MPM BIOIMPACT LLC More: the full row for MPM BIOIMPACT LLC 7,648,268 $45.4M 7.42% 0 13F-HR Timeline Lynx1 Capital Management LP in group Lynx1 Capital Management LP More: the full row for Lynx1 Capital Management LP 5,766,090 $34.2M 6.96% +1,365,248 13F-HR Timeline Group BVF INC/IL in group BVF INC/IL More: the full row for BVF INC/IL 5,750,683 $34.1M 1.38% 0 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 4,169,962 $24.7M <0.01% -47,971 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 2,943,325 $17.5M <0.01% -76,775 13F-HR Timeline Group DEERFIELD MANAGEMENT COMPANY, L.P. in group DEERFIELD MANAGEMENT COMPANY,… More: the full row for DEERFIELD MANAGEMENT COMPANY, L.P. 2,927,013 $17.4M 0.27% -928,539 13F-HR Timeline Group Blue Owl Capital Holdings LP More: the full row for Blue Owl Capital Holdings LP 2,510,972 $14.9M 4.62% +125,000 13F-HR Timeline Kynam Capital Management, LP More: the full row for Kynam Capital Management, LP 2,302,172 $13.7M 1.02% +206,174 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 1,984,407 $11.8M 0.01% -629,286 13F-HR Timeline Group ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 1,923,855 $11.4M 0.27% 0 13F-HR Timeline Group RTW INVESTMENTS, LP More: the full row for RTW INVESTMENTS, LP 1,705,960 $10.1M 0.12% 0 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 1,677,314 $9.95M <0.01% +69,722 13F-HR Timeline Group FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 1,416,036 $8.4M <0.01% -812,124 13F-HR Timeline Group Venrock Adviser, LLC More: the full row for Venrock Adviser, LLC 1,379,965 $8.18M 0.46% 0 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 1,295,320 $7.68M <0.01% +15,824 13F-HR Timeline Group Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 1,193,410 $7.08M 0.28% 0 13F-HR Timeline Group DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 1,183,821 $7.02M <0.01% -92,717 13F-HR Timeline Group Nextech Invest Ltd. More: the full row for Nextech Invest Ltd. 1,141,145 $6.77M 1.03% 0 13F-HR Timeline TANG CAPITAL MANAGEMENT LLC in group TANG CAPITAL MANAGEMENT LLC More: the full row for TANG CAPITAL MANAGEMENT LLC 1,121,138 $6.65M 0.26% 0 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 983,960 $5.83M <0.01% +281,822 13F-HR Timeline Group TWIN FOCUS CAPITAL PARTNERS, LLC More: the full row for TWIN FOCUS CAPITAL PARTNERS, LLC 595,489 $3.53M 0.45% 0 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 571,738 $3.39M <0.01% +4,957 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 557,189 $3.3M <0.01% -104,096 13F-HR/A Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 550,471 $3.26M <0.01% +39,643 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 529,408 $3.14M <0.01% +194,883 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 447,267 $2.65M <0.01% -5,936 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 402,638 $2.39M <0.01% -32,878 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 400,154 $2.37M <0.01% +158,062 13F-HR/A Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 300,885 $1.78M <0.01% +252,002 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 295,442 $1.75M <0.01% -331,139 13F-HR Timeline Group Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 263,817 $1.56M 0.15% 0 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 251,110 $1.49M <0.01% -17,357 13F-HR/A Timeline Group ALGERT GLOBAL LLC More: the full row for ALGERT GLOBAL LLC 236,092 $1.4M 0.02% +20,512 13F-HR/A Timeline UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 235,348 $1.4M -182,541 Timeline Cubist Systematic Strategies, LLC More: the full row for Cubist Systematic Strategies, LLC 222,318 $1.32M 0.02% new 13F-HR Timeline Voss Capital, LP More: the full row for Voss Capital, LP 221,473 $1.31M 0.08% -30,244 13F-HR/A Timeline Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 215,595 $1.28M <0.01% +34,910 13F-HR Timeline Group AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 197,920 $1.17M <0.01% +177,000 13F-HR Timeline Group Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 194,507 $1.15M 0.01% new 13F-HR/A Timeline Group Trexquant Investment LP More: the full row for Trexquant Investment LP 187,618 $1.11M 0.01% +68,276 13F-HR Timeline Assenagon Asset Management S.A. More: the full row for Assenagon Asset Management S.A. 177,685 $1.05M <0.01% +167,623 13F-HR Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 168,131 $997K <0.01% -17,952 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 167,979 $996K 0.05% +124,884 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 160,151 $950K +30,233 Timeline Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 152,409 $904K <0.01% +85,290 13F-HR Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 149,925 $889K <0.01% -5,956 13F-HR Timeline Group AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 141,069 $837K <0.01% +15,880 13F-HR Timeline Group Connor, Clark & Lunn Investment Managem… More: the full row for Connor, Clark & Lunn Investment Management Ltd. 139,024 $824K <0.01% +68,980 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 107,175 $636K <0.01% +80,684 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 102,312 $607K <0.01% +41,757 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 96,972 $575K new Timeline Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 90,318 $536K <0.01% +75,310 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 71,809 $426K <0.01% -2,296 13F-HR Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 56,777 $337K <0.01% +11,485 13F-HR Timeline Group Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 56,736 $336K <0.01% +21,537 13F-HR Timeline Group OXFORD ASSET MANAGEMENT LLP More: the full row for OXFORD ASSET MANAGEMENT LLP 56,486 $335K 0.11% new 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 50,363 $299K <0.01% +32,239 13F-HR Timeline Swiss National Bank More: the full row for Swiss National Bank 50,300 $298K <0.01% 0 13F-HR Timeline Quantinno Capital Management LP More: the full row for Quantinno Capital Management LP 49,525 $294K <0.01% new 13F-HR Timeline Focus Partners Wealth in group Focus Partners Wealth More: the full row for Focus Partners Wealth 3,498 $294K <0.01% new 13F-HR Timeline Group PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 48,652 $289K 0.02% +32,500 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 47,630 $282K <0.01% 0 13F-HR Timeline KENNEDY CAPITAL MANAGEMENT LLC More: the full row for KENNEDY CAPITAL MANAGEMENT LLC 46,011 $273K 0.01% +33,837 13F-HR Timeline Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 45,936 $272K <0.01% +26,709 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 43,237 $257K <0.01% +6,820 13F-HR Timeline EntryPoint Capital, LLC More: the full row for EntryPoint Capital, LLC 42,190 $250K 0.1% +31,072 13F-HR Timeline HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 42,109 $249K <0.01% new 13F-HR Timeline Rafferty Asset Management, LLC More: the full row for Rafferty Asset Management, LLC 40,729 $242K <0.01% +1,503 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 39,117 $232K <0.01% +6,378 13F-HR Timeline Group AXQ CAPITAL, LP More: the full row for AXQ CAPITAL, LP 32,669 $194K 0.07% new 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 31,868 $189K <0.01% -65,201 13F-HR/A Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 31,253 $185K <0.01% +2 13F-HR Timeline AlphaQuest LLC More: the full row for AlphaQuest LLC 29,019 $172K 0.01% +18,555 13F-HR Timeline TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 28,988 $172K <0.01% +6,850 13F-HR/A Timeline Caption Management, LLC More: the full row for Caption Management, LLC 28,389 $168K 0.01% -147,038 13F-HR Timeline Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 28,272 $168K -3,862 Timeline Mariner, LLC in group Mariner, LLC More: the full row for Mariner, LLC 28,151 $167K <0.01% +11,661 13F-HR Timeline Group INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 27,905 $165K <0.01% -9,467 13F-HR Timeline Creative Planning in group Creative Planning More: the full row for Creative Planning 27,376 $162K <0.01% -14,347 13F-HR Timeline Group Corton Capital Inc. More: the full row for Corton Capital Inc. 27,117 $161K 0.4% +5,405 13F-HR Timeline Magnetar Financial LLC in group Magnetar Financial LLC More: the full row for Magnetar Financial LLC 26,263 $156K <0.01% new 13F-HR Timeline Group Graham Capital Management, L.P. More: the full row for Graham Capital Management, L.P. 26,234 $156K 0.01% +6,957 13F-HR Timeline D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 25,619 $152K <0.01% +290 13F-HR Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 23,245 $138K <0.01% -8,209 13F-HR Timeline Group Birchview Capital, LP More: the full row for Birchview Capital, LP 20,000 $119K 0.09% 0 13F-HR Timeline JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 18,528 $110K <0.01% 0 13F-HR Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 17,826 $106K <0.01% -1,203 13F-HR Timeline Group FOX RUN MANAGEMENT, L.L.C. More: the full row for FOX RUN MANAGEMENT, L.L.C. 15,528 $92.1K 0.01% new 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 15,295 $90.7K <0.01% -3,563 13F-HR Timeline Group Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 14,996 $88.9K <0.01% +4,414 13F-HR Timeline Pale Fire Capital SE in group Pale Fire Capital More: the full row for Pale Fire Capital SE 14,615 $86.7K 0.01% new 13F-HR Timeline Group Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 13,942 $82.7K <0.01% new 13F-HR Timeline Group Compass Ion Advisors, LLC More: the full row for Compass Ion Advisors, LLC 13,904 $82.5K 0.01% new 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 13,285 $78K <0.01% -6,272 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 12,918 $76.6K <0.01% 0 13F-HR Timeline Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 12,714 $75.4K 0.02% +2,208 13F-HR Timeline Group Inscription Capital, LLC More: the full row for Inscription Capital, LLC 11,284 $66.9K 0.01% new 13F-HR Timeline ProShare Advisors LLC More: the full row for ProShare Advisors LLC 10,828 $64.2K <0.01% -1,837 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 10,671 $63.3K <0.01% -118,673 13F-HR Timeline Group SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 10,466 $62K <0.01% new 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 10,355 $61.4K 0.01% -1,498 13F-HR Timeline Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 7,641 $45.3K <0.01% 0 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 7,567 $44.9K <0.01% -615 13F-HR Timeline Group KLP KAPITALFORVALTNING AS More: the full row for KLP KAPITALFORVALTNING AS 6,800 $40.3K <0.01% 0 13F-HR Timeline Federation des caisses Desjardins du Qu… More: the full row for Federation des caisses Desjardins du Quebec 6,000 $35.6K <0.01% new 13F-HR Timeline WEXFORD CAPITAL LP More: the full row for WEXFORD CAPITAL LP 5,317 $31.5K 0.01% -13,409 13F-HR Timeline Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 5,240 $31.1K <0.01% 0 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 4,272 $25.3K <0.01% -36,714 13F-HR Timeline Group Point72 (DIFC) Ltd More: the full row for Point72 (DIFC) Ltd 3,553 $21.1K <0.01% new 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 3,520 $20.9K <0.01% +2,143 13F-HR Timeline Aquatic Capital Management LLC More: the full row for Aquatic Capital Management LLC 2,782 $16.5K <0.01% new 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 2,558 $15K <0.01% +1,438 13F-HR Timeline Group Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 1,873 $11.1K <0.01% +1,809 13F-HR Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 1,768 $10K <0.01% 0 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 1,660 $9.84K 0.01% +547 13F-HR Timeline Arax Advisory Partners More: the full row for Arax Advisory Partners 1,440 $8.54K <0.01% new 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 1,485 $8K <0.01% -2,994 13F-HR Timeline Group FNY Investment Advisers, LLC More: the full row for FNY Investment Advisers, LLC 1,365 $8K <0.01% new 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 1,251 $7.42K <0.01% -240 13F-HR Timeline PUBLIC EMPLOYEES RETIREMENT ASSOCIATION… More: the full row for PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO 1,150 $7K <0.01% 0 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 996 $5.91K <0.01% +645 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 968 $5.74K <0.01% -2,844 13F-HR Timeline Group QUADRANT CAPITAL GROUP LLC More: the full row for QUADRANT CAPITAL GROUP LLC 904 $5.36K <0.01% new 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 748 $4.44K <0.01% +159 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 556 $3.3K <0.01% +289 13F-HR Timeline SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 523 $3.1K <0.01% +134 13F-HR Timeline Optiver Holding B.V. in group Optiver Holding B.V. More: the full row for Optiver Holding B.V. 464 $2.75K <0.01% new 13F-HR Timeline Group NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 372 $2.21K <0.01% +92 13F-HR Timeline Essential Partners LLC More: the full row for Essential Partners LLC 331 $1.96K <0.01% +291 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 230 $1.36K <0.01% +156 13F-HR Timeline Group COMERICA BANK More: the full row for COMERICA BANK 195 $1.16K <0.01% +50 13F-HR Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 218 $1K <0.01% 0 13F-HR Timeline Group IFP Advisors, Inc More: the full row for IFP Advisors, Inc 147 $872 <0.01% +147 13F-HR/A Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 137 $812 <0.01% -1,228 13F-HR Timeline Parkside Financial Bank & Trust More: the full row for Parkside Financial Bank & Trust 60 $356 <0.01% 0 13F-HR Timeline Clearstead Advisors, LLC More: the full row for Clearstead Advisors, LLC 49 $291 <0.01% new 13F-HR Timeline True Wealth Design, LLC More: the full row for True Wealth Design, LLC 36 $214 <0.01% new 13F-HR Timeline ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 30 $178 <0.01% 0 13F-HR Timeline MassMutual Private Wealth & Trust, FSB More: the full row for MassMutual Private Wealth & Trust, FSB 27 $160 <0.01% new 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 2 $12 <0.01% +1 13F-HR Timeline Covestor Ltd More: the full row for Covestor Ltd 10 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios.