JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 11,063,862 $76.9M 0.04% +3,793,862 13F-HR/A Timeline Group Squadron Capital Management LLC More: the full row for Squadron Capital Management LLC 8,474,571 $59M 23.6% +1,774,571 13F-HR Timeline Spruce Street Capital LP More: the full row for Spruce Street Capital LP 6,262,114 $43M 10.34% +2,175,933 13F-HR Timeline Venrock Adviser, LLC More: the full row for Venrock Adviser, LLC 4,843,380 $33.7M 1.26% new 13F-HR Timeline ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 4,763,158 $33.2M 0.05% +493,158 13F-HR Timeline Group ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 4,715,864 $32.8M 0.72% +2,105,264 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 4,481,606 $31.2M 0.03% +1,291,944 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 3,907,265 $27.2M 0.02% +2,234,248 13F-HR Timeline Group VANGUARD GROUP INC group of 3 filers holding More: the full row for VANGUARD GROUP INC 3,555,506 $24.7M new Timeline RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 2,947,369 $20.5M 0.22% new 13F-HR Timeline Group Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 2,688,359 $18.7M 2.68% -380,000 13F-HR Timeline Group Driehaus Capital Management LLC More: the full row for Driehaus Capital Management LLC 2,132,053 $14.8M 0.11% +252,047 13F-HR Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 1,590,946 $11.1M <0.01% -329,153 13F-HR/A Timeline Group Polar Capital Holdings Plc in group Polar Capital Holdings Plc More: the full row for Polar Capital Holdings Plc 1,414,621 $9.85M 0.04% new 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 1,289,550 $8.98M <0.01% +22,047 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 1,011,572 $7.04M 0.01% +625,630 13F-HR Timeline Group Sio Capital Management, LLC More: the full row for Sio Capital Management, LLC 965,000 $6.72M 0.97% new 13F-HR Timeline Opaleye Management Inc. More: the full row for Opaleye Management Inc. 935,000 $6.51M 0.86% 0 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 848,683 $5.91M <0.01% -6,249 13F-HR Timeline Group GREAT POINT PARTNERS LLC More: the full row for GREAT POINT PARTNERS LLC 842,106 $5.86M 1.44% new 13F-HR Timeline EVENTIDE ASSET MANAGEMENT, LLC More: the full row for EVENTIDE ASSET MANAGEMENT, LLC 842,106 $5.86M 0.1% new 13F-HR Timeline Soleus Capital Management, L.P. More: the full row for Soleus Capital Management, L.P. 842,106 $5.86M 0.24% new 13F-HR Timeline Boxer Capital Management, LLC in group Boxer Capital Management, LLC More: the full row for Boxer Capital Management, LLC 842,106 $5.86M 0.77% new 13F-HR Timeline Group BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 729,055 $5.07M 0.12% -106,245 13F-HR Timeline Corient Private Wealth LP in group Corient Private Wealth LP More: the full row for Corient Private Wealth LP 719,582 $4.96M 0.01% 0 13F-HR Timeline Group ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 712,540 $4.96M 0.01% +185,822 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 699,039 $4.87M <0.01% +554,039 13F-HR Timeline Group Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 653,333 $4.55M 0.01% +497,804 13F-HR Timeline Commodore Capital LP in group Commodore Capital LP More: the full row for Commodore Capital LP 633,901 $4.41M 0.26% new 13F-HR Timeline Group STEMPOINT CAPITAL LP More: the full row for STEMPOINT CAPITAL LP 597,409 $4.16M 0.8% new 13F-HR/A Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 504,820 $3.51M 0.01% +317,443 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 451,918 $3.15M 0.19% +421,052 13F-HR Timeline Group Integral Health Asset Management, LLC More: the full row for Integral Health Asset Management, LLC 450,000 $3.13M 0.17% new 13F-HR Timeline Knott David M Jr More: the full row for Knott David M Jr 439,300 $3.06M 1.82% new 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 421,052 $2.93M 0.01% new 13F-HR/A Timeline Birchview Capital, LP More: the full row for Birchview Capital, LP 409,387 $2.85M 1.62% new 13F-HR Timeline TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 408,095 $2.84M <0.01% -164,740 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 357,040 $2.48M <0.01% +36,220 13F-HR Timeline Group PARSONS CAPITAL MANAGEMENT INC/RI More: the full row for PARSONS CAPITAL MANAGEMENT INC/RI 352,500 $2.45M 0.11% +89,500 13F-HR Timeline Jones Hill Capital LP More: the full row for Jones Hill Capital LP 342,752 $2.39M 0.51% 13F-HR Timeline SEVEN GRAND MANAGERS, LLC More: the full row for SEVEN GRAND MANAGERS, LLC 315,788 $2.2M 0.15% new 13F-HR Timeline AdvisorShares Investments LLC More: the full row for AdvisorShares Investments LLC 295,872 $2.06M 0.38% -23,638 13F-HR Timeline Eversept Partners, LP More: the full row for Eversept Partners, LP 277,899 $1.93M 0.13% new 13F-HR Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 252,457 $1.76M <0.01% -295,397 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 224,846 $1.56M <0.01% 0 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 221,969 $1.54M <0.01% -49,140 13F-HR Timeline Group Ally Bridge Group (NY) LLC More: the full row for Ally Bridge Group (NY) LLC 210,525 $1.47M 1.46% new 13F-HR Timeline DIADEMA PARTNERS LP More: the full row for DIADEMA PARTNERS LP 200,842 $1.4M 0.58% -188,553 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 198,463 $1.38M <0.01% +136,106 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 167,200 $1.16M <0.01% -17,800 13F-HR Timeline SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 166,614 $1.16M <0.01% +67,649 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 157,734 $1.1M <0.01% -7,719 13F-HR Timeline Group Informed Momentum Co LLC More: the full row for Informed Momentum Co LLC 130,935 $911K 0.11% -31,617 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 126,672 $882K <0.01% +85,204 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 125,941 $877K <0.01% +100,601 13F-HR Timeline Group RBF Capital, LLC More: the full row for RBF Capital, LLC 120,000 $835K 0.04% -20,000 13F-HR/A Timeline MGO ONE SEVEN LLC More: the full row for MGO ONE SEVEN LLC 100,000 $696K 0.01% 0 13F-HR Timeline Burkehill Global Management, LP More: the full row for Burkehill Global Management, LP 105,263 $665K 0.03% new 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 88,953 $619K <0.01% +28,953 13F-HR Timeline Group Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 73,595 $512K 0.01% new 13F-HR Timeline Group MANGROVE PARTNERS IM, LLC More: the full row for MANGROVE PARTNERS IM, LLC 71,705 $499K 0.04% +44,325 13F-HR Timeline LMR Partners LLP in group LMR Partners LLP More: the full row for LMR Partners LLP 63,584 $443K <0.01% +7,984 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 63,426 $441K <0.01% -74,807 13F-HR Timeline Group Hillsdale Investment Management Inc. More: the full row for Hillsdale Investment Management Inc. 53,600 $373K 0.01% new 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 53,081 $369K <0.01% 0 13F-HR Timeline Group Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 50,773 $353K 0.14% -180,350 13F-HR Timeline apricus wealth, LLC More: the full row for apricus wealth, LLC 47,462 $330K 0.16% 0 13F-HR Timeline Verdad Advisers, LP More: the full row for Verdad Advisers, LP 47,149 $328K 0.37% new 13F-HR Timeline FIFTH LANE CAPITAL, LP More: the full row for FIFTH LANE CAPITAL, LP 45,000 $313K 0.38% new 13F-HR Timeline Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 42,141 $293K <0.01% +15,894 13F-HR Timeline Group OMERS ADMINISTRATION Corp More: the full row for OMERS ADMINISTRATION Corp 41,600 $290K <0.01% -24,300 13F-HR Timeline Catalyst Funds Management Pty Ltd More: the full row for Catalyst Funds Management Pty Ltd 34,057 $237K 0.04% new 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 33,606 $234K <0.01% -7,687 13F-HR Timeline Group AlTi Global, Inc. in group AlTi Global, Inc. More: the full row for AlTi Global, Inc. 31,975 $223K <0.01% 0 13F-HR Timeline Group Pale Fire Capital SE in group Pale Fire Capital More: the full row for Pale Fire Capital SE 31,650 $220K 0.02% -12,900 13F-HR Timeline Group BANK OF NOVA SCOTIA in group BANK OF NOVA SCOTIA More: the full row for BANK OF NOVA SCOTIA 30,600 $213K <0.01% new 13F-HR Timeline Group Robertson Stephens Wealth Management, L… More: the full row for Robertson Stephens Wealth Management, LLC 25,000 $174K <0.01% 0 13F-HR Timeline Diametric Capital, LP More: the full row for Diametric Capital, LP 24,006 $167K 0.04% new 13F-HR Timeline Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 23,247 $162K <0.01% +10,031 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 22,442 $156K <0.01% new 13F-HR Timeline Group GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 19,566 $136K 0.01% new 13F-HR Timeline Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 16,120 $112K <0.01% -5,535 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 15,414 $107K <0.01% -7,120 13F-HR Timeline Group Scientech Research LLC More: the full row for Scientech Research LLC 14,609 $102K 0.08% new 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 14,350 $99.9K <0.01% new 13F-HR Timeline Lido Advisors, LLC in group Lido Advisors, LLC More: the full row for Lido Advisors, LLC 13,905 $96.8K <0.01% 0 13F-HR Timeline Group Graham Capital Management, L.P. More: the full row for Graham Capital Management, L.P. 13,493 $93.9K <0.01% -12,115 13F-HR Timeline Keebeck Wealth Management More: the full row for Keebeck Wealth Management 13,000 $90.5K 0.01% new 13F-HR Timeline State of Wyoming More: the full row for State of Wyoming 12,581 $87.6K 0.01% new 13F-HR Timeline Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 12,498 $87K <0.01% -40,946 13F-HR Timeline Group World Investment Advisors More: the full row for World Investment Advisors 10,444 $72.7K <0.01% 0 13F-HR Timeline Bedel Financial Consulting, Inc. More: the full row for Bedel Financial Consulting, Inc. 10,000 $69.6K 0.01% 0 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 8,320 $57.9K <0.01% +5,280 13F-HR Timeline Group ANTIPODES PARTNERS Ltd More: the full row for ANTIPODES PARTNERS Ltd 3,035 $21.1K <0.01% new 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 2,000 $13.9K <0.01% 0 13F-HR Timeline American Capital Advisory, LLC More: the full row for American Capital Advisory, LLC 1,954 $13.6K 0.01% 0 13F-HR Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 684 $4.86K <0.01% 0 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 95 $1K <0.01% -1,944 13F-HR Timeline Group SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 41 $285 <0.01% -16 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 36 $251 <0.01% new 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 5 $34 <0.01% 0 13F-HR Timeline Group