TRV GP IV, LLC More: the full row for TRV GP IV, LLC 13,863,975 $116M 42.51% -2,995,100 13F-HR Timeline FARALLON CAPITAL MANAGEMENT, L.L.C. More: the full row for FARALLON CAPITAL MANAGEMENT, L.L.C. 10,757,000 $90.4M 0.51% +1,600,000 13F-HR/A Timeline EcoR1 Capital, LLC More: the full row for EcoR1 Capital, LLC 10,630,736 $89.3M 4.29% 0 13F-HR Timeline Boxer Capital Management, LLC in group Boxer Capital Management, LLC More: the full row for Boxer Capital Management, LLC 9,771,485 $82.1M 26.16% 0 13F-HR/A Timeline Group TCG Crossover Management, LLC More: the full row for TCG Crossover Management, LLC 8,536,196 $71.7M 3.53% -2,199,804 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 6,029,928 $50.7M 0.24% +22 13F-HR Timeline Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 5,883,188 $49.4M 1.93% +2,518,374 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 5,646,919 $47.4M <0.01% +183,653 13F-HR Timeline Group Nextech Invest Ltd. More: the full row for Nextech Invest Ltd. 5,533,980 $46.5M 7.08% 0 13F-HR Timeline VANGUARD GROUP INC group of 2 filers holding More: the full row for VANGUARD GROUP INC 5,072,216 $42.6M +1,025,047 Timeline GILEAD SCIENCES, INC. in group GILEAD SCIENCES, INC. More: the full row for GILEAD SCIENCES, INC. 4,854,443 $40.8M 2.28% 0 13F-HR Timeline Group T. Rowe Price Investment Management, In… More: the full row for T. Rowe Price Investment Management, Inc. 3,526,359 $29.6M 0.02% +357,133 13F-HR Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 3,472,207 $29.2M 0.06% +224,744 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 3,365,205 $28.3M <0.01% +1,982,519 13F-HR Timeline Group Paradigm Biocapital Advisors LP in group Paradigm Biocapital Advisors … More: the full row for Paradigm Biocapital Advisors LP 3,086,184 $25.9M 0.77% new 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 2,919,450 $24.5M 0.05% new 13F-HR Timeline Group Bain Capital Life Sciences Investors, L… in group Bain Capital Life Sciences In… More: the full row for Bain Capital Life Sciences Investors, LLC 2,712,008 $22.8M 1.51% 0 13F-HR Timeline Group ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 2,511,000 $21.1M 0.03% -3,394,349 13F-HR Timeline Group JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 2,302,274 $19.3M 0.01% new 13F-HR Timeline Group RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 2,000,000 $16.8M 0.21% 0 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 1,882,777 $15.8M <0.01% +113,864 13F-HR Timeline Group Nantahala Capital Management, LLC in group Nantahala Capital Management,… More: the full row for Nantahala Capital Management, LLC 1,809,948 $15.2M 0.94% -1,629,646 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 1,509,475 $12.7M <0.01% +1,401,296 13F-HR Timeline Group Commodore Capital LP in group Commodore Capital LP More: the full row for Commodore Capital LP 1,500,000 $12.6M 0.62% 0 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 1,489,518 $12.5M 0.01% -253,173 13F-HR Timeline Group Deep Track Capital, LP More: the full row for Deep Track Capital, LP 1,454,562 $12.2M 0.34% new 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 1,295,401 $10.9M 0.01% -476,903 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 1,031,917 $8.67M <0.01% +936,624 13F-HR Timeline Group Logos Global Management LP More: the full row for Logos Global Management LP 950,000 $7.98M 0.79% new 13F-HR Timeline Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 928,012 $7.8M <0.01% +485,049 13F-HR Timeline Group FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 926,904 $7.79M <0.01% +801,697 13F-HR Timeline Group Vivo Capital, LLC More: the full row for Vivo Capital, LLC 776,699 $6.52M 0.53% +176,699 13F-HR Timeline Candriam S.C.A. More: the full row for Candriam S.C.A. 708,812 $5.95M 0.03% 0 13F-HR Timeline BESSEMER GROUP INC in group BESSEMER GROUP INC More: the full row for BESSEMER GROUP INC 708,398 $5.95M 0.01% +14 13F-HR Timeline Group ArrowMark Colorado Holdings LLC More: the full row for ArrowMark Colorado Holdings LLC 708,385 $5.95M 0.11% 0 13F-HR Timeline DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 672,735 $5.65M <0.01% +147,637 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 658,292 $5.53M <0.01% +56,845 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 605,561 $5.09M <0.01% +5,053 13F-HR Timeline Group Avoro Capital Advisors LLC More: the full row for Avoro Capital Advisors LLC 545,000 $4.58M 0.06% new 13F-HR Timeline D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 430,379 $3.62M <0.01% new 13F-HR Timeline Group GREAT LAKES ADVISORS, LLC More: the full row for GREAT LAKES ADVISORS, LLC 423,851 $3.56M 0.03% new 13F-HR Timeline VOLORIDGE INVESTMENT MANAGEMENT, LLC More: the full row for VOLORIDGE INVESTMENT MANAGEMENT, LLC 384,207 $3.23M 0.01% new 