HHLR ADVISORS, LTD. in group HHLR ADVISORS, LTD. More: the full row for HHLR ADVISORS, LTD. 4,484,672 $82.7M 2.02% 0 13F-HR Timeline Group INFINITUM ASSET MANAGEMENT, LLC More: the full row for INFINITUM ASSET MANAGEMENT, LLC 3,868,923 $71.4M 13.13% +450,000 13F-HR Timeline MONTANOVA CAPITAL, LLC More: the full row for MONTANOVA CAPITAL, LLC 3,703,452 $68.3M 2.07% +290,664 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 3,407,549 $62.9M <0.01% +1,349,480 13F-HR Timeline Group ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 3,027,328 $55.9M 1.34% 0 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 2,046,138 $37.8M <0.01% +207,762 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 2,029,531 $37.4M <0.01% +545,991 13F-HR Timeline Group Octagon Capital Advisors LP More: the full row for Octagon Capital Advisors LP 1,971,054 $36.4M 5.68% +25,000 13F-HR Timeline NOVO HOLDINGS A/S More: the full row for NOVO HOLDINGS A/S 1,942,142 $35.8M 2.31% +70,000 13F-HR Timeline Sofinnova Investments, Inc. More: the full row for Sofinnova Investments, Inc. 1,696,752 $31.3M 1.92% 0 13F-HR Timeline General Catalyst Group Management, LLC More: the full row for General Catalyst Group Management, LLC 1,494,786 $27.6M 0.91% 0 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 1,027,628 $19M <0.01% +286,836 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 716,288 $13.2M <0.01% +120,270 13F-HR Timeline Group HSG Holding Ltd in group HSG Holding Ltd More: the full row for HSG Holding Ltd 663,308 $13M 0.68% 0 13F-HR Timeline Group The filing omitted confidential holdings, a later amendment may add them. Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 700,000 $12.9M 0.51% 0 13F-HR Timeline Group Fund 1 Investments, LLC in group Fund 1 Investments, LLC More: the full row for Fund 1 Investments, LLC 619,851 $11.4M 1.4% +91,456 13F-HR Timeline Group UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 508,563 $9.38M +392,420 Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 431,939 $7.97M <0.01% +92,743 13F-HR Timeline Group COOPERMAN LEON G More: the full row for COOPERMAN LEON G 421,278 $7.77M 0.24% 0 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 392,022 $7.23M <0.01% +290,668 13F-HR/A Timeline Group Hidden Lake Asset Management LP More: the full row for Hidden Lake Asset Management LP 314,036 $5.79M 2.31% -292,815 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 296,916 $5.48M 0.03% +150,000 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 286,104 $5.28M <0.01% +109,935 13F-HR Timeline Group FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 256,422 $4.73M <0.01% new 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 243,486 $4.49M <0.01% +55,284 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 231,167 $4.27M <0.01% +24,412 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 180,223 $3.33M <0.01% new 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 135,518 $2.5M +102,218 Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 129,935 $2.4M <0.01% +12,723 13F-HR/A Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 128,307 $2.37M 0.01% -76,048 13F-HR Timeline Group Burkehill Global Management, LP More: the full row for Burkehill Global Management, LP 100,000 $1.84M 0.1% new 13F-HR Timeline Anson Funds Management LP in group Anson Funds Management LP More: the full row for Anson Funds Management LP 99,887 $1.84M 0.2% new 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 81,746 $1.51M <0.01% +15,417 13F-HR Timeline Group Corient Private Wealth LP group of 2 filers holding More: the full row for Corient Private Wealth LP 67,000 $1.24M new Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 63,283 $1.17M <0.01% +4,505 13F-HR Timeline Group Moody Aldrich Partners LLC More: the full row for Moody Aldrich Partners LLC 59,454 $1.1M 0.21% -12,121 13F-HR Timeline Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 47,663 $879K <0.01% 0 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 45,977 $848K <0.01% +15,230 13F-HR/A Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 42,268 $780K <0.01% +39,697 13F-HR Timeline Group AlphaQuest LLC More: the full row for AlphaQuest LLC 41,449 $765K 0.05% new 13F-HR Timeline SECTORAL ASSET MANAGEMENT INC More: the full row for SECTORAL ASSET MANAGEMENT INC 39,235 $724K 0.45% +3,655 13F-HR Timeline SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 36,942 $682K <0.01% +9,469 13F-HR Timeline ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 36,136 $667K 0.01% -11,449 13F-HR Timeline Swiss National Bank More: the full row for Swiss National Bank 35,500 $655K <0.01% +9,100 13F-HR Timeline Rafferty Asset Management, LLC More: the full row for Rafferty Asset Management, LLC 34,361 $634K <0.01% +18,612 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 33,803 $624K <0.01% -151 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 28,200 $520K <0.01% 0 13F-HR Timeline Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 27,768 $512K <0.01% +18,314 13F-HR Timeline