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Disclosery

IONS IONIS PHARMACEUTICALS INC

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Stock (common), issuer CIK 874015

485 managers (495 13F filers) reported a position in IONS shares at 2025-12-31, 170,227,106 shares in all. 94 filers opened a position and 43 filers sold out during the quarter.

Managers
485
13F filers
495
New
94
Added
167
Reduced
142
Sold out
43
Shares held by filers
170,227,106

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q4 2025

Filers in the available 13F reports with a share position at 2025-12-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
EXCHANGE TRADED CONCEPTS, LLC21,094$1.67M0.01%+3,02413F-HRTimeline
CANADA LIFE ASSURANCE Coin group CANADA LIFE ASSURANCE Co20,894$1.65M<0.01%-25,23413F-HRTimelineGroup
Nicollet Investment Management, Inc.20,523$1.62M0.51%+11513F-HRTimeline
GILDER GAGNON HOWE & CO LLC19,275$1.52M0.02%new13F-HRTimeline
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC18,762$1.48M<0.01%+11,94713F-HRTimelineGroup
AlphaCentric Advisors LLC18,523$1.47M1.46%13F-HRTimeline
Quantedge Capital Pte Ltd18,500$1.46M0.7%new13F-HRTimeline
Elo Mutual Pension Insurance Co18,417$1.46M0.02%new13F-HRTimeline
Dana Investment Advisors, Inc.18,026$1.43M0.04%-79213F-HRTimeline
Tidal Investments LLCin group Tidal Investments LLC17,908$1.42M0.01%new13F-HRTimelineGroup
INCEPTIONR LLC17,850$1.41M0.39%+10,22913F-HRTimeline
WORLDQUANT MILLENNIUM ADVISORS LLC17,410$1.38M0.01%new13F-HRTimeline
J. Safra Sarasin Holding AGin group J. Safra Sarasin Holding AG17,404$1.38M0.02%new13F-HRTimelineGroup
XTX Topco Ltdin group XTX Topco Ltd16,917$1.34M0.04%new13F-HRTimelineGroup
Allianz Asset Management GmbHin group Allianz SE16,716$1.32M<0.01%+5,21613F-HRTimelineGroup
NORTH STAR ASSET MANAGEMENT INC16,610$1.31M0.05%013F-HRTimeline
PUBLIC EMPLOYEES RETIREMENT ASSOCIATION…15,589$1.23M<0.01%013F-HRTimeline
IQ EQ FUND MANAGEMENT (IRELAND) Ltd15,168$1.2M0.08%-11613F-HRTimeline
LMR Partners LLPin group LMR Partners LLP15,000$1.19M0.01%-22,60013F-HRTimelineGroup
BROWN ADVISORY INCin group BROWN ADVISORY INC14,965$1.18M<0.01%+93913F-HRTimelineGroup
DNB Asset Management ASin group DNB Asset Management AS14,838$1.17M<0.01%+5,53013F-HRTimelineGroup
M&G PLCin group M&G PLC14,423$1.14M0.01%new13F-HRTimelineGroup
Dynasty Wealth Management, LLC13,990$1.11M0.01%-35113F-HRTimeline
Bleakley Financial Group, LLC13,875$1.1M0.02%-313F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…13,816$1.09M<0.01%+1,70313F-HRTimelineGroup
Cinctive Capital Management LP13,726$1.09M0.06%-160,09313F-HRTimeline
Friedenthal Financial13,115$1.04M0.53%new13F-HRTimeline
Lighthouse Investment Partners, LLCin group Lighthouse Investment Partner…13,082$1.03M0.03%new13F-HRTimelineGroup
Westmount Partners, LLC12,961$1.03M0.26%013F-HRTimeline
Annis Gardner Whiting Capital Advisors,…12,801$1.01M0.19%013F-HRTimeline
SBI Okasan Asset Management Co.Ltd.12,600$1.01M0.06%13F-HRTimeline
DARK FOREST CAPITAL MANAGEMENT LP12,691$1M0.05%-33,40113F-HRTimeline
TRUIST FINANCIAL CORPin group TRUIST FINANCIAL CORP12,659$1M<0.01%+7,84713F-HRTimelineGroup
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding12,600$996K+7Timeline
Federation des caisses Desjardins du Qu…12,553$993K<0.01%new13F-HRTimeline
AMALGAMATED BANK12,455$985K0.01%+26013F-HRTimeline
NORTHWESTERN MUTUAL WEALTH MANAGEMENT COin group NORTHWESTERN MUTUAL INVESTMEN…11,998$949K<0.01%-78413F-HR/ATimelineGroup
HORIZON KINETICS ASSET MANAGEMENT LLC11,952$946K0.01%-52413F-HRTimeline
COMMONWEALTH EQUITY SERVICES, LLC11,806$934K<0.01%-1,54313F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.11,646$921K<0.01%+1,47913F-HRTimelineGroup
OPPENHEIMER ASSET MANAGEMENT INC.in group OPPENHEIMER ASSET MANAGEMENT …11,264$891K0.01%new13F-HRTimelineGroup
Plancorp, LLC11,208$887K0.03%013F-HRTimeline
Baader Bank Aktiengesellschaft11,097$866K0.07%+86913F-HRTimeline
Cetera Investment Advisers10,856$859K<0.01%+3,98313F-HRTimeline
MONTANOVA CAPITAL, LLC10,800$854K0.02%013F-HRTimeline
VIRGINIA RETIREMENT SYSTEMS ET Al10,600$839K<0.01%new13F-HRTimeline
Blueshift Asset Management, LLC10,443$826K0.24%-1,01713F-HRTimeline
Vident Advisory, LLCin group Vident Advisory, LLC10,235$810K0.01%-1,31613F-HRTimelineGroup
Cypress Capital, LLC10,000$791K0.22%013F-HRTimeline
Thrivent Financial for Lutheransin group Thrivent Financial for Luther…9,962$788K<0.01%013F-HRTimelineGroup
Summit Trail Advisors, LLC9,943$787K0.01%+3,73813F-HRTimeline
Ares Systematic Credit Ltd9,916$784K0.64%13F-HRTimeline
&PARTNERS9,723$769K<0.01%-2,94013F-HRTimeline
MetLife Investment Management, LLCin group MetLife Investment Management…9,674$765K<0.01%+24613F-HRTimelineGroup
TWO SIGMA SECURITIES, LLC9,649$763K0.1%new13F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC9,602$760K0.01%new13F-HRTimeline
KBC Group NVin group KBC Group NV9,052$716K<0.01%+4,35313F-HRTimelineGroup
Aigen Investment Management, LP8,861$701K0.16%-4,71713F-HRTimeline
ASSETMARK, INCin group ASSETMARK, INC8,650$684K<0.01%+8,57513F-HRTimelineGroup
NEOS Investment Management LLC8,557$677K<0.01%-3,74913F-HRTimeline
Tema ETFs LLC8,557$677K0.05%-3,74913F-HRTimeline
WEALTH ENHANCEMENT ADVISORY SERVICES, L…8,256$673K<0.01%+81713F-HRTimeline
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…8,454$669K0.18%-4,02213F-HRTimelineGroup
SECTORAL ASSET MANAGEMENT INC8,365$662K0.53%-84013F-HRTimeline
denkapparat Operations GmbH8,364$662K0.36%-1,60413F-HRTimeline
Utah Retirement Systems8,300$657K0.01%013F-HRTimeline
Maryland State Retirement & Pension Sys…8,284$655K0.01%013F-HRTimeline
M&T Bank Corpin group M&T Bank Corp8,150$644K<0.01%+2,14013F-HR/ATimelineGroup
COMMERCE BANKin group COMMERCE BANK8,111$642K<0.01%+50413F-HRTimelineGroup
FIFTH THIRD BANCORPin group FIFTH THIRD BANK, NATIONAL AS…7,888$624K<0.01%-5613F-HRTimelineGroup
Meeder Advisory Services, Inc.group of 2 filers holding7,872$623K+389Timeline
Persistent Asset Partners Ltd7,807$618K0.3%new13F-HRTimeline
Stratos Wealth Partners, LTD.in group Stratos Wealth Partners, LTD.7,740$612K0.01%-2413F-HRTimelineGroup
Graham Capital Management, L.P.7,596$601K0.02%-9,56713F-HRTimeline
Fiduciary Trust Coin group Fiduciary Trust Co7,399$585K0.01%+1,02213F-HRTimelineGroup
SILVERCREST ASSET MANAGEMENT GROUP LLC7,242$573K<0.01%+12413F-HRTimeline
Savant Capital, LLCin group Savant Capital, LLC7,189$569K<0.01%-4813F-HRTimelineGroup
ProShare Advisors LLC7,154$566K<0.01%+1,47613F-HRTimeline
Callan Family Office, LLC7,104$562K0.01%new13F-HRTimeline
O'SHAUGHNESSY ASSET MANAGEMENT, LLC7,032$556K<0.01%+1,73513F-HRTimeline
Swiss Life Asset Management Ltdin group Swiss Life Asset Management L…6,903$546K<0.01%+7613F-HRTimelineGroup
PSP Research LLC6,800$538K0.47%13F-HRTimeline
PRAXIS INVESTMENT MANAGEMENT INC6,770$536K0.03%013F-HRTimeline
Significant Wealth Partners LLC6,764$535K0.6%-8,20313F-HRTimeline
COLDSTREAM CAPITAL MANAGEMENT INC6,619$524K0.01%+2,14013F-HRTimeline
JONES FINANCIAL COMPANIES LLLPin group JONES FINANCIAL COMPANIES LLLP6,483$513K<0.01%-35113F-HRTimelineGroup
Legato Capital Management LLC6,155$487K0.04%-11,14513F-HRTimeline
REGIONS FINANCIAL CORPin group REGIONS FINANCIAL CORP6,089$482K<0.01%+2,28913F-HRTimelineGroup
Wedmont Private Capital5,536$460K0.02%+17313F-HRTimeline
Frank, Rimerman Advisors LLC5,781$457K0.03%+1613F-HRTimeline
Atria Investments, Inc5,655$447K0.01%-1,37513F-HRTimeline
MERCER GLOBAL ADVISORS INC /ADV5,554$439K<0.01%+1,80713F-HRTimeline
North Dakota State Investment Board5,480$434K0.02%13F-HRTimeline
DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD.in group DYMON ASIA CAPITAL (SINGAPORE…5,350$423K0.09%new13F-HRTimelineGroup
CAPTRUST FINANCIAL ADVISORS5,293$419K<0.01%new13F-HRTimeline
Vontobel Holding Ltd.in group Vontobel Holding Ltd.5,240$415K<0.01%new13F-HRTimelineGroup
US BANCORP \DE\in group US BANCORP \DE\5,141$407K<0.01%+43713F-HRTimelineGroup
HighTower Advisors, LLC5,122$405K<0.01%-33613F-HRTimeline
CWM, LLCin group CWM, LLC5,049$399K<0.01%+2,56113F-HRTimelineGroup
CIBC Asset Management Inc5,017$397K<0.01%+40913F-HRTimeline
OneDigital Investment Advisors LLC5,006$396K<0.01%+1,41813F-HRTimeline
Moisand Fitzgerald Tamayo, LLC5,000$396K0.04%013F-HRTimeline
NewEdge Advisors, LLC4,938$391K<0.01%+11613F-HRTimeline
Inspire Advisors, LLCin group Inspire Investing, LLC4,851$384K0.04%new13F-HRTimelineGroup
Harvest Fund Management Co., Ltdin group Harvest Fund Management Co., …4,816$381K0.01%+3,07013F-HRTimelineGroup
Granite Investment Partners, LLC4,806$380K0.02%-23,22713F-HRTimeline
FARALLON CAPITAL MANAGEMENT, L.L.C.4,800$380K<0.01%013F-HRTimelineThe filing omitted confidential holdings, a later amendment may add them.
