BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 5,450,445 $72.8M 0.71% +1,192,710 13F-HR Timeline Group BVF INC/IL in group BVF INC/IL More: the full row for BVF INC/IL 3,466,000 $46.3M 1.65% 0 13F-HR Timeline Group Soleus Capital Management, L.P. More: the full row for Soleus Capital Management, L.P. 3,011,818 $40.2M 2.78% +437,696 13F-HR Timeline NEA Management Company, LLC More: the full row for NEA Management Company, LLC 2,294,261 $30.6M 2.31% +1,044,260 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 2,070,683 $27.6M <0.01% -141,915 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 1,667,785 $22.3M <0.01% -4,457 13F-HR Timeline Group PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 1,633,208 $21.8M 0.82% -729,071 13F-HR Timeline Group EVENTIDE ASSET MANAGEMENT, LLC More: the full row for EVENTIDE ASSET MANAGEMENT, LLC 1,389,427 $18.5M 0.32% +123,774 13F-HR Timeline Saturn V Capital Management LP More: the full row for Saturn V Capital Management LP 1,185,520 $15.8M 6.41% +91,843 13F-HR Timeline BRAIDWELL LP More: the full row for BRAIDWELL LP 884,306 $11.8M 0.4% 0 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 784,079 $10.5M <0.01% -52,869 13F-HR Timeline Group AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 768,796 $10.3M <0.01% +166,324 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 754,154 $10.1M 0.01% -194,275 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 677,229 $9.04M <0.01% -42,691 13F-HR Timeline Group Vivo Capital, LLC More: the full row for Vivo Capital, LLC 610,500 $8.15M 0.83% 0 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 587,404 $7.84M <0.01% +2,224 13F-HR Timeline Group CAPTRUST FINANCIAL ADVISORS More: the full row for CAPTRUST FINANCIAL ADVISORS 570,441 $7.62M 0.02% +12,838 13F-HR Timeline Artisan Partners Limited Partnership More: the full row for Artisan Partners Limited Partnership 401,678 $5.36M 0.01% -52,968 13F-HR Timeline Pfizer Inc More: the full row for Pfizer Inc 349,406 $4.66M 0.81% 0 13F-HR Timeline Candriam S.C.A. More: the full row for Candriam S.C.A. 263,576 $3.52M 0.02% -14 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 262,874 $3.51M <0.01% +11,145 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 261,415 $3.49M <0.01% -30,897 13F-HR Timeline Group Quantinno Capital Management LP More: the full row for Quantinno Capital Management LP 243,042 $3.24M 0.01% +41,756 13F-HR Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 239,504 $3.2M 0.01% new 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 233,059 $3.11M <0.01% +1,023 13F-HR Timeline Group Hennion & Walsh Asset Management, Inc. More: the full row for Hennion & Walsh Asset Management, Inc. 174,493 $2.33M 0.09% +5,753 13F-HR Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 99,379 $1.33M <0.01% +14,554 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 89,049 $1.19M <0.01% +68,698 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 84,592 $1.13M <0.01% +16,353 13F-HR Timeline Group Paloma Partners Management Co in group Paloma Partners Management Co More: the full row for Paloma Partners Management Co 82,137 $1.1M 0.25% +60,849 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 78,076 $1.04M <0.01% +42,700 13F-HR/A Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 66,799 $892K <0.01% -1,967 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 59,625 $796K <0.01% +19,594 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 59,276 $791K <0.01% +51,264 13F-HR/A Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 55,917 $746K <0.01% -13,670 13F-HR Timeline Group GAGNON SECURITIES LLC in group GAGNON SECURITIES LLC More: the full row for GAGNON SECURITIES LLC 53,990 $721K 0.15% -320 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 52,477 $701K <0.01% -36,596 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 42,697 $570K <0.01% +503 13F-HR Timeline JNBA Financial Advisors More: the full row for JNBA Financial Advisors 38,091 $509K 0.05% 0 13F-HR Timeline Accredited Investors Inc. More: the full row for Accredited Investors Inc. 29,115 $389K 0.02% 0 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 28,391 $379K <0.01% 0 13F-HR/A Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 28,270 $377K <0.01% +4,590 13F-HR Timeline WEALTH ENHANCEMENT ADVISORY SERVICES, L… More: the full row for WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 26,269 $362K <0.01% -270 13F-HR Timeline HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 26,386 $352K <0.01% new 13F-HR Timeline DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 24,572 $328K <0.01% new 13F-HR Timeline Group ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 20,391 $272K <0.01% -8,407 13F-HR Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 19,872 $265K <0.01% 0 13F-HR Timeline