Venrock Adviser, LLC More: the full row for Venrock Adviser, LLC 3,851,654 $18.5M 0.69% +11,404 13F-HR Timeline ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 3,832,843 $18.4M 0.4% -7,657 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 2,415,841 $11.6M 0.01% +1,387,292 13F-HR Timeline Group ACORN CAPITAL ADVISORS, LLC More: the full row for ACORN CAPITAL ADVISORS, LLC 1,540,266 $7.39M 2.1% -32,757 13F-HR Timeline Rosalind Advisors, Inc. More: the full row for Rosalind Advisors, Inc. 1,531,814 $7.35M 3.01% -125,726 13F-HR Timeline EVENTIDE ASSET MANAGEMENT, LLC More: the full row for EVENTIDE ASSET MANAGEMENT, LLC 1,410,815 $6.77M 0.11% +153,815 13F-HR Timeline Deep Track Capital, LP More: the full row for Deep Track Capital, LP 1,313,137 $6.3M 0.13% -541,118 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 1,025,318 $4.92M <0.01% -274,438 13F-HR Timeline Group SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 987,090 $4.74M 0.81% +161,514 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 877,347 $4.21M <0.01% +71,970 13F-HR Timeline Group ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 700,000 $3.36M 0.01% 0 13F-HR Timeline Group DCF Advisers, LLC More: the full row for DCF Advisers, LLC 691,988 $3.32M 1.25% -83,600 13F-HR Timeline Boxer Capital Management, LLC in group Boxer Capital Management, LLC More: the full row for Boxer Capital Management, LLC 640,000 $3.07M 0.4% -75,000 13F-HR Timeline Group DAFNA Capital Management LLC More: the full row for DAFNA Capital Management LLC 498,361 $2.39M 0.54% +43,343 13F-HR Timeline Nan Fung Group Holdings Ltd More: the full row for Nan Fung Group Holdings Ltd 460,000 $2.21M 1.82% 0 13F-HR Timeline Knott David M Jr More: the full row for Knott David M Jr 350,000 $1.68M 1% +64,818 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 238,302 $1.14M <0.01% +4,588 13F-HR Timeline Group AdvisorShares Investments LLC More: the full row for AdvisorShares Investments LLC 195,604 $939K 0.17% +97,546 13F-HR Timeline HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 187,052 $897K <0.01% new 13F-HR Timeline ROYCE & ASSOCIATES LP More: the full row for ROYCE & ASSOCIATES LP 155,050 $744K 0.01% new 13F-HR Timeline Pale Fire Capital SE in group Pale Fire Capital More: the full row for Pale Fire Capital SE 153,505 $737K 0.06% 0 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 147,925 $710K <0.01% -152,305 13F-HR Timeline Group Stonepine Capital Management, LLC More: the full row for Stonepine Capital Management, LLC 134,060 $643K 0.57% -205,842 13F-HR Timeline Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 132,153 $634K 0.09% 0 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 106,349 $510K <0.01% +7,315 13F-HR Timeline Group PEAK6 LLC in group PEAK6 LLC More: the full row for PEAK6 LLC 62,597 $300K 0.01% -220,910 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 51,588 $248K <0.01% +3,657 13F-HR Timeline Group Fore Capital, LLC More: the full row for Fore Capital, LLC 36,421 $175K 0.41% -30,000 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 31,592 $151K <0.01% -19,490 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 31,278 $150K 0.01% -207,112 13F-HR Timeline Group PDS Planning, Inc More: the full row for PDS Planning, Inc 30,344 $145K 0.01% 0 13F-HR Timeline BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 29,404 $141K <0.01% 0 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 29,126 $140K <0.01% +3,723 13F-HR Timeline Group AXQ CAPITAL, LP More: the full row for AXQ CAPITAL, LP 29,114 $140K 0.02% new 13F-HR Timeline OXFORD ASSET MANAGEMENT LLP More: the full row for OXFORD ASSET MANAGEMENT LLP 22,277 $107K 0.04% new 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 19,684 $94.5K <0.01% -4,412,875 13F-HR Timeline Group Graham Capital Management, L.P. More: the full row for Graham Capital Management, L.P. 18,263 $87.7K <0.01% -17,246 13F-HR Timeline Formidable Asset Management, LLC More: the full row for Formidable Asset Management, LLC 10,649 $87.1K 0.01% new 13F-HR Timeline Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 18,000 $86.4K <0.01% new 13F-HR Timeline Group Mitsubishi UFJ Asset Management (UK) Lt… in group Mitsubishi UFJ Trust & Bankin… More: the full row for Mitsubishi UFJ Asset Management (UK) Ltd. 15,000 $72K 0.04% new 