BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 4,257,735 $43M 0.48% +1,579,182 13F-HR Timeline Group BVF INC/IL in group BVF INC/IL More: the full row for BVF INC/IL 3,466,000 $35M 1.43% 0 13F-HR Timeline Group Soleus Capital Management, L.P. More: the full row for Soleus Capital Management, L.P. 2,574,122 $26M 2.04% +9,035 13F-HR Timeline PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 2,362,279 $23.9M 0.85% 0 13F-HR/A Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 2,212,598 $22.4M <0.01% +33,534 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 1,672,242 $16.9M <0.01% +20,261 13F-HR Timeline Group EVENTIDE ASSET MANAGEMENT, LLC More: the full row for EVENTIDE ASSET MANAGEMENT, LLC 1,265,653 $12.8M 0.25% 0 13F-HR Timeline NEA Management Company, LLC More: the full row for NEA Management Company, LLC 1,250,001 $12.6M 0.97% 0 13F-HR Timeline Saturn V Capital Management LP More: the full row for Saturn V Capital Management LP 1,093,677 $11.1M 5.58% +29,894 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 948,429 $9.59M 0.01% +112,406 13F-HR Timeline Group BRAIDWELL LP More: the full row for BRAIDWELL LP 884,306 $8.94M 0.31% 0 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 836,948 $8.46M <0.01% -39,943 13F-HR Timeline Group JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 796,981 $8.14M <0.01% +148,863 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 719,920 $7.28M <0.01% +27,548 13F-HR Timeline Group Commodore Capital LP in group Commodore Capital LP More: the full row for Commodore Capital LP 695,650 $7.03M 0.52% +295,650 13F-HR Timeline Group Vivo Capital, LLC More: the full row for Vivo Capital, LLC 610,500 $6.17M 0.82% 0 13F-HR Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 602,472 $6.09M <0.01% +155,301 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 585,180 $5.92M <0.01% -294,612 13F-HR Timeline Group CAPTRUST FINANCIAL ADVISORS More: the full row for CAPTRUST FINANCIAL ADVISORS 557,603 $5.64M 0.01% +89,507 13F-HR Timeline Artisan Partners Limited Partnership More: the full row for Artisan Partners Limited Partnership 454,646 $4.6M 0.01% -36,861 13F-HR Timeline Pfizer Inc More: the full row for Pfizer Inc 349,406 $3.53M 0.71% 0 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 292,312 $2.96M <0.01% -7,764 13F-HR Timeline Group Candriam S.C.A. More: the full row for Candriam S.C.A. 263,590 $2.66M 0.02% 0 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 251,729 $2.54M <0.01% -36,530 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 232,036 $2.35M <0.01% -5,670 13F-HR/A Timeline Group Quantinno Capital Management LP More: the full row for Quantinno Capital Management LP 201,286 $2.04M 0.01% new 13F-HR Timeline Hennion & Walsh Asset Management, Inc. More: the full row for Hennion & Walsh Asset Management, Inc. 168,740 $1.71M 0.08% +24,708 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 89,073 $901K <0.01% -28,686 13F-HR/A Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 84,825 $858K <0.01% +22,049 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 69,587 $704K <0.01% 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 68,766 $695K <0.01% +4,641 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 68,239 $690K <0.01% -15,675 13F-HR Timeline Group GAGNON SECURITIES LLC in group GAGNON SECURITIES LLC More: the full row for GAGNON SECURITIES LLC 54,310 $549K 0.12% +1,831 13F-HR Timeline Group PFM Health Sciences, LP More: the full row for PFM Health Sciences, LP 53,349 $539K 0.04% -105,397 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 42,194 $427K <0.01% +3,439 13F-HR/A Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 40,031 $405K <0.01% +18,715 13F-HR Timeline Group JNBA Financial Advisors More: the full row for JNBA Financial Advisors 38,091 $385K 0.04% 0 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 35,376 $358K <0.01% -21,823 13F-HR/A Timeline Group TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 35,278 $357K -67,760 Timeline Accredited Investors Inc. More: the full row for Accredited Investors Inc. 29,115 $294K 0.02% 0 13F-HR Timeline ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 28,798 $291K <0.01% -1,230 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 28,391 $287K <0.01% 0 13F-HR/A Timeline Trexquant Investment LP More: the full row for Trexquant Investment LP 26,920 $272K <0.01% +15,280 13F-HR Timeline WEALTH ENHANCEMENT ADVISORY SERVICES, L… More: the full row for WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 26,539 $268K <0.01% +162 13F-HR Timeline EntryPoint Capital, LLC More: the full row for EntryPoint Capital, LLC 24,687 $250K 0.11% +3,840 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 23,680 $239K <0.01% 0 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 