TRV GP IV, LLC More: the full row for TRV GP IV, LLC 16,859,075 $52.1M 64.97% 0 13F-HR Timeline TCG Crossover Management, LLC More: the full row for TCG Crossover Management, LLC 10,736,000 $33.2M 3.24% new 13F-HR Timeline EcoR1 Capital, LLC More: the full row for EcoR1 Capital, LLC 10,630,736 $32.8M 1.31% -2,700,000 13F-HR Timeline Boxer Capital Management, LLC in group Boxer Capital Management, LLC More: the full row for Boxer Capital Management, LLC 10,380,999 $32.1M 2.73% 13F-HR Timeline Group Nextech Invest Ltd. More: the full row for Nextech Invest Ltd. 5,533,980 $17.1M 2.77% 0 13F-HR Timeline GILEAD SCIENCES, INC. in group GILEAD SCIENCES, INC. More: the full row for GILEAD SCIENCES, INC. 4,854,443 $15M 0.97% 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 4,378,503 $13.5M <0.01% +17,168 13F-HR Timeline Group FARALLON CAPITAL MANAGEMENT, L.L.C. More: the full row for FARALLON CAPITAL MANAGEMENT, L.L.C. 4,000,000 $12.4M 0.07% new 13F-HR Timeline VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 3,985,225 $12.3M <0.01% +339,922 13F-HR Timeline Group T. Rowe Price Investment Management, In… More: the full row for T. Rowe Price Investment Management, Inc. 3,345,551 $10.3M 0.01% -1,677,595 13F-HR Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 3,279,196 $10.1M 0.02% +592,000 13F-HR Timeline Group Nantahala Capital Management, LLC in group Nantahala Capital Management,… More: the full row for Nantahala Capital Management, LLC 2,804,410 $8.67M 0.61% new 13F-HR Timeline Group Bain Capital Life Sciences Investors, L… in group Bain Capital Life Sciences In… More: the full row for Bain Capital Life Sciences Investors, LLC 2,712,008 $8.38M 0.99% 0 13F-HR Timeline Group Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 2,603,897 $8.05M 0.36% 0 13F-HR Timeline Group Blue Owl Capital Holdings LP More: the full row for Blue Owl Capital Holdings LP 1,732,152 $5.35M 1.23% new 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 1,626,759 $5.03M <0.01% -1,067,366 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 1,386,449 $4.29M <0.01% +18,187 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 1,231,199 $3.8M <0.01% -1,087,009 13F-HR Timeline Group Casdin Capital, LLC More: the full row for Casdin Capital, LLC 1,188,349 $3.67M 0.25% 0 13F-HR Timeline BESSEMER GROUP INC in group BESSEMER GROUP INC More: the full row for BESSEMER GROUP INC 708,384 $2.19M <0.01% 0 13F-HR Timeline Group ArrowMark Colorado Holdings LLC More: the full row for ArrowMark Colorado Holdings LLC 708,385 $2.19M 0.03% 0 13F-HR Timeline DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 662,776 $2.05M <0.01% +302,087 13F-HR Timeline Group SCHRODER INVESTMENT MANAGEMENT GROUP More: the full row for SCHRODER INVESTMENT MANAGEMENT GROUP 655,158 $2.03M <0.01% new 13F-HR Timeline SAMSARA BIOCAPITAL, LLC More: the full row for SAMSARA BIOCAPITAL, LLC 630,000 $1.95M 0.27% 0 13F-HR Timeline ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 550,000 $1.7M 0.04% new 13F-HR Timeline Group JACOBS LEVY EQUITY MANAGEMENT, INC More: the full row for JACOBS LEVY EQUITY MANAGEMENT, INC 517,426 $1.6M 0.01% new 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 513,429 $1.59M <0.01% +26,192 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 513,079 $1.59M <0.01% +33,829 13F-HR Timeline Group ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 495,106 $1.53M <0.01% new 13F-HR Timeline Group UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 491,024 $1.52M -25,109 Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 486,888 $1.5M <0.01% -56,609 13F-HR Timeline Group SUPERSTRING CAPITAL MANAGEMENT LP More: the full row for SUPERSTRING CAPITAL MANAGEMENT LP 474,955 $1.47M 1.29% -124,093 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 394,397 $1.22M 0.01% new 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 372,544 $1.15M +356,236 Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 320,070 $989K <0.01% -21,907 13F-HR/A Timeline Group Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 287,052 $887K 0.01% +144,476 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 272,233 $841K <0.01% +96,864 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 249,646 $771K <0.01% new 13F-HR Timeline Group CONGRESS ASSET MANAGEMENT CO More: the full row for CONGRESS ASSET MANAGEMENT CO 227,989 $704K <0.01% +18,919 13F-HR Timeline TRV GP VI, LLC More: the full row for TRV GP VI, LLC 194,174 $600K 0.51% 13F-HR Timeline Nuveen Asset Management, LLC in group TIAA More: the full row for Nuveen Asset Management, LLC 192,259 $594K <0.01% -12,562 13F-HR Timeline Group ALGERT GLOBAL LLC More: the full row for ALGERT GLOBAL LLC 162,300 $502K 0.01% new 