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Disclosery

PRME PRIME MEDICINE INC

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COM (common), issuer CIK 1894562

179 managers (183 13F filers) reported a position in PRME shares at 2025-12-31, 96,985,328 shares in all. 41 filers opened a position and 26 filers sold out during the quarter.

Managers
179
13F filers
183
New
41
Added
66
Reduced
40
Sold out
26
Shares held by filers
96,985,328

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q4 2025

Filers in the available 13F reports with a share position at 2025-12-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
Alphabet Inc.in group Alphabet Inc.16,562,498$57.5M2.23%013F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.8,268,843$28.7M<0.01%+2,617,98413F-HRTimelineGroup
VANGUARD GROUP INCgroup of 2 filers holding6,491,523$22.5M+1,545,674Timeline
T. Rowe Price Investment Management, In…5,995,183$20.8M0.01%-3,221,91413F-HR/ATimeline
ARK Investment Management LLCin group ARK Investment Management LLC5,368,526$18.6M0.12%-109,32513F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP5,095,510$17.7M<0.01%+3,798,88413F-HRTimelineGroup
Sumitomo Mitsui Trust Group, Inc.in group Sumitomo Mitsui Trust Group, …3,245,506$11.3M0.01%-384,41813F-HRTimelineGroup
Amova Asset Management Americas, Inc.in group Amova Asset Management Americ…3,245,506$11.2M0.13%-384,41813F-HRTimelineGroup
Casdin Capital, LLC3,167,175$11M0.68%013F-HRTimeline
Balyasny Asset Management L.P.in group Balyasny Asset Management3,124,362$10.8M0.02%+3,076,48913F-HRTimelineGroup
Woodline Partners LP3,002,844$10.4M0.04%+36213F-HRTimeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC2,628,429$9.12M<0.01%+861,53313F-HRTimelineGroup
UBS Group AGgroup of 2 filers holding2,539,683$8.81M+2,234,910Timeline
FMR LLCin group FMR LLC2,176,646$7.55M<0.01%-636,42913F-HRTimelineGroup
TWO SIGMA INVESTMENTS, LPgroup of 2 filers holding2,012,824$6.98M+1,565,157Timeline
MWG Caph Ltd1,792,210$6.22M8.59%13F-HRTimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC1,755,768$6.09M<0.01%+1,345,03213F-HR/ATimelineGroup
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.1,551,369$5.38M<0.01%-664,48313F-HRTimelineGroup
FARALLON CAPITAL MANAGEMENT, L.L.C.1,240,843$4.31M0.02%-3,509,15713F-HRTimelineThe filing omitted confidential holdings, a later amendment may add them.
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…1,176,727$4.08M0.01%+592,30313F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY1,169,898$4.06M<0.01%+438,89413F-HR/ATimelineGroup
RENAISSANCE TECHNOLOGIES LLC1,149,159$3.99M0.01%+14,48913F-HRTimeline
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co936,815$3.25M<0.01%+363,65713F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP842,153$2.92M<0.01%+234,16413F-HRTimelineGroup
Greenwich Wealth Management LLC740,001$2.57M0.11%+20,00013F-HRTimeline
HRT FINANCIAL LP655,351$2.27M0.01%+433,88713F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/648,012$2.25M<0.01%+537,17013F-HRTimelineGroup
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.551,030$1.91M<0.01%new13F-HRTimelineGroup
MOORE CAPITAL MANAGEMENT, LP500,000$1.74M0.04%013F-HRTimeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO435,710$1.51M<0.01%+392,32113F-HRTimelineGroup
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC415,821$1.44M<0.01%+1,61013F-HRTimelineGroup
HighTower Advisors, LLC400,110$1.39M<0.01%+66,35513F-HRTimeline
BARCLAYS PLCin group BARCLAYS PLC363,826$1.26M<0.01%+247,92613F-HRTimelineGroup
