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Catalio Capital Management, LP

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13F filer, CIK 1958125, NEW YORK, NY

Catalio Capital Management, LP reported $540,929,537 across 38 holdings for the quarter ended 2025-09-30, in a 13F-HR filed 2025-11-14. Its ten largest share positions make up 55.94% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001958125-25-000009

Period
2025-09-30
Reported value
$541M
Holdings
38
Top 10 weight
55.94%
New
10
Sold out
12

Part of the filer group Catalio Capital Management, LP

  • Catalio Capital GP, LLC
  • Petrocheilos George C
  • Vogelstein R Jacob
How groups are built

Stakes and trades reported after 2025-09-30

13D, 13G and Form 4 filings by this filer's group, dated after the 13F period, on securities the quarter does not hold as shares.

  • FRACTYL HEALTH, INC.: 13G 736,807 shares, 5.6% of the class, 13G filed 2026-10-13, 0001958125-26-000008
    Accepted , ingested

Largest buys vs the previous quarter

SecurityShares changeApprox. value
ABBVnew+154,834$35.9M
REGNnew+35,344$19.9M
ABVXnew+162,141$13.8M
SUPNnew+287,090$13.7M
EXASnew+248,987$13.6M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
EWexited-390,932-$30.6M
GILDexited-226,875-$25.2M
TEVAexited-1,170,372-$19.6M
CORTexited-239,125-$17.6M
BBIOreduced-304,982-$15.8M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q3 2025

Share positions as resolved from 13F-HR 0001958125-25-000009, largest first. % of portfolio is the value over $540,929,537, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
LLYELI LILLY & COQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: 23,682 shares; 2025Q2: 53,916 shares; 2025Q3: 57,376 shares 57,376$43.8M8.09%+3,460Timeline
ABBVABBVIE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 154,834 shares 154,834$35.9M6.63%newTimeline
BBIOBRIDGEBIO PHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 898,458 shares; 2025Q1: 962,883 shares; 2025Q2: 927,711 shares; 2025Q3: 622,729 shares 622,729$32.3M5.98%-304,982Timeline
ISRGINTUITIVE SURGICAL INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 36,910 shares; 2025Q1: 36,499 shares; 2025Q2: 56,674 shares; 2025Q3: 71,343 shares 71,343$31.9M5.9%+14,669Timeline
ASNDASCENDIS PHARMA A/SQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 215,587 shares; 2025Q1: 195,523 shares; 2025Q2: 179,926 shares; 2025Q3: 144,954 shares 144,954$28.8M5.33%-34,972Timeline
SLNOSOLENO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: 160,962 shares; 2025Q2: 409,944 shares; 2025Q3: 418,245 shares 418,245$28.3M5.23%+8,301Timeline
DNTHDIANTHUS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 763,471 shares; 2025Q1: 763,471 shares; 2025Q2: 746,527 shares; 2025Q3: 667,615 shares 667,615$26.3M4.86%-78,912Timeline
BSXBOSTON SCIENTIFIC CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 72,925 shares; 2025Q1: not reported; 2025Q2: 229,046 shares; 2025Q3: 262,972 shares 262,972$25.7M4.75%+33,926Timeline
SNDXSYNDAX PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: 1,733,701 shares; 2025Q2: 2,104,512 shares; 2025Q3: 1,614,717 shares 1,614,717$24.8M4.59%-489,795Timeline
CYTKCYTOKINETICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 457,587 shares; 2025Q1: 585,812 shares; 2025Q2: 601,439 shares; 2025Q3: 451,581 shares 451,581$24.8M4.59%-149,858Timeline
NTRANATERA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 97,297 shares; 2025Q3: 148,369 shares 148,369$23.9M4.42%+51,072Timeline
REGNREGENERON PHARMACEUTICALSQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: 12,261 shares; 2025Q2: not reported; 2025Q3: 35,344 shares 35,344$19.9M3.67%newTimeline
GPCRSTRUCTURE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 569,395 shares; 2025Q1: 704,864 shares; 2025Q2: 670,575 shares; 2025Q3: 651,810 shares 651,810$18.3M3.37%-18,765Timeline
QUREUNIQURE NVQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 901,973 shares; 2025Q1: 830,325 shares; 2025Q2: 417,443 shares; 2025Q3: 282,940 shares 282,940$16.5M3.05%-134,503Timeline
IRONDISC MEDICINE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 179,815 shares; 2025Q1: not reported; 2025Q2: 30,661 shares; 2025Q3: 216,527 shares 216,527$14.3M2.65%+185,866Timeline
ABVXABIVAX SAQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 162,141 shares 162,141$13.8M2.54%newTimeline
SUPNSUPERNUS PHARMACEUTICALSQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 287,090 shares 287,090$13.7M2.54%newTimeline
EXASEXACT SCIENCES CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 309,103 shares; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 248,987 shares 248,987$13.6M2.52%newTimeline
PHATPHATHOM PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 672,290 shares; 2025Q3: 1,128,521 shares 1,128,521$13.3M2.46%+456,231Timeline
ADPTADAPTIVE BIOTECHNOLOGIES CORQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: 611,639 shares; 2025Q2: 1,396,445 shares; 2025Q3: 884,890 shares 884,890$13.2M2.45%-511,555Timeline
RNAMAVIDITY BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 263,256 shares 263,256$11.5M2.12%newTimeline
ADMAADMA BIOLOGICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 512,724 shares; 2025Q1: not reported; 2025Q2: 569,704 shares; 2025Q3: 684,508 shares 684,508$10M1.86%+114,804Timeline
RAREULTRAGENYX PHARMACEUTICAL INQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 213,402 shares; 2025Q3: 291,262 shares 291,262$8.76M1.62%+77,860Timeline
GUTSFRACTYL HEALTH INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 214,236 shares; 2025Q1: 214,236 shares; 2025Q2: 214,236 shares; 2025Q3: 5,214,236 shares 5,214,236$8.29M1.53%+5,000,000Timeline
GRALGRAIL INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 137,928 shares 137,928$8.16M1.51%newTimeline
TARAPROTARA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 1,088,691 shares; 2025Q1: 1,088,691 shares; 2025Q2: 1,626,370 shares; 2025Q3: 1,500,793 shares 1,500,793$6.53M1.21%-125,577Timeline
SEPNSEPTERNA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 1,024,245 shares; 2025Q1: 1,024,245 shares; 2025Q2: 294,360 shares; 2025Q3: 294,360 shares 294,360$5.54M1.02%0Timeline
CDTXCIDARA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 53,333 shares 53,333$5.11M0.94%newTimeline
KYTXKYVERNA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 586,909 shares; 2025Q1: 586,909 shares; 2025Q2: 586,909 shares; 2025Q3: 586,909 shares 586,909$3.52M0.65%0Timeline
ELDNELEDON PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 1,061,132 shares 1,061,132$2.75M0.51%newTimeline
OMOUTSET MED INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: 166,666 shares; 2025Q2: 166,666 shares; 2025Q3: 118,279 shares 118,279$1.67M0.31%-48,387Timeline
MGXMETAGENOMI THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 528,993 shares; 2025Q1: 528,993 shares; 2025Q2: 528,993 shares; 2025Q3: 528,993 shares 528,993$1.25M0.23%0Timeline
ATAIBECKLEY INCATAIBECKLEY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 196,858 shares; 2025Q1: 196,858 shares; 2025Q2: 196,858 shares; 2025Q3: 196,858 shares 196,858$1.04M0.19%0
HYPRHYPERFINE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 760,035 shares; 2025Q1: 760,035 shares; 2025Q2: 760,035 shares; 2025Q3: 684,541 shares 684,541$993K0.18%-75,494Timeline
MLTXMOONLAKE IMMUNOTHERAPEUTICSQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: 114,616 shares; 2025Q2: 162,596 shares; 2025Q3: 133,131 shares 133,131$955K0.18%-29,465Timeline
KPTIKARYOPHARM THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: 155,622 shares; 2025Q2: 146,013 shares; 2025Q3: 142,984 shares 142,984$935K0.17%-3,029Timeline
PVLAPALVELLA THERAPEUTICS INC NEQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 12,010 shares 12,010$753K0.14%newTimeline
FTHFAETH THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 14,718 shares; 2025Q3: 14,718 shares 14,718$139K0.03%0Timeline

Sold out in Q3 2025

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
EWEDWARDS LIFESCIENCES CORP390,932$30.6Mshares
GILDGILEAD SCIENCES INC226,875$25.2Mshares
TEVATEVA PHARMACEUTICAL INDS LTD1,170,372$19.6Mshares
CORTCORCEPT THERAPEUTICS INC239,125$17.6Mshares
HALOHALOZYME THERAPEUTICS INC191,529$9.96Mshares
WGSGENEDX HOLDINGS CORP61,507$5.68Mshares
REPLREPLIMUNE GROUP INC330,337$3.07Mshares
ZBIOZENAS BIOPHARMA INC215,314$2.09Mshares
VIRVIR BIOTECHNOLOGY INC388,303$1.96Mshares
FULCFULCRUM THERAPEUTICS INC188,304$1.3Mshares
BCAXBICARA THERAPEUTICS INC97,800$909Kshares
Mersana Therapeutics IncMersana Therapeutics Inc1,567,413$464Kshares

How Q3 2025 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001958125-25-000009 base2025-11-14acceptance time not in the bulk data set