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Disclosery

PRME PRIME MEDICINE INC

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COM (common), issuer CIK 1894562

165 managers (167 13F filers) reported a position in PRME shares at 2025-09-30, 92,348,059 shares in all. 52 filers opened a position and 7 filers sold out during the quarter.

Managers
165
13F filers
167
New
52
Added
63
Reduced
31
Sold out
7
Shares held by filers
92,348,059

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q3 2025

Filers in the available 13F reports with a share position at 2025-09-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
Alphabet Inc.in group Alphabet Inc.16,562,498$91.8M3.81%+1,500,00013F-HRTimelineGroup
T. Rowe Price Investment Management, In…9,217,097$51.1M0.03%+2,732,31013F-HRTimeline
BlackRock, Inc.in group BlackRock, Inc.5,650,859$31.3M<0.01%+1,165,03113F-HRTimelineGroup
ARK Investment Management LLCin group ARK Investment Management LLC5,477,851$30.3M0.18%+3,155,18213F-HRTimelineGroup
VANGUARD GROUP INCgroup of 2 filers holding4,945,849$27.4M+1,295,148Timeline
FARALLON CAPITAL MANAGEMENT, L.L.C.4,750,000$26.3M0.15%+4,000,00013F-HR/ATimeline
Sumitomo Mitsui Trust Group, Inc.in group Sumitomo Mitsui Trust Group, …3,629,924$20.1M0.01%+2,035,40613F-HRTimelineGroup
Amova Asset Management Americas, Inc.in group Amova Asset Management Americ…3,629,924$20M0.19%+2,040,80713F-HRTimelineGroup
Casdin Capital, LLC3,167,175$17.5M1.46%+1,600,00013F-HRTimeline
Woodline Partners LP3,002,482$16.6M0.08%new13F-HRTimeline
RA CAPITAL MANAGEMENT, L.P.in group RA CAPITAL MANAGEMENT, L.P.3,000,000$16.6M0.2%new13F-HRTimelineGroup
FMR LLCin group FMR LLC2,813,075$15.6M<0.01%-931,35213F-HRTimelineGroup
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.2,215,852$12.3M0.01%new13F-HRTimelineGroup
MWG Management Ltd.1,792,210$9.93M12.21%013F-HRTimeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC1,766,896$9.79M<0.01%+256,14713F-HRTimelineGroup
EcoR1 Capital, LLC1,543,326$8.55M0.41%new13F-HRTimeline
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC1,418,463$7.86M0.01%+1,270,46713F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP1,296,626$7.18M<0.01%+57,28913F-HRTimelineGroup
RENAISSANCE TECHNOLOGIES LLC1,134,670$6.29M0.01%+911,27013F-HRTimeline
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC900,142$4.99M<0.01%+378,63413F-HRTimelineGroup
ADAGE CAPITAL PARTNERS GP, L.L.C.in group ADAGE CAPITAL PARTNERS GP, L.…771,361$4.27M0.01%new13F-HRTimelineGroup
Invesco Ltd.in group Invesco Ltd.762,078$4.22M<0.01%+748,41613F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY731,004$4.05M<0.01%+143,32813F-HR/ATimelineGroup
Greenwich Wealth Management LLC720,001$3.99M0.2%-126,20013F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP607,989$3.37M<0.01%+95,75513F-HRTimelineGroup
Schonfeld Strategic Advisors LLC593,039$3.29M0.02%-225,47913F-HRTimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…584,424$3.24M<0.01%+101,69613F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co573,158$3.18M<0.01%+54,53013F-HRTimelineGroup
MOORE CAPITAL MANAGEMENT, LP500,000$2.77M0.06%013F-HRTimeline
TWO SIGMA INVESTMENTS, LPin group TWO SIGMA INVESTMENTS, LP447,667$2.48M<0.01%+189,24413F-HRTimelineGroup
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC414,211$2.29M<0.01%-10,14413F-HRTimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC410,736$2.28M<0.01%+203,72813F-HRTimelineGroup
Bollard Group LLC361,136$2M0.05%013F-HRTimeline
HighTower Advisors, LLC333,755$1.85M<0.01%+312,40113F-HRTimeline
UBS Group AGin group UBS Group AG304,773$1.69M<0.01%+109,44613F-HRTimelineGroup
Nuveen, LLCin group TIAA225,843$1.25M<0.01%+17,94913F-HRTimelineGroup
HRT FINANCIAL LP221,464$1.23M<0.01%+157,29713F-HRTimeline
CHELSEA COUNSEL CO208,210$1.15M0.51%013F-HRTimeline
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…205,325$1.14M<0.01%new13F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp197,729$1.1M<0.01%+35,67713F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN197,014$1.09M<0.01%+95,86313F-HRTimelineGroup
Green Alpha Advisors, LLC190,353$1.05M1.02%+111,35913F-HRTimeline
Man Group plcin group Man Group plc189,588$1.05M<0.01%new13F-HRTimelineGroup
JBF Capital, Inc.188,900$1.05M0.15%new13F-HR/ATimeline
DNB Asset Management ASin group DNB Asset Management AS182,133$1.01M<0.01%new13F-HRTimelineGroup
TD Asset Management Inc181,048$1M<0.01%+158,13813F-HRTimeline
VOLORIDGE INVESTMENT MANAGEMENT, LLC170,021$942K<0.01%new13F-HRTimeline
BRIDGEWAY CAPITAL MANAGEMENT, LLC164,800$913K0.02%-50,00013F-HRTimeline
SIMPLEX TRADING, LLC157,897$874K0.02%-35,71813F-HRTimeline
Ikarian Capital, LLCin group Ikarian Capital, LLC150,000$831K0.17%new13F-HRTimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\132,769$736K<0.01%+7,32413F-HRTimelineGroup
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding127,183$705K+2,255Timeline
Steward Partners Investment Advisory, L…126,387$700K<0.01%new13F-HRTimeline
FRED ALGER MANAGEMENT, LLCin group FRED ALGER MANAGEMENT, LLC122,654$680K<0.01%-260,54013F-HRTimelineGroup
IQ EQ FUND MANAGEMENT (IRELAND) Ltd120,773$669K0.05%+87,11313F-HRTimeline
FIL Ltdin group FIL Ltd116,329$644K<0.01%-94113F-HRTimelineGroup
BARCLAYS PLCin group BARCLAYS PLC115,900$642K<0.01%+1,09813F-HR/ATimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/110,842$614K<0.01%-33,66913F-HR/ATimelineGroup
RHUMBLINE ADVISERS109,787$608K<0.01%+11,81513F-HRTimeline
ALLIANCEBERNSTEIN L.P.108,690$602K<0.01%-58,73013F-HRTimeline
Palumbo Wealth Management LLC92,535$513K0.16%-90,82313F-HRTimeline
Redmile Group, LLCin group Redmile Group, LLC87,118$483K0.05%-1,987,23213F-HRTimelineGroup
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC85,892$476K<0.01%+58,74713F-HRTimelineGroup
Diametric Capital, LP81,271$450K0.17%-24,25913F-HRTimeline
PRICE T ROWE ASSOCIATES INC /MD/74,502$413K<0.01%+9,18213F-HRTimeline
Keystone Financial Group70,855$393K0.03%new13F-HR/ATimeline
COMMONWEALTH EQUITY SERVICES, LLC63,168$350K<0.01%+48,22613F-HRTimeline
TUDOR INVESTMENT CORP ET AL62,981$349K<0.01%new13F-HR/ATimeline
Brevan Howard Capital Management LPin group Brevan Howard Capital Managem…62,242$345K<0.01%new13F-HRTimelineGroup
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC61,572$341K<0.01%new13F-HRTimelineGroup
NISA INVESTMENT ADVISORS, LLC60,446$335K<0.01%+56,21013F-HRTimeline
Engineers Gate Manager LP55,597$308K<0.01%new13F-HRTimeline
BOOTHBAY FUND MANAGEMENT, LLC55,050$305K0.01%new13F-HRTimeline
XTX Topco Ltdin group XTX Topco Ltd48,225$267K0.01%-85,26513F-HRTimelineGroup