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 365,680 $3.07M <0.01% +227,030 13F-HR/A Timeline Group Soleus Capital Management, L.P. More: the full row for Soleus Capital Management, L.P. 300,000 $2.52M 0.13% -430,000 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 287,499 $2.42M <0.01% +35,226 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 253,288 $2.13M <0.01% new 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 251,793 $2.12M <0.01% -282,828 13F-HR/A Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 246,072 $2.07M -156,212 Timeline STEMPOINT CAPITAL LP More: the full row for STEMPOINT CAPITAL LP 245,378 $2.06M 0.42% +36,578 13F-HR Timeline READYSTATE ASSET MANAGEMENT LP More: the full row for READYSTATE ASSET MANAGEMENT LP 245,109 $2.06M 0.1% -173,408 13F-HR Timeline Cubist Systematic Strategies, LLC More: the full row for Cubist Systematic Strategies, LLC 240,655 $2.02M 0.03% new 13F-HR Timeline TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 238,532 $2M +216,314 Timeline FRED ALGER MANAGEMENT, LLC in group FRED ALGER MANAGEMENT, LLC More: the full row for FRED ALGER MANAGEMENT, LLC 230,316 $1.93M 0.01% +38,979 13F-HR Timeline Group CONGRESS ASSET MANAGEMENT CO More: the full row for CONGRESS ASSET MANAGEMENT CO 228,120 $1.92M 0.01% +926 13F-HR Timeline Fisher Asset Management, LLC More: the full row for Fisher Asset Management, LLC 210,352 $1.77M <0.01% -13,725 13F-HR Timeline Trexquant Investment LP More: the full row for Trexquant Investment LP 199,081 $1.67M 0.02% new 13F-HR Timeline TRV GP VI, LLC More: the full row for TRV GP VI, LLC 194,174 $1.63M 1.49% 0 13F-HR Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 192,348 $1.62M <0.01% +4,351 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 160,478 $1.35M <0.01% -116,624 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 155,447 $1.31M <0.01% +108,302 13F-HR/A Timeline Group Rafferty Asset Management, LLC More: the full row for Rafferty Asset Management, LLC 145,316 $1.22M <0.01% new 13F-HR Timeline Blue Owl Capital Holdings LP More: the full row for Blue Owl Capital Holdings LP 119,416 $1M 0.31% -695,000 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 107,839 $906K <0.01% -4,434 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 102,270 $859K <0.01% -3,740 13F-HR Timeline ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 81,238 $682K 0.01% new 13F-HR Timeline AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 79,175 $665K <0.01% +229 13F-HR Timeline Group DekaBank Deutsche Girozentrale More: the full row for DekaBank Deutsche Girozentrale 60,000 $497K <0.01% 0 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 59,149 $497K <0.01% +6,488 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 55,300 $465K <0.01% -10,200 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 55,005 $462K <0.01% +5,788 13F-HR Timeline Group TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 53,572 $450K <0.01% new 13F-HR/A Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 47,726 $401K <0.01% 0 13F-HR Timeline Group Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 44,699 $376K -1,486 Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 40,669 $343K <0.01% +2,268 13F-HR Timeline Y-Intercept (Hong Kong) Ltd More: the full row for Y-Intercept (Hong Kong) Ltd 36,963 $310K 0.01% new 13F-HR Timeline Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 36,189 $303K <0.01% new 13F-HR Timeline Group Janney Montgomery Scott LLC More: the full row for Janney Montgomery Scott LLC 36,000 $302K <0.01% -3,500 13F-HR Timeline Creative Planning in group Creative Planning More: the full row for Creative Planning 35,244 $296K <0.01% new 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 33,916 $285K <0.01% -32,759 13F-HR/A Timeline Group Harvest Investment Services, LLC More: the full row for Harvest Investment Services, LLC 31,840 $267K 0.05% new 13F-HR Timeline PROFUND ADVISORS LLC More: the full row for PROFUND ADVISORS LLC 31,288 $263K 0.01% new 13F-HR Timeline Clear Harbor Asset Management, LLC More: the full row for Clear Harbor Asset Management, LLC 30,300 $255K 0.02% +1 13F-HR/A Timeline J. Goldman & Co LP More: the full row for J. Goldman & Co LP 29,036 $244K 0.01% new 13F-HR Timeline INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 28,152 $236K <0.01% -17,523 13F-HR Timeline Simplicity Wealth,LLC More: the full row for Simplicity Wealth,LLC 26,961 $226K 0.01% 0 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 26,653 $224K 0.01% +22 13F-HR Timeline Group Verition Fund Management LLC More: the full row for Verition Fund Management LLC 24,752 $208K <0.01% new 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 22,694 $191K <0.01% -6,111 13F-HR Timeline Group Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 22,532 $189K 0.05% +3,912 13F-HR Timeline Group BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 21,500 $181K <0.01% -103,500 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 20,548 $173K <0.01% +2,901 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 19,502 $164K 0.01% -2,269 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 18,102 $152K <0.01% -12,189 13F-HR Timeline Group TD Asset Management Inc More: the full row for TD Asset Management Inc 18,072 $152K <0.01% new 13F-HR Timeline LOS ANGELES CAPITAL MANAGEMENT LLC More: the full row for LOS ANGELES CAPITAL MANAGEMENT LLC 17,185 $144K <0.01% +6,895 13F-HR Timeline ProShare Advisors LLC More: the full row for ProShare Advisors LLC 16,230 $136K <0.01% -3,545 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 15,576 $131K <0.01% +9,000 13F-HR Timeline DRW Securities, LLC More: the full row for DRW Securities, LLC 14,778 $129K 0.01% new 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 15,090 $127K <0.01% +6,481 13F-HR Timeline Group AXQ CAPITAL, LP More: the full row for AXQ CAPITAL, LP 13,468 $113K 0.04% new 13F-HR Timeline VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 13,465 $113K <0.01% -7,830 13F-HR Timeline Group STATE BOARD OF ADMINISTRATION OF FLORID… More: the full row for STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 12,780 $107K <0.01% 0 13F-HR Timeline Quantinno Capital Management LP More: the full row for Quantinno Capital Management LP 12,275 $103K <0.01% new 13F-HR Timeline Corient Private Wealth LP in group Corient Private Wealth LP More: the full row for Corient Private Wealth LP 11,500 $96.6K <0.01% new 13F-HR Timeline Group Corton Capital Inc. More: the full row for Corton Capital Inc. 11,387 $95.7K 0.24% new 13F-HR Timeline MERCER GLOBAL ADVISORS INC /ADV More: the full row for MERCER GLOBAL ADVISORS INC /ADV 11,326 $95.1K <0.01% new 13F-HR Timeline Belvedere Trading LLC More: the full row for Belvedere Trading LLC 10,845 $91.1K 0.01% -386 13F-HR Timeline SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 10,045 $84.4K <0.01% new 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 7,729 $64.9K <0.01% +6,352 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 6,445 $54.1K <0.01% -540 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 6,444 $54.1K <0.01% -3,029 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 6,426 $54K <0.01% +848 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 5,993 $50.3K <0.01% -1,837 13F-HR Timeline Group Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 4,950 $41.6K <0.01% +2,879 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 4,870 $41K <0.01% -35 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 4,788 $40.2K <0.01% +3 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 2,394 $20.1K <0.01% -271 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 1,740 $14.6K <0.01% +700 13F-HR Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 1,618 $14K <0.01% 0 13F-HR Timeline Arax Advisory Partners More: the full row for Arax Advisory Partners 1,202 $10.1K <0.01% new 13F-HR Timeline AlphaQuest LLC More: the full row for AlphaQuest LLC 1,086 $9.12K <0.01% new 13F-HR Timeline TFC Financial Management, Inc. More: the full row for TFC Financial Management, Inc. 800 $6.72K <0.01% +500 13F-HR Timeline Optiver Holding B.V. in group Optiver Holding B.V. More: the full row for Optiver Holding B.V. 614 $5.16K <0.01% new 13F-HR Timeline Group OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 591 $4.99K <0.01% +91 13F-HR Timeline Group GAMMA Investing LLC More: the full row for GAMMA Investing LLC 464 $3.9K <0.01% +399 13F-HR Timeline FEDERATED HERMES, INC. in group FEDERATED HERMES, INC. More: the full row for FEDERATED HERMES, INC. 362 $3.04K <0.01% 0 13F-HR Timeline Group Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 355 $3K <0.01% 0 13F-HR Timeline Group IFP Advisors, Inc More: the full row for IFP Advisors, Inc 233 $1.96K <0.01% 0 13F-HR/A Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 212 $1.78K <0.01% 0 13F-HR Timeline Group Rockefeller Capital Management L.P. in group Rockefeller Capital Managemen… More: the full row for Rockefeller Capital Management L.P. 122 $1.02K <0.01% new 13F-HR Timeline Group SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 54 $454 <0.01% +43 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 53 $445 <0.01% -6,136 13F-HR Timeline Group Allworth Financial LP More: the full row for Allworth Financial LP 38 $320 <0.01% +3 13F-HR Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 25 $210 <0.01% new 13F-HR Timeline ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 20 $168 <0.01% new 13F-HR Timeline Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 3 $25 <0.01% 0 13F-HR Timeline Covestor Ltd More: the full row for Covestor Ltd 32 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios.