FMR LLC in group FMR LLC More: the full row for FMR LLC 2,816,494 $87.1M <0.01% +9,052 13F-HR Timeline Group TCG Crossover Management, LLC More: the full row for TCG Crossover Management, LLC 1,204,891 $37.2M 1.07% new 13F-HR Timeline Aberdeen Group plc in group Aberdeen Group plc More: the full row for Aberdeen Group plc 1,141,824 $35.3M 0.06% 0 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 860,352 $26.6M <0.01% +5,989 13F-HR Timeline Group BRAIDWELL LP More: the full row for BRAIDWELL LP 847,151 $26.2M 0.87% -80,373 13F-HR Timeline First Light Asset Management, LLC More: the full row for First Light Asset Management, LLC 647,743 $20M 1.79% new 13F-HR Timeline VANGUARD GROUP INC group of 4 filers holding More: the full row for VANGUARD GROUP INC 608,998 $18.8M new Timeline BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 607,788 $18.8M 0.11% -295,612 13F-HR Timeline Group 5AM Venture Management, LLC More: the full row for 5AM Venture Management, LLC 606,660 $18.8M 5.21% 0 13F-HR Timeline Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 328,000 $10.1M 0.28% 0 13F-HR Timeline Bollard Group LLC More: the full row for Bollard Group LLC 302,953 $9.36M 0.29% 0 13F-HR Timeline KENNEDY CAPITAL MANAGEMENT LLC More: the full row for KENNEDY CAPITAL MANAGEMENT LLC 286,682 $8.86M 0.19% +77,457 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 268,273 $8.29M <0.01% +4,713 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 229,595 $7.1M 0.01% +198,677 13F-HR Timeline Group ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 226,600 $7M 0.15% -348,000 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 213,505 $6.6M <0.01% +4,380 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 164,419 $5.08M 0.01% -35,227 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 164,055 $5.07M <0.01% new 13F-HR Timeline Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 157,537 $4.87M 0.7% new 13F-HR Timeline Group AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 143,432 $4.43M <0.01% new 13F-HR/A Timeline Group Opaleye Management Inc. More: the full row for Opaleye Management Inc. 123,000 $3.8M 0.5% -91,747 13F-HR Timeline Soleus Capital Management, L.P. More: the full row for Soleus Capital Management, L.P. 121,684 $3.76M 0.15% new 13F-HR Timeline D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 116,120 $3.59M <0.01% -4,130 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 112,664 $3.48M <0.01% -7,747 13F-HR/A Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 100,000 $3.09M 0.01% -100,000 13F-HR/A Timeline ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 83,679 $2.59M 0.03% -27,509 13F-HR Timeline Prosight Management, LP More: the full row for Prosight Management, LP 79,872 $2.47M 0.4% -155,128 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 78,353 $2.42M <0.01% +6,098 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 68,598 $2.12M <0.01% -423,734 13F-HR Timeline Group Connor, Clark & Lunn Investment Managem… More: the full row for Connor, Clark & Lunn Investment Management Ltd. 66,994 $2.07M <0.01% -4,663 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 64,848 $2M <0.01% -29,587 13F-HR Timeline Group RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 64,196 $1.98M <0.01% +9,595 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 62,426 $1.93M <0.01% -30,277 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 58,348 $1.8M <0.01% -242,472 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 58,870 $1.7M <0.01% +53,091 13F-HR/A Timeline Group BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 46,137 $1.43M 0.03% new 13F-HR Timeline PFM Health Sciences, LP More: the full row for PFM Health Sciences, LP 46,129 $1.43M 0.15% +3,405 13F-HR Timeline Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 43,098 $1.33M 0.02% +3,598 13F-HR Timeline Group Tetragon Partners GP Ltd in group Tetragon Partners GP Ltd More: the full row for Tetragon Partners GP Ltd 37,588 $1.16M 0.23% new 13F-HR Timeline Group Aldebaran Capital, LLC More: the full row for Aldebaran Capital, LLC 37,184 $1.15M 0.88% -169 13F-HR Timeline SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 36,870 $1.14M <0.01% +21,619 13F-HR Timeline Group UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 30,369 $939K -1,019 Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 29,240 $904K <0.01% -8,139 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 29,110 $900K <0.01% -3,351 13F-HR Timeline Group Clearstead Advisors, LLC More: the full row for Clearstead Advisors, LLC 26,760 $827K 0.01% +20,260 13F-HR Timeline MONIMUS CAPITAL MANAGEMENT, LP More: the full row for MONIMUS CAPITAL MANAGEMENT, LP 26,753 $827K 0.23% +159 13F-HR Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 24,760 $765K <0.01% -1,098 13F-HR Timeline Group TD Asset Management Inc More: the full row for TD Asset Management Inc 20,400 $631K <0.01% new 13F-HR Timeline SECTORAL ASSET MANAGEMENT INC More: the full row for SECTORAL ASSET MANAGEMENT INC 19,059 $628K 0.52% -23,196 13F-HR Timeline GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 18,873 $583K 0.04% -44,403 13F-HR Timeline AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 16,934 $523K <0.01% new 