RTW INVESTMENTS, LP More: the full row for RTW INVESTMENTS, LP 6,959,032 $123M 1.23% +4,667,660 13F-HR Timeline Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 1,902,320 $33.6M 0.9% +275,000 13F-HR Timeline Clearbridge Investments, LLC in group Franklin Resources More: the full row for Clearbridge Investments, LLC 1,808,035 $31.9M 0.03% -1,711,302 13F-HR Timeline Group UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 1,782,409 $31.4M +1,475,855 Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 1,687,846 $29.8M 0.02% +700,803 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 1,440,406 $25.4M <0.01% -3,261,305 13F-HR Timeline Group BAMCO INC /NY/ in group Baron Capital More: the full row for BAMCO INC /NY/ 1,418,005 $25M 0.07% +46,762 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 1,246,520 $22M 1.64% +377,740 13F-HR/A Timeline Group Rock Springs Capital Management LP More: the full row for Rock Springs Capital Management LP 811,546 $14.3M 0.73% +20,353 13F-HR Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 752,858 $13.3M <0.01% -965,597 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 635,213 $11.2M <0.01% +161,650 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 602,954 $10.6M <0.01% -345,717 13F-HR Timeline C WorldWide Group Holding A/S in group C WorldWide Group Holding A/S More: the full row for C WorldWide Group Holding A/S 510,000 $9M 0.16% 0 13F-HR Timeline Group B Group, Inc. More: the full row for B Group, Inc. 400,000 $7.06M 5.23% 0 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 388,769 $6.86M <0.01% +246,395 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 387,800 $6.84M <0.01% +5,341 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 382,062 $6.74M 0.01% new 13F-HR Timeline Group Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 373,399 $6.59M 0.04% new 13F-HR Timeline Group SCHRODER INVESTMENT MANAGEMENT GROUP More: the full row for SCHRODER INVESTMENT MANAGEMENT GROUP 299,844 $5.29M <0.01% +142,783 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 293,703 $5.18M <0.01% +284,296 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 289,705 $5.11M <0.01% +169,825 13F-HR/A Timeline Group NAN FUNG TRINITY (HK) LTD More: the full row for NAN FUNG TRINITY (HK) LTD 269,975 $4.76M 0.38% 0 13F-HR Timeline D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 238,609 $4.21M <0.01% +204,319 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 231,802 $4.09M <0.01% +170,400 13F-HR Timeline Group Hennion & Walsh Asset Management, Inc. More: the full row for Hennion & Walsh Asset Management, Inc. 204,982 $3.62M 0.12% +44,945 13F-HR Timeline XY Capital Ltd More: the full row for XY Capital Ltd 202,304 $3.57M 3.63% new 13F-HR Timeline SUPERSTRING CAPITAL MANAGEMENT LP More: the full row for SUPERSTRING CAPITAL MANAGEMENT LP 196,853 $3.47M 1.86% -3,775 13F-HR Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 181,133 $3.2M <0.01% new 13F-HR Timeline Group DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 173,946 $3.07M <0.01% +127,261 13F-HR Timeline Group Campbell & CO Investment Adviser LLC More: the full row for Campbell & CO Investment Adviser LLC 170,117 $3M 0.14% new 13F-HR Timeline NEXTBio Capital Management LP More: the full row for NEXTBio Capital Management LP 163,362 $2.88M 1.69% 13F-HR Timeline ENVESTNET ASSET MANAGEMENT INC in group ENVESTNET ASSET MANAGEMENT INC More: the full row for ENVESTNET ASSET MANAGEMENT INC 151,318 $2.67M <0.01% -100,712 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 149,434 $2.64M <0.01% +67,253 13F-HR/A Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 136,428 $2.41M <0.01% +90 13F-HR Timeline Group Privium Fund Management B.V. More: the full row for Privium Fund Management B.V. 132,189 $2.33M 0.43% 0 13F-HR Timeline Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 107,651 $1.9M <0.01% new 13F-HR Timeline Mirae Asset Global Investments Co., Ltd. in group Mirae Asset Global Investment… More: the full row for Mirae Asset Global Investments Co., Ltd. 103,118 $1.82M 0.01% -1,981 13F-HR Timeline Group PRINCIPAL FINANCIAL GROUP INC group of 2 filers holding More: the full row for PRINCIPAL FINANCIAL GROUP INC 101,782 $1.8M -3,773 Timeline DCF Advisers, LLC More: the full row for DCF Advisers, LLC 97,500 $1.72M 0.57% +5,500 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 96,442 $1.7M <0.01% -49,561 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 93,140 $1.64M <0.01% -81,992 13F-HR Timeline Group RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 92,837 $1.64M <0.01% -91,929 13F-HR Timeline Group ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 92,107 $1.62M 0.01% +39,491 13F-HR Timeline Group Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 90,000 $1.59M 0.01% new 13F-HR Timeline Group TD Asset Management Inc More: the full row for TD Asset Management Inc 86,640 $1.53M <0.01% -34,888 13F-HR Timeline HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 83,793 $1.48M <0.01% +57,025 13F-HR Timeline NEOS Investment Management LLC More: the full row for NEOS Investment Management LLC 75,165 $1.33M 0.01% +13,098 13F-HR Timeline BNP PARIBAS ASSET MANAGEMENT Holding S.