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Disclosery

PYXS PYXIS ONCOLOGY INC

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Stock (common), issuer CIK 1782223

72 managers (73 13F filers) reported a position in PYXS shares at 2025-09-30, 26,829,632 shares in all. 14 filers opened a position and 15 filers sold out during the quarter.

Managers
72
13F filers
73
New
14
Added
11
Reduced
31
Sold out
15
Shares held by filers
26,829,632

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

Each filer's latest stake. The shares are the aggregate the reporting persons state, which can include entities that file no 13F.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q3 2025

Filers in the available 13F reports with a share position at 2025-09-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
Pfizer Inc7,032,770$15.6M3.57%013F-HRTimeline
Laurion Capital Management LP3,625,974$8.05M1.1%013F-HRTimeline
TANG CAPITAL MANAGEMENT LLCin group TANG CAPITAL MANAGEMENT LLC2,500,000$5.55M0.21%013F-HRTimelineGroup
VANGUARD GROUP INCin group VANGUARD GROUP INC2,163,962$4.8M<0.01%+14,56613F-HRTimelineGroup
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC1,178,307$2.62M0.08%new13F-HRTimelineGroup
Palo Alto Investors LP1,037,421$2.3M0.43%013F-HRTimeline
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC815,331$1.81M<0.01%-2,724,52913F-HRTimelineGroup
STEMPOINT CAPITAL LP689,538$1.53M0.31%new13F-HRTimeline
BlackRock, Inc.in group BlackRock, Inc.683,702$1.52M<0.01%-243,10313F-HRTimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/615,922$1.37M<0.01%+593,85313F-HR/ATimelineGroup
RENAISSANCE TECHNOLOGIES LLC576,336$1.28M<0.01%+158,51413F-HRTimeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC544,508$1.21M<0.01%+33,54513F-HRTimelineGroup
683 Capital Management, LLCin group 683 Capital Management, LLC525,000$1.17M0.11%-20,00013F-HRTimelineGroup
Longaeva Partners L.P.503,214$1.12M0.24%new13F-HRTimeline
Driehaus Capital Management LLC418,632$929K0.01%new13F-HRTimeline
UBS Group AGin group UBS Group AG373,727$830K<0.01%-22,36913F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC337,359$749K<0.01%new13F-HRTimelineGroup
Decheng Capital LLC326,810$726K0.13%013F-HRTimeline
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC303,700$674K<0.01%-32,38413F-HRTimelineGroup
SCHULHOFF & CO INC275,000$610K0.26%013F-HRTimeline
NewEdge Wealth, LLC116,006$454K0.01%013F-HRTimeline
STATE STREET CORPin group STATE STREET CORP202,055$449K<0.01%+16,00013F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp165,044$366K<0.01%013F-HRTimelineGroup
PIER 88 INVESTMENT PARTNERS LLC151,730$337K0.06%-215,44013F-HRTimeline
DIADEMA PARTNERS LP150,000$333K0.23%new13F-HRTimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…137,531$305K<0.01%+23,17213F-HRTimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC125,454$279K<0.01%-98,82013F-HRTimelineGroup
Walleye Capital LLCin group Walleye Capital LLC119,561$265K<0.01%new13F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY106,607$237K<0.01%-53,56713F-HR/ATimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP100,773$224K<0.01%-1,44313F-HRTimelineGroup
TWO SIGMA INVESTMENTS, LPgroup of 2 filers holding99,025$220KnewTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA77,980$173K<0.01%-8,38513F-HRTimelineGroup
BRIDGEWAY CAPITAL MANAGEMENT, LLC76,700$170K<0.01%-65,59513F-HRTimeline
Cable Car Capital, LP61,606$137K0.06%013F-HRTimeline
COMMONWEALTH EQUITY SERVICES, LLC61,155$136K<0.01%013F-HRTimeline
JACOBS LEVY EQUITY MANAGEMENT, INC60,333$134K<0.01%new13F-HRTimeline
Velan Capital Investment Management LP55,000$122K0.11%+15,00013F-HRTimeline
UNIVERSITY OF CHICAGO48,731$108K0.05%013F-HRTimeline
ACADIAN ASSET MANAGEMENT LLCin group ACADIAN ASSET MANAGEMENT LLC43,082$94K<0.01%+24,14013F-HRTimelineGroup
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP36,516$81.1K<0.01%013F-HRTimelineGroup
Persistent Asset Partners Ltd34,632$76.9K0.06%new13F-HR/ATimeline
Cubist Systematic Strategies, LLC33,061$73.4K<0.01%new13F-HRTimeline
Qube Research & Technologies Ltd30,808$68.4K<0.01%-72,25513F-HRTimeline
Cetera Investment Advisers27,760$61.6K<0.01%-1,00013F-HRTimeline
Point72 Asia (Singapore) Pte. Ltd.18,057$40.1K0.01%-1,17113F-HRTimeline
XTX Topco Ltdin group XTX Topco Ltd17,699$39.3K<0.01%-18,68113F-HRTimelineGroup
PRUDENTIAL FINANCIAL INCin group PRUDENTIAL FINANCIAL INC16,300$36.2K<0.01%new13F-HRTimelineGroup
FMR LLCin group FMR LLC15,455$34.3K<0.01%-79,39113F-HRTimelineGroup
HRT FINANCIAL LP15,398$34K<0.01%-35,27013F-HRTimeline
LPL Financial LLC14,002$31.1K<0.01%-19713F-HRTimeline
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC13,832$30.7K<0.01%-72,93113F-HRTimelineGroup
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…12,982$28.8K<0.01%-1,67513F-HRTimelineGroup
China Universal Asset Management Co., L…10,871$24.1K<0.01%-1,57113F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.15,221$19.5K<0.01%-2,50013F-HRTimelineGroup
SIMPLEX TRADING, LLC7,433$16K<0.01%-5,18213F-HRTimeline
Winthrop Capital Management, LLC6,000$13K<0.01%013F-HRTimeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO4,513$10K<0.01%+2,44513F-HR/ATimelineGroup
BARCLAYS PLCin group BARCLAYS PLC2,961$6.57K<0.01%-1,89313F-HR/ATimelineGroup
Mirae Asset Global Investments Co., Ltd.in group Mirae Asset Global Investment…2,398$5.32K<0.01%+513F-HRTimelineGroup
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS1,717$3.81K<0.01%-11613F-HRTimelineGroup
GF FUND MANAGEMENT CO. LTD.1,334$2.96K<0.01%-9513F-HRTimeline
CITIGROUP INCin group CITIGROUP INC1,281$2.84K<0.01%-7,64613F-HRTimelineGroup
NISA INVESTMENT ADVISORS, LLC961$2.13K<0.01%013F-HRTimeline
Physician Wealth Advisors, Inc.943$2.09K<0.01%013F-HRTimeline
JONES FINANCIAL COMPANIES LLLPin group JONES FINANCIAL COMPANIES LLLP500$1.07K<0.01%-1,00013F-HRTimelineGroup
CWM, LLCin group CWM, LLC414$1K<0.01%-6,12213F-HRTimelineGroup
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…434$964<0.01%-15713F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN285$633<0.01%-41413F-HRTimelineGroup
NewEdge Advisors, LLC250$555<0.01%013F-HRTimeline
Arax Advisory Partners14$31<0.01%new13F-HRTimeline
NORTHWESTERN MUTUAL WEALTH MANAGEMENT COin group NORTHWESTERN MUTUAL INVESTMEN…12$27<0.01%013F-HRTimelineGroup
SBI Securities Co., Ltd.2$4<0.01%+113F-HRTimeline

Events

  • GordonMD Global Investments LP and 3 other reporting persons reported 20,441,948 PYXS shares, 16.4% of the class, as of 2026-10-01, in a 13G/A filed 2026-10-09. 0000919574-26-006818

    Accepted , ingested

  • Coastlands Capital LP and 4 other reporting persons reported 6,448,907 PYXS shares, 5.42% of the class, as of 2026-10-01, in a 13G filed 2026-10-05. 0001104659-26-113597

    Accepted , ingested

  • GordonMD Global Investments LP and 3 other reporting persons reported 27,988,714 PYXS shares, 17.5% of the class, as of 2026-10-01, in a 13G/A filed 2026-10-02. 0000919574-26-006608

    Accepted , ingested