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Allostery Investments LP

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13F filer, CIK 1978599, Stamford, CT

Allostery Investments LP reported $7,850,255 across 20 holdings for the quarter ended 2025-06-30, in a 13F-HR filed 2025-08-14. Its ten largest share positions make up 82.66% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001013594-25-001022

Period
2025-06-30
Reported value
$7.85M
Holdings
20
Top 10 weight
82.66%
New
5
Sold out
26

Largest buys vs the previous quarter

SecurityShares changeApprox. value
RZLTnew+119,294$532K
FULCnew+40,353$278K
AKROadded+4,500$240K
TNGXnew+40,000$205K
Tourmaline Bio Incnew+9,356$150K

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
ABVXreduced-932,304-$7.13M
MERUS N Vreduced-115,657-$6.08M
KALVreduced-418,302-$4.73M
APGEreduced-104,000-$4.52M
CNTAreduced-330,024-$4.34M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q2 2025

Share positions as resolved from 13F-HR 0001013594-25-001022, largest first. % of portfolio is the value over $7,850,256, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
ABVXABIVAX SAQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: not loaded; 2024Q1: not loaded; 2024Q2: not loaded; 2024Q3: not loaded; 2024Q4: 591,253 shares; 2025Q1: 1,099,654 shares; 2025Q2: 167,350 shares 167,350$1.28M16.31%-932,304Timeline
AKROAKERO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: not loaded; 2024Q1: not loaded; 2024Q2: not loaded; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: 18,000 shares; 2025Q2: 22,500 shares 22,500$1.2M15.29%+4,500Timeline
AMLXAMYLYX PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: not loaded; 2024Q1: not loaded; 2024Q2: not loaded; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: 266,099 shares; 2025Q2: 120,119 shares 120,119$770K9.81%-145,980Timeline
CNTACENTESSA PHARMACEUTICALS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: not loaded; 2024Q1: not loaded; 2024Q2: not loaded; 2024Q3: not loaded; 2024Q4: 284,517 shares; 2025Q1: 382,524 shares; 2025Q2: 52,500 shares 52,500$690K8.79%-330,024Timeline
EOLSEVOLUS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: not loaded; 2024Q1: not loaded; 2024Q2: not loaded; 2024Q3: not loaded; 2024Q4: 431,117 shares; 2025Q1: 412,754 shares; 2025Q2: 60,000 shares 60,000$553K7.04%-352,754Timeline
RZLTREZOLUTE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: not loaded; 2024Q1: not loaded; 2024Q2: not loaded; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 119,294 shares 119,294$532K6.78%newTimeline
MERUS N VMERUS N VQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: not loaded; 2024Q1: not loaded; 2024Q2: not loaded; 2024Q3: not loaded; 2024Q4: 21,735 shares; 2025Q1: 124,657 shares; 2025Q2: 9,000 shares 9,000$473K6.03%-115,657
KALVKALVISTA PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: not loaded; 2024Q1: not loaded; 2024Q2: not loaded; 2024Q3: not loaded; 2024Q4: 479,100 shares; 2025Q1: 458,302 shares; 2025Q2: 40,000 shares 40,000$452K5.76%-418,302Timeline
FULCFULCRUM THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: not loaded; 2024Q1: not loaded; 2024Q2: not loaded; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 40,353 shares 40,353$278K3.54%newTimeline
APGEAPOGEE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: not loaded; 2024Q1: not loaded; 2024Q2: not loaded; 2024Q3: not loaded; 2024Q4: 100,000 shares; 2025Q1: 110,000 shares; 2025Q2: 6,000 shares 6,000$261K3.32%-104,000Timeline
VERONA PHARMA PLCVERONA PHARMA PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: not loaded; 2024Q1: not loaded; 2024Q2: not loaded; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: 12,500 shares; 2025Q2: 2,500 shares 2,500$236K3.01%-10,000
TNGXTANGO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: not loaded; 2024Q1: not loaded; 2024Q2: not loaded; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 40,000 shares 40,000$205K2.61%newTimeline
BBIOBRIDGEBIO PHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: not loaded; 2024Q1: not loaded; 2024Q2: not loaded; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: 80,000 shares; 2025Q2: 4,000 shares 4,000$173K2.2%-76,000Timeline
CYTKCYTOKINETICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: not loaded; 2024Q1: not loaded; 2024Q2: not loaded; 2024Q3: not loaded; 2024Q4: 65,000 shares; 2025Q1: 70,000 shares; 2025Q2: 5,000 shares 5,000$165K2.1%-65,000Timeline
Tourmaline Bio IncTourmaline Bio IncQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: not loaded; 2024Q1: not loaded; 2024Q2: not loaded; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 9,356 shares 9,356$150K1.91%new
LEGNLEGEND BIOTECH CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: not loaded; 2024Q1: not loaded; 2024Q2: not loaded; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: 4,750 shares; 2025Q2: 4,000 shares 4,000$142K1.81%-750Timeline
NKTRNEKTAR THERAPEUTICSQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: not loaded; 2024Q1: not loaded; 2024Q2: not loaded; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 4,000 shares 4,000$103K1.32%newTimeline
PROMIS NEUROSCIENCES INCPROMIS NEUROSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: not loaded; 2024Q1: not loaded; 2024Q2: not loaded; 2024Q3: not loaded; 2024Q4: 195,111 shares; 2025Q1: 233,703 shares; 2025Q2: 155,720 shares 155,720$76.3K0.97%-77,983
ACLXARCELLX INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: not loaded; 2024Q1: not loaded; 2024Q2: not loaded; 2024Q3: not loaded; 2024Q4: 35,000 shares; 2025Q1: 44,000 shares; 2025Q2: 1,000 shares 1,000$65.8K0.84%-43,000Timeline
AVTXAVALO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: not loaded; 2024Q1: not loaded; 2024Q2: not loaded; 2024Q3: not loaded; 2024Q4: 73,314 shares; 2025Q1: 107,141 shares; 2025Q2: 9,000 shares 9,000$44.9K0.57%-98,141Timeline