Bollard Group LLC361,136$1.25M0.03%013F-HRTimeline
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN294,496$1.02M<0.01%+97,48213F-HRTimelineGroup
Verition Fund Management LLC290,983$1.01M0.01%new13F-HRTimeline
Nuveen, LLCin group TIAA251,636$873K<0.01%+25,79313F-HRTimelineGroup
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…248,227$861K<0.01%+42,90213F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp246,770$856K<0.01%+49,04113F-HRTimelineGroup
CHELSEA COUNSEL CO227,000$788K0.34%+18,79013F-HRTimeline
DARK FOREST CAPITAL MANAGEMENT LP225,859$784K0.04%new13F-HRTimeline
Squarepoint Ops LLCin group Squarepoint Ops LLC218,042$757K<0.01%+178,44113F-HRTimelineGroup
Green Alpha Advisors, LLC190,883$662K0.61%+53013F-HRTimeline
Rafferty Asset Management, LLC187,711$651K<0.01%new13F-HRTimeline
IQ EQ FUND MANAGEMENT (IRELAND) Ltd178,519$619K0.04%+57,74613F-HRTimeline
Jump Financial, LLCin group Jump Financial, LLC171,931$597K0.01%new13F-HRTimelineGroup
Swiss National Bank170,100$590K<0.01%new13F-HRTimeline
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\147,943$513K<0.01%+15,17413F-HRTimelineGroup
BRIDGEWAY CAPITAL MANAGEMENT, LLC134,800$468K0.01%-30,00013F-HRTimeline
Keystone Financial Group129,665$450K0.03%+58,81013F-HRTimeline
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding123,832$429K-3,351Timeline
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…121,391$421K<0.01%+120,25213F-HR/ATimelineGroup
Steward Partners Investment Advisory, L…118,406$411K<0.01%-7,98113F-HRTimeline
FIL Ltdin group FIL Ltd115,602$401K<0.01%-72713F-HRTimelineGroup
Graham Capital Management, L.P.114,680$398K0.01%new13F-HRTimeline
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC112,870$392K<0.01%-787,27213F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.108,690$377K<0.01%013F-HRTimeline
RHUMBLINE ADVISERS108,409$376K<0.01%-1,37813F-HRTimeline
PRICE T ROWE ASSOCIATES INC /MD/104,553$363K<0.01%+30,05113F-HRTimeline
GROUP ONE TRADING LLC103,213$358K0.01%new13F-HRTimeline
Virtu Financial LLCin group Virtu Financial LLC94,778$329K0.01%+82,94813F-HRTimelineGroup
Qube Research & Technologies Ltd94,670$329K<0.01%new13F-HRTimeline
TD Asset Management Inc94,148$327K<0.01%-86,90013F-HRTimeline
CALIFORNIA STATE TEACHERS RETIREMENT SY…86,929$302K<0.01%+83,27513F-HRTimeline
Palumbo Wealth Management LLC85,539$297K0.07%-6,99613F-HRTimeline
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP84,054$292K<0.01%new13F-HRTimelineGroup
Legal & General Group Plcin group Legal & General Group Plc80,749$280K<0.01%+73,99813F-HRTimelineGroup
XTX Topco Ltdin group XTX Topco Ltd72,935$253K0.01%+24,71013F-HRTimelineGroup
PROFUND ADVISORS LLC69,605$242K0.01%new13F-HRTimeline
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…64,886$225K0.06%new13F-HRTimelineGroup
JANUS HENDERSON GROUP PLCin group Janus Henderson60,900$210K<0.01%new13F-HRTimelineGroup
Engineers Gate Manager LP60,490$210K<0.01%+4,89313F-HRTimeline
&PARTNERS60,352$209K<0.01%+48,50413F-HRTimeline
MetLife Investment Management, LLCin group MetLife Investment Management…57,570$200K<0.01%+14,57313F-HRTimelineGroup
Invesco Ltd.in group Invesco Ltd.56,779$197K<0.01%-705,29913F-HRTimelineGroup
Brevan Howard Capital Management LPin group Brevan Howard Capital Managem…56,088$195K<0.01%-6,15413F-HRTimelineGroup
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC54,082$188K<0.01%-7,49013F-HRTimelineGroup
Quadrature Capital Ltdin group Quadrature Capital Ltd52,866$183K<0.01%+42,68413F-HRTimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC51,335$178K<0.01%-1,367,12813F-HRTimelineGroup
CITIGROUP INCin group CITIGROUP INC51,229$178K<0.01%+46,07813F-HRTimelineGroup
Tidal Investments LLCin group Tidal Investments LLC50,244$174K<0.01%new13F-HRTimelineGroup
Walleye Capital LLCin group Walleye Capital LLC46,139$160K<0.01%new13F-HRTimelineGroup
Mutual Advisors, LLC45,200$157K<0.01%013F-HRTimeline
Elevate Capital Advisors, LLC42,666$148K0.1%new13F-HRTimeline
IvyRock Asset Management (HK) Ltd41,800$145K0.08%013F-HRTimeline
JONES FINANCIAL COMPANIES LLLPin group JONES FINANCIAL COMPANIES LLLP40,403$140K<0.01%+30,82813F-HRTimelineGroup
Corient Private Wealth LPin group Corient Private Wealth LP38,777$135K<0.01%013F-HR/ATimelineGroup
Caitong International Asset Management …38,696$134K0.03%new13F-HR/ATimeline
GSA CAPITAL PARTNERS LLP38,510$134K0.01%new13F-HRTimeline
IEQ CAPITAL, LLC37,136$129K<0.01%+46913F-HRTimeline
Mariner, LLCin group Mariner, LLC36,290$126K<0.01%+18,07113F-HRTimelineGroup
Polymer Capital Management (US) LLC35,981$125K0.02%+15,19013F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC35,036$122K<0.01%+11,80813F-HRTimeline
CENTRAL TRUST Co34,995$121K<0.01%new13F-HRTimeline
COMMONWEALTH EQUITY SERVICES, LLC34,399$119K<0.01%-28,76913F-HRTimeline
AXQ CAPITAL, LP33,405$116K0.03%-11,41313F-HRTimeline
LPL Financial LLC32,924$114K<0.01%+1,88513F-HRTimeline
ENVESTNET ASSET MANAGEMENT INCin group ENVESTNET ASSET MANAGEMENT INC32,576$113K<0.01%new13F-HRTimelineGroup
Crestwood Advisors Group, LLC31,973$111K<0.01%+28613F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …31,602$110K<0.01%+4,47013F-HRTimelineGroup
SG Americas Securities, LLC30,954$107K<0.01%new13F-HRTimeline
China Universal Asset Management Co., L…29,414$102K0.01%-1,23613F-HRTimeline
WEALTH ENHANCEMENT ADVISORY SERVICES, L…26,098$96.6K<0.01%-68013F-HRTimeline
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC27,044$93.8K<0.01%-4,76313F-HRTimelineGroup
TRANSCEND CAPITAL ADVISORS, LLC26,500$92K0.01%new13F-HRTimeline
ProShare Advisors LLC26,158$90.8K<0.01%+7,05913F-HRTimeline
CWM, LLCin group CWM, LLC25,427$88K<0.01%+7513F-HRTimelineGroup
Abacus Planning Group, Inc.25,188$87.4K0.01%013F-HRTimeline
NOMURA HOLDINGS INCin group NOMURA ASSET MANAGEMENT CO LTD24,789$86K<0.01%-12613F-HRTimelineGroup
ARIZONA STATE RETIREMENT SYSTEM24,085$83.6K<0.01%new13F-HRTimeline
VOLORIDGE INVESTMENT MANAGEMENT, LLC23,121$80.2K<0.01%-146,90013F-HRTimeline
THOMPSON DAVIS & CO., INC.22,740$78.9K0.05%-4,83313F-HRTimeline
Scientech Research LLC22,393$77.7K0.05%new13F-HRTimeline
Police & Firemen's Retirement System of…21,166$73.4K<0.01%013F-HRTimeline
SHELTON WEALTH MANAGEMENT, LLC20,066$69.6K0.03%+2,73413F-HRTimeline
KLP KAPITALFORVALTNING AS18,500$64.2K<0.01%new13F-HRTimeline
Creative Planningin group Creative Planning17,892$62.1K<0.01%-5,19013F-HRTimelineGroup
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC17,491$60.7K<0.01%+4,64213F-HRTimelineGroup
Clarius Group, LLC16,080$55.8K<0.01%013F-HRTimeline
LEVIN CAPITAL STRATEGIES, L.P.15,000$52K<0.01%013F-HRTimeline
Kingsview Wealth Management, LLC15,000$52K<0.01%-9,75013F-HRTimeline
MARTINGALE ASSET MANAGEMENT L P14,808$51.4K<0.01%new13F-HRTimeline
Sanctuary Advisors, LLC14,659$50.9K<0.01%+33613F-HRTimeline
Prime Capital Investment Advisors, LLC14,055$48.8K<0.01%-32413F-HRTimeline
Sterling Investment Advisors, Ltd.13,400$46.5K0.01%+3,40013F-HRTimeline
JTC Employer Solutions Trustee Ltd13,249$46K<0.01%013F-HRTimeline
OPPENHEIMER & CO INCin group OPPENHEIMER ASSET MANAGEMENT …12,433$43.1K<0.01%new13F-HRTimelineGroup
TEACHER RETIREMENT SYSTEM OF TEXAS12,235$42.5K<0.01%new13F-HRTimeline