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 11,873 $57K <0.01% +9,317 13F-HR Timeline Group Millington Financial Advisors, LLC More: the full row for Millington Financial Advisors, LLC 10,000 $54K 0.02% new 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 10,900 $52.3K <0.01% new 13F-HR Timeline Group Mayflower Financial Advisors, LLC More: the full row for Mayflower Financial Advisors, LLC 10,290 $49.4K 0.01% new 13F-HR Timeline Centiva Capital, LP More: the full row for Centiva Capital, LP 10,000 $48K <0.01% new 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 6,400 $30.7K <0.01% new 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 5,952 $28.7K <0.01% new 13F-HR Timeline Group Quent Capital, LLC More: the full row for Quent Capital, LLC 4,453 $21.4K <0.01% new 13F-HR Timeline NATIONAL BANK OF CANADA /FI/ in group NATIONAL BANK OF CANADA /FI/ More: the full row for NATIONAL BANK OF CANADA /FI/ 5,132 $17.4K <0.01% -276 13F-HR Timeline Group GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 3,462 $16.6K <0.01% -7,263 13F-HR Timeline North Star Investment Management Corp. More: the full row for North Star Investment Management Corp. 3,380 $16.2K <0.01% +880 13F-HR Timeline Federation des caisses Desjardins du Qu… More: the full row for Federation des caisses Desjardins du Quebec 3,121 $14.9K <0.01% 0 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 2,978 $14.3K <0.01% +50 13F-HR Timeline Group IAG Wealth Partners, LLC More: the full row for IAG Wealth Partners, LLC 2,750 $13.2K <0.01% 0 13F-HR Timeline Advisory Services Network, LLC More: the full row for Advisory Services Network, LLC 2,060 $9.89K <0.01% new 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 2,244 $9.69K <0.01% -20,199 13F-HR/A Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 862 $4.14K <0.01% 0 13F-HR Timeline Group Ancora Advisors LLC in group Ancora Advisors LLC More: the full row for Ancora Advisors LLC 653 $3.13K <0.01% new 13F-HR Timeline Group HARBOUR INVESTMENTS, INC. More: the full row for HARBOUR INVESTMENTS, INC. 250 $1.2K <0.01% 0 13F-HR Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 221 $1.1K <0.01% -26 13F-HR Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 200 $960 <0.01% 0 13F-HR Timeline Avalon Trust Co More: the full row for Avalon Trust Co 197 $946 <0.01% 0 13F-HR Timeline Atlantic Edge Private Wealth Management… More: the full row for Atlantic Edge Private Wealth Management, LLC 137 $658 <0.01% 0 13F-HR Timeline Tidemark, LLC More: the full row for Tidemark, LLC 131 $629 <0.01% 0 13F-HR Timeline AMERIFLEX GROUP, INC. More: the full row for AMERIFLEX GROUP, INC. 131 $629 <0.01% 0 13F-HR Timeline TD Waterhouse Canada Inc. More: the full row for TD Waterhouse Canada Inc. 117 $580 <0.01% -1,916 13F-HR Timeline Hilton Head Capital Partners, LLC More: the full row for Hilton Head Capital Partners, LLC 117 $562 <0.01% 0 13F-HR Timeline NewEdge Advisors, LLC More: the full row for NewEdge Advisors, LLC 95 $456 <0.01% 0 13F-HR/A Timeline NVWM, LLC More: the full row for NVWM, LLC 59 $283 <0.01% 0 13F-HR Timeline CENTRAL TRUST Co More: the full row for CENTRAL TRUST Co 26 $125 <0.01% 0 13F-HR Timeline Westside Investment Management, Inc. More: the full row for Westside Investment Management, Inc. 26 $125 <0.01% 0 13F-HR Timeline City State Bank More: the full row for City State Bank 25 $120 <0.01% 0 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 20 $96 <0.01% 0 13F-HR Timeline McIlrath & Eck, LLC More: the full row for McIlrath & Eck, LLC 10 $48 <0.01% 0 13F-HR Timeline NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO in group NORTHWESTERN MUTUAL INVESTMEN… More: the full row for NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 7 $34 <0.01% 0 13F-HR Timeline Group CNB Bank More: the full row for CNB Bank 4 $19 <0.01% 0 13F-HR Timeline CoreCap Advisors, LLC More: the full row for CoreCap Advisors, LLC 3 $14 <0.01% 0 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 1 $5 <0.01% new 13F-HR Timeline MCGUIRE CAPITAL ADVISORS INC More: the full row for MCGUIRE CAPITAL ADVISORS INC 1 $5 <0.01% 0 13F-HR Timeline FNY Investment Advisers, LLC More: the full row for FNY Investment Advisers, LLC 100 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. TSFG, LLC More: the full row for TSFG, LLC 2 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios.