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SECTORAL ASSET MANAGEMENT INC

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13F filer, CIK 1274413, MONTREAL, Quebec, Canada

SECTORAL ASSET MANAGEMENT INC reported $124,752,405 across 74 holdings for the quarter ended 2025-12-31, in a 13F-HR filed 2026-02-09. Its ten largest share positions make up 46.07% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001104659-26-011921

Period
2025-12-31
Reported value
$125M
Holdings
74
Top 10 weight
46.07%
New
6
Sold out
14

Largest buys vs the previous quarter

SecurityShares changeApprox. value
EVMNnew+589,005$10.1M
COGTnew+32,685$1.16M
JNJadded+5,000$1.03M
AMGNadded+2,730$894K
SIadded+62,153$889K

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
GPCRreduced-198,000-$13.8M
VTYXreduced-1,010,322-$9.12M
RCUSreduced-311,125-$7.41M
ANABexited-194,485-$5.96M
IMTXreduced-497,479-$5.22M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q4 2025

Share positions as resolved from 13F-HR 0001104659-26-011921, largest first. % of portfolio is the value over $124,752,405, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
EVMNEVOMMUNE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 589,005 shares 589,005$10.1M8.08%newTimeline
CTNMCONTINEUM THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 800,887 shares; 2024Q4: 800,787 shares; 2025Q1: 800,787 shares; 2025Q2: 800,787 shares; 2025Q3: 800,787 shares; 2025Q4: 800,787 shares 800,787$9.15M7.34%0Timeline
LLYELI LILLY & COQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 10,996 shares; 2024Q4: 12,546 shares; 2025Q1: 9,416 shares; 2025Q2: 8,976 shares; 2025Q3: 9,376 shares; 2025Q4: 7,276 shares 7,276$7.82M6.27%-2,100Timeline
SISHOULDER INNOVATIONS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 430,282 shares; 2025Q4: 492,435 shares 492,435$7.04M5.64%+62,153Timeline
UNHUNITEDHEALTH GROUP INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 13,125 shares; 2024Q4: 14,625 shares; 2025Q1: 12,895 shares; 2025Q2: 16,745 shares; 2025Q3: 13,545 shares; 2025Q4: 13,595 shares 13,595$4.49M3.6%+50Timeline
AMGNAMGEN INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 7,090 shares; 2024Q4: 12,550 shares; 2025Q1: 10,385 shares; 2025Q2: 11,270 shares; 2025Q3: 10,340 shares; 2025Q4: 13,070 shares 13,070$4.28M3.43%+2,730Timeline
JNJJOHNSON & JOHNSONQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 25,900 shares; 2024Q4: 22,900 shares; 2025Q1: 21,800 shares; 2025Q2: 19,300 shares; 2025Q3: 15,300 shares; 2025Q4: 20,300 shares 20,300$4.2M3.37%+5,000Timeline
ABBVABBVIE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 15,800 shares; 2024Q4: 18,800 shares; 2025Q1: 14,800 shares; 2025Q2: 14,800 shares; 2025Q3: 14,800 shares; 2025Q4: 16,800 shares 16,800$3.84M3.08%+2,000Timeline
VRTXVERTEX PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 4,840 shares; 2024Q4: 3,670 shares; 2025Q1: 4,725 shares; 2025Q2: 6,945 shares; 2025Q3: 7,715 shares; 2025Q4: 8,005 shares 8,005$3.63M2.91%+290Timeline
ABTABBOTT LABORATORIESQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 19,398 shares; 2024Q4: 24,398 shares; 2025Q1: 18,698 shares; 2025Q2: 15,198 shares; 2025Q3: 17,198 shares; 2025Q4: 23,498 shares 23,498$2.94M2.36%+6,300Timeline
REGNREGENERON PHARMACEUTICALSQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 3,400 shares; 2024Q4: 3,400 shares; 2025Q1: 2,773 shares; 2025Q2: 2,773 shares; 2025Q3: 3,968 shares; 2025Q4: 3,715 shares 3,715$2.87M2.3%-253Timeline
ISRGINTUITIVE SURGICAL INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 3,050 shares; 2024Q4: 3,050 shares; 2025Q1: 5,250 shares; 2025Q2: 5,250 shares; 2025Q3: 5,750 shares; 2025Q4: 4,850 shares 4,850$2.75M2.2%-900Timeline
BSXBOSTON SCIENTIFIC CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 33,026 shares; 2024Q4: 32,526 shares; 2025Q1: 24,226 shares; 2025Q2: 21,126 shares; 2025Q3: 22,126 shares; 2025Q4: 27,626 shares 27,626$2.63M2.11%+5,500Timeline
ARGXARGENX SEQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 3,997 shares; 2024Q4: 3,430 shares; 2025Q1: 3,103 shares; 2025Q2: 4,085 shares; 2025Q3: 3,890 shares; 2025Q4: 2,894 shares 2,894$2.43M1.95%-996Timeline
DHRDANAHER CORP DELQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 4,775 shares; 2024Q4: 7,275 shares; 2025Q1: 10,575 shares; 2025Q2: 10,575 shares; 2025Q3: 10,575 shares; 2025Q4: 10,575 shares 10,575$2.42M1.94%0Timeline
SYKSTRYKER CORPORATIONQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 7,450 shares; 2024Q4: 6,400 shares; 2025Q1: 6,100 shares; 2025Q2: 3,900 shares; 2025Q3: 4,300 shares; 2025Q4: 6,550 shares 6,550$2.3M1.85%+2,250Timeline
TMOTHERMO FISHER SCIENTIFIC INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 5,250 shares; 2024Q4: 4,750 shares; 2025Q1: 3,250 shares; 2025Q2: 3,900 shares; 2025Q3: 3,900 shares; 2025Q4: 3,900 shares 3,900$2.26M1.81%0Timeline
MRKMERCK & CO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 24,000 shares; 2024Q4: 24,500 shares; 2025Q1: 26,900 shares; 2025Q2: 20,900 shares; 2025Q3: 16,400 shares; 2025Q4: 21,400 shares 21,400$2.25M1.81%+5,000Timeline
GILDGILEAD SCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 61,065 shares; 2024Q4: 51,310 shares; 2025Q1: 32,020 shares; 2025Q2: 19,690 shares; 2025Q3: 19,550 shares; 2025Q4: 17,885 shares 17,885$2.2M1.76%-1,665Timeline
INSMINSMED INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 9,681 shares; 2024Q4: 7,371 shares; 2025Q1: 15,230 shares; 2025Q2: 14,880 shares; 2025Q3: 13,425 shares; 2025Q4: 11,182 shares 11,182$1.95M1.56%-2,243Timeline
DXCMDEXCOM INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 10,700 shares; 2024Q4: not reported; 2025Q1: 15,000 shares; 2025Q2: 13,200 shares; 2025Q3: 20,700 shares; 2025Q4: 28,700 shares 28,700$1.9M1.53%+8,000Timeline
VERAVERA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 7,428 shares; 2024Q4: 5,700 shares; 2025Q1: 28,348 shares; 2025Q2: 41,418 shares; 2025Q3: 30,188 shares; 2025Q4: 36,858 shares 36,858$1.87M1.5%+6,670Timeline
GPCRSTRUCTURE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 24,395 shares; 2024Q4: 49,250 shares; 2025Q1: 33,695 shares; 2025Q2: 51,369 shares; 2025Q3: 221,872 shares; 2025Q4: 23,872 shares 23,872$1.66M1.33%-198,000Timeline
BNTXBIONTECH SEQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 13,155 shares; 2024Q4: 18,950 shares; 2025Q1: 17,175 shares; 2025Q2: 16,160 shares; 2025Q3: 17,660 shares; 2025Q4: 17,218 shares 17,218$1.64M1.31%-442Timeline
EWEDWARDS LIFESCIENCES CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 25,850 shares; 2024Q4: 7,850 shares; 2025Q1: not reported; 2025Q2: 15,000 shares; 2025Q3: 15,000 shares; 2025Q4: 17,250 shares 17,250$1.47M1.18%+2,250Timeline
AZNASTRAZENECA PLC-SPONS ADRQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 21,340 shares; 2024Q4: 14,650 shares; 2025Q1: 18,790 shares; 2025Q2: 18,640 shares; 2025Q3: 18,750 shares; 2025Q4: 15,232 shares 15,232$1.4M1.12%-3,518Timeline
SMMTSUMMIT THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 26,700 shares; 2024Q4: 30,000 shares; 2025Q1: 69,240 shares; 2025Q2: 65,220 shares; 2025Q3: 74,070 shares; 2025Q4: 79,625 shares 79,625$1.39M1.12%+5,555Timeline
RCUSARCUS BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 75,522 shares; 2024Q4: 69,552 shares; 2025Q1: 26,870 shares; 2025Q2: 257,270 shares; 2025Q3: 368,070 shares; 2025Q4: 56,945 shares 56,945$1.36M1.09%-311,125Timeline
SNDXSYNDAX PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 63,300 shares; 2025Q3: 79,430 shares; 2025Q4: 61,200 shares 61,200$1.29M1.03%-18,230Timeline
TARSTARSUS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 11,300 shares; 2024Q4: 20,300 shares; 2025Q1: 17,250 shares; 2025Q2: 18,535 shares; 2025Q3: 18,405 shares; 2025Q4: 14,740 shares 14,740$1.21M0.97%-3,665Timeline
ALNYALNYLAM PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 9,690 shares; 2024Q4: 8,300 shares; 2025Q1: 5,205 shares; 2025Q2: 3,323 shares; 2025Q3: 3,273 shares; 2025Q4: 2,990 shares 2,990$1.19M0.95%-283Timeline
RAPPRAPPORT THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 179,860 shares; 2025Q3: 43,480 shares; 2025Q4: 38,925 shares 38,925$1.18M0.95%-4,555Timeline
COGTCOGENT BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 84,400 shares; 2024Q4: 73,800 shares; 2025Q1: 79,020 shares; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 32,685 shares 32,685$1.16M0.93%newTimeline
MLYSMINERALYS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 329,513 shares; 2024Q4: 380,883 shares; 2025Q1: 370,513 shares; 2025Q2: 382,415 shares; 2025Q3: 33,885 shares; 2025Q4: 31,625 shares 31,625$1.15M0.92%-2,260Timeline
TRVITREVI THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 81,800 shares; 2025Q2: 134,150 shares; 2025Q3: 105,950 shares; 2025Q4: 84,255 shares 84,255$1.05M0.85%-21,695Timeline
ROIVROIVANT SCIENCES LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 45,127 shares; 2024Q4: 34,500 shares; 2025Q1: 48,907 shares; 2025Q2: 50,007 shares; 2025Q3: 50,007 shares; 2025Q4: 45,347 shares 45,347$984K0.79%-4,660Timeline
TECXTECTONIC THERAPEUTIC INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 98,970 shares; 2025Q3: 192,770 shares; 2025Q4: 42,255 shares 42,255$881K0.71%-150,515Timeline
VTYXVENTYX BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 931,620 shares; 2025Q3: 1,107,267 shares; 2025Q4: 96,945 shares 96,945$875K0.7%-1,010,322Timeline
BBIOBRIDGEBIO PHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 15,085 shares; 2024Q4: 11,500 shares; 2025Q1: 16,085 shares; 2025Q2: 16,085 shares; 2025Q3: 13,650 shares; 2025Q4: 11,170 shares 11,170$854K0.68%-2,480Timeline
UTHRUNITED THERAPEUTICS CORP DELQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,060 shares; 2024Q4: 595 shares; 2025Q1: 765 shares; 2025Q2: 765 shares; 2025Q3: 765 shares; 2025Q4: 1,723 shares 1,723$840K0.67%+958Timeline
BOLDBOUNDLESS BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 678,574 shares; 2024Q4: 678,574 shares; 2025Q1: 678,574 shares; 2025Q2: 678,574 shares; 2025Q3: 678,574 shares; 2025Q4: 678,574 shares 678,574$814K0.65%0Timeline
ONCBEONE MEDICINES LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,637 shares; 2024Q4: 2,010 shares; 2025Q1: 2,927 shares; 2025Q2: 7,716 shares; 2025Q3: 7,201 shares; 2025Q4: 2,665 shares 2,665$810K0.65%-4,536Timeline
RDNTRADNET INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 20,000 shares; 2025Q2: 12,500 shares; 2025Q3: 10,000 shares; 2025Q4: 11,000 shares 11,000$785K0.63%+1,000Timeline
AVBPARRIVENT BIOPHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 10,090 shares; 2025Q2: 35,580 shares; 2025Q3: 39,235 shares; 2025Q4: 38,255 shares 38,255$770K0.62%-980Timeline
QUREUNIQURE NVQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 153,000 shares; 2024Q4: 71,500 shares; 2025Q1: 57,550 shares; 2025Q2: 55,450 shares; 2025Q3: 30,740 shares; 2025Q4: 30,585 shares 30,585$732K0.59%-155Timeline
ASNDASCENDIS PHARMA A/SQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,141 shares; 2024Q4: 1,600 shares; 2025Q1: 2,091 shares; 2025Q2: 3,471 shares; 2025Q3: 3,601 shares; 2025Q4: 3,254 shares 3,254$694K0.56%-347Timeline
LENZLENZ THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 977,245 shares; 2024Q4: 977,245 shares; 2025Q1: 977,245 shares; 2025Q2: 977,245 shares; 2025Q3: not reported; 2025Q4: 42,500 shares 42,500$680K0.55%newTimeline
PFEPFIZER INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 114,650 shares; 2024Q4: 77,650 shares; 2025Q1: 59,650 shares; 2025Q2: 77,150 shares; 2025Q3: 77,150 shares; 2025Q4: 27,150 shares 27,150$676K0.54%-50,000Timeline
INSPINSPIRE MED SYS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 7,200 shares 7,200$664K0.53%newTimeline
IONSIONIS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 9,440 shares; 2024Q4: 7,200 shares; 2025Q1: 9,440 shares; 2025Q2: 9,205 shares; 2025Q3: 9,205 shares; 2025Q4: 8,365 shares 8,365$662K0.53%-840Timeline
IMTXIMMATICS N.VQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 332,270 shares; 2025Q3: 560,494 shares; 2025Q4: 63,015 shares 63,015$662K0.53%-497,479Timeline
HNGEHINGE HEALTH INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 9,206 shares; 2025Q3: 11,206 shares; 2025Q4: 14,206 shares 14,206$660K0.53%+3,000Timeline
BMRNBIOMARIN PHARMACEUTICAL INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 36,870 shares; 2024Q4: 29,400 shares; 2025Q1: 23,530 shares; 2025Q2: 23,530 shares; 2025Q3: 25,030 shares; 2025Q4: 10,880 shares 10,880$647K0.52%-14,150Timeline
ALHCALIGNMENT HEALTHCARE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 54,500 shares; 2025Q4: 31,500 shares 31,500$622K0.5%-23,000Timeline
FOLDAMICUS THERAPEUTICQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 141,335 shares; 2024Q4: 135,620 shares; 2025Q1: 107,585 shares; 2025Q2: 119,585 shares; 2025Q3: 119,105 shares; 2025Q4: 43,300 shares 43,300$617K0.49%-75,805Timeline
PRVAPRIVIA HEALTH GROUP INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 52,000 shares; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 36,500 shares; 2025Q4: 26,000 shares 26,000$616K0.49%-10,500Timeline
CARLCARLSMED INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 47,700 shares 47,700$589K0.47%newTimeline
PTCTPTC THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 7,600 shares; 2024Q4: 5,800 shares; 2025Q1: 8,350 shares; 2025Q2: 8,535 shares; 2025Q3: 8,535 shares; 2025Q4: 7,715 shares 7,715$586K0.47%-820Timeline
OMDAOMADA HEALTH INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 34,500 shares; 2025Q3: 27,500 shares; 2025Q4: 36,500 shares 36,500$576K0.46%+9,000Timeline
NKTRNEKTAR THERAPEUTICSQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 13,485 shares 13,485$570K0.46%newTimeline
KURAKURA ONCOLOGY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 323,572 shares; 2025Q3: 395,872 shares; 2025Q4: 54,110 shares 54,110$562K0.45%-341,762Timeline
NBIXNEUROCRINE BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 12,515 shares; 2024Q4: 11,800 shares; 2025Q1: 2,905 shares; 2025Q2: 2,960 shares; 2025Q3: 2,960 shares; 2025Q4: 2,675 shares 2,675$379K0.3%-285Timeline
BIIBBIOGEN INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 6,027 shares; 2024Q4: 3,852 shares; 2025Q1: 2,855 shares; 2025Q2: 2,375 shares; 2025Q3: 2,375 shares; 2025Q4: 2,155 shares 2,155$379K0.3%-220Timeline
CYTKCYTOKINETICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 28,593 shares; 2024Q4: 24,500 shares; 2025Q1: 18,068 shares; 2025Q2: 11,723 shares; 2025Q3: 10,223 shares; 2025Q4: 5,893 shares 5,893$374K0.3%-4,330Timeline
JAZZJAZZ PHARMACEUTICALS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,274 shares; 2024Q4: 1,750 shares; 2025Q1: 2,274 shares; 2025Q2: 2,274 shares; 2025Q3: 2,244 shares; 2025Q4: 2,049 shares 2,049$348K0.28%-195Timeline
SPRYARS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 98,640 shares; 2024Q4: 106,007 shares; 2025Q1: 100,205 shares; 2025Q2: 65,785 shares; 2025Q3: 81,785 shares; 2025Q4: 29,803 shares 29,803$347K0.28%-51,982Timeline
RPRXROYALTY PHARMA PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 16,430 shares; 2024Q4: 7,200 shares; 2025Q1: 9,280 shares; 2025Q2: 9,280 shares; 2025Q3: 9,280 shares; 2025Q4: 8,470 shares 8,470$327K0.26%-810Timeline
ILMNILLUMINA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 5,745 shares; 2024Q4: 4,370 shares; 2025Q1: 3,682 shares; 2025Q2: 2,782 shares; 2025Q3: 2,727 shares; 2025Q4: 2,472 shares 2,472$324K0.26%-255Timeline
AXSMAXSOME THERAPEUTICS INC.Quarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 820 shares; 2025Q1: 1,020 shares; 2025Q2: 1,020 shares; 2025Q3: 1,020 shares; 2025Q4: 1,740 shares 1,740$318K0.25%+720Timeline
INCYINCYTE CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 2,500 shares; 2025Q1: 6,145 shares; 2025Q2: 6,060 shares; 2025Q3: 3,030 shares; 2025Q4: 2,750 shares 2,750$272K0.22%-280Timeline
TEMTEMPUS AI INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 2,160 shares; 2025Q2: 3,760 shares; 2025Q3: 3,760 shares; 2025Q4: 4,500 shares 4,500$266K0.21%+740Timeline
MDGLMADRIGAL PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,045 shares; 2024Q4: 570 shares; 2025Q1: 730 shares; 2025Q2: 730 shares; 2025Q3: 730 shares; 2025Q4: 352 shares 352$205K0.16%-378Timeline
ORICORIC PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 20,000 shares; 2025Q2: 231,485 shares; 2025Q3: 328,655 shares; 2025Q4: 22,480 shares 22,480$184K0.15%-306,175Timeline
MRNAMODERNA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 13,960 shares; 2024Q4: 4,350 shares; 2025Q1: 5,600 shares; 2025Q2: 5,600 shares; 2025Q3: 5,600 shares; 2025Q4: 5,005 shares 5,005$148K0.12%-595Timeline

Sold out in Q4 2025

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
ANABANAPTYSBIO INC194,485$5.96Mshares
BCAXBICARA THERAPEUTICS INC266,495$4.21Mshares
SLDBSOLID BIOSCIENCES INC633,052$3.91Mshares
MBXMBX BIOSCIENCES INC194,898$3.41Mshares
XBISPDR SERIES TRUST34,000$3.41Mshares
ZBIOZENAS BIOPHARMA INC152,025$3.37Mshares
PVLAPALVELLA THERAPEUTICS INC NE49,115$3.08Mshares
TILINSTIL BIO INC161,380$2.88Mshares
MERUS N VMERUS N V11,545$1.09Mshares
CITHE CIGNA GROUP1,800$519Kshares
BMYBRISTOL-MYERS SQUIBB CO10,800$487Kshares
ZLABZAI LAB LTD12,590$427Kshares
PCVXVAXCYTE INC4,205$151Kshares
MLTXMOONLAKE IMMUNOTHERAPEUTICS956$6.86Kshares

How Q4 2025 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001104659-26-011921 base2026-02-09acceptance time not in the bulk data set