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Disclosery

OBIO ORCHESTRA BIOMED HLDGS INC

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COMMON STOCK (common), issuer CIK 1814114

62 managers (63 13F filers) reported a position in OBIO shares at 2025-12-31, 21,701,762 shares in all. 19 filers opened a position and 5 filers sold out during the quarter.

Managers
62
13F filers
63
New
19
Added
17
Reduced
14
Sold out
5
Shares held by filers
21,701,762

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q4 2025

Filers in the available 13F reports with a share position at 2025-12-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
RTW INVESTMENTS, LP8,306,063$34.5M0.35%013F-HRTimeline
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC5,127,256$21.3M0.39%-165,30013F-HRTimelineGroup
VANGUARD GROUP INCin group VANGUARD GROUP INC1,604,556$6.66M<0.01%+122,68113F-HRTimelineGroup
Alyeska Investment Group, L.P.in group Alyeska Investment Group, L.P.1,000,000$4.15M0.01%-365,48213F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.630,901$2.62M<0.01%-33,43213F-HRTimelineGroup
Affinity Asset Advisors, LLC572,804$2.38M0.17%-154,46813F-HRTimeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC473,363$1.97M<0.01%+86,56413F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/364,645$1.51M<0.01%-56,96713F-HRTimeline
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co263,788$1.09M<0.01%+83,34913F-HRTimelineGroup
Knott David M Jr250,000$1.04M0.48%+55,00013F-HRTimeline
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC243,473$1.01M<0.01%-130,51413F-HRTimelineGroup
683 Capital Management, LLCin group 683 Capital Management, LLC204,076$847K0.07%new13F-HRTimelineGroup
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC173,765$721K<0.01%+108,24113F-HRTimelineGroup
MARSHALL WACE, LLPin group MARSHALL WACE, LLP171,681$712K<0.01%new13F-HRTimelineGroup
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.161,946$672K<0.01%new13F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP159,033$660K<0.01%+58,30013F-HRTimelineGroup
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…155,130$644K<0.01%+57,02513F-HRTimelineGroup
RENAISSANCE TECHNOLOGIES LLC151,300$628K<0.01%-229,20813F-HRTimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC134,073$556K<0.01%+110,44313F-HR/ATimelineGroup
DAFNA Capital Management LLC126,841$526K0.12%-236,79513F-HRTimeline
TWO SIGMA INVESTMENTS, LPgroup of 2 filers holding113,652$472KnewTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP110,899$460K<0.01%+8,32713F-HRTimelineGroup
Qube Research & Technologies Ltd106,742$443K<0.01%+80,80813F-HRTimeline
ExodusPoint Capital Management, LP95,635$397K<0.01%new13F-HRTimeline
BARCLAYS PLCin group BARCLAYS PLC94,517$392K<0.01%+94,51613F-HRTimelineGroup
IFP Advisors, Inc86,698$360K0.01%013F-HRTimeline
MORGAN STANLEYin group MORGAN STANLEY81,851$340K<0.01%+71,52813F-HR/ATimelineGroup
OMERS ADMINISTRATION Corp67,100$278K<0.01%new13F-HRTimeline
Holos Integrated Wealth LLC51,595$222K0.12%013F-HRTimeline
XTX Topco Ltdin group XTX Topco Ltd50,358$209K0.01%+15,54013F-HRTimelineGroup
Hudson Bay Capital Management LPin group Hudson Bay Capital Management…49,425$205K<0.01%new13F-HRTimelineGroup
TD Asset Management Inc45,692$190K<0.01%-46,98613F-HRTimeline
Squarepoint Ops LLCin group Squarepoint Ops LLC44,343$184K<0.01%new13F-HRTimelineGroup
NewEdge Advisors, LLC44,083$183K<0.01%013F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …32,518$135K<0.01%013F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC30,175$125K<0.01%-23,82713F-HRTimelineGroup
Meramec Financial Planners, LLC30,000$117K0.05%13F-HRTimeline
BRIDGEWAY CAPITAL MANAGEMENT, LLC25,000$104K<0.01%013F-HRTimeline
Lighthouse Investment Partners, LLCin group Lighthouse Investment Partner…24,900$103K<0.01%new13F-HRTimelineGroup
Daytona Street Capital LLC21,500$89.2K0.07%13F-HRTimeline
Cresset Asset Management, LLC20,000$83K<0.01%new13F-HRTimeline
CITIGROUP INCin group CITIGROUP INC19,458$80.8K<0.01%+19,41713F-HRTimelineGroup
HighTower Advisors, LLC18,275$75.8K<0.01%013F-HRTimeline
Balyasny Asset Management L.P.in group Balyasny Asset Management18,268$75.8K<0.01%new13F-HRTimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/17,547$72.8K<0.01%-13,57213F-HRTimelineGroup
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS17,007$70.6K<0.01%+16,44313F-HRTimelineGroup
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC16,290$67.6K<0.01%-82213F-HRTimelineGroup
Creative Planningin group Creative Planning16,290$67.6K<0.01%-81113F-HRTimelineGroup
Virtu Financial LLCin group Virtu Financial LLC13,623$57K<0.01%new13F-HRTimelineGroup
ABLE Financial Group, LLC13,402$55.6K0.01%013F-HRTimeline
UBS Group AGin group UBS Group AG11,389$47.3K<0.01%+7,57413F-HRTimelineGroup
GSA CAPITAL PARTNERS LLP10,773$45K<0.01%new13F-HRTimeline
China Universal Asset Management Co., L…9,201$38.2K<0.01%new13F-HRTimeline
CANADA PENSION PLAN INVESTMENT BOARD7,100$29.5K<0.01%new13F-HRTimeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO4,586$19K<0.01%+4,11613F-HRTimelineGroup
Mirae Asset Global Investments Co., Ltd.in group Mirae Asset Global Investment…2,744$11.4K<0.01%new13F-HRTimelineGroup
HARBOUR INVESTMENTS, INC.1,988$8.25K<0.01%013F-HRTimeline
GF FUND MANAGEMENT CO. LTD.1,109$4.6K<0.01%new13F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…646$2.68K<0.01%new13F-HRTimelineGroup
Optiver Holding B.V.in group Optiver Holding B.V.312$1.29K<0.01%013F-HRTimelineGroup
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA371$1K<0.01%-5,99213F-HRTimelineGroup
SBI Securities Co., Ltd.6$25<0.01%013F-HRTimeline