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Catalio Capital Management, LP

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13F filer, CIK 1958125, NEW YORK, NY

Catalio Capital Management, LP reported $478,704,496 across 41 holdings for the quarter ended 2026-03-31, in a 13F-HR filed 2026-05-15. Its ten largest share positions make up 54.46% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001958125-26-000003

Period
2026-03-31
Reported value
$479M
Holdings
41
Top 10 weight
54.46%
New
9
Sold out
13

Part of the filer group Catalio Capital Management, LP

How groups are built

Stakes and trades reported after 2026-03-31

13D, 13G and Form 4 filings by this filer's group, dated after the 13F period, on securities the quarter does not hold as shares.

  • FRACTYL HEALTH, INC.: 13G 736,807 shares, 5.6% of the class, 13G filed 2026-10-13, 0001958125-26-000008
    Accepted , ingested

Largest buys vs the previous quarter

SecurityShares changeApprox. value
DFTXnew+1,037,984$19.6M
INCYnew+182,101$17.1M
RAREadded+688,247$14.4M
TERNadded+272,073$14.3M
CRVSnew+891,933$13M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
LLYexited-25,923-$27.9M
JNJexited-120,840-$25M
REGNexited-29,797-$23M
GILDreduced-125,407-$17.5M
ISRGexited-27,209-$15.4M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q1 2026

