BVF INC/IL in group BVF INC/IL More: the full row for BVF INC/IL 2,590,303 $81.3M 2.59% 0 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 1,702,157 $53.4M <0.01% -12,511 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 1,302,974 $40.9M <0.01% +141,085 13F-HR Timeline Group VANGUARD GROUP INC group of 4 filers holding More: the full row for VANGUARD GROUP INC 706,303 $22.2M new Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 646,914 $20.3M <0.01% +35,399 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 640,001 $20.1M 0.08% +377,068 13F-HR/A Timeline Opaleye Management Inc. More: the full row for Opaleye Management Inc. 300,000 $9.41M 1.24% +7,410 13F-HR Timeline GW&K Investment Management, LLC More: the full row for GW&K Investment Management, LLC 232,141 $7.28M 0.06% new 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 229,766 $7.21M <0.01% +8,200 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 204,920 $6.43M <0.01% new 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 193,148 $6.06M <0.01% +18,240 13F-HR Timeline Group DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 133,360 $4.18M <0.01% +90,025 13F-HR Timeline Group TLS Advisors LLC More: the full row for TLS Advisors LLC 114,867 $3.6M 8.55% +66,944 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 98,638 $3.09M <0.01% new 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 93,490 $2.93M <0.01% +3,087 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 74,984 $2.35M <0.01% +6,600 13F-HR Timeline Group UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 72,816 $2.28M +46,769 Timeline Stonepine Capital Management, LLC More: the full row for Stonepine Capital Management, LLC 69,500 $2.18M 1.92% -45,500 13F-HR Timeline Simcoe Capital LLC More: the full row for Simcoe Capital LLC 68,053 $2.13M 1.96% new 13F-HR Timeline PANAGORA ASSET MANAGEMENT INC More: the full row for PANAGORA ASSET MANAGEMENT INC 58,662 $1.84M 0.01% +37,433 13F-HR Timeline HighVista Strategies LLC More: the full row for HighVista Strategies LLC 46,814 $1.47M 0.41% -66,103 13F-HR Timeline CM Management, LLC More: the full row for CM Management, LLC 40,000 $1.25M 1.05% 0 13F-HR Timeline RBF Capital, LLC More: the full row for RBF Capital, LLC 30,000 $941K 0.05% 0 13F-HR/A Timeline STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 28,894 $906K <0.01% new 13F-HR Timeline Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 28,495 $894K 0.01% new 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 27,151 $852K <0.01% -2,224 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 26,075 $818K <0.01% +16,360 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 23,998 $753K <0.01% +7,901 13F-HR Timeline Group BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 17,580 $551K 0.01% 0 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 17,390 $546K <0.01% +7,797 13F-HR Timeline Group NANO CAP NEW MILLENNIUM GROWTH FUND L P More: the full row for NANO CAP NEW MILLENNIUM GROWTH FUND L P 17,000 $533K 0.5% +2,000 13F-HR Timeline ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 14,663 $460K <0.01% new 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 14,519 $455K <0.01% new 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 12,706 $399K <0.01% 0 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 11,705 $367K <0.01% +121 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 11,018 $346K <0.01% -924 13F-HR Timeline Group DIVERSIFIED MANAGEMENT INC More: the full row for DIVERSIFIED MANAGEMENT INC 10,000 $314K 0.05% 0 13F-HR Timeline REGIONS FINANCIAL CORP in group REGIONS FINANCIAL CORP More: the full row for REGIONS FINANCIAL CORP 9,250 $290K <0.01% new 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 8,447 $265K <0.01% +8,323 13F-HR Timeline Group Caption Management, LLC More: the full row for Caption Management, LLC 7,433 $233K 0.01% new 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 6,803 $214K <0.01% new 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 6,782 $213K <0.01% new 13F-HR Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 5,677 $178K <0.01% 0 13F-HR Timeline Group MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 4,600 $144K <0.01% +102 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 3,865 $121K <0.01% -6,890 13F-HR/A Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 3,992 $121K <0.01% +157 13F-HR/A Timeline Group OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 3,444 $108K <0.01% -100 13F-HR Timeline Group Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 2,856 $89.6K <0.01% 0 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 2,362 $74.1K <0.01% 0 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 2,193 $68.8K <0.01% +41 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 1,965 $61.6K <0.01% -12,857 13F-HR Timeline Group State of Alaska, Department of Revenue More: the full row for State of Alaska, Department of Revenue 1,050 $32K <0.01% 0 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 1,002 $31K <0.01% -241 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 959 $30.1K <0.01% 0 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 854 $26.8K <0.01% -122 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 819 $25.7K <0.01% +41 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 753 $23.6K <0.01% +198 13F-HR Timeline Group Costello Asset Management, INC More: the full row for Costello Asset Management, INC 600 $18.8K 0.01% 0 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 572 $17.9K <0.01% +103 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 514 $16.1K <0.01% -71 13F-HR Timeline NATIXIS in group Natixis Investment Managers More: the full row for NATIXIS 372 $11.7K <0.01% 0 13F-HR Timeline Group Truvestments Capital LLC More: the full row for Truvestments Capital LLC 290 $9.1K <0.01% 0 13F-HR Timeline LOS ANGELES CAPITAL MANAGEMENT LLC More: the full row for LOS ANGELES CAPITAL MANAGEMENT LLC 190 $5.96K <0.01% -19,142 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 152 $4.77K <0.01% +39 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 145 $4.55K <0.01% -88 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 113 $3.54K <0.01% -21 13F-HR Timeline Group Optiver Holding B.V. in group Optiver Holding B.V. More: the full row for Optiver Holding B.V. 90 $2.82K <0.01% +24 13F-HR/A Timeline Group US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 67 $2.1K <0.01% new 13F-HR Timeline Group EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 59 $1.85K <0.01% -10 13F-HR/A Timeline Group Ancora Advisors LLC in group Ancora Advisors LLC More: the full row for Ancora Advisors LLC 31 $972 <0.01% 0 13F-HR Timeline Group PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 25 $784 <0.01% 0 13F-HR Timeline Group MH & ASSOCIATES SECURITIES MANAGEMENT C… More: the full row for MH & ASSOCIATES SECURITIES MANAGEMENT CORP /ADV 20 $628 <0.01% 0 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 19 $596 <0.01% 0 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 14 $439 <0.01% +2 13F-HR Timeline Root Financial Partners, LLC More: the full row for Root Financial Partners, LLC 13 $408 <0.01% new 13F-HR Timeline Larson Financial Group LLC More: the full row for Larson Financial Group LLC 10 $314 <0.01% new 13F-HR Timeline True Wealth Design, LLC More: the full row for True Wealth Design, LLC 4 $126 <0.01% +1 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 3 $95 <0.01% -7 13F-HR Timeline ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 3 $94 <0.01% 0 13F-HR Timeline TD Waterhouse Canada Inc. More: the full row for TD Waterhouse Canada Inc. 1 $33 <0.01% 0 13F-HR Timeline MAI Capital Management More: the full row for MAI Capital Management 1 $32 <0.01% new 13F-HR Timeline