BVF INC/IL in group BVF INC/IL More: the full row for BVF INC/IL 1,276,595 $72.6M 2.94% new 13F-HR Timeline Group VANGUARD GROUP INC group of 2 filers holding More: the full row for VANGUARD GROUP INC 952,558 $54.2M +223,066 Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 940,953 $53.5M +719,062 Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 929,151 $52.9M <0.01% +857,012 13F-HR/A Timeline Group FARALLON CAPITAL MANAGEMENT, L.L.C. More: the full row for FARALLON CAPITAL MANAGEMENT, L.L.C. 791,000 $45M 0.25% new 13F-HR/A Timeline TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 613,145 $34.9M +533,750 Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 609,114 $34.7M <0.01% +193,888 13F-HR Timeline Group EMERALD ADVISERS, LLC group of 2 filers holding More: the full row for EMERALD ADVISERS, LLC 556,451 $31.7M new Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 545,994 $31.1M 0.02% -103,039 13F-HR Timeline Group Nantahala Capital Management, LLC in group Nantahala Capital Management,… More: the full row for Nantahala Capital Management, LLC 418,522 $23.8M 1.47% -291,239 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 361,073 $20.5M 0.02% new 13F-HR Timeline Group 22NW, LP More: the full row for 22NW, LP 331,115 $18.8M 9.81% +185,000 13F-HR Timeline Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 303,200 $17.3M 0.16% new 13F-HR Timeline Group GREAT POINT PARTNERS LLC More: the full row for GREAT POINT PARTNERS LLC 300,000 $17.1M 7.13% new 13F-HR Timeline PRIMECAP MANAGEMENT CO/CA/ More: the full row for PRIMECAP MANAGEMENT CO/CA/ 289,050 $16.4M 0.01% -10,668 13F-HR Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 278,541 $15.8M 0.02% +31,481 13F-HR Timeline ARMISTICE CAPITAL, LLC More: the full row for ARMISTICE CAPITAL, LLC 268,000 $15.2M 0.48% +144,000 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 233,059 $13.3M 0.06% -13,086 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 226,897 $12.9M <0.01% +194,865 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 225,236 $12.8M <0.01% +92,863 13F-HR Timeline Group GILDER GAGNON HOWE & CO LLC More: the full row for GILDER GAGNON HOWE & CO LLC 224,828 $12.8M 0.13% +195,926 13F-HR Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 182,814 $10.4M 0.02% -203,476 13F-HR Timeline Group VOLORIDGE INVESTMENT MANAGEMENT, LLC More: the full row for VOLORIDGE INVESTMENT MANAGEMENT, LLC 171,776 $9.77M 0.03% new 13F-HR Timeline Nationale-Nederlanden Powszechne Towarz… More: the full row for Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. 153,846 $8.75M 0.68% new 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 128,999 $7.34M <0.01% +78,894 13F-HR Timeline Group Boxer Capital Management, LLC in group Boxer Capital Management, LLC More: the full row for Boxer Capital Management, LLC 125,000 $7.11M 2.27% 0 13F-HR/A Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 123,658 $7.04M 0.02% new 13F-HR Timeline Group Sofinnova Investments, Inc. More: the full row for Sofinnova Investments, Inc. 118,419 $6.74M 0.41% new 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 114,664 $6.52M <0.01% +48,735 13F-HR Timeline Group Quinn Opportunity Partners LLC More: the full row for Quinn Opportunity Partners LLC 109,868 $6.25M 0.46% new 13F-HR Timeline Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 107,678 $6.13M 0.04% new 13F-HR/A Timeline Group FRED ALGER MANAGEMENT, LLC in group FRED ALGER MANAGEMENT, LLC More: the full row for FRED ALGER MANAGEMENT, LLC 91,807 $5.22M 0.02% +39,096 13F-HR Timeline Group Trexquant Investment LP More: the full row for Trexquant Investment LP 91,480 $5.21M 0.05% new 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 90,822 $5.17M <0.01% -110,549 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 90,000 $5.12M <0.01% new 13F-HR Timeline Group Simplify Asset Management Inc. More: the full row for Simplify Asset Management Inc. 87,174 $4.96M 0.1% +35,176 13F-HR Timeline Stonepine Capital Management, LLC More: the full row for Stonepine Capital Management, LLC 85,000 $4.84M 3.93% +34,800 13F-HR Timeline Informed Momentum Co LLC More: the full row for Informed Momentum Co LLC 78,209 $4.4M 0.5% +54,053 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 77,055 $4.38M <0.01% +14,605 13F-HR Timeline Group SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 76,450 $4.35M 0.1% +29,497 13F-HR Timeline DIADEMA PARTNERS LP More: the full row for DIADEMA PARTNERS LP 75,000 $4.27M 2.97% new 13F-HR Timeline Moody Aldrich Partners LLC More: the full row for Moody Aldrich Partners LLC 73,716 $4.19M 0.8% +28,304 13F-HR Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 72,007 $4.1M 0.41% +56,211 13F-HR Timeline Group Longaeva Partners L.P. More: the full row for Longaeva Partners L.P. 62,729 $3.57M 0.76% new 13F-HR Timeline WOLVERINE TRADING, LLC More: the full row for WOLVERINE TRADING, LLC 57,758 $3.4M 0.07% +42,686 13F-HR Timeline Artia Global Partners LP More: the full row for Artia Global Partners LP 57,999 $3.3M 0.58% new 13F-HR/A Timeline DAFNA Capital Management LLC More: the full row for DAFNA Capital Management LLC 54,998 $3.13M 0.77% +44,998 13F-HR Timeline STEMPOINT CAPITAL LP More: the full row for STEMPOINT CAPITAL LP 53,201 $3.03M 0.61% new 13F-HR Timeline F/m Investments LLC More: the full row for F/m Investments LLC 53,088 $3.02M 0.12% new 13F-HR Timeline SUPERSTRING CAPITAL MANAGEMENT LP More: the full row for SUPERSTRING CAPITAL MANAGEMENT LP 51,270 $2.92M 2.87% new 13F-HR Timeline Eversept Partners, LP More: the full row for Eversept Partners, LP 49,890 $2.84M 0.22% -65,110 13F-HR Timeline Propel Bio Management, LLC More: the full row for Propel Bio Management, LLC 49,000 $2.79M 2.79% new 13F-HR Timeline Connor, Clark & Lunn Investment Managem… More: the full row for Connor, Clark & Lunn Investment Management Ltd. 48,617 $2.77M 0.01% +27,282 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 47,959 $2.73M <0.01% -19,602 13F-HR/A Timeline Group Cambridge Investment Research Advisors,… More: the full row for Cambridge Investment Research Advisors, Inc. 46,636 $2.65M 0.01% +34,554 13F-HR Timeline READYSTATE ASSET MANAGEMENT LP More: the full row for READYSTATE ASSET MANAGEMENT LP 45,042 $2.56M 0.12% new 13F-HR Timeline AWM Investment Company, Inc. More: the full row for AWM Investment Company, Inc. 40,000 $2.28M 0.21% new 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 39,967 $2.27M <0.01% +24,691 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 39,321 $2.24M <0.01% +21,544 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 38,490 $2.19M <0.01% +14,346 13F-HR Timeline Group Deuterium Capital Management, LLC More: the full row for Deuterium Capital Management, LLC 37,349 $2.13M 3.08% 0 13F-HR Timeline Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 36,107 $2.05M 0.02% new 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 34,500 $1.96M <0.01% new 13F-HR Timeline Group Jain Global LLC More: the full row for Jain Global LLC 32,787 $1.87M 0.02% -96,031 13F-HR Timeline BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 30,140 $1.71M 0.04% -36,000 13F-HR Timeline Headlands Technologies LLC More: the full row for Headlands Technologies LLC 29,830 $1.7M 0.14% +27,308 13F-HR Timeline ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 27,335 $1.55M <0.01% -393,623 13F-HR Timeline Group Palumbo Wealth Management LLC More: the full row for Palumbo Wealth Management LLC 26,154 $1.49M 0.48% +2,382 13F-HR Timeline Verition Fund Management LLC More: the full row for Verition Fund Management LLC 24,415 $1.39M 0.01% new 13F-HR Timeline Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 17,630 $1M 0.01% new 13F-HR Timeline Erste Asset Management GmbH in group Erste Asset Management