ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 2,252,987 $7.48M 0.15% 0 13F-HR Timeline Group Atlas Venture Life Science Advisors, LLC More: the full row for Atlas Venture Life Science Advisors, LLC 2,092,106 $6.95M 0.8% 0 13F-HR Timeline Carlyle Group Inc. in group Carlyle Group Inc. More: the full row for Carlyle Group Inc. 1,102,741 $3.62M 0.03% 0 13F-HR Timeline Group ACORN CAPITAL ADVISORS, LLC More: the full row for ACORN CAPITAL ADVISORS, LLC 493,425 $1.64M 0.56% -310,000 13F-HR Timeline VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 321,051 $1.07M <0.01% +25,642 13F-HR Timeline Group ARCH Venture Management, LLC More: the full row for ARCH Venture Management, LLC 320,482 $1.06M 0.16% 0 13F-HR Timeline Pfizer Inc More: the full row for Pfizer Inc 277,777 $922K 0.39% 0 13F-HR Timeline Sanofi More: the full row for Sanofi 244,083 $810K 0.26% 0 13F-HR Timeline Opaleye Management Inc. More: the full row for Opaleye Management Inc. 213,363 $708K 0.09% new 13F-HR/A Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 106,113 $352K <0.01% +17,617 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 99,600 $331K <0.01% +52,300 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 59,932 $199K <0.01% -33,073 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 51,268 $170K <0.01% -53,504 13F-HR Timeline Group Monaco Asset Management SAM More: the full row for Monaco Asset Management SAM 50,919 $169K 0.05% -260,218 13F-HR Timeline ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 48,373 $159K <0.01% +18,634 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 46,825 $155K <0.01% +15,319 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 45,728 $152K <0.01% +35,611 13F-HR Timeline Group Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 27,777 $92.2K 0.01% 0 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 25,374 $84.2K <0.01% new 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 25,033 $83.1K <0.01% -6,920 13F-HR Timeline Group HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 24,698 $81K <0.01% +9,862 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 21,237 $70.5K <0.01% 0 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 20,353 $67.6K <0.01% new 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 20,000 $66.4K <0.01% new 13F-HR/A Timeline Group Scientech Research LLC More: the full row for Scientech Research LLC 15,510 $51.5K 0.03% new 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 13,606 $45.2K <0.01% +8,360 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 5,478 $18.2K <0.01% -5,865 13F-HR/A Timeline Group EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 4,640 $15.4K <0.01% -385 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 3,364 $11.2K <0.01% -12,503 13F-HR Timeline Group FEDERATED HERMES, INC. in group FEDERATED HERMES, INC. More: the full row for FEDERATED HERMES, INC. 2,273 $7.55K <0.01% -101 13F-HR Timeline Group Global Retirement Partners, LLC More: the full row for Global Retirement Partners, LLC 1,500 $4.98K <0.01% -3,500 13F-HR Timeline Arax Advisory Partners More: the full row for Arax Advisory Partners 1,111 $3.69K <0.01% -104 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 1,035 $3.44K <0.01% -490 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 976 $3.24K <0.01% -5,506 13F-HR Timeline Group Rockefeller Capital Management L.P. in group Rockefeller Capital Managemen… More: the full row for Rockefeller Capital Management L.P. 577 $1.92K <0.01% 0 13F-HR/A Timeline Group JONES FINANCIAL COMPANIES LLLP in group JONES FINANCIAL COMPANIES LLLP More: the full row for JONES FINANCIAL COMPANIES LLLP 500 $1.66K <0.01% new 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 454 $1.51K <0.01% 0 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 324 $1.08K <0.01% +320 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 308 $1.02K <0.01% -124 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 235 $1K <0.01% -818 13F-HR Timeline Group NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 166 $551 <0.01% 0 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 157 $521 <0.01% -7,999 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 132 $437 <0.01% -55 13F-HR Timeline Group Allworth Financial LP More: the full row for Allworth Financial LP 98 $326 <0.01% -512 13F-HR Timeline Federation des caisses Desjardins du Qu… More: the full row for Federation des caisses Desjardins du Quebec 70 $231 <0.01% 0 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 34 $113 <0.01% 0 13F-HR Timeline NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO in group NORTHWESTERN MUTUAL INVESTMEN… More: the full row for NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 30 $100 <0.01% new 13F-HR/A Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 19 $63 <0.01% -803 13F-HR Timeline Group HARBOUR INVESTMENTS, INC. More: the full row for HARBOUR INVESTMENTS, INC. 11 $37 <0.01% 0 13F-HR Timeline AdvisorNet Financial, Inc More: the full row for AdvisorNet Financial, Inc 2 $7 <0.01% 0 13F-HR Timeline DANSKE BANK A/S More: the full row for DANSKE BANK A/S 1 $3 <0.01% 0 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 54 $0 0% -165 13F-HR Timeline Group Value filed as zero, left out of ratios.