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Frazier Life Sciences Management, L.P.

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13F filer, CIK 1892134, PALO ALTO, CA

Frazier Life Sciences Management, L.P. reported $3,886,526,658 across 38 holdings for the quarter ended 2026-03-31, in a 13F-HR filed 2026-05-15. Its ten largest share positions make up 73.49% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001892134-26-000002

Period
2026-03-31
Reported value
$3.89B
Holdings
38
Top 10 weight
73.49%
New
4
Sold out
6

Largest buys vs the previous quarter

SecurityShares changeApprox. value
MIRMadded+884,563$81.7M
BCRXnew+4,009,240$38.2M
ERASadded+1,945,752$31.5M
PVLAadded+160,000$19.9M
ACRSnew+4,925,374$18.5M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
RNAMexited-983,125-$70.9M
ABVXexited-378,300-$51M
RAPTexited-983,333-$33.3M
RVMDreduced-121,769-$11.8M
TVTXexited-241,592-$9.23M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q1 2026

Share positions as resolved from 13F-HR 0001892134-26-000002, largest first. % of portfolio is the value over $3,886,526,658, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
MIRMMIRUM PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 6,570,392 shares; 2024Q4: 6,570,392 shares; 2025Q1: 6,795,121 shares; 2025Q2: 6,795,121 shares; 2025Q3: 6,795,121 shares; 2025Q4: 6,795,121 shares; 2026Q1: 7,679,684 shares 7,679,684$709M18.25%+884,563Timeline
NAMSNEWAMSTERDAM PHARMA COMPANYQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 12,855,194 shares; 2024Q4: 15,916,418 shares; 2025Q1: 16,116,418 shares; 2025Q2: 16,607,074 shares; 2025Q3: 16,701,956 shares; 2025Q4: 16,943,774 shares; 2026Q1: 16,943,774 shares 16,943,774$542M13.96%0Timeline
ERASERASCA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 19,391,687 shares; 2024Q4: 19,391,687 shares; 2025Q1: 22,575,851 shares; 2025Q2: 22,729,436 shares; 2025Q3: 22,729,436 shares; 2025Q4: 22,729,436 shares; 2026Q1: 24,675,188 shares 24,675,188$399M10.27%+1,945,752Timeline
BBIOBRIDGEBIO PHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 3,760,457 shares; 2024Q4: 3,800,457 shares; 2025Q1: 3,800,457 shares; 2025Q2: 3,800,457 shares; 2025Q3: 3,845,457 shares; 2025Q4: 3,545,557 shares; 2026Q1: 3,448,139 shares 3,448,139$256M6.59%-97,418Timeline
ARQTARCUTIS BIOTHERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 8,785,284 shares; 2024Q4: 8,785,284 shares; 2025Q1: 8,785,284 shares; 2025Q2: 9,874,511 shares; 2025Q3: 9,874,511 shares; 2025Q4: 9,874,511 shares; 2026Q1: 9,874,511 shares 9,874,511$233M5.99%0Timeline
MBXMBX BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 5,985,347 shares; 2024Q4: 5,985,347 shares; 2025Q1: 5,985,347 shares; 2025Q2: 5,985,347 shares; 2025Q3: 6,652,013 shares; 2025Q4: 6,652,013 shares; 2026Q1: 6,652,013 shares 6,652,013$199M5.11%0Timeline
PHATPHATHOM PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 10,109,279 shares; 2024Q4: 10,109,279 shares; 2025Q1: 10,109,279 shares; 2025Q2: 12,466,489 shares; 2025Q3: 12,466,489 shares; 2025Q4: 12,466,489 shares; 2026Q1: 12,466,489 shares 12,466,489$139M3.56%0Timeline
MAZEMAZE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 4,129,001 shares; 2025Q2: 4,567,275 shares; 2025Q3: 4,567,274 shares; 2025Q4: 4,567,274 shares; 2026Q1: 4,567,274 shares 4,567,274$136M3.51%0Timeline
KRYSKRYSTAL BIOTECH INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 988,460 shares; 2024Q4: 788,460 shares; 2025Q1: 688,460 shares; 2025Q2: 688,460 shares; 2025Q3: 688,460 shares; 2025Q4: 488,460 shares; 2026Q1: 481,307 shares 481,307$124M3.2%-7,153Timeline
TRVITREVI THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 7,381,090 shares; 2024Q4: 10,664,774 shares; 2025Q1: 10,259,409 shares; 2025Q2: 10,259,409 shares; 2025Q3: 10,259,409 shares; 2025Q4: 10,259,409 shares; 2026Q1: 9,939,547 shares 9,939,547$119M3.05%-319,862Timeline
PVLAPALVELLA THERAPEUTICS INC NEQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 653,892 shares; 2025Q1: 690,012 shares; 2025Q2: 722,400 shares; 2025Q3: 722,400 shares; 2025Q4: 722,400 shares; 2026Q1: 882,400 shares 882,400$110M2.83%+160,000Timeline
KALVKALVISTA PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 3,687,867 shares; 2024Q4: 4,887,867 shares; 2025Q1: 4,887,867 shares; 2025Q2: 4,887,867 shares; 2025Q3: 5,039,867 shares; 2025Q4: 5,039,867 shares; 2026Q1: 4,961,108 shares 4,961,108$99.9M2.57%-78,759Timeline
IRONDISC MEDICINE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 1,754,834 shares; 2024Q4: 1,754,834 shares; 2025Q1: 1,754,834 shares; 2025Q2: 1,654,834 shares; 2025Q3: 1,438,534 shares; 2025Q4: 1,260,000 shares; 2026Q1: 1,354,852 shares 1,354,852$86.6M2.23%+94,852Timeline
CYTKCYTOKINETICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 554,731 shares; 2025Q3: 890,445 shares; 2025Q4: 934,642 shares; 2026Q1: 1,159,879 shares 1,159,879$76.4M1.97%+225,237Timeline
RVMDREVOLUTION MEDICINES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 997,455 shares; 2024Q4: 997,455 shares; 2025Q1: 997,455 shares; 2025Q2: 997,455 shares; 2025Q3: 997,455 shares; 2025Q4: 797,455 shares; 2026Q1: 675,686 shares 675,686$65.7M1.69%-121,769Timeline
DYNDYNE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 1,443,341 shares; 2025Q2: 1,505,984 shares; 2025Q3: 2,718,105 shares; 2025Q4: 3,153,082 shares; 2026Q1: 3,153,082 shares 3,153,082$57.2M1.47%0Timeline
SVRASAVARA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 8,157,385 shares; 2024Q4: 8,660,379 shares; 2025Q1: 11,462,301 shares; 2025Q2: 11,462,301 shares; 2025Q3: 11,462,301 shares; 2025Q4: 9,862,301 shares; 2026Q1: 9,720,852 shares 9,720,852$53.1M1.37%-141,449Timeline
TARSTARSUS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 1,587,527 shares; 2024Q4: 1,587,527 shares; 2025Q1: 1,397,527 shares; 2025Q2: 1,397,527 shares; 2025Q3: 1,167,527 shares; 2025Q4: 728,644 shares; 2026Q1: 728,644 shares 728,644$51.1M1.32%0Timeline
VORVOR BIOPHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 2,543,939 shares; 2026Q1: 2,543,939 shares 2,543,939$45.4M1.17%0Timeline
AGIOAGIOS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 1,044,154 shares; 2024Q4: 1,069,754 shares; 2025Q1: 1,069,854 shares; 2025Q2: 1,279,754 shares; 2025Q3: 1,279,754 shares; 2025Q4: 1,279,754 shares; 2026Q1: 1,256,080 shares 1,256,080$42.5M1.09%-23,674Timeline
BCRXBIOCRYST PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 4,009,240 shares 4,009,240$38.2M0.98%newTimeline
ZLABZAI LAB LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 350,000 shares; 2025Q2: 1,308,138 shares; 2025Q3: 1,627,320 shares; 2025Q4: 1,902,320 shares; 2026Q1: 1,902,320 shares 1,902,320$35.8M0.92%0Timeline
AURAAURA BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 5,100,000 shares; 2025Q3: 5,100,000 shares; 2025Q4: 5,100,000 shares; 2026Q1: 5,100,000 shares 5,100,000$34.1M0.88%0Timeline
ACADACADIA PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 470,338 shares; 2024Q4: 470,338 shares; 2025Q1: 470,338 shares; 2025Q2: not reported; 2025Q3: 613,837 shares; 2025Q4: 1,297,198 shares; 2026Q1: 1,438,198 shares 1,438,198$32M0.82%+141,000Timeline
