Lynx1 Capital Management LP in group Lynx1 Capital Management LP More: the full row for Lynx1 Capital Management LP 10,763,288 $151M 23.92% +356,713 13F-HR Timeline Group BVF INC/IL in group BVF INC/IL More: the full row for BVF INC/IL 8,650,158 $122M 3.87% -177,554 13F-HR Timeline Group RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 7,676,697 $108M 1.14% 0 13F-HR Timeline Group RTW INVESTMENTS, LP More: the full row for RTW INVESTMENTS, LP 5,933,815 $83.4M 0.83% 0 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 5,136,045 $72.2M <0.01% 0 13F-HR Timeline Group Avoro Capital Advisors LLC More: the full row for Avoro Capital Advisors LLC 1,800,000 $25.3M 0.25% 0 13F-HR Timeline TORONTO DOMINION BANK in group TORONTO DOMINION BANK More: the full row for TORONTO DOMINION BANK 1,397,873 $19.7M 0.04% new 13F-HR Timeline Group Troluce Capital Advisors LLC More: the full row for Troluce Capital Advisors LLC 990,472 $13.9M 1.47% +617,260 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 937,898 $13.2M 0.01% +641,972 13F-HR Timeline Group Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 712,300 $10M 0.12% 0 13F-HR Timeline Group 5AM Venture Management, LLC More: the full row for 5AM Venture Management, LLC 572,665 $8.05M 2.24% 0 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 455,618 $6.41M <0.01% +21,217 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 412,416 $5.8M <0.01% +49,035 13F-HR Timeline Group Squadron Capital Management LLC More: the full row for Squadron Capital Management LLC 325,000 $4.57M 1.83% +10,000 13F-HR Timeline Foresite Capital Management VI LLC in group Foresite Capital Management V… More: the full row for Foresite Capital Management VI LLC 315,492 $4.44M 0.96% new 13F-HR Timeline Group BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 282,891 $3.98M 0.09% +170,707 13F-HR Timeline CenterBook Partners LP More: the full row for CenterBook Partners LP 216,574 $3.05M 0.16% -66,867 13F-HR Timeline HighVista Strategies LLC More: the full row for HighVista Strategies LLC 213,212 $3M 0.83% -27,312 13F-HR Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 91,108 $1.28M <0.01% -149,656 13F-HR Timeline Group Occam Crest Management LP More: the full row for Occam Crest Management LP 80,000 $1.12M 0.7% new 13F-HR Timeline Trexquant Investment LP More: the full row for Trexquant Investment LP 69,808 $982K 0.01% +15,032 13F-HR Timeline AdvisorShares Investments LLC More: the full row for AdvisorShares Investments LLC 67,034 $942K 0.17% -78 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 65,464 $920K <0.01% +39,206 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 52,090 $732K 0.01% +7,644 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 44,795 $630K <0.01% -36,191 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 40,483 $569K <0.01% +4,838 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 32,685 $460K <0.01% -143 13F-HR Timeline Group DIADEMA PARTNERS LP More: the full row for DIADEMA PARTNERS LP 26,836 $377K 0.16% new 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 25,830 $363K <0.01% -25,574 13F-HR Timeline Group Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 20,920 $294K 0.08% +512 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 20,614 $290K <0.01% new 13F-HR Timeline TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 18,560 $261K <0.01% new 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 18,853 $246K <0.01% -28 13F-HR/A Timeline Group HighTower Advisors, LLC More: the full row for HighTower Advisors, LLC 15,600 $219K <0.01% 0 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 13,507 $190K 0.01% +3,400 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 11,049 $155K <0.01% +228 13F-HR Timeline Group Lion Point Capital, LP More: the full row for Lion Point Capital, LP 10,200 $143K 0.86% 0 13F-HR Timeline Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 6,794 $95.5K 0.04% new 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 5,925 $83.3K <0.01% -4,100 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 4,394 $61.8K <0.01% +2,276 13F-HR Timeline Group Mirae Asset Global Investments Co., Ltd. in group Mirae Asset Global Investment… More: the full row for Mirae Asset Global Investments Co., Ltd. 3,235 $45.5K <0.01% +221 13F-HR/A Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 2,590 $36K <0.01% +780 13F-HR Timeline Group North Star Investment Management Corp. More: the full row for North Star Investment Management Corp. 2,200 $30.9K <0.01% new 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 1,733 $24.4K <0.01% -2,671 13F-HR Timeline Group GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 1,384 $19.5K <0.01% +166 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 1,310 $18.4K <0.01% -27 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 1,250 $17.6K <0.01% 0 13F-HR/A Timeline Group Arkos Global Advisors More: the full row for Arkos Global Advisors 1,180 $17K <0.01% new 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 665 $9.35K <0.01% -105 13F-HR Timeline Group Ancora Advisors LLC in group Ancora Advisors LLC More: the full row for Ancora Advisors LLC 284 $3.99K <0.01% new 13F-HR Timeline Group Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 100 $1.47K <0.01% new 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 83 $1.17K <0.01% +35 13F-HR Timeline Cornerstone Financial Management LLC More: the full row for Cornerstone Financial Management LLC 32 $450 <0.01% new 13F-HR/A Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 20 $281 <0.01% 0 13F-HR Timeline