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Prosight Management, LP

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13F filer, CIK 1617201, DALLAS, TX

Prosight Management, LP reported $410,062,650 across 39 holdings for the quarter ended 2025-06-30, in a 13F-HR filed 2025-08-14. Its ten largest share positions make up 62.72% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001420506-25-002021

Period
2025-06-30
Reported value
$410M
Holdings
39
Top 10 weight
62.72%
New
9
Sold out
8

Largest buys vs the previous quarter

SecurityShares changeApprox. value
UNHnew+110,000$34.3M
LKFTadded+458,751$12.8M
FOLDadded+2,100,661$12M
CRNXnew+298,123$8.57M
CONnew+312,105$6.42M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
SDGRexited-385,000-$7.6M
MIRMreduced-143,326-$7.29M
ISRGexited-14,000-$6.93M
ABCLexited-2,815,652-$6.28M
BBIOreduced-137,313-$5.93M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q2 2025

Share positions as resolved from 13F-HR 0001420506-25-002021, largest first. % of portfolio is the value over $410,062,650, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
LKFTLAKEFRONT BIOTHERAPEUTICS NVQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,028,843 shares; 2024Q4: 1,025,000 shares; 2025Q1: 1,314,898 shares; 2025Q2: 1,773,649 shares 1,773,649$49.6M12.11%+458,751Timeline
UNHUNITEDHEALTH GROUP INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 110,000 shares 110,000$34.3M8.37%newTimeline
MGTXMEIRAGTX HLDGS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 4,900,570 shares; 2024Q4: 4,390,837 shares; 2025Q1: 3,691,546 shares; 2025Q2: 4,587,423 shares 4,587,423$29.9M7.29%+895,877Timeline
ADCTADC THERAPEUTICS SAQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 9,636,237 shares; 2024Q4: 9,515,000 shares; 2025Q1: 9,543,004 shares; 2025Q2: 10,467,771 shares 10,467,771$28.1M6.84%+924,767Timeline
BBIOBRIDGEBIO PHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,086,810 shares; 2024Q4: 995,000 shares; 2025Q1: 610,000 shares; 2025Q2: 472,687 shares 472,687$20.4M4.98%-137,313Timeline
ROIVROIVANT SCIENCES LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,721,512 shares; 2024Q4: 1,500,000 shares; 2025Q1: 1,826,163 shares; 2025Q2: 1,808,539 shares 1,808,539$20.4M4.97%-17,624Timeline
FOLDAMICUS THERAPEUTICQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 920,000 shares; 2025Q1: 1,379,383 shares; 2025Q2: 3,480,044 shares 3,480,044$19.9M4.86%+2,100,661Timeline
JANXJANUX THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 205,000 shares; 2024Q4: 329,768 shares; 2025Q1: 689,901 shares; 2025Q2: 853,904 shares 853,904$19.7M4.81%+164,003Timeline
KURAKURA ONCOLOGY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 705,109 shares; 2024Q4: 1,325,000 shares; 2025Q1: 2,078,315 shares; 2025Q2: 3,181,184 shares 3,181,184$18.4M4.48%+1,102,869Timeline
ZYMEZYMEWORKS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 917,599 shares; 2024Q4: 820,000 shares; 2025Q1: 957,229 shares; 2025Q2: 1,309,904 shares 1,309,904$16.4M4.01%+352,675Timeline
ICLRICON PUB LTD COQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 85,000 shares; 2025Q1: 60,099 shares; 2025Q2: 98,558 shares 98,558$14.3M3.5%+38,459Timeline
ARGXARGENX SEQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 13,700 shares; 2025Q2: 22,000 shares 22,000$12.1M2.96%+8,300Timeline
MIRMMIRUM PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 465,825 shares; 2024Q4: 451,127 shares; 2025Q1: 343,326 shares; 2025Q2: 200,000 shares 200,000$10.2M2.48%-143,326Timeline
SNDXSYNDAX PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 554,103 shares; 2024Q4: 620,000 shares; 2025Q1: 609,252 shares; 2025Q2: 1,079,673 shares 1,079,673$10.1M2.47%+470,421Timeline
TECXTECTONIC THERAPEUTIC INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 137,614 shares; 2024Q4: not reported; 2025Q1: 398,885 shares; 2025Q2: 442,056 shares 442,056$8.78M2.14%+43,171Timeline
CRNXCRINETICS PHARMACEUTICALS INQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 298,123 shares 298,123$8.57M2.09%newTimeline
CTMXCYTOMX THERAPEUTICS INC.Quarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 3,022,109 shares; 2024Q4: 3,905,000 shares; 2025Q1: 3,930,008 shares; 2025Q2: 3,517,113 shares 3,517,113$7.98M1.95%-412,895Timeline
IMVTIMMUNOVANT INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 370,000 shares; 2024Q4: 305,523 shares; 2025Q1: 360,000 shares; 2025Q2: 479,400 shares 479,400$7.67M1.87%+119,400Timeline
BHVNBIOHAVEN LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 100,000 shares; 2025Q2: 539,071 shares 539,071$7.61M1.85%+439,071Timeline
CONCONCENTRA GROUP HOLDINGS PARQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 312,105 shares 312,105$6.42M1.57%newTimeline
LIVNLIVANOVA PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 90,000 shares; 2024Q4: 70,000 shares; 2025Q1: 127,300 shares; 2025Q2: 140,000 shares 140,000$6.3M1.54%+12,700Timeline
DXCMDEXCOM INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 160,000 shares; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 70,000 shares 70,000$6.11M1.49%newTimeline
CDNACAREDX INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 80,000 shares; 2025Q1: 136,593 shares; 2025Q2: 302,808 shares 302,808$5.92M1.44%+166,215Timeline
SEMSELECT MED HLDGS CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 26,065 shares; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 353,820 shares 353,820$5.37M1.31%newTimeline
STTKSHATTUCK LABS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 5,678,726 shares; 2024Q4: 6,638,935 shares; 2025Q1: 6,638,935 shares; 2025Q2: 6,638,935 shares 6,638,935$5.26M1.28%0Timeline
ACHCACADIA HEALTHCARE COMPANY INQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 5,666 shares; 2024Q4: 692,000 shares; 2025Q1: 290,000 shares; 2025Q2: 211,816 shares 211,816$4.81M1.17%-78,184Timeline
CRBPCORBUS PHARMACEUTICALS HLDGSQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 130,000 shares; 2024Q4: 270,000 shares; 2025Q1: 575,136 shares; 2025Q2: 579,893 shares 579,893$4M0.98%+4,757Timeline
RCKTROCKET PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 159,369 shares; 2024Q4: 1,088,706 shares; 2025Q1: 1,480,000 shares; 2025Q2: 1,580,588 shares 1,580,588$3.87M0.94%+100,588Timeline
SGHTSIGHT SCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 531,222 shares; 2024Q4: 908,847 shares; 2025Q1: 969,287 shares; 2025Q2: 871,687 shares 871,687$3.6M0.88%-97,600Timeline
AXGNAXOGEN INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 282,809 shares 282,809$3.07M0.75%newTimeline
LNTHLANTHEUS HLDGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 34,576 shares 34,576$2.83M0.69%newTimeline
MURAL ONCOLOGY PUB LTD COMURAL ONCOLOGY PUB LTD COQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 570,620 shares; 2024Q4: 466,822 shares; 2025Q1: 422,743 shares; 2025Q2: 900,000 shares 900,000$2.22M0.54%+477,257
PRTAPROTHENA CORP PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 483,467 shares; 2024Q4: 418,122 shares; 2025Q1: 408,122 shares; 2025Q2: 267,800 shares 267,800$1.63M0.4%-140,322Timeline
KIDSORTHOPEDIATRICS CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 73,647 shares 73,647$1.58M0.39%newTimeline
PLRXPLIANT THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 334,263 shares; 2025Q2: 837,400 shares 837,400$971K0.24%+503,137Timeline
RNTXREIN THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 372,157 shares; 2024Q4: 404,979 shares; 2025Q1: 430,000 shares; 2025Q2: 427,919 shares 427,919$599K0.15%-2,081Timeline
OKURONKURE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 63,754 shares; 2025Q1: 186,570 shares; 2025Q2: 159,692 shares 159,692$382K0.09%-26,878Timeline
ERASERASCA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,984,010 shares; 2024Q4: 947,110 shares; 2025Q1: 947,110 shares; 2025Q2: 240,295 shares 240,295$305K0.07%-706,815Timeline
PEPGPEPGEN INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 243,980 shares 243,980$271K0.07%newTimeline

Sold out in Q2 2025

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
SDGRSCHRODINGER INC385,000$7.6Mshares
ISRGINTUITIVE SURGICAL INC14,000$6.93Mshares
ABCLABCELLERA BIOLOGICS INC2,815,652$6.28Mshares
HAEHAEMONETICS CORP MASS65,400$4.16Mshares
BLUEPRINT MEDICINES CORPBLUEPRINT MEDICINES CORP36,512$3.23Mshares
ADUSADDUS HOMECARE CORP24,045$2.38Mshares
SYRESPYRE THERAPEUTICS INC74,921$1.21Mshares
IMNMIMMUNOME INC23,618$159Kshares

How Q2 2025 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001420506-25-002021 base2025-08-14acceptance time not in the bulk data set