Federation des caisses Desjardins du Qu…12,000$41.6K<0.01%-3,90013F-HRTimeline
Integrity Advisory Solutions, LLC11,689$40.6K0.01%new13F-HRTimeline
Callan Family Office, LLCin group Callan Family Office, LLC11,292$39.2K<0.01%new13F-HRTimelineGroup
NEUBERGER BERMAN GROUP LLCin group NEUBERGER BERMAN GROUP LLC10,915$37.9K<0.01%new13F-HRTimelineGroup
LAZARD ASSET MANAGEMENT LLCin group LAZARD ASSET MANAGEMENT LLC10,844$37.6K<0.01%new13F-HRTimelineGroup
VICTORY CAPITAL MANAGEMENT INC10,801$37.5K<0.01%+61113F-HRTimeline
RHODES INVESTMENT ADVISORS INC /ADV10,750$37.3K0.03%13F-HRTimeline
PRELUDE CAPITAL MANAGEMENT, LLC10,200$35.4K<0.01%-12,28313F-HRTimeline
Forum Financial Management, LPin group Forum Financial Management, LP10,000$34.7K<0.01%new13F-HRTimelineGroup
Glen Eagle Advisors, LLC10,000$34.7K<0.01%new13F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS9,823$34.1K<0.01%-9,83313F-HRTimelineGroup
Zurcher Kantonalbank (Zurich Cantonalba…8,814$30.6K<0.01%new13F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND8,434$29.3K<0.01%013F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.8,428$29.2K<0.01%+1,47813F-HRTimelineGroup
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…6,827$23.7K<0.01%013F-HRTimelineGroup
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…5,901$20.5K<0.01%013F-HRTimelineGroup
Sterling Capital Management LLC5,736$19.9K<0.01%+54213F-HRTimeline
LANARK FINANCIAL, INC.5,000$17.4K<0.01%-2,50013F-HRTimeline
SIGNATUREFD, LLC5,000$17.4K<0.01%013F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA4,889$17K<0.01%+3,04613F-HRTimelineGroup
NISA INVESTMENT ADVISORS, LLC4,546$15.8K<0.01%-55,90013F-HRTimeline
GF FUND MANAGEMENT CO. LTD.3,547$12.3K<0.01%-21513F-HRTimeline
Financial Connections Group, Inc.3,712$12K<0.01%013F-HRTimeline
AMALGAMATED BANK3,126$11K<0.01%+1,16913F-HRTimeline
Allworth Financial LP3,115$10.8K<0.01%+2,10913F-HRTimeline
MTM Investment Management, LLC3,090$10.7K<0.01%new13F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…1,762$6.11K<0.01%013F-HRTimelineGroup
Scarborough Advisors, LLC1,257$4.36K<0.01%+75213F-HRTimeline
NewEdge Advisors, LLC1,000$3.47K<0.01%013F-HRTimeline
Corsicana & Co.1,000$3.47K<0.01%013F-HRTimeline
Leonteq Securities AG915$3.17K<0.01%013F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…807$2.8K<0.01%-3,08513F-HRTimelineGroup
Fairman Group, LLC500$1.74K<0.01%013F-HRTimeline
ROTHSCHILD INVESTMENT LLC345$1.2K<0.01%013F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…319$1.11K<0.01%013F-HRTimelineGroup
SBI Securities Co., Ltd.303$1.05K<0.01%-69713F-HRTimeline
Fortitude Family Office, LLC296$1.03K<0.01%013F-HRTimeline
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.398$1K<0.01%013F-HRTimelineGroup
Basecamp Wealth Advisors LLC287$996<0.01%13F-HRTimeline
Parkside Financial Bank & Trust285$989<0.01%013F-HRTimeline
MAI Capital Management274$951<0.01%013F-HRTimeline
CIBC Private Wealth Group LLCin group CIBC Bancorp USA Inc.267$926<0.01%new13F-HRTimelineGroup
Essential Partners LLC221$767<0.01%+1113F-HRTimeline
Optiver Holding B.V.in group Optiver Holding B.V.160$555<0.01%-73813F-HRTimelineGroup
Global Retirement Partners, LLC146$507<0.01%new13F-HRTimeline
True Wealth Design, LLC115$400<0.01%013F-HRTimeline
GAMMA Investing LLC111$385<0.01%new13F-HRTimeline
Sunbelt Securities, Inc.80$278<0.01%013F-HRTimeline
Farther Finance Advisors, LLC71$246<0.01%013F-HRTimeline
IFP Advisors, Inc10$35<0.01%+113F-HRTimeline
Covestor Ltd31$00%013F-HRTimelineValue filed as zero, left out of ratios.