TCG Crossover Management, LLC More: the full row for TCG Crossover Management, LLC 10,000,000 $21.5M 0.62% 0 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 7,741,245 $16.6M <0.01% +593,479 13F-HR Timeline Group VANGUARD GROUP INC group of 5 filers holding More: the full row for VANGUARD GROUP INC 6,922,134 $14.9M +6,869,078 Timeline ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 4,038,785 $8.68M 0.01% +596,336 13F-HR Timeline Group Foresite Capital Management IV, LLC in group Foresite Capital Management V… More: the full row for Foresite Capital Management IV, LLC 3,887,200 $8.36M 3.53% 0 13F-HR Timeline Group Merck & Co., Inc. in group Merck & Co., Inc. More: the full row for Merck & Co., Inc. 3,545,719 $7.62M 2.18% 0 13F-HR Timeline Group D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 3,332,835 $7.17M 0.01% +967,684 13F-HR Timeline Group 683 Capital Management, LLC in group 683 Capital Management, LLC More: the full row for 683 Capital Management, LLC 3,200,000 $6.88M 0.64% -150,000 13F-HR Timeline Group Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 2,935,253 $6.31M 0.01% -330,322 13F-HR Timeline Group Nantahala Capital Management, LLC in group Nantahala Capital Management,… More: the full row for Nantahala Capital Management, LLC 2,815,983 $6.05M 0.38% new 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 2,286,218 $4.92M <0.01% +210,998 13F-HR Timeline Group JACOBS LEVY EQUITY MANAGEMENT, INC More: the full row for JACOBS LEVY EQUITY MANAGEMENT, INC 2,154,361 $4.63M 0.02% -18,841 13F-HR Timeline Spruce Street Capital LP More: the full row for Spruce Street Capital LP 2,101,068 $4.52M 1.09% +983,082 13F-HR Timeline Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 2,082,606 $4.48M 0.64% 0 13F-HR Timeline Group Kynam Capital Management, LP More: the full row for Kynam Capital Management, LP 2,000,000 $4.3M 0.27% 0 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 1,979,226 $4.26M <0.01% +646,312 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 1,865,526 $4.01M <0.01% +51,228 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 1,796,104 $3.86M <0.01% -435,067 13F-HR Timeline Group MEDICI CAPITAL LLC More: the full row for MEDICI CAPITAL LLC 1,652,520 $3.55M 4.97% +152,000 13F-HR Timeline Eversept Partners, LP More: the full row for Eversept Partners, LP 1,351,106 $2.9M 0.19% +344,943 13F-HR Timeline Euclidean Capital LLC More: the full row for Euclidean Capital LLC 1,307,858 $2.81M 0.72% 0 13F-HR Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 1,287,691 $2.77M <0.01% -255,959 13F-HR Timeline TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 1,279,306 $2.75M <0.01% +239,650 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 1,092,903 $2.35M <0.01% +57,749 13F-HR Timeline Group DEERFIELD MANAGEMENT COMPANY, L.P. in group DEERFIELD MANAGEMENT COMPANY,… More: the full row for DEERFIELD MANAGEMENT COMPANY, L.P. 1,055,192 $2.27M 0.03% 0 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 1,050,000 $2.26M 0.14% -58,000 13F-HR Timeline Group DAFNA Capital Management LLC More: the full row for DAFNA Capital Management LLC 908,351 $1.95M 0.44% 0 13F-HR Timeline Elmind Capital, LP More: the full row for Elmind Capital, LP 900,000 $1.94M 0.55% 0 13F-HR Timeline MACKENZIE FINANCIAL CORP More: the full row for MACKENZIE FINANCIAL CORP 857,354 $1.84M <0.01% +197,186 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 787,408 $1.69M <0.01% +121,917 13F-HR Timeline Group AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 711,334 $1.53M <0.01% +111,765 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 692,256 $1.49M <0.01% +104,603 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 620,424 $1.33M <0.01% -546,393 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 604,562 $1.3M <0.01% +166,603 13F-HR Timeline Group PANAGORA ASSET MANAGEMENT INC More: the full row for PANAGORA ASSET MANAGEMENT INC 590,388 $1.27M <0.01% -259,910 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 559,896 $1.2M 0.02% -32,943 13F-HR Timeline Group BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 559,726 $1.2M 0.03% 0 13F-HR Timeline Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 500,000 $1.07M 0.06% new 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 399,464 $859K <0.01% -594,449 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 380,908 $819K <0.01% +246,402 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 364,567 $784K <0.01% +45,495 13F-HR Timeline Group DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 283,817 $610K <0.01% +84,691 13F-HR Timeline Group AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 271,272 $583K <0.01% -83,027 13F-HR/A Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 265,067 $570K <0.01% -14,401 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 252,297 $542K <0.01% +34,435 13F-HR Timeline Group NANO CAP NEW MILLENNIUM GROWTH FUND L P More: the full row for NANO CAP NEW MILLENNIUM GROWTH FUND L P 200,000 $430K 0.4% 0 13F-HR Timeline CANADA PENSION PLAN INVESTMENT BOARD More: the full row for CANADA PENSION PLAN INVESTMENT BOARD 183,200 $394K <0.01% +10,900 13F-HR Timeline Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 154,930 $333K <0.01% +21,682 13F-HR Timeline Group Utah Retirement Systems More: the full row for Utah Retirement Systems 154,290 $332K <0.01% +20,572 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 145,344 $312K <0.01% +25,933 13F-HR Timeline Group BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 142,500 $306K 0.01% +27,500 13F-HR Timeline PUBLIC EMPLOYEES RETIREMENT SYSTEM OF O… More: the full row for PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO 136,000 $292K <0.01% 0 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 107,597 $231K <0.01% -183,583 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 101,327 $218K <0.01% -599 13F-HR Timeline Odyssean, LLC More: the full row for Odyssean, LLC 89,783 $193K 0.07% new 13F-HR Timeline STRS OHIO More: the full row for STRS OHIO 86,500 $186K <0.01% -23,900 13F-HR Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 80,091 $172K <0.01% +56,989 13F-HR Timeline Group GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 78,207 $168K 0.01% -147,359 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 77,545 $167K <0.01% -16,002 13F-HR Timeline Group Blackstone Inc. in group Blackstone Inc. More: the full row for Blackstone Inc. 77,145 $166K <0.01% +10,286 13F-HR Timeline Group The filing omitted confidential holdings, a later amendment may add them. Jasper Ridge Partners, L.P. More: the full row for Jasper Ridge Partners, L.P. 73,531 $158K <0.01% -21,537 13F-HR Timeline DZ BANK AG Deutsche Zentral Genossensch… in group DZ BANK AG Deutsche Zentral G… More: the full row for DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main 69,666 $150K <0.01% new 13F-HR Timeline Group SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 68,477 $147K <0.01% -13,540 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 92,940 $145K <0.01% 0 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 66,131 $142K <0.01% -5,756 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 56,100 $121K <0.01% -103 13F-HR Timeline Cannell & Spears LLC More: the full row for Cannell & Spears LLC 54,642 $117K <0.01% 0 13F-HR/A Timeline SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 53,846 $116K <0.01% +36,962 13F-HR Timeline Group HSBC HOLDINGS PLC in group HSBC HOLDINGS PLC More: the full row for HSBC HOLDINGS PLC 48,523 $105K <0.01% +2 13F-HR Timeline Group IEQ CAPITAL, LLC More: the full row for IEQ CAPITAL, LLC 47,080 $101K <0.01% new 13F-HR Timeline MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 42,661 $91.7K <0.01% +5,390 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 42,591 $91.6K <0.01% -356,096 13F-HR Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 36,208 $77.8K <0.01% new 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 37,379 $75.5K <0.01% +4,756 13F-HR/A Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 34,526 $74.2K <0.01% -55,582 13F-HR/A Timeline Group Vontobel Holding Ltd. in group Vontobel Holding Ltd. More: the full row for Vontobel Holding Ltd. 30,000 $64.5K <0.01% 0 13F-HR Timeline Group CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 28,985 $62.3K <0.01% +16,821 13F-HR Timeline Group Cerity Partners LLC in group Cerity Partners LLC More: the full row for Cerity Partners LLC 26,976 $58K <0.01% +13,294 13F-HR Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 26,148 $56.2K <0.01% -2,681 13F-HR Timeline Group DIVERSIFIED TRUST CO More: the full row for DIVERSIFIED TRUST CO 25,895 $55.7K <0.01% +11,793 13F-HR Timeline INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 23,954 $51.5K <0.01% -10,556 13F-HR Timeline PRUDENTIAL FINANCIAL INC in group PRUDENTIAL FINANCIAL INC More: the full row for PRUDENTIAL FINANCIAL INC 23,795 $51.2K <0.01% -8,430 13F-HR Timeline Group Verdad Advisers, LP More: the full row for Verdad Advisers, LP 23,554 $50.6K 0.06% new 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 23,426 $50.4K <0.01% 0 13F-HR Timeline WEALTH ENHANCEMENT ADVISORY SERVICES, L… More: the full row for WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 18,197 $43.9K <0.01% new 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 20,027 $43.1K <0.01% -2,358 13F-HR Timeline Group Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 19,486 $41.9K <0.01% -42,787 13F-HR Timeline Group Bronte Capital Management Pty Ltd. More: the full row for Bronte Capital Management Pty Ltd. 19,282 $41.5K <0.01% 0 13F-HR Timeline Mariner, LLC in group Mariner, LLC More: the full row for Mariner, LLC 18,799 $40.4K <0.01% new 13F-HR Timeline Group VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 15,478 $33.3K <0.01% +1,549 13F-HR Timeline Group NEUBERGER BERMAN GROUP LLC in group NEUBERGER BERMAN GROUP LLC More: the full row for NEUBERGER BERMAN GROUP LLC 14,528 $31.2K <0.01% +355 13F-HR Timeline Group HAMILTON LANE ADVISORS LLC More: the full row for HAMILTON LANE ADVISORS LLC 14,400 $31K 0.02% new 13F-HR Timeline ProShare Advisors LLC More: the full row for ProShare Advisors LLC 13,188 $28.4K <0.01% -1,484 13F-HR Timeline Merit Financial Group, LLC More: the full row for Merit Financial Group, LLC 10,928 $23.5K <0.01% new 13F-HR Timeline HighTower Advisors, LLC More: the full row for HighTower Advisors, LLC 10,760 $23.1K <0.01% +749 13F-HR Timeline CAPTRUST FINANCIAL ADVISORS More: the full row for CAPTRUST FINANCIAL ADVISORS 10,648 $22.9K <0.01% new 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 10,310 $22.2K <0.01% 0 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 8,346 $17.9K <0.01% +2,307 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 8,175 $17.6K <0.01% 0 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 7,047 $15K <0.01% +2,369 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 5,943 $12.8K <0.01% -33,577 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 4,894 $10.5K <0.01% -46 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 4,639 $9.97K <0.01% -1,516 13F-HR Timeline Group Essential Partners LLC More: the full row for Essential Partners LLC 3,857 $8.29K <0.01% +3,426 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 2,806 $6.03K <0.01% -1,615 13F-HR Timeline Optiver Holding B.V. in group Optiver Holding B.V. More: the full row for Optiver Holding B.V. 1,701 $3.66K <0.01% new 13F-HR/A Timeline Group State of Wyoming More: the full row for State of Wyoming 1,645 $3.54K <0.01% new 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 1,523 $3.27K <0.01% +448 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 1,016 $2.18K <0.01% 0 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 887 $1.91K <0.01% +383 13F-HR/A Timeline Group Physician Wealth Advisors, Inc. More: the full row for Physician Wealth Advisors, Inc. 752 $1.62K <0.01% 0 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 627 $1.35K <0.01% new 13F-HR Timeline True Wealth Design, LLC More: the full row for True Wealth Design, LLC 593 $1.27K <0.01% +30 13F-HR Timeline Federation des caisses Desjardins du Qu… More: the full row for Federation des caisses Desjardins du Quebec 415 $892 <0.01% 0 13F-HR Timeline Hughes Financial Services, LLC More: the full row for Hughes Financial Services, LLC 412 $886 <0.01% -141 13F-HR Timeline Wilmington Savings Fund Society, FSB More: the full row for Wilmington Savings Fund Society, FSB 400 $860 <0.01% 0 13F-HR Timeline Rockefeller Capital Management L.P. in group Rockefeller Capital Managemen… More: the full row for Rockefeller Capital Management L.P. 367 $789 <0.01% 0 13F-HR Timeline Group MARK SHEPTOFF FINANCIAL PLANNING, LLC More: the full row for MARK SHEPTOFF FINANCIAL PLANNING, LLC 300 $771 <0.01% 0 13F-HR Timeline Basecamp Wealth Advisors LLC More: the full row for Basecamp Wealth Advisors LLC 329 $707 <0.01% 0 13F-HR Timeline Root Financial Partners, LLC More: the full row for Root Financial Partners, LLC 305 $656 <0.01% new 13F-HR Timeline Advisory Services Network, LLC More: the full row for Advisory Services Network, LLC 271 $583 <0.01% new 13F-HR Timeline Fortitude Family Office, LLC More: the full row for Fortitude Family Office, LLC 255 $548 <0.01% new 13F-HR Timeline ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 240 $516 <0.01% +31 13F-HR Timeline NATIONAL BANK OF CANADA /FI/ in group NATIONAL BANK OF CANADA /FI/ More: the full row for NATIONAL BANK OF CANADA /FI/ 200 $430 <0.01% 0 13F-HR Timeline Group Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 156 $395 <0.01% new 13F-HR Timeline Arax Advisory Partners More: the full row for Arax Advisory Partners 179 $385 <0.01% new 13F-HR Timeline MAI Capital Management More: the full row for MAI Capital Management 67 $145 <0.01% new 13F-HR Timeline Lloyd Advisory Services, LLC. More: the full row for Lloyd Advisory Services, LLC. 48 $103 <0.01% new 13F-HR Timeline Kingdom Financial Group LLC. More: the full row for Kingdom Financial Group LLC. 48 $103 <0.01% 0 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 20 $43 <0.01% 0 13F-HR Timeline Sunbelt Securities, Inc. More: the full row for Sunbelt Securities, Inc. 17 $37 <0.01% new 13F-HR Timeline FIFTH THIRD BANCORP in group FIFTH THIRD BANK, NATIONAL AS… More: the full row for FIFTH THIRD BANCORP 6 $13 <0.01% new 13F-HR Timeline Group IFP Advisors, Inc More: the full row for IFP Advisors, Inc 6 $13 <0.01% -41 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 2 $4 <0.01% new 13F-HR Timeline