Vivo Capital, LLC More: the full row for Vivo Capital, LLC 11,420,000 $43.7M 3.64% 0 13F-HR/A Timeline Caligan Partners LP More: the full row for Caligan Partners LP 7,967,207 $30.5M 2.16% new 13F-HR Timeline PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 6,431,743 $24.6M 0.49% +5,628,533 13F-HR/A Timeline Group RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 4,401,500 $16.9M 0.18% 0 13F-HR Timeline Group Commodore Capital LP in group Commodore Capital LP More: the full row for Commodore Capital LP 4,401,500 $16.9M 0.98% 0 13F-HR Timeline Group Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 3,760,439 $14.4M 0.03% +3,285,000 13F-HR Timeline Group ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 3,405,553 $13M 0.02% new 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 3,032,697 $11.6M 0.01% +2,708,607 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 2,851,791 $10.9M 0.04% +910 13F-HR/A Timeline VANGUARD GROUP INC group of 3 filers holding More: the full row for VANGUARD GROUP INC 2,703,208 $10.4M new Timeline Spruce Street Capital LP More: the full row for Spruce Street Capital LP 2,198,502 $8.42M 2.02% 0 13F-HR Timeline Sessa Capital IM, L.P. More: the full row for Sessa Capital IM, L.P. 2,198,457 $8.42M 0.16% 0 13F-HR Timeline BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 1,481,660 $5.67M 0.13% new 13F-HR Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 1,476,106 $5.65M <0.01% +1,192,461 13F-HR/A Timeline Group Ensign Peak Advisors, Inc More: the full row for Ensign Peak Advisors, Inc 1,375,610 $5.27M 0.01% new 13F-HR/A Timeline Soleus Capital Management, L.P. More: the full row for Soleus Capital Management, L.P. 1,050,000 $4.02M 0.16% new 13F-HR Timeline Propel Bio Management, LLC More: the full row for Propel Bio Management, LLC 1,012,790 $3.89M 2.45% +359,909 13F-HR Timeline Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 903,094 $3.46M 0.04% +322,766 13F-HR Timeline Group Blackstone Inc. in group Blackstone Inc. More: the full row for Blackstone Inc. 860,170 $3.29M 0.01% -1,283,415 13F-HR Timeline Group The filing omitted confidential holdings, a later amendment may add them. ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 768,627 $2.94M 0.03% +682,514 13F-HR Timeline Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 575,000 $2.2M 0.13% new 13F-HR Timeline Monashee Investment Management LLC More: the full row for Monashee Investment Management LLC 500,000 $1.92M 1.04% new 13F-HR Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 463,925 $1.78M <0.01% +227,465 13F-HR Timeline Group AWM Investment Company, Inc. More: the full row for AWM Investment Company, Inc. 400,000 $1.53M 0.17% +200,000 13F-HR Timeline DV Trading LLC More: the full row for DV Trading LLC 400,000 $1.53M 0.14% new 13F-HR Timeline STEMPOINT CAPITAL LP More: the full row for STEMPOINT CAPITAL LP 375,000 $1.44M 0.28% +228,442 13F-HR/A Timeline HB Wealth Management, LLC More: the full row for HB Wealth Management, LLC 307,500 $1.18M 0.01% 0 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 302,036 $1.16M <0.01% +182,519 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 301,326 $1.15M <0.01% +284,087 13F-HR Timeline Group SEVEN GRAND MANAGERS, LLC More: the full row for SEVEN GRAND MANAGERS, LLC 275,000 $1.05M 0.07% new 13F-HR Timeline Simplify Asset Management Inc. More: the full row for Simplify Asset Management Inc. 187,230 $717K 0.01% -20,997 13F-HR Timeline TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 181,185 $694K <0.01% new 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 113,940 $436K <0.01% +62,592 13F-HR Timeline Group Seven Fleet Capital Management LP More: the full row for Seven Fleet Capital Management LP 100,000 $383K 0.12% new 13F-HR/A Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 74,231 $284K <0.01% +61,109 13F-HR Timeline Group Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 69,732 $267K 0.1% +49,942 13F-HR Timeline Kestra