13F-HR/A Timeline Fisher Asset Management, LLC More: the full row for Fisher Asset Management, LLC 154,947 $479K <0.01% 0 13F-HR Timeline DekaBank Deutsche Girozentrale More: the full row for DekaBank Deutsche Girozentrale 60,000 $438K <0.01% 0 13F-HR Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 138,247 $427K <0.01% -4,960 13F-HR Timeline Group FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 126,553 $391K <0.01% +110,126 13F-HR Timeline Group ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 121,993 $377K <0.01% new 13F-HR Timeline D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 114,827 $355K <0.01% new 13F-HR Timeline Group AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 110,448 $341K <0.01% +12,162 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 103,020 $318K <0.01% -8,715 13F-HR Timeline Group PDT Partners, LLC More: the full row for PDT Partners, LLC 102,807 $318K 0.03% new 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 99,774 $308K <0.01% -26,507 13F-HR/A Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 95,229 $294K <0.01% +44,465 13F-HR Timeline Group Swiss National Bank More: the full row for Swiss National Bank 94,900 $293K <0.01% +11,000 13F-HR Timeline GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 86,445 $267K 0.02% +41,173 13F-HR Timeline Verition Fund Management LLC More: the full row for Verition Fund Management LLC 81,045 $250K <0.01% +49,025 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 77,937 $241K 0.02% +33,746 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 71,196 $220K +3,034 Timeline LOS ANGELES CAPITAL MANAGEMENT LLC More: the full row for LOS ANGELES CAPITAL MANAGEMENT LLC 70,452 $218K <0.01% new 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 65,740 $203K <0.01% +1,895 13F-HR/A Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 64,940 $201K <0.01% 0 13F-HR Timeline Aristides Capital LLC More: the full row for Aristides Capital LLC 64,300 $199K 0.06% new 13F-HR Timeline TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 60,614 $187K <0.01% -2,682 13F-HR Timeline Ensign Peak Advisors, Inc More: the full row for Ensign Peak Advisors, Inc 57,319 $177K <0.01% +28,700 13F-HR Timeline Nebula Research & Development LLC More: the full row for Nebula Research & Development LLC 51,924 $160K 0.02% +41,023 13F-HR Timeline Jain Global LLC More: the full row for Jain Global LLC 49,792 $154K <0.01% 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 46,992 $145K <0.01% +8,316 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 45,015 $139K <0.01% +4,248 13F-HR/A Timeline Janney Montgomery Scott LLC More: the full row for Janney Montgomery Scott LLC 40,000 $124K <0.01% 0 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 37,961 $117K <0.01% 0 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 36,653 $113K <0.01% +7,128 13F-HR/A Timeline Group Graham Capital Management, L.P. More: the full row for Graham Capital Management, L.P. 34,804 $108K <0.01% new 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 31,313 $96.8K <0.01% -21,527 13F-HR Timeline Group HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 31,146 $96K <0.01% new 13F-HR Timeline Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 30,991 $95.9K -3,181 Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 29,534 $91.3K <0.01% +584 13F-HR Timeline Group INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 27,919 $86.3K <0.01% -2,991 13F-HR Timeline Simplicity Wealth,LLC More: the full row for Simplicity Wealth,LLC 26,961 $83.3K 0.02% 0 13F-HR Timeline Catalina Capital Group, LLC More: the full row for Catalina Capital Group, LLC 26,593 $82.2K 0.03% new 13F-HR Timeline Clear Harbor Asset Management, LLC More: the full row for Clear Harbor Asset Management, LLC 25,495 $78.8K 0.01% 0 13F-HR Timeline VIRTUS ADVISERS, LLC in group Virtus Investment Advisers, L… More: the full row for VIRTUS ADVISERS, LLC 24,945 $77.1K 0.03% +13,961 13F-HR Timeline Group Corton Capital Inc. More: the full row for Corton Capital Inc. 24,408 $75.4K 0.04% new 13F-HR Timeline Corebridge Financial, Inc. in group Corebridge Financial, Inc. More: the full row for Corebridge Financial, Inc. 23,719 $73.3K <0.01% -1,790 13F-HR Timeline Group China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 22,777 $70.4K 0.01% +2,170 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 22,292 $68.9K <0.01% +7,599 13F-HR Timeline Group SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 21,963 $68K <0.01% +2,319 13F-HR Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 21,500 $66.4K <0.01% new 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 20,998 $65K <0.01% +4,813 13F-HR Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 19,631 $60.7K <0.01% -8,633 13F-HR Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 19,296 $59.6K <0.01% +69 13F-HR Timeline Group ProShare Advisors LLC More: the full row for ProShare Advisors LLC 18,524 $57.2K <0.01% +3,178 13F-HR Timeline EXCHANGE TRADED CONCEPTS, LLC More: the full row for EXCHANGE TRADED CONCEPTS, LLC 17,426 $53.8K <0.01% 0 13F-HR Timeline VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 15,149 $46.8K <0.01% -1,162 13F-HR/A Timeline Group Sequoia Financial Advisors, LLC More: the full row for Sequoia Financial Advisors, LLC 14,631 $45.2K <0.01% new 13F-HR/A Timeline TEACHER RETIREMENT SYSTEM OF TEXAS More: the full row for TEACHER RETIREMENT SYSTEM OF TEXAS 14,544 $45K <0.01% +3,831 13F-HR Timeline ARIZONA STATE RETIREMENT SYSTEM More: the full row for ARIZONA STATE RETIREMENT SYSTEM 13,976 $43.2K <0.01% +1,670 13F-HR Timeline Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 13,494 $41.7K <0.01% -332 13F-HR Timeline Bleakley Financial Group, LLC More: the full row for Bleakley Financial Group, LLC 12,849 $39.7K <0.01% -1,578 13F-HR Timeline Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 12,843 $39.7K <0.01% new 13F-HR Timeline Group STATE BOARD OF ADMINISTRATION OF FLORID… More: the full row for STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 12,780 $39.5K <0.01% 0 13F-HR Timeline SHERBROOKE PARK ADVISERS LLC More: the full row for SHERBROOKE PARK ADVISERS LLC 12,307 $38K 0.01% new 13F-HR Timeline JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 11,631 $35.9K <0.01% 0 13F-HR Timeline Group AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 11,198 $34.6K <0.01% new 13F-HR Timeline Group Stonebrook Private Inc. More: the full row for Stonebrook Private Inc. 10,992 $34K 0.01% new 13F-HR Timeline Dynamic Technology Lab Private Ltd More: the full row for Dynamic Technology Lab Private Ltd 10,764 $33K 0.01% new 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 9,218 $28.5K <0.01% 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 8,837 $27.3K <0.01% -9,370,960 13F-HR Timeline Group US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 6,997 $21.6K <0.01% +6,732 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 6,693 $20.7K <0.01% new 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 6,576 $20.3K <0.01% 0 13F-HR/A Timeline KLP KAPITALFORVALTNING AS More: the full row for KLP KAPITALFORVALTNING AS 6,300 $19.5K <0.01% 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 5,809 $17.9K <0.01% -8,956 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 4,378 $13.5K <0.01% 0 13F-HR Timeline Group R Squared Ltd More: the full row for R Squared Ltd 3,140 $9.7K 0.01% 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 2,255 $6.97K <0.01% 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 2,067 $6.39K <0.01% +1,998 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 1,934 $6K <0.01% -4,866 13F-HR Timeline Group AMALGAMATED BANK More: the full row for AMALGAMATED BANK 1,618 $5K <0.01% 0 13F-HR Timeline Lindbrook Capital, LLC More: the full row for Lindbrook Capital, LLC 1,356 $4.19K <0.01% new 13F-HR Timeline Fortitude Family Office, LLC More: the full row for Fortitude Family Office, LLC 1,198 $3.7K <0.01% +569 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 819 $2.53K <0.01% 0 13F-HR Timeline Group CoreCap Advisors, LLC More: the full row for CoreCap Advisors, LLC 748 $2.31K <0.01% new 13F-HR Timeline Brooklyn Investment Group More: the full row for Brooklyn Investment Group 687 $2.12K <0.01% new 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 474 $1.46K <0.01% new 13F-HR Timeline SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 346 $1.07K <0.01% new 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 330 $1.02K <0.01% -371 13F-HR/A Timeline Group Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 355 $1K <0.01% 0 13F-HR Timeline Group TFC Financial Management, Inc. More: the full row for TFC Financial Management, Inc. 300 $927 <0.01% 0 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 49 $151 <0.01% 0 13F-HR Timeline ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 40 $124 <0.01% -55 13F-HR Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 0 $68 <0.01% new 13F-HR Timeline Amount filed as zero, left out of ratios. SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 11 $34 <0.01% 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 71 $0 0% +61 13F-HR Timeline Group Value filed as zero, left out of ratios. Covestor Ltd More: the full row for Covestor Ltd 10 $0 0% +1 13F-HR Timeline Value filed as zero, left out of ratios. CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.