DAFNA Capital Management LLC

13F filer, CIK 1389933, LOS ANGELES, CA

DAFNA Capital Management LLC reported $423,312,439 across 84 holdings for the quarter ended 2024-09-30, in a 13F-HR filed 2024-11-14. Its ten largest share positions make up 48.91% of the portfolio.

Filed 2024-11-14 (acceptance time not in the bulk data set), ingested 2026-10-07 18:26:56 UTC13F-HR 0001389932-24-000020

Period: 2024-09-30
Reported value: $423M
Holdings: 84
Top 10 weight: 48.91%
New: 6
Sold out: 5

Largest buys vs the previous quarter

Security	Shares change	Approx. value
LXEOnew	+250,583	$2.27M
BLUEPRINT MEDICINES CORPadded	+17,000	$1.57M
IDYAadded	+49,197	$1.56M
ASNDadded	+8,600	$1.28M
GPCRadded	+29,000	$1.27M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

Security	Shares change	Approx. value
MORPHIC HLDG INCexited	-231,748	-$7.9M
XBIreduced	-43,500	-$4.3M
VKTXreduced	-63,501	-$4.02M
SNDXreduced	-130,372	-$2.51M
2SEVENTY BIO INC COMMON STO…reduced	-420,680	-$1.99M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q3 2024

Share positions as resolved from 13F-HR 0001389932-24-000020, largest first. % of portfolio is the value over $423,312,439, the sum of the share positions whose value is usable for ratios (method).