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 16,175 $500K <0.01% -135,538 13F-HR Timeline Group ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 15,286 $472K <0.01% -83 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 14,027 $434K <0.01% -169 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 13,929 $431K <0.01% new 13F-HR Timeline Group Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 13,799 $427K 0.12% +337 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 13,001 $402K 0.02% -17,006 13F-HR Timeline Group AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 12,534 $387K <0.01% new 13F-HR Timeline Group Creative Planning in group Creative Planning More: the full row for Creative Planning 12,446 $385K <0.01% new 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 12,033 $372K <0.01% -2,271 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 11,621 $359K 0.01% new 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 11,466 $354K <0.01% +2,241 13F-HR Timeline Group DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 10,077 $311K <0.01% +2 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 9,345 $289K <0.01% +1,756 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 7,675 $237K <0.01% new 13F-HR Timeline Group AlphaCentric Advisors LLC More: the full row for AlphaCentric Advisors LLC 6,849 $212K 0.21% +373 13F-HR Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 6,724 $208K <0.01% 0 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 6,706 $207K <0.01% -15,737 13F-HR Timeline Group China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 6,332 $196K 0.01% +282 13F-HR Timeline Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 6,194 $191K +206 Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 5,000 $155K <0.01% 0 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 4,600 $142K <0.01% -400 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 2,816 $87K <0.01% -3 13F-HR Timeline Group Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 2,638 $81.5K <0.01% 0 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 1,829 $56.5K <0.01% +1,363 13F-HR Timeline Group Caption Management, LLC More: the full row for Caption Management, LLC 1,449 $44.8K <0.01% new 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 1,351 $41.8K <0.01% -7,791 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 1,147 $35.5K <0.01% +114 13F-HR Timeline Group US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 1,136 $35.1K <0.01% +1,099 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 1,122 $34.7K <0.01% 0 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 1,000 $30.9K <0.01% -50 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 914 $28.3K <0.01% +162 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 851 $26.3K <0.01% -78 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 595 $18.4K <0.01% -81 13F-HR Timeline HighMark Wealth Management LLC More: the full row for HighMark Wealth Management LLC 587 $18.1K 0.01% 0 13F-HR Timeline Federation des caisses Desjardins du Qu… More: the full row for Federation des caisses Desjardins du Quebec 500 $15.5K <0.01% 0 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 415 $12.8K <0.01% +48 13F-HR Timeline Rockefeller Capital Management L.P. in group Rockefeller Capital Managemen… More: the full row for Rockefeller Capital Management L.P. 370 $11.4K <0.01% new 13F-HR Timeline Group GAMMA Investing LLC More: the full row for GAMMA Investing LLC 330 $10.2K <0.01% +301 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 313 $9.68K <0.01% -224 13F-HR Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 102 $3.14K <0.01% -271 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 65 $2.01K <0.01% +3 13F-HR Timeline Marshall & Sterling Wealth Advisors Inc. More: the full row for Marshall & Sterling Wealth Advisors Inc. 50 $1.55K <0.01% new 13F-HR Timeline Essential Partners LLC More: the full row for Essential Partners LLC 37 $1.14K <0.01% new 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 26 $804 <0.01% new 13F-HR Timeline Group Caldwell Trust Co More: the full row for Caldwell Trust Co 20 $618 <0.01% 0 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 19 $588 <0.01% +17 13F-HR/A Timeline Group Global Wealth Strategies & Associates More: the full row for Global Wealth Strategies & Associates 18 $556 <0.01% 0 13F-HR Timeline Fortitude Family Office, LLC More: the full row for Fortitude Family Office, LLC 15 $464 <0.01% new 13F-HR Timeline HUNTINGTON NATIONAL BANK in group HUNTINGTON NATIONAL BANK More: the full row for HUNTINGTON NATIONAL BANK 13 $402 <0.01% new 13F-HR Timeline Group ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 11 $340 <0.01% new 13F-HR Timeline Sunbelt Securities, Inc. More: the full row for Sunbelt Securities, Inc. 8 $247 <0.01% +3 13F-HR Timeline MAI Capital Management More: the full row for MAI Capital Management 7 $217 <0.01% new 13F-HR Timeline True Wealth Design, LLC More: the full row for True Wealth Design, LLC 7 $217 <0.01% +2 13F-HR Timeline Root Financial Partners, LLC More: the full row for Root Financial Partners, LLC 5 $155 <0.01% new 13F-HR Timeline Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 3 $93 <0.01% -161 13F-HR Timeline