Prospera Financial Services Inc4,759$376K0.01%+17813F-HRTimeline
Brooklyn Investment Group4,669$373K0.02%new13F-HRTimeline
Sanctuary Advisors, LLC4,502$356K<0.01%+86513F-HRTimeline
Kestra Advisory Services, LLCin group Kestra Advisory Services, LLC4,451$352K<0.01%-52113F-HRTimelineGroup
CREDIT AGRICOLE S Ain group CREDIT AGRICOLE S A4,410$349K<0.01%-30013F-HRTimelineGroup
AE Wealth Management LLC4,403$348K<0.01%new13F-HRTimeline
Vise Technologies, Inc.4,305$341K0.01%new13F-HRTimeline
Voleon Capital Management LP4,288$339K0.01%+1,22813F-HRTimeline
Checchi Capital Advisers, LLC4,272$338K0.02%+3913F-HRTimeline
BANK OF NOVA SCOTIAin group BANK OF NOVA SCOTIA4,189$331K<0.01%+68013F-HRTimelineGroup
Janney Montgomery Scott LLC4,177$330K<0.01%new13F-HRTimeline
COMERICA BANK3,997$316K<0.01%+1,81013F-HRTimeline
Prime Capital Investment Advisors, LLC3,981$315K<0.01%+4713F-HRTimeline
MACKENZIE FINANCIAL CORP3,891$307K<0.01%+30313F-HRTimeline
Pinnacle Wealth Planning Services, Inc.3,864$306K0.03%-1,24913F-HRTimeline
STRS OHIO3,788$300K<0.01%+7213F-HRTimeline
GROUP ONE TRADING LLC3,778$299K0.01%-1,01813F-HRTimeline
Cambria Investment Management, L.P.3,684$291K0.02%new13F-HRTimeline
TUDOR INVESTMENT CORP ET AL3,661$290K<0.01%new13F-HRTimeline
BERKSHIRE ASSET MANAGEMENT LLC/PA3,630$287K0.01%+1613F-HRTimeline
Avanza Fonder AB3,596$284K0.01%new13F-HRTimeline
PARK AVENUE SECURITIES LLCin group PARK AVENUE SECURITIES LLC3,571$283K<0.01%new13F-HRTimelineGroup
Marex Group Ltdin group Marex Group Ltd3,524$279K<0.01%-3,19813F-HRTimelineGroup
Everhart Financial Group, Inc.3,465$274K0.03%new13F-HRTimeline
MITCHELL & PAHL PRIVATE WEALTH, LLC3,379$267K0.11%-19313F-HRTimeline
PRINCIPAL FINANCIAL GROUP INCgroup of 2 filers holding3,339$264K-1,557Timeline
NWAM LLC3,238$262K0.01%013F-HRTimeline
Eurizon Capital SGR S.p.A.3,314$261K<0.01%13F-HRTimeline
MML INVESTORS SERVICES, LLC3,264$258K<0.01%new13F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…3,263$258K0.01%+21813F-HRTimelineGroup
ANB BANK3,193$253K0.1%-3813F-HRTimeline
GF FUND MANAGEMENT CO. LTD.3,183$252K<0.01%-24613F-HRTimeline
WESTFIELD CAPITAL MANAGEMENT CO LP3,157$250K<0.01%+6413F-HRTimeline
Raab & Moskowitz Asset Management LLC3,115$246K0.05%013F-HRTimeline
Crossmark Global Holdings, Inc.3,102$245K<0.01%new13F-HRTimeline
Venturi Wealth Management, LLC3,061$242K0.01%new13F-HRTimeline
Argent Trust Co3,018$239K0.01%new13F-HRTimeline
B. Riley Wealth Advisors, Inc.2,975$235K0.01%new13F-HRTimeline
Cambridge Investment Research Advisors,…2,957$234K<0.01%new13F-HRTimeline
NORDEN GROUP LLC2,935$232K0.02%new13F-HRTimeline
HB Wealth Management, LLC2,922$231K<0.01%new13F-HRTimeline
Impact Partnership Wealth, LLC2,905$230K0.03%new13F-HRTimeline
AXXCESS WEALTH MANAGEMENT, LLC2,877$228K<0.01%new13F-HR/ATimeline
Advisors Asset Management, Inc.2,835$224K<0.01%-2,61913F-HR/ATimeline
Campbell & CO Investment Adviser LLC2,784$220K0.01%new13F-HRTimeline
Mitsubishi UFJ Asset Management Co., Lt…in group Mitsubishi UFJ Trust & Bankin…2,750$219K<0.01%-2,65713F-HRTimelineGroup