Group Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 20,400 $376K <0.01% new 13F-HR/A Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 19,972 $368K <0.01% +2,392 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 18,561 $342K <0.01% +5,539 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 17,794 $328K <0.01% +17,770 13F-HR Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 17,110 $316K <0.01% 0 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 15,179 $280K <0.01% +3,276 13F-HR Timeline Group Verition Fund Management LLC More: the full row for Verition Fund Management LLC 15,045 $278K <0.01% -41,457 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 15,016 $277K <0.01% -33 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 14,790 $273K <0.01% 0 13F-HR Timeline Group Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 14,814 $273K +89 Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 14,355 $265K <0.01% +2,902 13F-HR Timeline DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 14,158 $261K <0.01% new 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 13,991 $258K <0.01% -418 13F-HR/A Timeline Group AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 11,823 $218K <0.01% -2,513 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 10,037 $185K <0.01% -11,530 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 7,783 $144K <0.01% 0 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 7,454 $137K <0.01% +7,409 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 7,111 $131K 0.01% +240 13F-HR Timeline Caption Management, LLC More: the full row for Caption Management, LLC 7,000 $129K 0.01% new 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 6,255 $115K <0.01% 0 13F-HR Timeline Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 4,816 $88.9K 0.03% +837 13F-HR Timeline Group Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 3,258 $60.1K <0.01% +2,849 13F-HR Timeline KLP KAPITALFORVALTNING AS More: the full row for KLP KAPITALFORVALTNING AS 3,100 $57.2K <0.01% 0 13F-HR Timeline Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 2,352 $43.4K <0.01% 0 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 2,068 $38.2K <0.01% +2,047 13F-HR Timeline Group WEXFORD CAPITAL LP More: the full row for WEXFORD CAPITAL LP 1,567 $28.9K 0.01% -3,952 13F-HR Timeline BESSEMER GROUP INC in group BESSEMER GROUP INC More: the full row for BESSEMER GROUP INC 1,395 $26K <0.01% new 13F-HR Timeline Group US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 1,287 $23.7K <0.01% +160 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 1,283 $23.7K <0.01% -5,386 13F-HR Timeline Group AMALGAMATED BANK More: the full row for AMALGAMATED BANK 963 $18K <0.01% 0 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 873 $16.1K <0.01% +10 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 478 $8.82K <0.01% +309 13F-HR Timeline Group SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 368 $6.79K <0.01% +350 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 313 $5.78K <0.01% -21 13F-HR Timeline Optiver Holding B.V. in group Optiver Holding B.V. More: the full row for Optiver Holding B.V. 306 $5.65K <0.01% new 13F-HR Timeline Group Arax Advisory Partners More: the full row for Arax Advisory Partners 288 $5.31K <0.01% new 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 281 $5K <0.01% -178 13F-HR Timeline Group Versant Capital Management, Inc More: the full row for Versant Capital Management, Inc 190 $3.51K <0.01% -186 13F-HR Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 111 $2K <0.01% 0 13F-HR Timeline Group GAMMA Investing LLC More: the full row for GAMMA Investing LLC 85 $1.57K <0.01% -14 13F-HR Timeline Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 82 $1.51K <0.01% 0 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 60 $1.11K <0.01% +4 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 48 $886 <0.01% +23 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 37 $683 <0.01% 0 13F-HR Timeline Group Allworth Financial LP More: the full row for Allworth Financial LP 24 $443 <0.01% -99 13F-HR Timeline ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 20 $369 <0.01% 0 13F-HR Timeline PRINCIPAL SECURITIES, INC. in group PRINCIPAL FINANCIAL GROUP INC More: the full row for PRINCIPAL SECURITIES, INC. 16 $295 <0.01% 0 13F-HR Timeline Group Larson Financial Group LLC More: the full row for Larson Financial Group LLC 14 $258 <0.01% new 13F-HR Timeline MONTAG A & ASSOCIATES INC More: the full row for MONTAG A & ASSOCIATES INC 11 $203 <0.01% new 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 8 $148 <0.01% new 13F-HR Timeline Group Clearstead Advisors, LLC More: the full row for Clearstead Advisors, LLC 1 $19 <0.01% 0 13F-HR Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 1 $18 <0.01% 0 13F-HR/A Timeline Essential Partners LLC More: the full row for Essential Partners LLC 1 $18 <0.01% new 13F-HR Timeline Covestor Ltd More: the full row for Covestor Ltd 11 $0 0% +7 13F-HR Timeline Value filed as zero, left out of ratios.