Balyasny Asset Management L.P.in group Balyasny Asset Management47,873$265K<0.01%new13F-HRTimelineGroup
Jain Global LLC44,849$248K<0.01%new13F-HRTimeline
AXQ CAPITAL, LP44,818$248K0.1%+7,23113F-HRTimeline
Mutual Advisors, LLC45,200$243K0.01%013F-HRTimeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO43,389$240K<0.01%+10,35413F-HR/ATimelineGroup
MetLife Investment Management, LLCin group MetLife Investment Management…42,997$238K<0.01%+3,98313F-HRTimelineGroup
IvyRock Asset Management (HK) Ltd41,800$232K0.1%new13F-HRTimeline
Squarepoint Ops LLCin group Squarepoint Ops LLC39,601$219K<0.01%+3,77513F-HRTimelineGroup
Corient Private Wealth LPin group Corient Private Wealth LP38,777$215K<0.01%new13F-HRTimelineGroup
IEQ CAPITAL, LLC36,667$203K<0.01%+83713F-HRTimeline
PEAK6 LLCin group PEAK6 LLC35,063$194K<0.01%new13F-HR/ATimelineGroup
ExodusPoint Capital Management, LP33,494$186K<0.01%new13F-HRTimeline
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC31,807$176K<0.01%+30,24313F-HRTimelineGroup
Crestwood Advisors Group, LLC31,687$176K<0.01%013F-HRTimeline
LPL Financial LLC31,039$172K<0.01%new13F-HRTimeline
China Universal Asset Management Co., L…30,650$170K0.01%+4,28013F-HRTimeline
WEALTH ENHANCEMENT ADVISORY SERVICES, L…26,778$157K<0.01%+77113F-HRTimeline
THOMPSON DAVIS & CO., INC.27,573$153K0.09%new13F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …27,132$150K<0.01%+6,15313F-HRTimelineGroup
BANK OF NOVA SCOTIAin group BANK OF NOVA SCOTIA25,500$141K<0.01%new13F-HRTimelineGroup
CWM, LLCin group CWM, LLC25,352$140K<0.01%-10,40913F-HRTimelineGroup
Abacus Planning Group, Inc.25,188$140K0.02%new13F-HRTimeline
Turtle Creek Wealth Advisors, LLC25,000$138K0.01%new13F-HRTimeline
NOMURA HOLDINGS INCin group NOMURA ASSET MANAGEMENT CO LTD24,915$138K<0.01%new13F-HRTimelineGroup
Kingsview Wealth Management, LLC24,750$137K<0.01%-25013F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC23,228$129K<0.01%-7,58213F-HRTimeline
Creative Planningin group Creative Planning23,082$128K<0.01%+12,93713F-HRTimelineGroup
PRELUDE CAPITAL MANAGEMENT, LLC22,483$125K0.01%-18,80513F-HRTimeline
Police & Firemen's Retirement System of…21,166$117K<0.01%+4,07413F-HRTimeline
Polymer Capital Management (US) LLC20,791$115K0.02%new13F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS19,656$109K<0.01%-7,07913F-HRTimelineGroup
ProShare Advisors LLC19,099$106K<0.01%+2,22813F-HRTimeline
Owen LaRue, LLC19,032$105K0.04%new13F-HRTimeline
Mariner, LLCin group Mariner, LLC18,219$101K<0.01%new13F-HRTimelineGroup
SHELTON WEALTH MANAGEMENT, LLC17,332$96K0.04%new13F-HRTimeline
Clarius Group, LLC16,080$89.1K0.01%013F-HRTimeline
Federation des caisses Desjardins du Qu…15,900$88.1K<0.01%-5,30013F-HRTimeline
LEVIN CAPITAL STRATEGIES, L.P.15,000$83.1K0.01%-125,00013F-HRTimeline
Prime Capital Investment Advisors, LLC14,379$79.7K<0.01%-1,65213F-HRTimeline
Sanctuary Advisors, LLC14,323$79.3K<0.01%new13F-HR/ATimeline
JTC Employer Solutions Trustee Ltd13,249$73K0.01%013F-HRTimeline
Hudson Bay Capital Management LPin group Hudson Bay Capital Management…13,025$72.2K<0.01%new13F-HR/ATimelineGroup
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC12,849$71.2K<0.01%-4,37313F-HRTimelineGroup
&PARTNERS11,848$70.6K<0.01%new13F-HRTimeline
Virtu Financial LLCin group Virtu Financial LLC11,830$66K<0.01%-71513F-HRTimelineGroup
VICTORY CAPITAL MANAGEMENT INC10,190$56.5K<0.01%new13F-HRTimeline
Quadrature Capital Ltdin group Quadrature Capital Ltd10,182$56.3K<0.01%new13F-HRTimelineGroup
Sterling Investment Advisors, Ltd.10,000$55.4K0.01%new13F-HRTimeline
JONES FINANCIAL COMPANIES LLLPin group JONES FINANCIAL COMPANIES LLLP9,575$49K<0.01%new13F-HRTimelineGroup
NEW YORK STATE COMMON RETIREMENT FUND8,434$46.7K<0.01%013F-HRTimeline
LANARK FINANCIAL, INC.7,500$41.5K<0.01%new13F-HRTimeline
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…6,827$37.8K<0.01%+6,34513F-HRTimelineGroup
Legal & General Group Plcin group Legal & General Group Plc6,751$37.4K<0.01%+1,85213F-HRTimelineGroup
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.6,950$37.4K<0.01%+6,82213F-HRTimelineGroup
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…5,901$32.7K<0.01%+2,00013F-HRTimelineGroup
Arax Advisory Partners5,406$29.9K<0.01%new13F-HRTimeline
Sterling Capital Management LLC5,194$28.8K<0.01%+3,61813F-HRTimeline
CITIGROUP INCin group CITIGROUP INC5,151$28.5K<0.01%-29,60813F-HRTimelineGroup
SIGNATUREFD, LLC5,000$27.7K<0.01%+4,00013F-HRTimeline
NATIONAL BANK OF CANADA /FI/in group NATIONAL BANK OF CANADA /FI/4,500$24.9K<0.01%-94,30713F-HRTimelineGroup
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…3,892$21.6K<0.01%-8,35413F-HRTimelineGroup
GF FUND MANAGEMENT CO. LTD.3,762$20.8K<0.01%+40413F-HRTimeline
CALIFORNIA STATE TEACHERS RETIREMENT SY…3,654$20.2K<0.01%new13F-HRTimeline
Financial Connections Group, Inc.3,712$20K0.01%new13F-HRTimeline
AMALGAMATED BANK1,957$11K<0.01%013F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA1,843$11K<0.01%-3,30213F-HRTimelineGroup
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…1,762$9.76K<0.01%+40013F-HRTimelineGroup
FSA Wealth Management LLC1,500$8.31K<0.01%new13F-HRTimeline
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…1,139$6.31K<0.01%new13F-HRTimelineGroup
Allworth Financial LP1,006$5.57K<0.01%new13F-HRTimeline
NewEdge Advisors, LLC1,000$5.54K<0.01%new13F-HRTimeline
SBI Securities Co., Ltd.1,000$5.54K<0.01%+27313F-HRTimeline
Corsicana & Co.1,000$5.54K<0.01%13F-HRTimeline
Leonteq Securities AG915$5.07K<0.01%013F-HRTimeline
Optiver Holding B.V.in group Optiver Holding B.V.898$4.97K<0.01%new13F-HRTimelineGroup
Scarborough Advisors, LLC505$2.8K<0.01%new13F-HRTimeline
Fairman Group, LLC500$2.77K<0.01%013F-HRTimeline
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.398$2K<0.01%013F-HRTimelineGroup
ROTHSCHILD INVESTMENT LLC345$1.91K<0.01%013F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…319$1.77K<0.01%013F-HRTimelineGroup
Fortitude Family Office, LLC296$1.64K<0.01%013F-HRTimeline
Parkside Financial Bank & Trust285$1.58K<0.01%013F-HRTimeline
MAI Capital Management274$1.52K<0.01%-34113F-HRTimeline
Essential Partners LLC210$1.16K<0.01%013F-HRTimeline
PRINCIPAL SECURITIES, INC.in group PRINCIPAL FINANCIAL GROUP INC200$1.11K<0.01%-8013F-HRTimelineGroup
True Wealth Design, LLC115$638<0.01%013F-HRTimeline
Sunbelt Securities, Inc.80$443<0.01%new13F-HRTimeline
Farther Finance Advisors, LLC71$393<0.01%+4513F-HRTimeline
IFP Advisors, Inc9$50<0.01%+113F-HR/ATimeline
Larson Financial Group LLC6$33<0.01%-19413F-HRTimeline
Covestor Ltd31$00%013F-HRTimelineValue filed as zero, left out of ratios.