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Disclosery

SPRO SPERO THERAPEUTICS INC

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COM (common), issuer CIK 1701108

57 managers (61 13F filers) reported a position in SPRO shares at 2026-06-30, 21,453,770 shares in all. 22 filers opened a position and 12 filers sold out during the quarter.

Managers
57
13F filers
61
New
22
Added
16
Reduced
6
Sold out
12
Shares held by filers
21,453,770

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q2 2026

Filers in the available 13F reports with a share position at 2026-06-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
GSK plc9,190,606$20.3M3.37%013F-HRTimeline
Pfizer Inc2,362,348$5.34M3.13%013F-HRTimeline
VANGUARD GROUP INCgroup of 3 filers holding2,349,320$5.19M+259,879Timeline
RENAISSANCE TECHNOLOGIES LLC947,904$2.09M<0.01%-241,33113F-HRTimeline
Alphabet Inc.in group Alphabet Inc.889,979$1.97M<0.01%013F-HRTimelineGroup
SUSQUEHANNA INTERNATIONAL GROUP, LLPgroup of 3 filers holding793,013$1.75M+459,898Timeline
BlackRock, Inc.in group BlackRock, Inc.594,404$1.31M<0.01%+161,20213F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC566,329$1.25M<0.01%+46,40713F-HRTimelineGroup
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC521,705$1.15M<0.01%new13F-HRTimelineGroup
TWO SIGMA INVESTMENTS, LPin group TWO SIGMA INVESTMENTS, LP382,814$846K<0.01%-502,81713F-HRTimelineGroup
ARROWSTREET CAPITAL, LIMITED PARTNERSHIPin group ARROWSTREET CAPITAL, LIMITED …332,970$736K<0.01%new13F-HRTimelineGroup
GSA CAPITAL PARTNERS LLP285,906$632K0.04%+7,60213F-HRTimeline
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP274,820$608K<0.01%+245,05213F-HRTimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC256,985$568K<0.01%new13F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP214,751$475K<0.01%013F-HRTimelineGroup
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC158,097$349K<0.01%+51,75213F-HRTimelineGroup
UBS Group AGin group UBS Group AG139,680$309K<0.01%+136,67113F-HRTimelineGroup
BRIDGEWAY CAPITAL MANAGEMENT, LLC114,800$254K<0.01%013F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP108,274$239K<0.01%-12,71013F-HRTimelineGroup
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.104,377$231K<0.01%+44,70913F-HRTimelineGroup
Ionic Capital Management LLC102,698$227K0.21%-93,24113F-HRTimeline
Federation des caisses Desjardins du Qu…91,900$202K<0.01%new13F-HRTimeline
Shay Capital LLC72,391$160K0.02%+2,03713F-HRTimeline
Invesco Ltd.in group Invesco Ltd.64,245$142K<0.01%+18,87113F-HRTimelineGroup
SIMPLEX TRADING, LLC61,312$135K<0.01%+31,00813F-HRTimeline
Verdad Advisers, LP51,335$113K0.11%+17,88013F-HRTimeline
XTX Topco Ltdin group XTX Topco Ltd50,536$112K<0.01%new13F-HRTimelineGroup
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC36,811$81.4K<0.01%new13F-HRTimelineGroup
Capital Asset Advisory Services LLC32,548$71.9K<0.01%013F-HRTimeline
AXXCESS WEALTH MANAGEMENT, LLC32,548$71.9K<0.01%new13F-HRTimeline
Three Seasons Wealth, LLC30,000$66.3K0.01%013F-HRTimeline
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co28,565$63.1K<0.01%013F-HRTimelineGroup
Global Retirement Partners, LLC25,000$55.2K<0.01%13F-HRTimeline
OPPENHEIMER & CO INCin group OPPENHEIMER ASSET MANAGEMENT …22,850$50.5K<0.01%new13F-HRTimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC19,298$42.6K<0.01%new13F-HRTimelineGroup
Assenagon Asset Management S.A.18,636$41.2K<0.01%013F-HR/ATimeline
DLK Investment Management, LLC31,355$40.8K0.02%new13F-HRTimeline
Qube Research & Technologies Ltd13,644$30.2K<0.01%new13F-HRTimeline
SG Americas Securities, LLC11,268$25K<0.01%new13F-HRTimeline
GROUP ONE TRADING LLC10,869$24K<0.01%new13F-HRTimeline
TWO SIGMA SECURITIES, LLC10,576$23.4K<0.01%new13F-HRTimeline
PRUDENTIAL FINANCIAL INCin group PRUDENTIAL FINANCIAL INC10,400$23K<0.01%new13F-HRTimelineGroup
CITIGROUP INCin group CITIGROUP INC9,625$21.3K<0.01%-9,51013F-HRTimelineGroup
FNY Investment Advisers, LLC8,300$18K0.01%+3,00013F-HRTimeline
JONES FINANCIAL COMPANIES LLLPin group JONES FINANCIAL COMPANIES LLLP7,678$17.4K<0.01%013F-HRTimelineGroup
Integrated Wealth Concepts LLC6,000$13.3K<0.01%new13F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA2,014$4K<0.01%new13F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY914$2.02K<0.01%-3,63813F-HRTimelineGroup
FMR LLCin group FMR LLC300$663<0.01%new13F-HRTimelineGroup
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.290$640<0.01%013F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO236$533<0.01%013F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN200$442<0.01%013F-HRTimelineGroup
Rialto Wealth Management, LLC172$381<0.01%new13F-HRTimeline
US BANCORP \DE\in group US BANCORP \DE\151$334<0.01%013F-HRTimelineGroup
SBI Securities Co., Ltd.13$29<0.01%+413F-HRTimeline
Farther Finance Advisors, LLC10$22<0.01%013F-HRTimeline
INTERNATIONAL ASSETS INVESTMENT MANAGEM…0$00%new13F-HRTimelineValue filed as zero, left out of ratios. Amount filed as zero, left out of ratios.