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Catalio Capital Management, LP

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13F filer, CIK 1958125, NEW YORK, NY

Catalio Capital Management, LP reported $565,790,302 across 45 holdings for the quarter ended 2025-12-31, in a 13F-HR/A filed 2026-09-02. Its ten largest share positions make up 51.19% of the portfolio.

Accepted , ingested 13F-HR/A 0001958125-26-000007

Period
2025-12-31
Reported value
$566M
Holdings
45
Top 10 weight
51.19%
New
13
Sold out
6

Part of the filer group Catalio Capital Management, LP

  • Catalio Capital GP, LLC
  • Petrocheilos George C
  • Vogelstein R Jacob
How groups are built

Stakes and trades reported after 2025-12-31

13D, 13G and Form 4 filings by this filer's group, dated after the 13F period, on securities the quarter does not hold as shares.

  • FRACTYL HEALTH, INC.: 13G 736,807 shares, 5.6% of the class, 13G filed 2026-10-13, 0001958125-26-000008
    Accepted , ingested

Largest buys vs the previous quarter

SecurityShares changeApprox. value
GILDnew+289,312$35.5M
BMYnew+647,899$34.9M
JNJnew+120,840$25M
EWnew+187,048$15.9M
MLYSnew+331,849$12M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
ABBVexited-154,834-$35.9M
LLYreduced-31,453-$33.8M
GPCRreduced-398,909-$27.7M
ISRGreduced-44,134-$25M
NTRAreduced-86,096-$19.7M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q4 2025