Group NEOS Investment Management LLC More: the full row for NEOS Investment Management LLC 17,011 $227K <0.01% +1,392 13F-HR Timeline Tema ETFs LLC More: the full row for Tema ETFs LLC 17,011 $227K 0.06% +1,392 13F-HR Timeline M Holdings Securities, Inc. More: the full row for M Holdings Securities, Inc. 17,848 $224K 0.04% new 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 16,642 $222K 0.01% new 13F-HR Timeline COMMONWEALTH EQUITY SERVICES, LLC More: the full row for COMMONWEALTH EQUITY SERVICES, LLC 16,415 $219K <0.01% -4,609 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 16,148 $216K <0.01% -2,722 13F-HR Timeline Group Pale Fire Capital SE in group Pale Fire Capital More: the full row for Pale Fire Capital SE 15,940 $213K 0.02% -1,700 13F-HR Timeline Group MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 15,712 $210K <0.01% -3,649 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 15,186 $203K <0.01% +1,054 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 15,012 $200K <0.01% -852 13F-HR Timeline Group INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 14,855 $198K <0.01% +734 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 13,711 $183K <0.01% -1,908 13F-HR Timeline Group Creative Planning in group Creative Planning More: the full row for Creative Planning 13,291 $177K <0.01% new 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 13,100 $175K <0.01% new 13F-HR Timeline Corton Capital Inc. More: the full row for Corton Capital Inc. 13,097 $175K 0.2% new 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 12,628 $169K 0.01% new 13F-HR Timeline Group Kestra Advisory Services, LLC in group Kestra Advisory Services, LLC More: the full row for Kestra Advisory Services, LLC 12,284 $164K <0.01% new 13F-HR Timeline Group PERKINS CAPITAL MANAGEMENT INC More: the full row for PERKINS CAPITAL MANAGEMENT INC 11,700 $156K 0.16% +350 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 11,519 $154K <0.01% -209 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 10,802 $144K <0.01% -12,445 13F-HR Timeline Group Focus Financial Network, Inc. More: the full row for Focus Financial Network, Inc. 10,691 $143K 0.01% 0 13F-HR Timeline Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 7,487 $100K 0.03% -5,533 13F-HR Timeline Group AlphaQuest LLC More: the full row for AlphaQuest LLC 7,087 $94.6K 0.01% +4,522 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 6,451 $86.1K <0.01% 0 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 5,549 $74.1K <0.01% +3,766 13F-HR Timeline Group Quarry LP More: the full row for Quarry LP 4,800 $64.1K 0.01% new 13F-HR Timeline Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 3,421 $45.7K <0.01% 0 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 3,180 $42.5K <0.01% -310 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 2,717 $36.3K <0.01% +1,417 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 2,647 $35.3K <0.01% +1,167 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 2,413 $32.2K <0.01% 0 13F-HR Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 1,128 $15K <0.01% 0 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 1,064 $14.2K 0.01% +818 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 906 $12.1K <0.01% +775 13F-HR Timeline ELEVATION POINT WEALTH PARTNERS, LLC More: the full row for ELEVATION POINT WEALTH PARTNERS, LLC 904 $12.1K <0.01% new 13F-HR/A Timeline RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 830 $11.1K <0.01% new 13F-HR Timeline Group NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 697 $9.3K <0.01% -293 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 610 $8.14K <0.01% new 13F-HR Timeline Group US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 563 $7.52K <0.01% 0 13F-HR Timeline Group CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 290 $4K <0.01% +230 13F-HR Timeline Group Versant Capital Management, Inc More: the full row for Versant Capital Management, Inc 224 $2.99K <0.01% -125 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 193 $2.58K <0.01% +179 13F-HR Timeline Group SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 124 $1.66K <0.01% new 13F-HR Timeline True Wealth Design, LLC More: the full row for True Wealth Design, LLC 115 $1.54K <0.01% +101 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 106 $1.42K <0.01% +39 13F-HR/A Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 0 $988 <0.01% 0 13F-HR Timeline Amount filed as zero, left out of ratios. ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 65 $868 <0.01% +45 13F-HR Timeline GeoWealth Management, LLC More: the full row for GeoWealth Management, LLC 43 $575 <0.01% new 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 17 $227 <0.01% 0 13F-HR Timeline Group CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.