BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 4,439,265 $5.11M <0.01% -62,457 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 4,234,804 $4.87M 0.01% +2,452,797 13F-HR/A Timeline Group VANGUARD GROUP INC group of 2 filers holding More: the full row for VANGUARD GROUP INC 3,536,082 $4.07M +11,051 Timeline TANG CAPITAL MANAGEMENT LLC in group TANG CAPITAL MANAGEMENT LLC More: the full row for TANG CAPITAL MANAGEMENT LLC 3,100,000 $3.56M 0.2% 0 13F-HR Timeline Group Sio Capital Management, LLC More: the full row for Sio Capital Management, LLC 2,582,655 $2.97M 0.9% -1,464,142 13F-HR Timeline Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 2,000,000 $2.3M 0.16% 0 13F-HR Timeline Redmile Group, LLC in group Redmile Group, LLC More: the full row for Redmile Group, LLC 1,569,793 $1.81M 0.17% +1,445,615 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 1,463,103 $1.68M <0.01% +50,064 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 1,393,338 $1.6M <0.01% -3,088,129 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 1,244,452 $1.43M <0.01% +29,540 13F-HR Timeline Group Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 1,217,590 $1.4M 0.46% +125,000 13F-HR Timeline Group Monaco Asset Management SAM More: the full row for Monaco Asset Management SAM 1,134,444 $1.3M 0.66% +894,444 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 1,044,141 $1.2M <0.01% +115,552 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 1,016,649 $1.17M <0.01% -3,256,793 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 1,016,389 $1.17M <0.01% +391,889 13F-HR Timeline SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 1,012,749 $1.16M 0.29% 0 13F-HR Timeline Group AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 880,222 $1.01M <0.01% +794,401 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 876,161 $1.01M <0.01% -1,634,715 13F-HR Timeline Group Connor, Clark & Lunn Investment Managem… More: the full row for Connor, Clark & Lunn Investment Management Ltd. 871,605 $1M <0.01% +78 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 593,248 $682K <0.01% -917,509 13F-HR/A Timeline Group ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 537,054 $614K <0.01% +438,286 13F-HR Timeline Group Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 504,245 $580K 0.01% +26,457 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 480,331 $552K <0.01% -5,333 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 454,606 $523K +103,023 Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 448,345 $516K <0.01% -40,372 13F-HR/A Timeline Group MACQUARIE GROUP LTD in group MACQUARIE GROUP LTD More: the full row for MACQUARIE GROUP LTD 430,000 $495K <0.01% 0 13F-HR/A Timeline Group QIMING U.S. VENTURES MANAGEMENT, LLC More: the full row for QIMING U.S. VENTURES MANAGEMENT, LLC 412,225 $474K 2.05% 0 13F-HR Timeline BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 352,865 $406K 0.01% +37,974 13F-HR Timeline TCG Crossover Management, LLC More: the full row for TCG Crossover Management, LLC 316,195 $364K 0.05% 0 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 309,612 $356K <0.01% -3,472,971 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 281,600 $324K 0.06% +157,070 13F-HR Timeline Group WEXFORD CAPITAL LP More: the full row for WEXFORD CAPITAL LP 279,231 $321K 0.08% -119,232 13F-HR Timeline CIBC WORLD MARKET INC. More: the full row for CIBC WORLD MARKET INC. 272,500 $313K <0.01% +205,000 13F-HR Timeline Shay Capital LLC More: the full row for Shay Capital LLC 261,524 $301K 0.09% +136,909 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 226,310 $260K <0.01% -1,055,319 13F-HR Timeline Group Graham Capital Management, L.P. More: the full row for Graham Capital Management, L.P. 217,646 $250K 0.01% new 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 208,656 $240K <0.01% -4,584 13F-HR Timeline TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 196,529 $226K -1,080,562 Timeline IEQ CAPITAL, LLC More: the full row for IEQ CAPITAL, LLC 194,189 $223K <0.01% new 13F-HR Timeline DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 191,840 $221K <0.01% +33,552 13F-HR Timeline Group Opaleye Management Inc. More: the full row for Opaleye Management Inc. 190,000 $218K 0.05% -90,000 13F-HR Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 175,112 $201K <0.01% -1,841 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 168,420 $194K <0.01% 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 134,610 $155K <0.01% +8,467 13F-HR Timeline Group HighTower Advisors, LLC More: the full row for HighTower Advisors, LLC 123,271 $142K <0.01% +18,985 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 117,062 $135K <0.01% -28,562 13F-HR Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 101,330 $117K <0.01% 0 13F-HR Timeline BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 98,600 $113K <0.01% -106,900 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 95,686 $111K <0.01% +54,400 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 85,928 $98.8K <0.01% -46,897 13F-HR/A Timeline RBF Capital, LLC More: the full row for RBF Capital, LLC 72,490 $83.4K 0.01% new 13F-HR Timeline D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 66,193 $76.1K <0.01% +13,962 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 61,363 $70.6K <0.01% -30,306 13F-HR/A Timeline Group Cutter & CO Brokerage, Inc. More: the full row for Cutter & CO Brokerage, Inc. 54,000 $62.1K 0.01% new 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 53,088 $61K <0.01% +50,193 13F-HR Timeline Group Cerity Partners LLC in group Cerity Partners LLC More: the full row for Cerity Partners LLC 49,106 $56.5K <0.01% new 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 48,951 $56.3K <0.01% -50,472 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 48,635 $55.9K <0.01% new 13F-HR/A Timeline Group INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 46,815 $53.8K <0.01% +15,404 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 45,052 $51.8K <0.01% -11,952 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 43,066 $49.5K <0.01% +5,943 13F-HR Timeline Group Velan Capital Investment Management LP More: the full row for Velan Capital Investment Management LP 40,000 $46K 0.05% +5,000 13F-HR Timeline BROWN ADVISORY INC in group BROWN ADVISORY INC More: the full row for BROWN ADVISORY INC 37,160 $42.7K <0.01% 0 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 36,978 $42.5K <0.01% -4,192 13F-HR Timeline Group MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 36,438 $41.9K <0.01% +1,560 13F-HR Timeline Group SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 35,764 $41.1K <0.01% 0 13F-HR/A Timeline Group SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 35,896 $41K <0.01% +10,746 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 30,328 $34.9K <0.01% 0 13F-HR Timeline Group Corebridge Financial, Inc. in group Corebridge Financial, Inc. More: the full row for Corebridge Financial, Inc. 29,774 $34.2K <0.01% -441 13F-HR Timeline Group Birchview Capital, LP More: the full row for Birchview Capital, LP 28,800 $33.1K 0.03% 0 13F-HR Timeline Palumbo Wealth Management LLC More: the full row for Palumbo Wealth Management LLC 26,498 $30.5K 0.01% +2,566 13F-HR Timeline ALGERT GLOBAL LLC More: the full row for ALGERT GLOBAL LLC 26,490 $30.5K <0.01% 0 13F-HR/A Timeline TWO SIGMA SECURITIES, LLC More: the full row for TWO SIGMA SECURITIES, LLC 24,855 $28.6K <0.01% new 13F-HR Timeline WEALTH ENHANCEMENT ADVISORY SERVICES, L… More: the full row for WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 24,483 $28.2K <0.01% new 13F-HR Timeline STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 24,300 $27.9K <0.01% -34,600 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 23,753 $27.3K <0.01% +258 13F-HR Timeline Group Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 21,148 $24.5K <0.01% new 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 18,974 $21.8K <0.01% 0 13F-HR/A Timeline VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 18,078 $20.8K <0.01% -1,130 13F-HR/A Timeline Group LPL Financial LLC More: the full row for LPL Financial LLC 18,029 $20.7K <0.01% +7,000 13F-HR Timeline Mariner, LLC in group Mariner, LLC More: the full row for Mariner, LLC 16,855 $19.4K <0.01% -5,250 13F-HR Timeline Group Farringdon Capital, Ltd. More: the full row for Farringdon Capital, Ltd. 16,461 $18.9K 0.01% new 13F-HR Timeline CIBC WORLD MARKETS CORP More: the full row for CIBC WORLD MARKETS CORP 13,485 $15.5K <0.01% new 13F-HR Timeline ProShare Advisors LLC More: the full row for ProShare Advisors LLC 13,156 $15.1K <0.01% -3,960 13F-HR Timeline Simplicity Wealth,LLC More: the full row for Simplicity Wealth,LLC 12,127 $13.9K <0.01% new 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 12,120 $13.9K <0.01% 0 13F-HR Timeline Avestar Capital, LLC More: the full row for Avestar Capital, LLC 11,412 $13.1K <0.01% 0 13F-HR Timeline FNY Investment Advisers, LLC More: the full row for FNY Investment Advisers, LLC 10,000 $11K 0.01% 0 13F-HR Timeline FEDERATED HERMES, INC. in group FEDERATED HERMES, INC. More: the full row for FEDERATED HERMES, INC. 9,495 $10.9K <0.01% new 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 8,427 $9.69K <0.01% +519 13F-HR Timeline Group GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 8,116 $9.33K <0.01% -26,733 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 5,981 $6.91K <0.01% 0 13F-HR Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 4,771 $5.49K <0.01% +4,375 13F-HR Timeline Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 4,650 $5.35K <0.01% 0 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 4,404 $5.07K <0.01% 0 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 4,454 $5K <0.01% -23,692 13F-HR/A Timeline Group Asset Dedication, LLC More: the full row for Asset Dedication, LLC 4,116 $4.73K <0.01% 0 13F-HR Timeline Fortitude Family Office, LLC More: the full row for Fortitude Family Office, LLC 3,177 $3.65K <0.01% 0 13F-HR Timeline UMB Bank, n.a. More: the full row for UMB Bank, n.a. 2,000 $2.3K <0.01% 0 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 1,969 $2.26K <0.01% +1,935 13F-HR Timeline Group SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 2,513 $2K <0.01% -147,041 13F-HR Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 1,594 $2K <0.01% 0 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 1,552 $1.78K <0.01% +1,262 13F-HR Timeline Group Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 1,092 $1.26K <0.01% -972 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 1,013 $1.17K <0.01% +447 13F-HR Timeline True Wealth Design, LLC More: the full row for True Wealth Design, LLC 832 $957 <0.01% +814 13F-HR Timeline Optiver Holding B.V. in group Optiver Holding B.V. More: the full row for Optiver Holding B.V. 806 $927 <0.01% -234 13F-HR Timeline Group Clearstead Advisors, LLC More: the full row for Clearstead Advisors, LLC 500 $575 <0.01% 0 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 387 $445 <0.01% new 13F-HR Timeline Group Rise Advisors, LLC More: the full row for Rise Advisors, LLC 327 $376 <0.01% new 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 138 $159 <0.01% 0 13F-HR Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 100 $107 <0.01% -639 13F-HR Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 7 $8 <0.01% 0 13F-HR Timeline Covestor Ltd More: the full row for Covestor Ltd 30 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.