Share positions as resolved from 13F-HR/A 0001958125-26-000007, largest first. % of portfolio is the value over $565,790,302, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
GILDGILEAD SCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 226,875 shares; 2025Q3: not reported; 2025Q4: 289,312 shares 289,312$35.5M6.28%newTimeline
BMYBRISTOL-MYERS SQUIBB COQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 499,151 shares; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 647,899 shares 647,899$34.9M6.18%newTimeline
BSXBOSTON SCIENTIFIC CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 72,925 shares; 2025Q1: not reported; 2025Q2: 229,046 shares; 2025Q3: 262,972 shares; 2025Q4: 360,428 shares 360,428$34.4M6.07%+97,456Timeline
BBIOBRIDGEBIO PHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 898,458 shares; 2025Q1: 962,883 shares; 2025Q2: 927,711 shares; 2025Q3: 622,729 shares; 2025Q4: 410,700 shares 410,700$31.4M5.55%-212,029Timeline
LLYELI LILLY & COQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: 23,682 shares; 2025Q2: 53,916 shares; 2025Q3: 57,376 shares; 2025Q4: 25,923 shares 25,923$27.9M4.92%-31,453Timeline
DNTHDIANTHUS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 763,471 shares; 2025Q1: 763,471 shares; 2025Q2: 746,527 shares; 2025Q3: 667,615 shares; 2025Q4: 653,572 shares 653,572$26.9M4.76%-14,043Timeline
ASNDASCENDIS PHARMA A/SQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 215,587 shares; 2025Q1: 195,523 shares; 2025Q2: 179,926 shares; 2025Q3: 144,954 shares; 2025Q4: 119,265 shares 119,265$25.4M4.49%-25,689Timeline
SNDXSYNDAX PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: 1,733,701 shares; 2025Q2: 2,104,512 shares; 2025Q3: 1,614,717 shares; 2025Q4: 1,196,807 shares 1,196,807$25.1M4.44%-417,910Timeline
JNJJOHNSON & JOHNSONQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 120,840 shares 120,840$25M4.42%newTimeline
REGNREGENERON PHARMACEUTICALSQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: 12,261 shares; 2025Q2: not reported; 2025Q3: 35,344 shares; 2025Q4: 29,797 shares 29,797$23M4.07%-5,547Timeline
GPCRSTRUCTURE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 569,395 shares; 2025Q1: 704,864 shares; 2025Q2: 670,575 shares; 2025Q3: 651,810 shares; 2025Q4: 252,901 shares 252,901$17.6M3.11%-398,909Timeline
SLNOSOLENO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: 160,962 shares; 2025Q2: 409,944 shares; 2025Q3: 418,245 shares; 2025Q4: 360,340 shares 360,340$16.7M2.95%-57,905Timeline
CYTKCYTOKINETICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 457,587 shares; 2025Q1: 585,812 shares; 2025Q2: 601,439 shares; 2025Q3: 451,581 shares; 2025Q4: 258,381 shares 258,381$16.4M2.9%-193,200Timeline
EWEDWARDS LIFESCIENCES CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 333,144 shares; 2025Q1: 435,588 shares; 2025Q2: 390,932 shares; 2025Q3: not reported; 2025Q4: 187,048 shares 187,048$15.9M2.82%newTimeline
ISRGINTUITIVE SURGICAL INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 36,910 shares; 2025Q1: 36,499 shares; 2025Q2: 56,674 shares; 2025Q3: 71,343 shares; 2025Q4: 27,209 shares 27,209$15.4M2.72%-44,134Timeline
NTRANATERA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 97,297 shares; 2025Q3: 148,369 shares; 2025Q4: 62,273 shares 62,273$14.3M2.52%-86,096Timeline
ADPTADAPTIVE BIOTECHNOLOGIES CORQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: 611,639 shares; 2025Q2: 1,396,445 shares; 2025Q3: 884,890 shares; 2025Q4: 821,195 shares 821,195$13.3M2.36%-63,695Timeline
ABVXABIVAX SAQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 162,141 shares; 2025Q4: 98,514 shares 98,514$13.3M2.35%-63,627Timeline
SUPNSUPERNUS PHARMACEUTICALSQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 287,090 shares; 2025Q4: 257,465 shares 257,465$12.8M2.26%-29,625Timeline
GUTSFRACTYL HEALTH INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 214,236 shares; 2025Q1: 214,236 shares; 2025Q2: 214,236 shares; 2025Q3: 5,214,236 shares; 2025Q4: 5,491,866 shares 5,491,866$12.1M2.14%+277,630Timeline
MLYSMINERALYS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 331,849 shares 331,849$12M2.13%newTimeline
PHATPHATHOM PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 672,290 shares; 2025Q3: 1,128,521 shares; 2025Q4: 698,996 shares 698,996$11.6M2.05%-429,525Timeline
ADMAADMA BIOLOGICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 512,724 shares; 2025Q1: not reported; 2025Q2: 569,704 shares; 2025Q3: 684,508 shares; 2025Q4: 564,461 shares 564,461$10.3M1.82%-120,047Timeline
ACLXARCELLX INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 156,109 shares 156,109$10.2M1.8%newTimeline
DYNDYNE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 519,715 shares 519,715$10.2M1.8%newTimeline
IRONDISC MEDICINE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 179,815 shares; 2025Q1: not reported; 2025Q2: 30,661 shares; 2025Q3: 216,527 shares; 2025Q4: 110,427 shares 110,427$8.77M1.55%-106,100Timeline
OCULOCULAR THERAPEUTIX INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 714,501 shares 714,501$8.67M1.53%newTimeline
SEPNSEPTERNA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 1,024,245 shares; 2025Q1: 1,024,245 shares; 2025Q2: 294,360 shares; 2025Q3: 294,360 shares; 2025Q4: 294,360 shares 294,360$8.21M1.45%0Timeline
TARAPROTARA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 1,088,691 shares; 2025Q1: 1,088,691 shares; 2025Q2: 1,626,370 shares; 2025Q3: 1,500,793 shares; 2025Q4: 1,446,254 shares 1,446,254$7.71M1.36%-54,539Timeline
QUREUNIQURE NVQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 901,973 shares; 2025Q1: 830,325 shares; 2025Q2: 417,443 shares; 2025Q3: 282,940 shares; 2025Q4: 288,345 shares 288,345$6.9M1.22%+5,405Timeline
OLMAOLEMA PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 267,058 shares 267,058$6.68M1.18%newTimeline
TERNTERNS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 136,958 shares 136,958$5.53M0.98%newTimeline
RAREULTRAGENYX PHARMACEUTICAL INQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 213,402 shares; 2025Q3: 291,262 shares; 2025Q4: 162,550 shares 162,550$3.74M0.66%-128,712Timeline
HTFLHEARTFLOW INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 113,857 shares 113,857$3.32M0.59%newTimeline
GRALGRAIL INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 137,928 shares; 2025Q4: 30,313 shares 30,313$2.59M0.46%-107,615Timeline
FULCFULCRUM THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: 202,139 shares; 2025Q2: 188,304 shares; 2025Q3: not reported; 2025Q4: 201,301 shares 201,301$2.28M0.4%newTimeline
BLLNBILLIONTOONE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 25,505 shares 25,505$2.09M0.37%newTimeline
ELDNELEDON PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 1,061,132 shares; 2025Q4: 1,259,820 shares 1,259,820$1.9M0.34%+198,688Timeline
HYPRHYPERFINE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 760,035 shares; 2025Q1: 760,035 shares; 2025Q2: 760,035 shares; 2025Q3: 684,541 shares; 2025Q4: 1,320,041 shares 1,320,041$1.29M0.23%+635,500Timeline
PVLAPALVELLA THERAPEUTICS INC NEQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 12,010 shares; 2025Q4: 10,452 shares 10,452$1.09M0.19%-1,558Timeline
KPTIKARYOPHARM THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: 155,622 shares; 2025Q2: 146,013 shares; 2025Q3: 142,984 shares; 2025Q4: 142,984 shares 142,984$1.05M0.19%0Timeline
MGXMETAGENOMI THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 528,993 shares; 2025Q1: 528,993 shares; 2025Q2: 528,993 shares; 2025Q3: 528,993 shares; 2025Q4: 528,993 shares 528,993$857K0.15%0Timeline
ATAIBECKLEY INCATAIBECKLEY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 196,858 shares; 2025Q1: 196,858 shares; 2025Q2: 196,858 shares; 2025Q3: 196,858 shares; 2025Q4: 196,858 shares 196,858$805K0.14%0
OMOUTSET MED INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: 166,666 shares; 2025Q2: 166,666 shares; 2025Q3: 118,279 shares; 2025Q4: 118,279 shares 118,279$439K0.08%0Timeline
FTHFAETH THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 14,718 shares; 2025Q3: 14,718 shares; 2025Q4: 14,718 shares 14,718$157K0.03%0Timeline

Sold out in Q4 2025

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
ABBVABBVIE INC154,834$35.9Mshares
EXASEXACT SCIENCES CORP248,987$13.6Mshares
RNAMAVIDITY BIOSCIENCES INC263,256$11.5Mshares
CDTXCIDARA THERAPEUTICS INC53,333$5.11Mshares
KYTXKYVERNA THERAPEUTICS INC586,909$3.52Mshares
MLTXMOONLAKE IMMUNOTHERAPEUTICS133,131$955Kshares

How Q4 2025 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001958125-26-000002 superseded2026-02-17acceptance time not in the bulk data set
13F-HR/A 0001958125-26-000007 baserestatement2026-09-02