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…2,726$216K<0.01%+52313F-HR/ATimelineGroup
Montis Financial, LLC2,700$214K0.04%new13F-HRTimeline
KOM Wealth Management Group, LLC2,695$213K0.15%new13F-HRTimeline
IFG Advisory, LLC2,678$212K0.01%new13F-HRTimeline
PharVision Advisers, LLC2,661$211K0.11%-92613F-HRTimeline
Motley Fool Asset Management LLCin group Motley Fool Asset Management …2,630$208K0.01%new13F-HRTimelineGroup
Ancora Advisors LLCin group Ancora Advisors LLC2,342$185K<0.01%+20513F-HRTimelineGroup
Larson Financial Group LLC2,340$185K0.01%+1,23013F-HRTimeline
SIGNATUREFD, LLC2,041$161K<0.01%+3813F-HRTimeline
Parallel Advisors, LLC1,882$149K<0.01%+513F-HRTimeline
Global Retirement Partners, LLC1,876$148K<0.01%+1,85313F-HRTimeline
GAMMA Investing LLC1,733$137K0.01%+39213F-HRTimeline
Sterling Capital Management LLC1,713$136K<0.01%+81513F-HRTimeline
Twin Lakes Capital Management, LLC1,500$119K0.05%013F-HRTimeline
Versant Capital Management, Inc1,496$118K0.01%+3113F-HRTimeline
DANSKE BANK A/S1,400$111K<0.01%013F-HRTimeline
Smartleaf Asset Management LLC1,388$110K<0.01%+1,28413F-HRTimeline
Employees Retirement System of Texas1,354$107K<0.01%new13F-HRTimeline
Root Financial Partners, LLC1,339$106K0.01%-113F-HRTimeline
INTERNATIONAL ASSETS INVESTMENT MANAGEM…1,217$96.3K0.01%-6,99013F-HRTimeline
Farther Finance Advisors, LLC1,199$94.9K<0.01%+63313F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…1,137$89.9K<0.01%+31013F-HRTimelineGroup
Bayforest Capital Ltd1,091$86.3K0.06%+93713F-HRTimeline
Steward Partners Investment Advisory, L…1,069$84.6K<0.01%013F-HRTimeline
Sunbelt Securities, Inc.1,014$80.2K0.01%013F-HRTimeline
IFP Advisors, Inc1,014$80.2K<0.01%-5613F-HRTimeline
Allworth Financial LP920$72.8K<0.01%+8013F-HRTimeline
MAI Capital Management900$71.2K<0.01%+63313F-HRTimeline
Arax Advisory Partners774$61.2K<0.01%new13F-HRTimeline
SUMMIT SECURITIES GROUP LLC748$59.2K0.01%new13F-HRTimeline
Elequin Capital, LP711$56.2K0.01%new13F-HRTimeline
HUNTINGTON NATIONAL BANKin group HUNTINGTON NATIONAL BANK695$55K<0.01%+4113F-HRTimelineGroup
AlphaQuest LLC670$53K<0.01%+21713F-HRTimeline
LOS ANGELES CAPITAL MANAGEMENT LLC700$51.9K<0.01%new13F-HRTimeline
QUADRANT CAPITAL GROUP LLC616$48.7K<0.01%013F-HRTimeline
AdvisorNet Financial, Inc613$48.5K<0.01%+14413F-HRTimeline
Laurel Wealth Advisors LLC600$47.5K0.01%new13F-HRTimeline
Archer Investment Corp600$47.5K0.01%013F-HRTimeline
Hilton Head Capital Partners, LLC599$47.4K0.03%13F-HRTimeline
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.481$38K<0.01%-24,22013F-HRTimelineGroup
Ascentis Wealth Management, LLCin group Ascentis Wealth Management, L…400$31.6K0.01%013F-HRTimelineGroup
Steigerwald, Gordon & Koch Inc.380$30.1K<0.01%013F-HRTimeline
Golden State Wealth Management, LLC376$29.7K<0.01%013F-HRTimeline
CoreCap Advisors, LLC370$29.3K<0.01%+32513F-HRTimeline
WELLINGTON-ALTUS USA INC.351$27.8K0.02%13F-HRTimeline
BROWN BROTHERS HARRIMAN & COin group BROWN BROTHERS HARRIMAN & CO341$27K<0.01%new13F-HRTimelineGroup
Salomon & Ludwin, LLC332$26.1K<0.01%013F-HRTimeline