Sold out in Q2 2025

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
ALKSALKERMES PLC115,000$3.8Mshares
AEROVATE THERAPEUTICS INCAEROVATE THERAPEUTICS INC1,421,568$3.57Mshares
ZURAZURA BIO LTD2,329,384$3Mshares
SPRINGWORKS THERAPEUTICS INCSPRINGWORKS THERAPEUTICS INC52,500$2.32Mshares
BEAMBEAM THERAPEUTICS INC92,754$1.81Mshares
SLNOSOLENO THERAPEUTICS INC20,000$1.43Mshares
PCVXVAXCYTE INC32,000$1.21Mshares
IONSIONIS PHARMACEUTICALS INC35,000$1.06Mshares
XENEXENON PHARMACEUTICALS INC30,000$1.01Mshares
INSMINSMED INC10,000$763Kshares
TARSTARSUS PHARMACEUTICALS INC13,600$699Kshares
GOSSGOSSAMER BIO INC613,028$674Kshares
PLRXPLIANT THERAPEUTICS INC441,686$596Kshares
CNTXCONTEXT THERAPEUTICS INC950,166$582Kshares
BIOMX INCBIOMX INC940,629$523Kshares
RALLYBIO CORPRALLYBIO CORP752,235$492Kshares
ELDNELEDON PHARMACEUTICALS INC100,000$339Kshares
CLYMCLIMB BIO INC244,988$299Kshares
ORKAORUKA THERAPEUTICS INC20,000$205Kshares
MDGLMADRIGAL PHARMACEUTICALS INC600$199Kshares
89BIO INC89BIO INC25,000$182Kshares
VIRVIR BIOTECHNOLOGY INC22,202$144Kshares
WVEWAVE LIFE SCIENCES LTD17,500$141Kshares
ARQTARCUTIS BIOTHERAPEUTICS INC7,500$117Kshares
EWTXEDGEWISE THERAPEUTICS INC3,000$66Kshares
LXEOLEXEO THERAPEUTICS INC5,054$17.5Kshares

How Q2 2025 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001013594-25-001022 base2025-08-14acceptance time not in the bulk data set