JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 3,729,659 $58.8M 0.03% +1,782,745 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 3,076,282 $48.5M <0.01% +1,243,302 13F-HR Timeline Group FARALLON CAPITAL MANAGEMENT, L.L.C. More: the full row for FARALLON CAPITAL MANAGEMENT, L.L.C. 2,772,262 $43.7M 0.23% +650,000 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. Krensavage Asset Management, LLC More: the full row for Krensavage Asset Management, LLC 2,766,390 $43.6M 15.41% +651,946 13F-HR Timeline VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 2,301,794 $36.3M <0.01% +362,965 13F-HR Timeline Group Deep Track Capital, LP More: the full row for Deep Track Capital, LP 1,956,867 $30.9M 0.7% new 13F-HR Timeline ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 885,126 $13.9M 0.02% +18,089 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 670,428 $10.6M 0.01% -277,656 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 645,791 $10.2M <0.01% +152,597 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 642,200 $10.1M 0.02% +162,600 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 523,715 $8.26M <0.01% +51,723 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 438,939 $6.92M 0.01% +138,939 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 428,748 $6.76M +242,926 Timeline Hillsdale Investment Management Inc. More: the full row for Hillsdale Investment Management Inc. 422,300 $6.66M 0.18% new 13F-HR Timeline Spruce Street Capital LP More: the full row for Spruce Street Capital LP 389,687 $6.15M 2.03% 13F-HR Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 385,276 $6.08M 0.01% +109,887 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 339,918 $5.36M <0.01% +57,287 13F-HR/A Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 253,811 $4M <0.01% +194,113 13F-HR Timeline Group AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 234,835 $3.7M <0.01% +7,990 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 229,889 $3.63M <0.01% +33,993 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 218,816 $3.45M <0.01% +52,383 13F-HR/A Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 218,636 $3.45M <0.01% +52,089 13F-HR Timeline Group DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 211,614 $3.34M <0.01% -58,454 13F-HR Timeline Group D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 167,714 $2.64M <0.01% -58,030 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 112,964 $1.78M <0.01% -10,853 13F-HR Timeline Group Connor, Clark & Lunn Investment Managem… More: the full row for Connor, Clark & Lunn Investment Management Ltd. 103,903 $1.64M <0.01% +26,397 13F-HR Timeline Stonepine Capital Management, LLC More: the full row for Stonepine Capital Management, LLC 100,000 $1.58M 1.25% -205,000 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 99,884 $1.58M <0.01% +80,064 13F-HR Timeline Group SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 98,782 $1.56M <0.01% +24,929 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 93,158 $1.47M <0.01% new 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 86,056 $1.36M <0.01% -78,704 13F-HR Timeline Group Opaleye Management Inc. More: the full row for Opaleye Management Inc. 75,000 $1.18M 0.16% new 13F-HR/A Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 72,588 $1.14M <0.01% +12,095 13F-HR Timeline Group PDT Partners, LLC More: the full row for PDT Partners, LLC 69,197 $1.09M 0.07% -16,825 13F-HR Timeline PANAGORA ASSET MANAGEMENT INC More: the full row for PANAGORA ASSET MANAGEMENT INC 66,990 $1.06M <0.01% new 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 65,978 $1.04M <0.01% +36,026 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 65,966 $1.04M <0.01% new 13F-HR Timeline Group DIADEMA PARTNERS LP More: the full row for DIADEMA PARTNERS LP 65,138 $1.03M 0.61% new 13F-HR Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 63,219 $997K <0.01% new 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 60,901 $960K -106,837 Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 54,989 $867K <0.01% +13,368 13F-HR Timeline Group Campbell & CO Investment Adviser LLC More: the full row for Campbell & CO Investment Adviser LLC 54,149 $854K 0.04% +35,294 13F-HR Timeline ARROWSTREET CAPITAL, LIMITED PARTNERSHIP in group ARROWSTREET CAPITAL, LIMITED … More: the full row for ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 52,728 $832K <0.01% new 13F-HR Timeline Group Assenagon Asset Management S.A. More: the full row for Assenagon Asset Management S.A. 45,877 $723K <0.01% -8,380 13F-HR Timeline Man Group plc in group Man Group plc More: the full row for Man Group plc 43,847 $691K <0.01% +3,691 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 41,357 $652K 0.05% new 13F-HR/A Timeline Group Informed Momentum Co LLC More: the full row for Informed Momentum Co LLC 40,952 $646K 0.07% new 13F-HR Timeline PRUDENTIAL FINANCIAL INC in group PRUDENTIAL FINANCIAL INC More: the full row for PRUDENTIAL FINANCIAL INC 40,015 $631K <0.01% new 13F-HR Timeline Group Sio Capital Management, LLC More: the full row for Sio Capital Management, LLC 40,000 $631K 0.1% new 13F-HR Timeline BANK OF MONTREAL /CAN/ in group BANK OF MONTREAL /CAN/ More: the full row for BANK OF MONTREAL /CAN/ 37,484 $591K <0.01% +3,616 13F-HR Timeline Group IEQ CAPITAL, LLC More: the full row for IEQ CAPITAL, LLC 36,385 $574K <0.01% -1,301 13F-HR Timeline AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 33,764 $532K <0.01% -14,807 13F-HR Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 33,740 $532K <0.01% 0 13F-HR Timeline Quantinno Capital Management LP More: the full row for Quantinno Capital Management LP 33,495 $528K <0.01% -3,631 13F-HR Timeline State of Wyoming More: the full row for State of Wyoming 32,887 $519K 0.06% new 13F-HR Timeline FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 32,720 $516K <0.01% new 13F-HR Timeline Group Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 32,389 $511K <0.01% +20,469 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 30,716 $484K <0.01% +15,117 13F-HR Timeline Group Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 30,000 $473K <0.01% new 13F-HR Timeline Group BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 29,700 $468K 0.01% 0 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 28,849 $455K <0.01% -2,060 13F-HR Timeline Thrivent Financial for Lutherans in group Thrivent Financial for Luther… More: the full row for Thrivent Financial for Lutherans 28,376 $448K <0.01% -5,665 13F-HR Timeline Group Portland Global Advisors LLC More: the full row for Portland Global Advisors LLC 24,275 $383K 0.04% 0 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 24,107 $380K <0.01% +1,055 13F-HR Timeline Group Headlands Technologies LLC More: the full row for Headlands Technologies LLC 22,596 $356K 0.03% new 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 20,666 $326K <0.01% +19 13F-HR Timeline Group STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 18,608 $293K <0.01% new 13F-HR Timeline Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 17,466 $275K 0.13% new 13F-HR Timeline Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 16,252 $256K +5,720 Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 14,410 $228K <0.01% +4,264 13F-HR Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 14,408 $227K <0.01% +7,849 13F-HR Timeline Group AlphaQuest LLC More: the full row for AlphaQuest LLC 14,178 $224K 0.01% +3,980 13F-HR Timeline Virtu Financial LLC in group Virtu Financial LLC More: the full row for Virtu Financial LLC 13,967 $220K 0.01% new 13F-HR Timeline Group Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 13,900 $219K <0.01% new 13F-HR Timeline Group Jain Global LLC More: the full row for Jain Global LLC 12,543 $198K <0.01% new 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 11,483 $182K <0.01% -4,960 13F-HR Timeline Group Kingsview Wealth Management, LLC More: the full row for Kingsview Wealth Management, LLC 10,653 $168K <0.01% new 13F-HR Timeline FOX RUN MANAGEMENT, L.L.C. More: the full row for FOX RUN MANAGEMENT, L.L.C. 10,182 $161K 0.02% new 13F-HR Timeline WEALTH ENHANCEMENT ADVISORY SERVICES, L… More: the full row for WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 10,721 $146K <0.01% +74 13F-HR Timeline CANADA PENSION PLAN INVESTMENT BOARD More: the full row for CANADA PENSION PLAN INVESTMENT BOARD 8,900 $140K <0.01% new 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 6,676 $105K <0.01% 0 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 6,071 $95.7K <0.01% -1,700 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 5,092 $80.3K <0.01% -10,215 13F-HR Timeline Group Clearstead Trust, LLC More: the full row for Clearstead Trust, LLC 5,064 $79.9K 0.01% 0 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 4,703 $74.2K 0.01% -4,044 