares; 2025Q4: 627,162 shares 627,162$13.6M2.81%-708,338Timeline
CRNXCRINETICS PHARMACEUTICALS INQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 298,123 shares; 2025Q3: 328,684 shares; 2025Q4: 262,904 shares 262,904$12.2M2.53%-65,780Timeline
AVTRAVANTOR INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 898,499 shares 898,499$10.3M2.13%newTimeline
STTKSHATTUCK LABS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 5,678,726 shares; 2024Q4: 6,638,935 shares; 2025Q1: 6,638,935 shares; 2025Q2: 6,638,935 shares; 2025Q3: 5,451,195 shares; 2025Q4: 2,381,502 shares 2,381,502$8.69M1.8%-3,069,693Timeline
LHLABCORP HOLDINGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 34,532 shares 34,532$8.66M1.79%newTimeline
WGSGENEDX HOLDINGS CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 55,000 shares 55,000$7.15M1.48%newTimeline
ALNYALNYLAM PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 17,109 shares 17,109$6.8M1.41%newTimeline
IMVTIMMUNOVANT INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 370,000 shares; 2024Q4: 305,523 shares; 2025Q1: 360,000 shares; 2025Q2: 479,400 shares; 2025Q3: 698,472 shares; 2025Q4: 243,404 shares 243,404$6.19M1.28%-455,068Timeline
CRBPCORBUS PHARMACEUTICALS HLDGSQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 130,000 shares; 2024Q4: 270,000 shares; 2025Q1: 575,136 shares; 2025Q2: 579,893 shares; 2025Q3: 343,400 shares; 2025Q4: 683,872 shares 683,872$5.57M1.15%+340,472Timeline
TECXTECTONIC THERAPEUTIC INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 137,614 shares; 2024Q4: not reported; 2025Q1: 398,885 shares; 2025Q2: 442,056 shares; 2025Q3: 379,254 shares; 2025Q4: 235,000 shares 235,000$4.9M1.01%-144,254Timeline
CDNACAREDX INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 80,000 shares; 2025Q1: 136,593 shares; 2025Q2: 302,808 shares; 2025Q3: 504,030 shares; 2025Q4: 250,000 shares 250,000$4.71M0.97%-254,030Timeline
TERNTERNS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 95,000 shares 95,000$3.84M0.79%newTimeline
RCKTROCKET PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 159,369 shares; 2024Q4: 1,088,706 shares; 2025Q1: 1,480,000 shares; 2025Q2: 1,580,588 shares; 2025Q3: 1,267,965 shares; 2025Q4: 743,942 shares 743,942$2.61M0.54%-524,023Timeline
KIDSORTHOPEDIATRICS CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 73,647 shares; 2025Q3: 308,707 shares; 2025Q4: 136,741 shares 136,741$2.43M0.5%-171,966Timeline
OKURONKURE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 63,754 shares; 2025Q1: 186,570 shares; 2025Q2: 159,692 shares; 2025Q3: 267,959 shares; 2025Q4: 816,909 shares 816,909$2.37M0.49%+548,950Timeline
BBIOBRIDGEBIO PHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,086,810 shares; 2024Q4: 995,000 shares; 2025Q1: 610,000 shares; 2025Q2: 472,687 shares; 2025Q3: 264,500 shares; 2025Q4: 30,000 shares 30,000$2.29M0.47%-234,500Timeline
ABVXABIVAX SAQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 17,000 shares 17,000$2.29M0.47%newTimeline
ACETADICET BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 250,244 shares 250,244$2.11M0.44%newTimeline
TEMTEMPUS AI INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 35,000 shares 35,000$2.07M0.43%newTimeline
TBITRUEBLUE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 79,476 shares; 2025Q4: 442,554 shares 442,554$2.01M0.42%+363,078Timeline
PLRXPLIANT THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 334,263 shares; 2025Q2: 837,400 shares; 2025Q3: 20,487 shares; 2025Q4: 1,555,744 shares 1,555,744$1.9M0.39%+1,535,257Timeline
RNTXREIN THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 372,157 shares; 2024Q4: 404,979 shares; 2025Q1: 430,000 shares; 2025Q2: 427,919 shares; 2025Q3: 567,898 shares; 2025Q4: 442,600 shares 442,600$513K0.11%-125,298Timeline

Sold out in Q4 2025

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
ISRGINTUITIVE SURGICAL INC48,711$21.8Mshares
DXCMDEXCOM INC195,217$13.1Mshares
CORCEPT THERAPEUTICS INCCORCEPT THERAPEUTICS INC147,800$12.3Mcall
BHVNBIOHAVEN LTD600,000$9.01Mshares
VRTXVERTEX PHARMACEUTICALS INC20,500$8.03Mshares
ACHCACADIA HEALTHCARE COMPANY IN250,000$6.19Mshares
ALGNALIGN TECHNOLOGY INC19,442$2.43Mshares
ARGXARGENX SE3,300$2.43Mshares
TWSTTWIST BIOSCIENCE CORP75,000$2.11Mshares
AKROAKERO THERAPEUTICS INC39,072$1.86Mshares
CTMXCYTOMX THERAPEUTICS INC.564,800$1.8Mshares
SGHTSIGHT SCIENCES INC439,941$1.51Mshares
SDGRSCHRODINGER INC34,830$699Kshares
PRTAPROTHENA CORP PLC20,000$195Kshares
ACTUACTUATE THERAPEUTICS INC885$5.92Kshares

How Q4 2025 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001420506-26-000422 base2026-02-13acceptance time not in the bulk data set