Advisory Services, LLC in group Kestra Advisory Services, LLC More: the full row for Kestra Advisory Services, LLC 61,741 $236K <0.01% +50,191 13F-HR Timeline Group Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 59,161 $227K <0.01% new 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 57,426 $220K <0.01% +41,014 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 55,697 $213K <0.01% +45,084 13F-HR Timeline Group Pathstone Holdings, LLC in group Pathstone Holdings, LLC More: the full row for Pathstone Holdings, LLC 50,650 $194K <0.01% 0 13F-HR Timeline Group Stonepine Capital Management, LLC More: the full row for Stonepine Capital Management, LLC 50,000 $192K 0.17% new 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 46,623 $179K <0.01% +39,225 13F-HR Timeline Group FIFTH LANE CAPITAL, LP More: the full row for FIFTH LANE CAPITAL, LP 46,500 $178K 0.22% +31,500 13F-HR Timeline COMMONWEALTH EQUITY SERVICES, LLC More: the full row for COMMONWEALTH EQUITY SERVICES, LLC 46,455 $178K <0.01% new 13F-HR Timeline Virtu Financial LLC in group Virtu Financial LLC More: the full row for Virtu Financial LLC 37,943 $145K 0.01% new 13F-HR Timeline Group AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 37,455 $143K <0.01% new 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 36,805 $141K <0.01% +6,831 13F-HR Timeline Group Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 35,264 $135K <0.01% new 13F-HR Timeline Group PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 34,124 $131K 0.01% new 13F-HR Timeline OMERS ADMINISTRATION Corp More: the full row for OMERS ADMINISTRATION Corp 29,700 $114K <0.01% -12,300 13F-HR Timeline Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 24,098 $92.3K <0.01% -7,049 13F-HR Timeline First PREMIER Bank More: the full row for First PREMIER Bank 18,986 $73K 0.02% 0 13F-HR Timeline Diametric Capital, LP More: the full row for Diametric Capital, LP 16,292 $62.4K 0.02% new 13F-HR Timeline Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 16,100 $61.7K <0.01% new 13F-HR Timeline Group Catalyst Funds Management Pty Ltd More: the full row for Catalyst Funds Management Pty Ltd 15,100 $57.8K 0.01% new 13F-HR Timeline Focus Partners Wealth in group Focus Partners Wealth More: the full row for Focus Partners Wealth 14,036 $53.8K <0.01% -5,165 13F-HR Timeline Group Miller Capital Partners, Inc. More: the full row for Miller Capital Partners, Inc. 12,870 $49.3K 0.02% new 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 11,911 $45.6K <0.01% +7,649 13F-HR Timeline Group Scientech Research LLC More: the full row for Scientech Research LLC 10,816 $41.4K 0.03% new 13F-HR Timeline State of Wyoming More: the full row for State of Wyoming 7,899 $30.3K <0.01% -1,072 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 7,775 $29.8K <0.01% +2,751 13F-HR Timeline Group PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 7,700 $29.5K <0.01% new 13F-HR Timeline Group Plante Moran Financial Advisors, LLC More: the full row for Plante Moran Financial Advisors, LLC 5,925 $22.7K <0.01% new 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 4,713 $18.1K <0.01% new 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 3,269 $12.5K <0.01% new 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 889 $3.4K <0.01% new 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 496 $1.9K <0.01% new 13F-HR Timeline Group MAI Capital Management More: the full row for MAI Capital Management 217 $832 <0.01% 0 13F-HR Timeline GS Investments, Inc. More: the full row for GS Investments, Inc. 200 $766 <0.01% 0 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 161 $617 <0.01% new 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 87 $329 <0.01% -1,903 13F-HR/A Timeline Group HARBOUR INVESTMENTS, INC. More: the full row for HARBOUR INVESTMENTS, INC. 50 $192 <0.01% 0 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 1 $0 0% new 13F-HR Timeline Group Value filed as zero, left out of ratios.