GmbH More: the full row for Erste Asset Management GmbH 17,000 $1M 0.01% new 13F-HR Timeline Group Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 17,270 $983K 0.71% new 13F-HR/A Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 17,049 $970K <0.01% +12,011 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 16,679 $949K <0.01% +7,670 13F-HR/A Timeline Group JACOBS LEVY EQUITY MANAGEMENT, INC More: the full row for JACOBS LEVY EQUITY MANAGEMENT, INC 14,946 $850K <0.01% -133,294 13F-HR Timeline CAXTON ASSOCIATES LLP More: the full row for CAXTON ASSOCIATES LLP 13,977 $795K 0.02% new 13F-HR Timeline SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 13,744 $782K <0.01% new 13F-HR Timeline Group HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 13,158 $748K <0.01% new 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 11,976 $682K <0.01% -5,822 13F-HR Timeline ENVESTNET ASSET MANAGEMENT INC in group ENVESTNET ASSET MANAGEMENT INC More: the full row for ENVESTNET ASSET MANAGEMENT INC 10,086 $574K <0.01% new 13F-HR Timeline Group HB Wealth Management, LLC More: the full row for HB Wealth Management, LLC 9,244 $526K <0.01% new 13F-HR Timeline Glenmede Investment Management, LP More: the full row for Glenmede Investment Management, LP 9,200 $523K <0.01% new 13F-HR Timeline DARK FOREST CAPITAL MANAGEMENT LP More: the full row for DARK FOREST CAPITAL MANAGEMENT LP 9,185 $523K 0.02% new 13F-HR/A Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 8,529 $485K 0.01% -84,652 13F-HR Timeline Kestra Advisory Services, LLC in group Kestra Advisory Services, LLC More: the full row for Kestra Advisory Services, LLC 7,650 $435K <0.01% new 13F-HR Timeline Group SummitTX Capital, L.P. More: the full row for SummitTX Capital, L.P. 6,798 $387K 0.02% -5,628 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 5,897 $336K 0.02% new 13F-HR Timeline Group TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 5,435 $309K <0.01% new 13F-HR/A Timeline Gainplan LLC More: the full row for Gainplan LLC 5,035 $286K 0.12% -9,965 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 5,426 $282K <0.01% +38 13F-HR Timeline Group Rangeley Capital, LLC More: the full row for Rangeley Capital, LLC 4,895 $279K 0.26% new 13F-HR Timeline LPL Financial LLC More: the full row for LPL Financial LLC 4,754 $271K <0.01% new 13F-HR Timeline FIFTH LANE CAPITAL, LP More: the full row for FIFTH LANE CAPITAL, LP 4,500 $256K 0.26% new 13F-HR Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 4,327 $246K <0.01% new 13F-HR Timeline Group Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 4,109 $234K <0.01% new 13F-HR Timeline Group Cubist Systematic Strategies, LLC More: the full row for Cubist Systematic Strategies, LLC 4,097 $233K <0.01% new 13F-HR Timeline Birchview Capital, LP More: the full row for Birchview Capital, LP 4,021 $229K 0.17% new 13F-HR Timeline Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 3,974 $226K <0.01% new 13F-HR Timeline GREAT LAKES ADVISORS, LLC More: the full row for GREAT LAKES ADVISORS, LLC 3,922 $223K <0.01% new 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 3,047 $173K <0.01% -3,890 13F-HR Timeline Group FNY Investment Advisers, LLC More: the full row for FNY Investment Advisers, LLC 2,602 $148K 0.05% +1,077 13F-HR Timeline Vontobel Holding Ltd. in group Vontobel Holding Ltd. More: the full row for Vontobel Holding Ltd. 1,900 $108K <0.01% new 13F-HR Timeline Group US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 1,810 $103K <0.01% -1,891 13F-HR Timeline Group Bayforest Capital Ltd More: the full row for Bayforest Capital Ltd 1,679 $95.5K 0.05% new 13F-HR Timeline BESSEMER GROUP INC in group BESSEMER GROUP INC More: the full row for BESSEMER GROUP INC 1,565 $90K <0.01% +1,480 13F-HR Timeline Group Allworth Financial LP More: the full row for Allworth Financial LP 676 $38.5K <0.01% -2,690 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 475 $27K <0.01% -4,949 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 434 $24.7K <0.01% +210 13F-HR Timeline Group SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 365 $20.8K <0.01% +19 13F-HR Timeline Group SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 260 $14.8K <0.01% 0 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 248 $14.1K <0.01% -269 13F-HR Timeline Group CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 243 $14K <0.01% -11,710 13F-HR Timeline Group Steward Partners Investment Advisory, L… More: the full row for Steward Partners Investment Advisory, LLC 213 $12.1K <0.01% +211 13F-HR Timeline Activest Wealth Management More: the full row for Activest Wealth Management 200 $11.4K <0.01% 0 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 156 $8.88K <0.01% -4 13F-HR Timeline JONES FINANCIAL COMPANIES LLLP in group JONES FINANCIAL COMPANIES LLLP More: the full row for JONES FINANCIAL COMPANIES LLLP 115 $6.73K <0.01% +22 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 100 $5.69K <0.01% new 13F-HR Timeline CIBC Private Wealth Group LLC in group CIBC Bancorp USA Inc. More: the full row for CIBC Private Wealth Group LLC 100 $5.69K <0.01% new 13F-HR Timeline Group Quantbot Technologies LP More: the full row for Quantbot Technologies LP 88 $5.01K <0.01% new 13F-HR Timeline BROWN BROTHERS HARRIMAN & CO in group BROWN BROTHERS HARRIMAN & CO More: the full row for BROWN BROTHERS HARRIMAN & CO 66 $3.75K <0.01% 0 13F-HR Timeline Group MTM Investment Management, LLC More: the full row for MTM Investment Management, LLC 66 $3.75K <0.01% new 13F-HR Timeline MassMutual Private Wealth & Trust, FSB More: the full row for MassMutual Private Wealth & Trust, FSB 64 $3.64K <0.01% new 13F-HR Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 59 $3.36K <0.01% -235 13F-HR/A Timeline Boreal Capital Management LLC More: the full row for Boreal Capital Management LLC 36 $2.05K <0.01% 0 13F-HR Timeline MAI Capital Management More: the full row for MAI Capital Management 33 $1.88K <0.01% new 13F-HR Timeline Global Retirement Partners, LLC More: the full row for Global Retirement Partners, LLC 27 $1.54K <0.01% 0 13F-HR Timeline AMERIFLEX GROUP, INC. More: the full row for AMERIFLEX GROUP, INC. 26 $1.48K <0.01% +13 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 25 $1.42K <0.01% -8 13F-HR Timeline ORG Partners LLC More: the full row for ORG Partners LLC 20 $1.14K <0.01% +20 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 19 $1.08K <0.01% -101 13F-HR/A Timeline Group Kimelman & Baird, LLC More: the full row for Kimelman & Baird, LLC 13 $740 <0.01% 0 13F-HR Timeline Medallion Wealth Advisors, LLC More: the full row for Medallion Wealth Advisors, LLC 13 $740 <0.01% 0 13F-HR Timeline PRINCIPAL SECURITIES, INC. in group PRINCIPAL FINANCIAL GROUP INC More: the full row for PRINCIPAL SECURITIES, INC. 12 $683 <0.01% +4 13F-HR Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 11 $626 <0.01% new 13F-HR Timeline HARBOUR INVESTMENTS, INC. More: the full row for HARBOUR INVESTMENTS, INC. 10 $569 <0.01% 0 13F-HR Timeline Arax Advisory Partners More: the full row for Arax Advisory Partners 9 $512 <0.01% new 13F-HR Timeline MONTAG A & ASSOCIATES INC More: the full row for MONTAG A & ASSOCIATES INC 7 $399 <0.01% new 13F-HR Timeline Arlington Trust Co LLC in group Arlington Trust Co LLC More: the full row for Arlington Trust Co LLC 6 $341 <0.01% 0 13F-HR Timeline Group Salomon & Ludwin, LLC More: the full row for Salomon & Ludwin, LLC 3 $182 <0.01% 0 13F-HR Timeline DANSKE BANK A/S More: the full row for DANSKE BANK A/S 2 $114 <0.01% 0 13F-HR/A Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 1 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. Covestor Ltd More: the full row for Covestor Ltd 0 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.