Cormorant Asset Management, LP More: the full row for Cormorant Asset Management, LP 17,878,594 $160M 8.07% 0 13F-HR Timeline DEERFIELD MANAGEMENT COMPANY, L.P. in group DEERFIELD MANAGEMENT COMPANY,… More: the full row for DEERFIELD MANAGEMENT COMPANY, L.P. 4,885,446 $43.7M 0.52% 0 13F-HR Timeline Group Omega Fund Management, LLC More: the full row for Omega Fund Management, LLC 3,289,661 $29.4M 18.05% 0 13F-HR Timeline EcoR1 Capital, LLC More: the full row for EcoR1 Capital, LLC 2,823,126 $25.3M 1.08% 0 13F-HR Timeline Alphabet Inc. in group Alphabet Inc. More: the full row for Alphabet Inc. 2,823,126 $25.3M 0.63% 0 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 2,818,348 $25.2M <0.01% -88,655 13F-HR Timeline Group ENAVATE SCIENCES GP, LLC More: the full row for ENAVATE SCIENCES GP, LLC 2,626,946 $23.5M 6.69% 0 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 2,528,762 $22.6M 0.02% -1,562 13F-HR Timeline Group NOVO HOLDINGS A/S More: the full row for NOVO HOLDINGS A/S 2,185,923 $19.6M 1.59% +224,606 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 2,088,297 $18.7M <0.01% +3,460 13F-HR Timeline Group Laurion Capital Management LP More: the full row for Laurion Capital Management LP 1,922,656 $17.2M 1.61% +457,718 13F-HR Timeline ARMISTICE CAPITAL, LLC More: the full row for ARMISTICE CAPITAL, LLC 1,328,000 $11.9M 0.39% +328,000 13F-HR Timeline Aisling Capital Management LP More: the full row for Aisling Capital Management LP 1,018,018 $9.11M 1.91% +453,393 13F-HR Timeline Paradigm Biocapital Advisors LP in group Paradigm Biocapital Advisors … More: the full row for Paradigm Biocapital Advisors LP 868,213 $7.77M 0.16% -1,393,536 13F-HR Timeline Group VANGUARD GROUP INC group of 3 filers holding More: the full row for VANGUARD GROUP INC 810,933 $7.26M new Timeline Octagon Capital Advisors LP More: the full row for Octagon Capital Advisors LP 719,000 $6.44M 0.71% -324,110 13F-HR Timeline ROYCE & ASSOCIATES LP More: the full row for ROYCE & ASSOCIATES LP 636,522 $5.7M 0.06% new 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 579,234 $5.19M <0.01% +17,247 13F-HR Timeline Group EVENTIDE ASSET MANAGEMENT, LLC More: the full row for EVENTIDE ASSET MANAGEMENT, LLC 541,181 $4.7M 0.08% -541,181 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 437,889 $3.92M <0.01% -365,245 13F-HR Timeline ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 400,000 $3.58M 0.01% -1,000,000 13F-HR Timeline Group Ensign Peak Advisors, Inc More: the full row for Ensign Peak Advisors, Inc 320,874 $2.87M 0.01% new 13F-HR/A Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 290,806 $2.6M <0.01% +11,760 13F-HR Timeline Group Casdin Capital, LLC More: the full row for Casdin Capital, LLC 282,312 $2.53M 0.19% 0 13F-HR Timeline Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 270,231 $2.42M 0.35% +50,000 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 265,954 $2.38M <0.01% +24,539 13F-HR Timeline Group SCHRODER INVESTMENT MANAGEMENT GROUP More: the full row for SCHRODER INVESTMENT MANAGEMENT GROUP 249,161 $2.16M <0.01% new 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 240,300 $2.15M <0.01% 0 13F-HR Timeline Group Granahan Investment Management, LLC More: the full row for Granahan Investment Management, LLC 231,040 $2.07M 0.1% new 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 226,278 $2.03M <0.01% +8,000 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 167,573 $1.5M <0.01% +72,922 13F-HR Timeline Group Sio Capital Management, LLC More: the full row for Sio Capital Management, LLC 130,628 $1.17M 0.17% 0 13F-HR Timeline Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 110,000 $984K 0.01% new 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 103,707 $928K <0.01% 0 13F-HR/A Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 102,258 $915K <0.01% +44,224 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 101,900 $912K <0.01% +27,600 13F-HR Timeline MOORE CAPITAL MANAGEMENT, LP More: the full row for MOORE CAPITAL MANAGEMENT, LP 100,000 $895K 0.03% 0 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 90,819 $813K <0.01% +64,347 13F-HR Timeline Group Tidal Investments LLC in group Tidal Investments LLC More: the full row for Tidal Investments LLC 82,172 $735K <0.01% new 13F-HR Timeline Group Tema ETFs LLC More: the full row for Tema ETFs LLC 82,172 $735K 0.05% new 13F-HR Timeline BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 80,884 $724K 0.02% +13,850 13F-HR Timeline HighVista Strategies LLC More: the full row for HighVista Strategies LLC 78,187 $700K 0.19% -151,076 13F-HR Timeline Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 71,925 $644K <0.01% +35,973 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 59,743 $535K 0.01% +31,110 13F-HR Timeline Group TD Asset Management Inc More: the full row for TD Asset Management Inc 57,572 $515K <0.01% -59,578 13F-HR Timeline Opaleye Management Inc. More: the full row for Opaleye Management Inc. 53,282 $477K 0.06% new 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 50,450 $452K <0.01% -42,919 13F-HR Timeline Group ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 48,122 $431K <0.01% new 13F-HR Timeline Avidity Partners Management LP More: the full row for Avidity Partners Management LP 43,853 $392K 0.08% new 13F-HR/A Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 43,374 $388K <0.01% +29,022 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 43,190 $387K <0.01% +31,675 13F-HR Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 35,692 $319K <0.01% -18,500 13F-HR Timeline Group ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 29,148 $260K <0.01% new 13F-HR Timeline Group AXQ CAPITAL, LP More: the full row for AXQ CAPITAL, LP 17,347 $155K 0.02% new 13F-HR Timeline Diametric Capital, LP More: the full row for Diametric Capital, LP 16,280 $146K 0.04% new 13F-HR Timeline Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 14,248 $128K <0.01% new 13F-HR Timeline Group Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 13,351 $119K <0.01% +429 13F-HR Timeline Group Aquatic Capital Management LLC More: the full row for Aquatic Capital Management LLC 11,793 $106K <0.01% new 13F-HR Timeline Bellevue Group AG in group Bellevue Group AG More: the full row for Bellevue Group AG 6,982 $62.5K <0.01% new 13F-HR Timeline Group Rockefeller Capital Management L.P. in group Rockefeller Capital Managemen… More: the full row for Rockefeller Capital Management L.P. 700 $6.26K <0.01% 0 13F-HR Timeline Group Accent Capital Management, LLC More: the full row for Accent Capital Management, LLC 335 $3K <0.01% new 13F-HR/A Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 300 $2.69K <0.01% 0 13F-HR/A Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 212 $1.9K <0.01% new 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 154 $1K <0.01% new 13F-HR Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 4 $36 <0.01% new 13F-HR Timeline