Share positions as resolved from 13F-HR 0001958125-26-000003, largest first. % of portfolio is the value over $478,704,496, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
DNTHDIANTHUS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 763,471 shares; 2025Q1: 763,471 shares; 2025Q2: 746,527 shares; 2025Q3: 667,615 shares; 2025Q4: 653,572 shares; 2026Q1: 560,308 shares 560,308$47M9.82%-93,264Timeline
BBIOBRIDGEBIO PHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 898,458 shares; 2025Q1: 962,883 shares; 2025Q2: 927,711 shares; 2025Q3: 622,729 shares; 2025Q4: 410,700 shares; 2026Q1: 432,014 shares 432,014$32.1M6.7%+21,314Timeline
ASNDASCENDIS PHARMA A/SQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 215,587 shares; 2025Q1: 195,523 shares; 2025Q2: 179,926 shares; 2025Q3: 144,954 shares; 2025Q4: 119,265 shares; 2026Q1: 129,111 shares 129,111$29.5M6.17%+9,846Timeline
BMYBRISTOL-MYERS SQUIBB COQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 499,151 shares; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 647,899 shares; 2026Q1: 420,727 shares 420,727$25.5M5.33%-227,172Timeline
SNDXSYNDAX PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: 1,733,701 shares; 2025Q2: 2,104,512 shares; 2025Q3: 1,614,717 shares; 2025Q4: 1,196,807 shares; 2026Q1: 1,043,670 shares 1,043,670$24.4M5.09%-153,137Timeline
GILDGILEAD SCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 226,875 shares; 2025Q3: not reported; 2025Q4: 289,312 shares; 2026Q1: 163,905 shares 163,905$22.8M4.77%-125,407Timeline
TERNTERNS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 136,958 shares; 2026Q1: 409,031 shares 409,031$21.6M4.5%+272,073Timeline
DFTXDEFINIUM THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 1,037,984 shares 1,037,984$19.6M4.1%newTimeline
SLNOSOLENO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: 160,962 shares; 2025Q2: 409,944 shares; 2025Q3: 418,245 shares; 2025Q4: 360,340 shares; 2026Q1: 577,808 shares 577,808$19.3M4.04%+217,468Timeline
BSXBOSTON SCIENTIFIC CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 72,925 shares; 2025Q1: not reported; 2025Q2: 229,046 shares; 2025Q3: 262,972 shares; 2025Q4: 360,428 shares; 2026Q1: 299,318 shares 299,318$18.8M3.92%-61,110Timeline
RAREULTRAGENYX PHARMACEUTICAL INQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 213,402 shares; 2025Q3: 291,262 shares; 2025Q4: 162,550 shares; 2026Q1: 850,797 shares 850,797$17.8M3.72%+688,247Timeline
INCYINCYTE CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 182,101 shares 182,101$17.1M3.58%newTimeline
CYTKCYTOKINETICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 457,587 shares; 2025Q1: 585,812 shares; 2025Q2: 601,439 shares; 2025Q3: 451,581 shares; 2025Q4: 258,381 shares; 2026Q1: 215,501 shares 215,501$14.2M2.97%-42,880Timeline
NTRANATERA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 97,297 shares; 2025Q3: 148,369 shares; 2025Q4: 62,273 shares; 2026Q1: 70,907 shares 70,907$14.2M2.96%+8,634Timeline
CRVSCORVUS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 891,933 shares 891,933$13M2.73%newTimeline
GPCRSTRUCTURE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 569,395 shares; 2025Q1: 704,864 shares; 2025Q2: 670,575 shares; 2025Q3: 651,810 shares; 2025Q4: 252,901 shares; 2026Q1: 255,379 shares 255,379$12.3M2.57%+2,478Timeline
MLYSMINERALYS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 331,849 shares; 2026Q1: 439,041 shares 439,041$11.9M2.48%+107,192Timeline
EWEDWARDS LIFESCIENCES CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 333,144 shares; 2025Q1: 435,588 shares; 2025Q2: 390,932 shares; 2025Q3: not reported; 2025Q4: 187,048 shares; 2026Q1: 144,607 shares 144,607$11.6M2.42%-42,441Timeline
MANEVERADERMICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 173,582 shares 173,582$11M2.29%newTimeline
ADPTADAPTIVE BIOTECHNOLOGIES CORQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: 611,639 shares; 2025Q2: 1,396,445 shares; 2025Q3: 884,890 shares; 2025Q4: 821,195 shares; 2026Q1: 722,784 shares 722,784$10M2.1%-98,411Timeline
HTFLHEARTFLOW INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 113,857 shares; 2026Q1: 403,588 shares 403,588$9.82M2.05%+289,731Timeline
KALVKALVISTA PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 426,551 shares 426,551$8.59M1.79%newTimeline
QUREUNIQURE NVQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 901,973 shares; 2025Q1: 830,325 shares; 2025Q2: 417,443 shares; 2025Q3: 282,940 shares; 2025Q4: 288,345 shares; 2026Q1: 491,116 shares 491,116$8.03M1.68%+202,771Timeline
IRONDISC MEDICINE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 179,815 shares; 2025Q1: not reported; 2025Q2: 30,661 shares; 2025Q3: 216,527 shares; 2025Q4: 110,427 shares; 2026Q1: 122,978 shares 122,978$7.86M1.64%+12,551Timeline
SEPNSEPTERNA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 1,024,245 shares; 2025Q1: 1,024,245 shares; 2025Q2: 294,360 shares; 2025Q3: 294,360 shares; 2025Q4: 294,360 shares; 2026Q1: 294,360 shares 294,360$7.07M1.48%0Timeline
ABVXABIVAX SAQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 162,141 shares; 2025Q4: 98,514 shares; 2026Q1: 47,193 shares 47,193$5.25M1.1%-51,321Timeline
DYNDYNE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 519,715 shares; 2026Q1: 282,954 shares 282,954$5.13M1.07%-236,761Timeline
ELDNELEDON PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 1,061,132 shares; 2025Q4: 1,259,820 shares; 2026Q1: 1,639,816 shares 1,639,816$5.05M1.06%+379,996Timeline
KPTIKARYOPHARM THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: 155,622 shares; 2025Q2: 146,013 shares; 2025Q3: 142,984 shares; 2025Q4: 142,984 shares; 2026Q1: 897,709 shares 897,709$5M1.04%+754,725Timeline
SUPNSUPERNUS PHARMACEUTICALSQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 287,090 shares; 2025Q4: 257,465 shares; 2026Q1: 62,019 shares 62,019$3.21M0.67%-195,446Timeline
TARAPROTARA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 1,088,691 shares; 2025Q1: 1,088,691 shares; 2025Q2: 1,626,370 shares; 2025Q3: 1,500,793 shares; 2025Q4: 1,446,254 shares; 2026Q1: 580,024 shares 580,024$3.02M0.63%-866,230Timeline
PHATPHATHOM PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 672,290 shares; 2025Q3: 1,128,521 shares; 2025Q4: 698,996 shares; 2026Q1: 247,767 shares 247,767$2.75M0.58%-451,229Timeline
NAMSNEWAMSTERDAM PHARMA COMPANYQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 83,554 shares 83,554$2.67M0.56%newTimeline
TYRATYRA BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 67,285 shares 67,285$2.58M0.54%newTimeline
IMCRIMMUNOCORE HLDGS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 84,352 shares 84,352$2.54M0.53%newTimeline
GUTSFRACTYL HEALTH INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 214,236 shares; 2025Q1: 214,236 shares; 2025Q2: 214,236 shares; 2025Q3: 5,214,236 shares; 2025Q4: 5,491,866 shares; 2026Q1: 5,491,866 shares 5,491,866$2.51M0.53%0Timeline
HYPRHYPERFINE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 760,035 shares; 2025Q1: 760,035 shares; 2025Q2: 760,035 shares; 2025Q3: 684,541 shares; 2025Q4: 1,320,041 shares; 2026Q1: 1,320,041 shares 1,320,041$1.43M0.3%0Timeline
MGXMETAGENOMI THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 528,993 shares; 2025Q1: 528,993 shares; 2025Q2: 528,993 shares; 2025Q3: 528,993 shares; 2025Q4: 528,993 shares; 2026Q1: 528,993 shares 528,993$709K0.15%0Timeline
ATAIATAIBECKLEY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 196,858 shares 196,858$697K0.15%newTimeline
FTHFAETH THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 14,718 shares; 2025Q3: 14,718 shares; 2025Q4: 14,718 shares; 2026Q1: 14,718 shares 14,718$464K0.1%0Timeline
OMOUTSET MED INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: 166,666 shares; 2025Q2: 166,666 shares; 2025Q3: 118,279 shares; 2025Q4: 118,279 shares; 2026Q1: 118,279 shares 118,279$454K0.09%0Timeline

Sold out in Q1 2026

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
LLYELI LILLY & CO25,923$27.9Mshares
JNJJOHNSON & JOHNSON120,840$25Mshares
REGNREGENERON PHARMACEUTICALS29,797$23Mshares
ISRGINTUITIVE SURGICAL INC27,209$15.4Mshares
ADMAADMA BIOLOGICS INC564,461$10.3Mshares
ACLXARCELLX INC156,109$10.2Mshares
OCULOCULAR THERAPEUTIX INC714,501$8.67Mshares
OLMAOLEMA PHARMACEUTICALS INC267,058$6.68Mshares
GRALGRAIL INC30,313$2.59Mshares
FULCFULCRUM THERAPEUTICS INC201,301$2.28Mshares
BLLNBILLIONTOONE INC25,505$2.09Mshares
PVLAPALVELLA THERAPEUTICS INC NE10,452$1.09Mshares
ATAIBECKLEY INCATAIBECKLEY INC196,858$805Kshares

How Q1 2026 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001958125-26-000003 base2026-05-15acceptance time not in the bulk data set