ASNDASCENDIS PHARMA A/SQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 133,333 shares; 2024Q4: 133,333 shares; 2025Q1: 133,333 shares; 2025Q2: 133,333 shares; 2025Q3: 133,333 shares; 2025Q4: 133,333 shares; 2026Q1: 133,333 shares 133,333$30.5M0.78%0Timeline
LXEOLEXEO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 1,250,786 shares; 2024Q4: 955,515 shares; 2025Q1: 955,515 shares; 2025Q2: 4,424,725 shares; 2025Q3: 4,424,725 shares; 2025Q4: 4,424,725 shares; 2026Q1: 4,424,725 shares 4,424,725$25.4M0.65%0Timeline
ALKSALKERMES PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 576,129 shares; 2024Q4: 601,129 shares; 2025Q1: 601,129 shares; 2025Q2: 1,000,647 shares; 2025Q3: 700,647 shares; 2025Q4: 700,647 shares; 2026Q1: 700,647 shares 700,647$24.8M0.64%0Timeline
ACRSACLARIS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 264,377 shares; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 4,925,374 shares 4,925,374$18.5M0.48%newTimeline
GLUEMONTE ROSA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 1,000,000 shares 1,000,000$16.4M0.42%newTimeline
IMCRIMMUNOCORE HLDGS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 108,762 shares; 2024Q4: 108,762 shares; 2025Q1: 301,170 shares; 2025Q2: 384,782 shares; 2025Q3: 384,782 shares; 2025Q4: 384,782 shares; 2026Q1: 484,782 shares 484,782$14.6M0.38%+100,000Timeline
MNKDMANNKIND CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 4,225,000 shares; 2026Q1: 5,900,000 shares 5,900,000$14.5M0.37%+1,675,000Timeline
VALNVALNEVA SEQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 1,458,333 shares; 2025Q3: 2,291,666 shares; 2025Q4: 2,291,666 shares; 2026Q1: 2,291,666 shares 2,291,666$14.3M0.37%0Timeline
EOLSEVOLUS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 2,435,550 shares; 2025Q3: 2,630,665 shares; 2025Q4: 2,630,665 shares; 2026Q1: 2,630,665 shares 2,630,665$10.8M0.28%0Timeline
NAMSWNEWAMSTERDAM PHARMA COMPANYQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 500,333 shares; 2024Q4: 500,333 shares; 2025Q1: 500,333 shares; 2025Q2: 500,333 shares; 2025Q3: 500,333 shares; 2025Q4: 500,333 shares; 2026Q1: 500,333 shares 500,333$10M0.26%0Timeline
ALLOALLOGENE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 2,867,750 shares; 2024Q4: 2,867,750 shares; 2025Q1: 3,868,750 shares; 2025Q2: 3,868,750 shares; 2025Q3: 3,868,750 shares; 2025Q4: 3,868,750 shares; 2026Q1: 3,796,668 shares 3,796,668$9.26M0.24%-72,082Timeline
AUTLAUTOLUS THERAPEUTICS LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 4,623,324 shares; 2024Q4: 4,623,324 shares; 2025Q1: 4,623,324 shares; 2025Q2: 4,623,324 shares; 2025Q3: 4,623,324 shares; 2025Q4: 4,623,324 shares; 2026Q1: 4,447,910 shares 4,447,910$6.14M0.16%-175,414Timeline
IBIOIBIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 1,953,467 shares; 2026Q1: 1,953,467 shares 1,953,467$3.71M0.1%0Timeline
XLOXILIO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 422,505 shares 422,505$3.55M0.09%newTimeline

Sold out in Q1 2026

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
RNAMAVIDITY BIOSCIENCES INC983,125$70.9Mshares
ABVXABIVAX SA378,300$51Mshares
RAPTRAPT THERAPEUTICS INC983,333$33.3Mshares
TVTXTRAVERE THERAPEUTICS INC241,592$9.23Mshares
DSGNDESIGN THERAPEUTICS INC521,000$4.89Mshares
XLOXilio Therapeutics Inc.5,915,091$3.79Mshares

How Q1 2026 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001892134-26-000002 base2026-05-15acceptance time not in the bulk data set