Soleus Capital Management, L.P. More: the full row for Soleus Capital Management, L.P. 8,167,100 $22.5M 1.77% +24,600 13F-HR Timeline ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 7,562,971 $20.9M 0.5% 0 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 7,110,105 $19.6M <0.01% +3,762,298 13F-HR Timeline Group Vivo Capital, LLC More: the full row for Vivo Capital, LLC 6,895,746 $19M 2.52% 0 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 5,706,632 $15.8M <0.01% -36,850 13F-HR Timeline Group Deep Track Capital, LP More: the full row for Deep Track Capital, LP 5,576,558 $15.4M 0.5% 0 13F-HR Timeline VANGUARD GROUP INC group of 2 filers holding More: the full row for VANGUARD GROUP INC 4,168,394 $11.5M +298,812 Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 3,907,887 $10.8M 0.01% +640,108 13F-HR Timeline Group Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 3,844,867 $10.6M 0.07% -906,639 13F-HR Timeline Candriam S.C.A. More: the full row for Candriam S.C.A. 2,153,969 $5.95M 0.04% 0 13F-HR Timeline ACORN CAPITAL ADVISORS, LLC More: the full row for ACORN CAPITAL ADVISORS, LLC 1,971,264 $5.44M 3.63% 0 13F-HR/A Timeline DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 1,706,201 $4.71M <0.01% +403,269 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 1,574,204 $4.35M <0.01% +57,726 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 1,433,834 $3.96M 0.01% +810,700 13F-HR Timeline Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 1,405,901 $3.88M <0.01% 13F-HR Timeline Group SUPERSTRING CAPITAL MANAGEMENT LP More: the full row for SUPERSTRING CAPITAL MANAGEMENT LP 1,357,153 $3.75M 4.47% -663,409 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 1,324,517 $3.66M <0.01% +37,474 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 1,117,442 $3.08M <0.01% -492,773 13F-HR Timeline Group Parkman Healthcare Partners LLC More: the full row for Parkman Healthcare Partners LLC 959,703 $2.65M 0.31% +130,598 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 933,106 $2.58M <0.01% +531,448 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 812,042 $2.24M <0.01% +614,816 13F-HR Timeline Group Driehaus Capital Management LLC More: the full row for Driehaus Capital Management LLC 763,486 $2.11M 0.02% -898,360 13F-HR Timeline Integral Health Asset Management, LLC More: the full row for Integral Health Asset Management, LLC 700,000 $1.93M 0.21% +250,000 13F-HR Timeline Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 695,159 $1.92M <0.01% +380,770 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 653,037 $1.8M <0.01% -51,334 13F-HR/A Timeline Group Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 594,190 $1.64M 0.02% +475,294 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 584,188 $1.61M <0.01% -6,983 13F-HR Timeline Group JACOBS LEVY EQUITY MANAGEMENT, INC More: the full row for JACOBS LEVY EQUITY MANAGEMENT, INC 494,877 $1.37M 0.01% new 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 453,981 $1.25M <0.01% +229,716 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 415,021 $1.15M <0.01% +71,971 13F-HR/A Timeline Group SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 413,822 $1.14M <0.01% +380,489 13F-HR Timeline SCHRODER INVESTMENT MANAGEMENT GROUP More: the full row for SCHRODER INVESTMENT MANAGEMENT GROUP 376,204 $1.1M <0.01% +272,696 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 385,477 $1.06M <0.01% -12,902 13F-HR Timeline Group SALEM INVESTMENT COUNSELORS INC More: the full row for SALEM INVESTMENT COUNSELORS INC 346,850 $957K 0.03% +125 13F-HR Timeline OCONNOR, A Distinct Business Unit of UB… More: the full row for OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 336,144 $928K 0.02% +195,844 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. ACUTA CAPITAL PARTNERS, LLC More: the full row for ACUTA CAPITAL PARTNERS, LLC 325,550 $899K 1.04% -121,950 13F-HR Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 321,163 $886K <0.01% +98,649 13F-HR Timeline Group Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 308,491 $851K 0.28% 0 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 301,612 $832K 0.01% -10,000 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 294,195 $812K <0.01% +242,365 13F-HR Timeline Group LPL Financial LLC More: the full row for LPL Financial LLC 240,575 $664K <0.01% -11,750 13F-HR Timeline Polymer Capital Management (HK) LTD More: the full row for Polymer Capital Management (HK) LTD 239,110 $660K 0.11% +62,110 13F-HR Timeline TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 237,072 $654K +142,383 Timeline Graham Capital Management, L.P. More: the full row for Graham Capital Management, L.P. 226,295 $625K 0.02% +93,296 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 206,450 $570K <0.01% 0 13F-HR/A Timeline Group SAMSARA BIOCAPITAL, LLC More: the full