… in group BNP PARIBAS ASSET MANAGEMENT … More: the full row for BNP PARIBAS ASSET MANAGEMENT Holding S.A. 65,814 $1.16M <0.01% new 13F-HR Timeline Group Long Corridor Asset Management Ltd More: the full row for Long Corridor Asset Management Ltd 65,800 $1.16M 0.08% 0 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 56,895 $1M <0.01% new 13F-HR Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 46,935 $827K <0.01% -22,220 13F-HR Timeline Group Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 40,005 $706K <0.01% new 13F-HR Timeline Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 38,457 $678K 0.18% +28,129 13F-HR Timeline Group WealthPlan Investment Management, LLC More: the full row for WealthPlan Investment Management, LLC 36,761 $648K 0.04% 0 13F-HR Timeline DekaBank Deutsche Girozentrale More: the full row for DekaBank Deutsche Girozentrale 36,648 $647K <0.01% 0 13F-HR Timeline MML INVESTORS SERVICES, LLC More: the full row for MML INVESTORS SERVICES, LLC 34,421 $607K <0.01% -11,063 13F-HR Timeline LPL Financial LLC More: the full row for LPL Financial LLC 31,114 $549K <0.01% -53,996 13F-HR Timeline DRW Securities, LLC More: the full row for DRW Securities, LLC 30,862 $544K 0.04% new 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 30,594 $540K <0.01% -7,960 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 29,523 $521K <0.01% new 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 23,879 $421K <0.01% -26,697 13F-HR Timeline Group BANK OF MONTREAL /CAN/ in group BANK OF MONTREAL /CAN/ More: the full row for BANK OF MONTREAL /CAN/ 22,099 $390K <0.01% -9,940 13F-HR Timeline Group Orion Porfolio Solutions, LLC More: the full row for Orion Porfolio Solutions, LLC 20,849 $368K <0.01% -27,668 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 19,032 $336K 0.01% new 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 17,771 $313K <0.01% -6,991 13F-HR Timeline Group Marks Group Wealth Management, Inc More: the full row for Marks Group Wealth Management, Inc 16,278 $287K 0.03% -245 13F-HR Timeline Legacy Wealth Asset Management, LLC More: the full row for Legacy Wealth Asset Management, LLC 15,903 $281K 0.07% -6,237 13F-HR Timeline Headlands Technologies LLC More: the full row for Headlands Technologies LLC 15,846 $280K 0.02% new 13F-HR Timeline Erste Asset Management GmbH in group Erste Asset Management GmbH More: the full row for Erste Asset Management GmbH 15,100 $269K <0.01% 0 13F-HR Timeline Group IvyRock Asset Management (HK) Ltd More: the full row for IvyRock Asset Management (HK) Ltd 14,979 $264K 0.14% -79,900 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 14,757 $260K <0.01% -6,614 13F-HR Timeline Group ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 13,618 $240K <0.01% new 13F-HR Timeline Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 12,339 $218K 0.1% new 13F-HR Timeline OPPENHEIMER ASSET MANAGEMENT INC. in group OPPENHEIMER ASSET MANAGEMENT … More: the full row for OPPENHEIMER ASSET MANAGEMENT INC. 10,608 $187K <0.01% -11,126 13F-HR Timeline Group Virtu Financial LLC in group Virtu Financial LLC More: the full row for Virtu Financial LLC 10,551 $186K 0.01% new 13F-HR Timeline Group SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 10,396 $183K <0.01% +642 13F-HR Timeline LMR Partners LLP in group LMR Partners LLP More: the full row for LMR Partners LLP 10,320 $182K <0.01% -122,348 13F-HR Timeline Group Quantinno Capital Management LP More: the full row for Quantinno Capital Management LP 10,085 $178K <0.01% +1,452 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 6,380 $113K 0.01% -2,000 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 5,151 $90.9K <0.01% -3,115 13F-HR Timeline Group Basecamp Wealth Advisors LLC More: the full row for Basecamp Wealth Advisors LLC 3,227 $56.9K 0.01% 13F-HR Timeline STOREBRAND ASSET MANAGEMENT AS More: the full row for STOREBRAND ASSET MANAGEMENT AS 2,580 $45.5K <0.01% 0 13F-HR Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 1,329 $23.4K <0.01% +753 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 979 $17K <0.01% +537 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 884 $15.6K <0.01% +87 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 804 $14.2K <0.01% +653 13F-HR Timeline Group GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 768 $13.5K <0.01% -261 13F-HR Timeline Horizon Investments, LLC More: the full row for Horizon Investments, LLC 735 $13K <0.01% -351 13F-HR Timeline Arax Advisory Partners More: the full row for Arax Advisory Partners 409 $7.21K <0.01% new 13F-HR Timeline Smartleaf Asset Management LLC More: the full row for Smartleaf Asset Management LLC 331 $5.84K <0.01% +149 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 325 $5.73K <0.01% new 13F-HR/A Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 319 $5.63K <0.01% -13 13F-HR Timeline Group Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 317 $5.59K <0.01% -34,421 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 302 $5.33K <0.01% -683 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 281 $4.96K <0.01% -10 13F-HR Timeline ASSETMARK, INC in group ASSETMARK, INC More: the full row for ASSETMARK, INC 233 $4.11K <0.01% +226 13F-HR Timeline Group Quent Capital, LLC More: the full row for Quent Capital, LLC 230 $4.06K <0.01% 0 13F-HR Timeline Parkside Financial Bank & Trust More: the full row for Parkside Financial Bank & Trust 213 $3.76K <0.01% new 13F-HR Timeline PRIVATE TRUST CO NA More: the full row for PRIVATE TRUST CO NA 206 $3.63K <0.01% 0 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 203 $3.58K <0.01% +27 13F-HR Timeline Group NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO in group NORTHWESTERN MUTUAL INVESTMEN… More: the full row for NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 202 $3.56K <0.01% 0 13F-HR/A Timeline Group Pinnacle Wealth Planning Services, Inc. More: the full row for Pinnacle Wealth Planning Services, Inc. 201 $3.55K <0.01% new 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 173 $3.05K <0.01% new 13F-HR Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 150 $3K <0.01% 0 13F-HR Timeline Group BESSEMER GROUP INC in group BESSEMER GROUP INC More: the full row for BESSEMER GROUP INC 145 $3K <0.01% new 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 159 $2.81K <0.01% +24 13F-HR Timeline Group IFP Advisors, Inc More: the full row for IFP Advisors, Inc 94 $1.66K <0.01% 0 13F-HR Timeline Transamerica Financial Advisors, LLC in group Transamerica Financial Adviso… More: the full row for Transamerica Financial Advisors, LLC 73 $1.29K <0.01% +56 13F-HR Timeline Group AMERIFLEX GROUP, INC. More: the full row for AMERIFLEX GROUP, INC. 62 $1.09K <0.01% -62 13F-HR Timeline TD PRIVATE CLIENT WEALTH LLC More: the full row for TD PRIVATE CLIENT WEALTH LLC 56 $988 <0.01% -16 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 50 $882 <0.01% 0 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 40 $706 <0.01% +19 13F-HR Timeline North Star Investment Management Corp. More: the full row for North Star Investment Management Corp. 27 $476 <0.01% new 13F-HR Timeline HUNTINGTON NATIONAL BANK in group HUNTINGTON NATIONAL BANK More: the full row for HUNTINGTON NATIONAL BANK 21 $370 <0.01% new 13F-HR Timeline Group CIBC Private Wealth Group LLC in group CIBC Bancorp USA Inc. More: the full row for CIBC Private Wealth Group LLC 21 $370 <0.01% new 13F-HR Timeline Group Global Retirement Partners, LLC More: the full row for Global Retirement Partners, LLC 20 $353 <0.01% -26 13F-HR Timeline MAI Capital Management More: the full row for MAI Capital Management 19 $336 <0.01% new 13F-HR Timeline Bell Investment Advisors, Inc More: the full row for Bell Investment Advisors, Inc 16 $283 <0.01% -41 13F-HR Timeline Ancora Advisors LLC in group Ancora Advisors LLC More: the full row for Ancora Advisors LLC 15 $265 <0.01% 0 13F-HR Timeline Group Crewe Advisors LLC More: the full row for Crewe Advisors LLC 12 $212 <0.01% new 13F-HR Timeline Clearstead Advisors, LLC More: the full row for Clearstead Advisors, LLC 9 $159 <0.01% new 13F-HR Timeline Rockefeller Capital Management L.P. in group Rockefeller Capital Managemen… More: the full row for Rockefeller Capital Management L.P. 8 $141 <0.01% new 13F-HR/A Timeline Group Blue Trust, Inc. More: the full row for Blue Trust, Inc. 5 $88 <0.01% 0 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 1 $18 <0.01% -734 13F-HR Timeline Group Larson Financial Group LLC More: the full row for Larson Financial Group LLC 1 $18 <0.01% -5 13F-HR Timeline