23,247 $235K <0.01% -15,561 13F-HR Timeline Group Paloma Partners Management Co in group Paloma Partners Management Co More: the full row for Paloma Partners Management Co 21,288 $215K 0.04% new 13F-HR Timeline Group COMMONWEALTH EQUITY SERVICES, LLC More: the full row for COMMONWEALTH EQUITY SERVICES, LLC 21,024 $213K <0.01% new 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 20,351 $206K <0.01% -19,309 13F-HR Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 19,872 $201K <0.01% -512 13F-HR Timeline Group MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 19,361 $196K <0.01% -364 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 18,870 $191K <0.01% -3,972 13F-HR Timeline Group Cresset Asset Management, LLC More: the full row for Cresset Asset Management, LLC 18,510 $187K <0.01% 0 13F-HR Timeline Pale Fire Capital SE in group Pale Fire Capital More: the full row for Pale Fire Capital SE 17,640 $178K 0.02% +182 13F-HR Timeline Group TRUST POINT INC. More: the full row for TRUST POINT INC. 17,247 $174K 0.02% -600 13F-HR Timeline Corebridge Financial, Inc. in group Corebridge Financial, Inc. More: the full row for Corebridge Financial, Inc. 16,019 $162K <0.01% -237 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 15,864 $160K <0.01% +349 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 15,619 $158K <0.01% +936 13F-HR Timeline Group NEOS Investment Management LLC More: the full row for NEOS Investment Management LLC 15,619 $158K <0.01% new 13F-HR Timeline Tema ETFs LLC More: the full row for Tema ETFs LLC 15,619 $158K 0.05% new 13F-HR Timeline Shay Capital LLC More: the full row for Shay Capital LLC 14,300 $145K 0.04% 0 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 14,132 $143K <0.01% +1,411 13F-HR Timeline Man Group plc in group Man Group plc More: the full row for Man Group plc 14,144 $143K <0.01% new 13F-HR Timeline Group INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 14,121 $143K <0.01% -2,528 13F-HR Timeline Virtus Investment Advisers, LLC group of 2 filers holding More: the full row for Virtus Investment Advisers, LLC 13,020 $132K +7,382 Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 11,728 $119K <0.01% +902 13F-HR Timeline Group PERKINS CAPITAL MANAGEMENT INC More: the full row for PERKINS CAPITAL MANAGEMENT INC 11,350 $115K 0.12% new 13F-HR Timeline SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 11,240 $114K <0.01% -3,406 13F-HR Timeline Focus Financial Network, Inc. More: the full row for Focus Financial Network, Inc. 10,691 $108K <0.01% new 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 8,012 $81K <0.01% -1,207 13F-HR/A Timeline Group Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 6,451 $65.2K <0.01% 0 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 3,490 $35.3K <0.01% 0 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 3,421 $34.6K <0.01% 0 13F-HR Timeline Group AlphaQuest LLC More: the full row for AlphaQuest LLC 2,565 $25.9K <0.01% -5,329 13F-HR Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 2,413 $24.4K <0.01% 0 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 1,783 $18K <0.01% +1,252 13F-HR Timeline Group OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 1,540 $15.6K <0.01% -16 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 1,480 $15K <0.01% -1,845 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 1,300 $13.1K <0.01% -195 13F-HR Timeline Group AMALGAMATED BANK More: the full row for AMALGAMATED BANK 1,128 $11K <0.01% +547 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 990 $10K <0.01% +73 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 563 $5.69K <0.01% +15 13F-HR Timeline Group Versant Capital Management, Inc More: the full row for Versant Capital Management, Inc 349 $3.53K <0.01% new 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 246 $2.49K <0.01% new 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 131 $1.32K <0.01% +32 13F-HR/A Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 60 $1K <0.01% +37 13F-HR Timeline Group Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 67 $677 <0.01% +29 13F-HR Timeline COLDSTREAM CAPITAL MANAGEMENT INC More: the full row for COLDSTREAM CAPITAL MANAGEMENT INC 53 $536 <0.01% new 13F-HR Timeline ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 20 $202 <0.01% +10 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 17 $172 <0.01% +8 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 14 $142 <0.01% 0 13F-HR Timeline Group True Wealth Design, LLC More: the full row for True Wealth Design, LLC 14 $142 <0.01% new 13F-HR Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 0 $51 <0.01% 0 13F-HR Timeline Amount filed as zero, left out of ratios. CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.