row for SAMSARA BIOCAPITAL, LLC 202,348 $558K 0.1% 0 13F-HR Timeline INFINITUM ASSET MANAGEMENT, LLC More: the full row for INFINITUM ASSET MANAGEMENT, LLC 200,000 $552K 0.18% 0 13F-HR/A Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 186,913 $516K <0.01% +605 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 160,725 $444K <0.01% -1,091,116 13F-HR/A Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 144,644 $399K <0.01% -658,692 13F-HR Timeline Group Trexquant Investment LP More: the full row for Trexquant Investment LP 139,609 $385K <0.01% -113,638 13F-HR Timeline EXCHANGE TRADED CONCEPTS, LLC More: the full row for EXCHANGE TRADED CONCEPTS, LLC 137,663 $380K 0.01% -5,256 13F-HR Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 127,887 $353K <0.01% new 13F-HR Timeline Group BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 126,830 $350K 0.01% 0 13F-HR Timeline AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 113,757 $314K <0.01% +532 13F-HR Timeline Group Cinctive Capital Management LP More: the full row for Cinctive Capital Management LP 109,997 $304K 0.02% 0 13F-HR Timeline E. Ohman J:or Asset Management AB More: the full row for E. Ohman J:or Asset Management AB 102,410 $283K 0.01% +22,032 13F-HR Timeline SummitTX Capital, L.P. More: the full row for SummitTX Capital, L.P. 100,133 $276K 0.01% 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 96,659 $267K <0.01% -1,233 13F-HR/A Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 91,174 $252K <0.01% +55,285 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 86,728 $239K <0.01% +73,603 13F-HR/A Timeline Group MARTINGALE ASSET MANAGEMENT L P More: the full row for MARTINGALE ASSET MANAGEMENT L P 83,038 $229K 0.01% -15,068 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 76,052 $210K <0.01% -1,428,186 13F-HR Timeline EntryPoint Capital, LLC More: the full row for EntryPoint Capital, LLC 73,293 $202K 0.09% +12,905 13F-HR Timeline J. Goldman & Co LP More: the full row for J. Goldman & Co LP 67,500 $186K 0.01% -168,331 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 64,100 $177K <0.01% -298,259 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 58,345 $161K <0.01% +34,945 13F-HR Timeline Group DIADEMA PARTNERS LP More: the full row for DIADEMA PARTNERS LP 56,098 $155K 0.12% +5,728 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 54,182 $150K <0.01% -4,998 13F-HR Timeline Group Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 44,420 $123K +1,806 Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 41,889 $116K <0.01% +923 13F-HR Timeline Group STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 41,502 $115K <0.01% +14,683 13F-HR Timeline INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 39,922 $110K <0.01% +21,451 13F-HR Timeline Man Group plc in group Man Group plc More: the full row for Man Group plc 38,472 $106K <0.01% new 13F-HR Timeline Group Corebridge Financial, Inc. in group Corebridge Financial, Inc. More: the full row for Corebridge Financial, Inc. 34,440 $95.1K <0.01% -511 13F-HR Timeline Group OXFORD ASSET MANAGEMENT LLP More: the full row for OXFORD ASSET MANAGEMENT LLP 33,027 $91.2K 0.04% +17,571 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. Cubist Systematic Strategies, LLC More: the full row for Cubist Systematic Strategies, LLC 28,327 $78.2K <0.01% +16,363 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 28,188 $77.8K <0.01% -600,207 13F-HR Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 25,165 $69.5K <0.01% +787 13F-HR Timeline Group Virtus Investment Advisers, LLC group of 2 filers holding More: the full row for Virtus Investment Advisers, LLC 24,913 $68.8K +14,125 Timeline HSBC HOLDINGS PLC in group HSBC HOLDINGS PLC More: the full row for HSBC HOLDINGS PLC 23,515 $66.4K <0.01% -12,383 13F-HR Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 21,880 $60.4K <0.01% -21,880 13F-HR Timeline Group AXQ CAPITAL, LP More: the full row for AXQ CAPITAL, LP 21,460 $59.2K 0.02% new 13F-HR Timeline STONERIDGE INVESTMENT PARTNERS LLC More: the full row for STONERIDGE INVESTMENT PARTNERS LLC 20,603 $57K 0.05% 0 13F-HR Timeline VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 19,796 $54.6K <0.01% -684 13F-HR/A Timeline Group AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 19,166 $52.9K <0.01% new 13F-HR Timeline Group ProShare Advisors LLC More: the full row for ProShare Advisors LLC 19,051 $52.6K <0.01% -4,770 13F-HR Timeline Dynamic Technology Lab Private Ltd More: the full row for Dynamic Technology Lab Private Ltd 18,578 $51K 0.01% new 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 17,571 $48.5K <0.01% 0 13F-HR/A Timeline PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 17,500 $48.3K <0.01% new 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 17,037 $47K <0.01% -973 13F-HR Timeline Velan Capital Investment Management LP More: the full row for Velan Capital Investment Management LP 17,000 $46.9K 0.05% 0 13F-HR Timeline CIBC WORLD MARKETS CORP More: the full row for CIBC WORLD MARKETS CORP 15,599 $43.1K <0.01% new 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 15,010 $41.4K <0.01% 0 13F-HR Timeline Vontobel Holding Ltd. in group Vontobel Holding Ltd. More: the full row for Vontobel Holding Ltd. 14,000 $38.6K <0.01% new 13F-HR Timeline Group Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 13,900 $38.4K <0.01% -48,501 13F-HR/A Timeline Group Baird Financial Group, Inc. in group Baird Financial Group, Inc. More: the full row for Baird Financial Group, Inc. 13,665 $37.7K <0.01% -355 13F-HR Timeline Group LANDSCAPE CAPITAL MANAGEMENT, L.L.C. in group LANDSCAPE CAPITAL MANAGEMENT,… More: the full row for LANDSCAPE CAPITAL MANAGEMENT, L.L.C. 13,196 $36.4K <0.01% 0 13F-HR Timeline Group Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 12,807 $35.3K 0.03% 0 13F-HR Timeline Nebula Research & Development LLC More: the full row for Nebula Research & Development LLC 12,637 $34.9K <0.01% -13,212 13F-HR Timeline STATE BOARD OF ADMINISTRATION OF FLORID… More: the full row for STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 12,440 $34.3K <0.01% 0 13F-HR Timeline Point72 (DIFC) Ltd More: the full row for Point72 (DIFC) Ltd 11,948 $33K <0.01% new 13F-HR Timeline Thrive Wealth Management, LLC More: the full row for Thrive Wealth Management, LLC 10,500 $29K 0.01% new 13F-HR Timeline Sio Capital Management, LLC More: the full row for Sio Capital Management, LLC 10,000 $27.6K 0.01% 0 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 6,923 $19.1K <0.01% +3,512 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 6,311 $17.4K <0.01% 0 13F-HR Timeline Group PUBLIC EMPLOYEES RETIREMENT SYSTEM OF O… More: the full row for PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO 5,673 $15.7K <0.01% new 13F-HR Timeline Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 5,640 $15.6K <0.01% 0 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 5,628 $15K <0.01% -4,334 13F-HR/A Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 5,171 $14.3K <0.01% 0 13F-HR Timeline CIBC Private Wealth Group LLC in group CIBC Bancorp USA Inc. More: the full row for CIBC Private Wealth Group LLC 5,000 $10.2K <0.01% +4,000 13F-HR Timeline Group AMALGAMATED BANK More: the full row for AMALGAMATED BANK 2,426 $7K <0.01% +981 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 2,450 $6.76K <0.01% new 13F-HR Timeline Group GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 2,174 $6K <0.01% +391 13F-HR Timeline Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 2,000 $5.52K <0.01% +1,663 13F-HR Timeline HHM Wealth Advisors, LLC More: the full row for HHM Wealth Advisors, LLC 1,400 $3.86K <0.01% 0 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 1,362 $3.76K <0.01% -112,559 13F-HR Timeline Group Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 1,152 $3.18K <0.01% -949 13F-HR Timeline COLDSTREAM CAPITAL MANAGEMENT INC More: the full row for COLDSTREAM CAPITAL MANAGEMENT INC 998 $2.75K <0.01% new 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 531 $1.47K <0.01% new 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 483 $1.33K <0.01% new 13F-HR Timeline Group CoreCap Advisors, LLC More: the full row for CoreCap Advisors, LLC 400 $1.1K <0.01% new 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 398 $1.1K <0.01% +54 13F-HR Timeline ELEVATION WEALTH PARTNERS, LLC More: the full row for ELEVATION WEALTH PARTNERS, LLC 281 $776 <0.01% 0 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 239 $660 <0.01% -62 13F-HR Timeline FEDERATED HERMES, INC. in group FEDERATED HERMES, INC. More: the full row for FEDERATED HERMES, INC. 225 $621 <0.01% -558 13F-HR Timeline Group MAI Capital Management More: the full row for MAI Capital Management 189 $522 <0.01% 0 13F-HR Timeline SUMMIT SECURITIES GROUP LLC More: the full row for SUMMIT SECURITIES GROUP LLC 184 $508 <0.01% new 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 85 $260 <0.01% new 13F-HR Timeline ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 35 $97 <0.01% -90 13F-HR Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 0 $11 <0.01% -114 13F-HR Timeline Amount filed as zero, left out of ratios. AlphaQuest LLC More: the full row for AlphaQuest LLC 1 $3 <0.01% 0 13F-HR Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 151 $0 0% 0 13F-HR Timeline Group Value filed as zero, left out of ratios. Capital Advisors, Ltd. LLC More: the full row for Capital Advisors, Ltd. LLC 89 $0 0% -94 13F-HR Timeline Value filed as zero, left out of ratios. CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 47 $0 0% -67 13F-HR Timeline Group Value filed as zero, left out of ratios. CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.