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 4,312 $68K <0.01% +2,527 13F-HR Timeline Group STRS OHIO More: the full row for STRS OHIO 3,200 $50.5K <0.01% new 13F-HR Timeline Pinnacle Wealth Planning Services, Inc. More: the full row for Pinnacle Wealth Planning Services, Inc. 2,529 $39.9K <0.01% new 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 2,438 $38.4K <0.01% +734 13F-HR Timeline Group Seven Fleet Capital Management LP More: the full row for Seven Fleet Capital Management LP 2,270 $35.8K 0.02% 13F-HR/A Timeline MEEDER ASSET MANAGEMENT INC in group Meeder Advisory Services, Inc. More: the full row for MEEDER ASSET MANAGEMENT INC 2,025 $31.9K <0.01% new 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 1,973 $31.1K <0.01% 0 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 1,679 $26.5K <0.01% +423 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 1,572 $24.8K <0.01% +181 13F-HR Timeline Essential Partners LLC More: the full row for Essential Partners LLC 1,516 $23.9K 0.01% 0 13F-HR Timeline Versant Capital Management, Inc More: the full row for Versant Capital Management, Inc 1,424 $22.5K <0.01% 0 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 1,422 $22.4K <0.01% -680 13F-HR Timeline Group GAMMA Investing LLC More: the full row for GAMMA Investing LLC 1,331 $21K <0.01% 0 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 1,148 $18.1K <0.01% 0 13F-HR Timeline Group SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 922 $14.5K <0.01% +75 13F-HR Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 857 $14K <0.01% +190 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 880 $13K <0.01% -301 13F-HR Timeline Group PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 786 $12.4K <0.01% -12 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 721 $11.4K <0.01% -1,154 13F-HR Timeline Group True Wealth Design, LLC More: the full row for True Wealth Design, LLC 645 $10.2K <0.01% 0 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 565 $8.91K <0.01% +117 13F-HR Timeline Rockefeller Capital Management L.P. in group Rockefeller Capital Managemen… More: the full row for Rockefeller Capital Management L.P. 514 $8.11K <0.01% new 13F-HR/A Timeline Group Smartleaf Asset Management LLC More: the full row for Smartleaf Asset Management LLC 410 $6.52K <0.01% 0 13F-HR Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 396 $6.25K <0.01% 0 13F-HR Timeline COMERICA BANK More: the full row for COMERICA BANK 367 $5.79K <0.01% 0 13F-HR Timeline Red Tortoise LLC More: the full row for Red Tortoise LLC 364 $5.74K <0.01% 0 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 340 $5.36K <0.01% -510 13F-HR Timeline Optiver Holding B.V. in group Optiver Holding B.V. More: the full row for Optiver Holding B.V. 258 $4.07K <0.01% 0 13F-HR Timeline Group ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 253 $3.99K <0.01% -12 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 228 $3.6K <0.01% -5 13F-HR Timeline Johnson Financial Group, Inc. in group Johnson Financial Group, Inc. More: the full row for Johnson Financial Group, Inc. 188 $2.96K <0.01% 0 13F-HR Timeline Group Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 169 $2.67K <0.01% 0 13F-HR Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 96 $2K <0.01% new 13F-HR Timeline Group Torren Management, LLC More: the full row for Torren Management, LLC 120 $1.89K <0.01% 13F-HR Timeline Parkside Financial Bank & Trust More: the full row for Parkside Financial Bank & Trust 71 $1.12K <0.01% 0 13F-HR Timeline LOS ANGELES CAPITAL MANAGEMENT LLC More: the full row for LOS ANGELES CAPITAL MANAGEMENT LLC 103 $1.12K <0.01% new 13F-HR Timeline Sunbelt Securities, Inc. More: the full row for Sunbelt Securities, Inc. 63 $994 <0.01% 0 13F-HR Timeline Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 51 $804 <0.01% new 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 18 $284 <0.01% -70 13F-HR Timeline Group RAFFA WEALTH MANAGEMENT, LLC More: the full row for RAFFA WEALTH MANAGEMENT, LLC 11 $173 <0.01% 0 13F-HR Timeline MAI Capital Management More: the full row for MAI Capital Management 7 $111 <0.01% new 13F-HR Timeline Arax Advisory Partners More: the full row for Arax Advisory Partners 6 $95 <0.01% -7,756 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 1 $16 <0.01% 0 13F-HR Timeline Covestor Ltd More: the full row for Covestor Ltd 15 $0 0% -1 13F-HR Timeline Value filed as zero, left out of ratios.