Security	Shares	Value	% of portfolio	Change	Timeline
XBISPDR SERIES TRUST	401,505	$39.7M	9.37%	-43,500	Timeline
STXSSTEREOTAXIS INC	13,680,554	$27.9M	6.59%	0	Timeline
RVMDREVOLUTION MEDICINES INC	517,994	$23.5M	5.55%	+6,100	Timeline
CYTKCYTOKINETICS INC	398,100	$21M	4.97%	0	Timeline
MERUS N VMERUS N V	412,573	$20.6M	4.87%	+3,128
ATRCATRICURE INC	641,673	$18M	4.25%	+2,500	Timeline
IDYAIDEAYA BIOSCIENCES INC	471,410	$14.9M	3.53%	+49,197	Timeline
IBBISHARES TR	102,500	$14.9M	3.53%	0	Timeline
ASNDASCENDIS PHARMA A/S	89,572	$13.4M	3.16%	+8,600	Timeline
AXGNAXOGEN INC	935,894	$13.1M	3.1%	0	Timeline
BLUEPRINT MEDICINES CORPBLUEPRINT MEDICINES CORP	121,763	$11.3M	2.66%	+17,000
XENEXENON PHARMACEUTICALS INC	273,739	$10.8M	2.55%	0	Timeline
DAWNDAY ONE BIOPHARMACEUTICALS I	750,363	$10.5M	2.47%	+83,900	Timeline
SNDXSYNDAX PHARMACEUTICALS INC	526,702	$10.1M	2.4%	-130,372	Timeline
BHVNBIOHAVEN LTD	187,130	$9.35M	2.21%	-31,600	Timeline
TNDMTANDEM DIABETES CARE INC	204,208	$8.66M	2.05%	0	Timeline
KALVKALVISTA PHARMACEUTICALS INC	723,678	$8.38M	1.98%	-83,295	Timeline
NBIXNEUROCRINE BIOSCIENCES INC	69,615	$8.02M	1.89%	-2,000	Timeline
KURAKURA ONCOLOGY INC	408,368	$7.98M	1.89%	-15,132	Timeline
VKTXVIKING THERAPEUTICS INC	125,616	$7.95M	1.88%	-63,501	Timeline
EWTXEDGEWISE THERAPEUTICS INC	227,906	$6.08M	1.44%	-62,291	Timeline
URGNUROGEN PHARMA LTD	458,915	$5.83M	1.38%	-10,085	Timeline
BCRXBIOCRYST PHARMACEUTICALS INC	667,000	$5.07M	1.2%	-37,500	Timeline
DXCMDEXCOM INC	65,552	$4.39M	1.04%	0	Timeline
KROSKEROS THERAPEUTICS INC	73,754	$4.28M	1.01%	+6,000	Timeline
ALECALECTOR INC	912,928	$4.25M	1%	0	Timeline
RCUSARCUS BIOSCIENCES INC	256,717	$3.93M	0.93%	+3,500	Timeline
LKFTLAKEFRONT BIOTHERAPEUTICS NV	130,175	$3.75M	0.89%	0	Timeline
PODDINSULET CORP	15,900	$3.7M	0.87%	0	Timeline
ALKSALKERMES PLC	120,700	$3.38M	0.8%	0	Timeline
LRMRLARIMAR THERAPEUTICS INC	494,274	$3.24M	0.76%	-145,700	Timeline
CATXPERSPECTIVE THERAPEUTICS INC	230,322	$3.07M	0.73%	-1,312	Timeline
2SEVENTY BIO INC COMMON STO…2SEVENTY BIO INC COMMON STOCK	630,029	$2.97M	0.7%	-420,680
ACELYRIN INCACELYRIN INC	602,894	$2.97M	0.7%	-90,715
ALLOALLOGENE THERAPEUTICS INC	1,050,118	$2.94M	0.69%	+445,018	Timeline
AQSTAQUESTIVE THERAPEUTICS INC	589,561	$2.94M	0.69%	+59,561	Timeline
IPSCCENTURY THERAPEUTICS INC	1,704,232	$2.91M	0.69%	0	Timeline
ASTRIA THERAPEUTICS INCASTRIA THERAPEUTICS INC	254,165	$2.8M	0.66%	-20,000
BCYCBICYCLE THERAPEUTICS PLC	122,200	$2.77M	0.65%	0	Timeline
STOKSTOKE THERAPEUTICS INC	207,427	$2.55M	0.6%	0	Timeline
BWAYBRAINSWAY LTD	251,346	$2.32M	0.55%	-46,309	Timeline
LXEOLEXEO THERAPEUTICS INC	250,583	$2.27M	0.54%	new	Timeline
ARAYACCURAY INC DEL	1,222,358	$2.2M	0.52%	0	Timeline
SPRYARS PHARMACEUTICALS INC	148,294	$2.15M	0.51%	-90,900	Timeline
INGNINOGEN INC	208,790	$2.03M	0.48%	0	Timeline
CNTACENTESSA PHARMACEUTICALS PLC	120,351	$1.92M	0.45%	-2,531	Timeline
MLYSMINERALYS THERAPEUTICS INC	146,500	$1.77M	0.42%	+27,500	Timeline
AUTLAUTOLUS THERAPEUTICS LTD	486,667	$1.77M	0.42%	+140,000	Timeline
IMTXIMMATICS N.V	145,000	$1.65M	0.39%	0	Timeline
ITEOS THERAPEUTICS INCITEOS THERAPEUTICS INC	161,584	$1.65M	0.39%	+17,224
PRQRPROQR THRAPEUTICS N V	905,582	$1.65M	0.39%	0	Timeline
CMPSCOMPASS PATHWAYS PLC	243,210	$1.53M	0.36%	0	Timeline
GPCRSTRUCTURE THERAPEUTICS INC	34,000	$1.49M	0.35%	+29,000	Timeline
IMVTIMMUNOVANT INC	51,996	$1.48M	0.35%	+4,080	Timeline
REGULUS THERAPEUTICS INCREGULUS THERAPEUTICS INC	895,200	$1.41M	0.33%	0
GOSSGOSSAMER BIO INC	1,419,262	$1.4M	0.33%	+10,000	Timeline
LCTXLINEAGE CELL THERAPEUTICS IN	1,350,708	$1.22M	0.29%	0	Timeline
MDWDMEDIWOUND LTD	64,479	$1.16M	0.28%	-60,000	Timeline
SUTRO BIOPHARMA INCSUTRO BIOPHARMA INC	329,579	$1.14M	0.27%	0
PYPDPOLYPID LTD	308,497	$1.06M	0.25%	+123,651	Timeline
NYXHNYXOAH S A	108,108	$1.03M	0.24%	0	Timeline
BNTXBIONTECH SE	8,500	$1.01M	0.24%	new	Timeline
ADICET BIO INCADICET BIO INC	600,000	$864K	0.2%	0
CGENCOMPUGEN LTD	447,202	$809K	0.19%	-15,000	Timeline
ACRVACRIVON THERAPEUTICS INC	112,414	$787K	0.19%	-8,937	Timeline
SAGE THERAPEUTICS INCSAGE THERAPEUTICS INC	108,200	$781K	0.18%	-8,000
GRALGRAIL INC	48,800	$671K	0.16%	new	Timeline
ADCTADC THERAPEUTICS SA	204,081	$643K	0.15%	0	Timeline
BDTXBLACK DIAMOND THERAPEUTICS I	125,000	$544K	0.13%	new	Timeline
Tourmaline Bio IncTourmaline Bio Inc	19,110	$491K	0.12%	-56,872
BIOMX INCBIOMX INC	401,136	$409K	0.1%	new
MASIMASIMO CORP	3,000	$400K	0.09%	0	Timeline
VSTMVERASTEM INC	127,700	$382K	0.09%	new	Timeline
APREAPREA THERAPEUTICS INC	137,174	$377K	0.09%	0	Timeline
FHTXFOGHORN THERAPEUTICS INC	37,664	$351K	0.08%	-4,186	Timeline
NGNENEUROGENE INC	7,775	$326K	0.08%	-3,225	Timeline
ADAPYADAPTIMMUNE THERAPEUTICS PLC S	341,064	$324K	0.08%	0	Timeline
ANROALTO NEUROSCIENCE INC	26,786	$306K	0.07%	-93,214	Timeline
STIMNEURONETICS INC	313,717	$238K	0.06%	0	Timeline
CMPXCOMPASS THERAPEUTICS INC	116,882	$215K	0.05%	0	Timeline
NEVRO CORPNEVRO CORP	38,000	$212K	0.05%	+10,000
SPROSPERO THERAPEUTICS INC	125,000	$168K	0.04%	0	Timeline
KARYOPHARM THERAPEUTICS INCKARYOPHARM THERAPEUTICS INC	192,678	$160K	0.04%	0

Principal amounts

Notes and convertibles filed as a face amount (PRN). A face amount is never added to a share count (H6).

Security	Type	Amount	Value	Change
ASCENDIS PHARMA A/SASCENDIS PHARMA A/S Convertible bond	principal	4,000,000	$4.68M	0

Sold out in Q3 2024

Positions in the previous quarter's report that this quarter's report no longer lists.

Security	Shares before	Value before	Type
MORPHIC HLDG INCMORPHIC HLDG INC	231,748	$7.9M	shares
PRCTPROCEPT BIOROBOTICS CORP	13,994	$855K	shares
SYRSSYROS PHARMACEUTICALS INC COM	135,850	$701K	shares
TERNTERNS PHARMACEUTICALS INC	86,000	$586K	shares
ORICORIC PHARMACEUTICALS INC	36,000	$255K	shares

How Q3 2024 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

Filing	Role	Amendment	Filed	Accepted	Ingested
13F-HR 0001389932-24-000020	base		2024-11-14	acceptance time not in the bulk data set	2026-10-07 18:26:56 UTC