JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 5,207,011 $27.2M 0.01% +65,395 13F-HR/A Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 3,394,968 $17.7M <0.01% +986,100 13F-HR Timeline Group VANGUARD GROUP INC group of 4 filers holding More: the full row for VANGUARD GROUP INC 2,893,063 $15.1M new Timeline Velan Capital Investment Management LP More: the full row for Velan Capital Investment Management LP 2,834,652 $14.8M 9.25% 0 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 2,831,208 $14.8M 0.01% +2,077,906 13F-HR Timeline Group Blackstone Inc. in group Blackstone Inc. More: the full row for Blackstone Inc. 2,265,514 $11.8M 0.04% +355,852 13F-HR Timeline Group The filing omitted confidential holdings, a later amendment may add them. Sio Capital Management, LLC More: the full row for Sio Capital Management, LLC 1,969,839 $10.3M 1.48% +254,445 13F-HR Timeline ACORN CAPITAL ADVISORS, LLC More: the full row for ACORN CAPITAL ADVISORS, LLC 1,752,115 $9.13M 2.59% 0 13F-HR Timeline Integral Health Asset Management, LLC More: the full row for Integral Health Asset Management, LLC 1,750,000 $9.12M 0.48% -500,000 13F-HR Timeline AIGH Capital Management LLC More: the full row for AIGH Capital Management LLC 1,622,733 $8.45M 1.73% new 13F-HR Timeline UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 1,402,864 $7.31M +187,327 Timeline 5AM Venture Management, LLC More: the full row for 5AM Venture Management, LLC 1,369,782 $7.14M 1.98% 0 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 1,177,200 $6.13M <0.01% +360,004 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 1,152,714 $6.01M 0.01% +1,124,607 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 1,068,558 $5.57M <0.01% +167,017 13F-HR Timeline Group Patient Square Capital LP More: the full row for Patient Square Capital LP 1,030,846 $5.37M 0.95% new 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 1,005,142 $5.24M <0.01% +434,264 13F-HR Timeline Group BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 971,614 $5.06M 0.03% 0 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 940,512 $4.9M 0.29% -196,287 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 925,918 $4.82M <0.01% +430,014 13F-HR Timeline Group J. Goldman & Co LP More: the full row for J. Goldman & Co LP 856,247 $4.46M 0.21% new 13F-HR Timeline Catalio Capital Management, LP More: the full row for Catalio Capital Management, LP 580,024 $3.02M 0.63% -866,230 13F-HR Timeline Assenagon Asset Management S.A. More: the full row for Assenagon Asset Management S.A. 567,621 $2.96M <0.01% +259,287 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 556,974 $2.9M <0.01% +381,645 13F-HR Timeline Group DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 531,267 $2.77M <0.01% +304,110 13F-HR Timeline Group Burkehill Global Management, LP More: the full row for Burkehill Global Management, LP 450,000 $2.34M 0.12% 0 13F-HR Timeline Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 443,401 $2.31M 0.01% +297,525 13F-HR/A Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 397,981 $2.07M <0.01% +334,489 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 374,852 $1.95M <0.01% +134,096 13F-HR Timeline Group Alyeska Investment Group, L.P. in group Alyeska Investment Group, L.P. More: the full row for Alyeska Investment Group, L.P. 350,000 $1.82M 0.01% 0 13F-HR Timeline Group OPPENHEIMER & CO INC in group OPPENHEIMER ASSET MANAGEMENT … More: the full row for OPPENHEIMER & CO INC 181,565 $946K 0.01% -42,202 13F-HR Timeline Group Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 177,004 $922K <0.01% +62,673 13F-HR Timeline CIBC WORLD MARKET INC. More: the full row for CIBC WORLD MARKET INC. 175,495 $914K <0.01% -53,400 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 147,888 $770K <0.01% +45,389 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 129,671 $676K <0.01% +36,149 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 125,700 $655K <0.01% -141,107 13F-HR Timeline SUPERSTRING CAPITAL MANAGEMENT LP More: the full row for SUPERSTRING CAPITAL MANAGEMENT LP 121,457 $633K 0.45% -238,543 13F-HR Timeline PRUDENTIAL FINANCIAL INC in group PRUDENTIAL FINANCIAL INC More: the full row for PRUDENTIAL FINANCIAL INC 119,530 $623K <0.01% new 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 116,626 $608K <0.01% +9,780 13F-HR Timeline Group ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 116,305 $606K 0.01% new 13F-HR Timeline AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 92,969 $484K <0.01% +28,811 13F-HR Timeline Group BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 70,330 $366K 0.01% +25,500 13F-HR Timeline AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 66,805 $348K <0.01% +52,124 13F-HR Timeline Group Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 66,779 $348K 0.01% new 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 63,860 $333K <0.01% -22,641 13F-HR Timeline Group TRUIST FINANCIAL CORP in group TRUIST FINANCIAL CORP More: the full row for TRUIST FINANCIAL CORP 60,000 $313K <0.01% +20,000 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 58,801 $306K 0.01% -56,562 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 57,095 $297K <0.01% +56,212 13F-HR Timeline Group Marex Group Ltd in group Marex Group Ltd More: the full row for Marex Group Ltd 55,250 $288K <0.01% -30,000 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 53,975 $281K <0.01% +28,879 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 50,731 $264K <0.01% -533,797 13F-HR Timeline Group JACOBS LEVY EQUITY MANAGEMENT, INC More: the full row for JACOBS LEVY EQUITY MANAGEMENT, INC 50,255 $262K <0.01% new 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 48,262 $251K <0.01% -6,795 13F-HR Timeline Group ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 44,029 $229K <0.01% +1,640 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 37,838 $197K <0.01% +5,176 13F-HR Timeline Group NANO CAP NEW MILLENNIUM GROWTH FUND L P More: the full row for NANO CAP NEW MILLENNIUM GROWTH FUND L P 36,500 $190K 0.18% +1,500 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 36,306 $190K <0.01% +15,570 13F-HR Timeline LPL Financial LLC More: the full row for LPL Financial LLC 36,130 $188K <0.01% +80 13F-HR Timeline FOX RUN MANAGEMENT, L.L.C. More: the full row for FOX RUN MANAGEMENT, L.L.C. 35,965 $174K 0.03% new 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 32,075 $167K <0.01% +5,210 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 30,697 $160K <0.01% -9,105 13F-HR/A Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 28,776 $150K <0.01% +24,377 13F-HR Timeline Group WINTON GROUP Ltd in group WINTON GROUP Ltd More: the full row for WINTON GROUP Ltd 28,100 $146K 0.01% new 13F-HR Timeline Group MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 24,101 $126K <0.01% +7,747 13F-HR Timeline Group Almanack Investment Partners, LLC. More: the full row for Almanack Investment Partners, LLC. 23,782 $124K 0.02% 0 13F-HR Timeline Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 21,200 $110K <0.01% -686 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 21,490 $104K <0.01% +6,906 13F-HR/A Timeline Group BAILARD, INC. More: the full row for BAILARD, INC. 18,617 $97K <0.01% -5,800 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 17,961 $93.6K <0.01% +447 13F-HR Timeline Group Trexquant Investment LP More: the full row for Trexquant Investment LP 17,933 $93.4K <0.01% new 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 17,569 $91.5K <0.01% +7,648 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 14,476 $75.4K <0.01% -224 13F-HR Timeline Group INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 13,789 $71.8K <0.01% -32 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 13,548 $70.6K <0.01% +2,464 13F-HR Timeline Group AXQ CAPITAL, LP More: the full row for AXQ CAPITAL, LP 13,002 $67.7K 0.01% +2,187 13F-HR Timeline Cerity Partners LLC in group Cerity Partners LLC More: the full row for Cerity Partners LLC 12,748 $66.4K <0.01% new 13F-HR Timeline Group TORONTO DOMINION BANK in group TORONTO DOMINION BANK More: the full row for TORONTO DOMINION BANK 12,470 $65K <0.01% new 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 11,007 $57.3K <0.01% +3,390 13F-HR Timeline Group COMMONWEALTH EQUITY SERVICES, LLC More: the full row for COMMONWEALTH EQUITY SERVICES, LLC 11,000 $57.3K <0.01% 0 13F-HR Timeline Virtu Financial LLC in group Virtu Financial LLC More: the full row for Virtu Financial LLC 10,212 $53K <0.01% -58,744 13F-HR Timeline Group Essential Partners LLC More: the full row for Essential Partners LLC 9,872 $51.4K 0.02% +77 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 7,900 $41.2K <0.01% -7,100 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 5,846 $30.5K <0.01% +5,781 13F-HR Timeline Group NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 4,800 $25K <0.01% new 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 4,603 $24K <0.01% +2,530 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 4,490 $23.4K <0.01% +1,553 13F-HR Timeline Group SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 4,449 $23.2K <0.01% new 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 3,500 $18K <0.01% -989 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 3,298 $17.2K <0.01% 0 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 2,811 $14.6K <0.01% +642 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 2,676 $13.9K <0.01% 0 13F-HR Timeline Group Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 1,703 $8.87K <0.01% -329 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 1,297 $6.76K <0.01% -17,103 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 577 $3.01K <0.01% new 13F-HR Timeline MAI Capital Management More: the full row for MAI Capital Management 148 $772 <0.01% new 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 130 $678 <0.01% new 13F-HR/A Timeline Group PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 121 $630 <0.01% -1 13F-HR Timeline Group Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 117 $590 <0.01% +62 13F-HR Timeline Aspect Partners, LLC More: the full row for Aspect Partners, LLC 106 $552 <0.01% new 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 103 $537 <0.01% 0 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 100 $521 <0.01% 0 13F-HR Timeline Group Allworth Financial LP More: the full row for Allworth Financial LP 83 $433 <0.01% new 13F-HR Timeline Basecamp Wealth Advisors LLC More: the full row for Basecamp Wealth Advisors LLC 82 $427 <0.01% new 13F-HR Timeline ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 43 $224 <0.01% +42 13F-HR Timeline True Wealth Design, LLC More: the full row for True Wealth Design, LLC 24 $126 <0.01% new 13F-HR Timeline Sunbelt Securities, Inc. More: the full row for Sunbelt Securities, Inc. 12 $63 <0.01% new 13F-HR Timeline SJS Investment Consulting Inc. More: the full row for SJS Investment Consulting Inc. 8 $42 <0.01% new 13F-HR Timeline Root Financial Partners, LLC More: the full row for Root Financial Partners, LLC 5 $26 <0.01% new 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 2 $10 <0.01% new 13F-HR Timeline Wealth Preservation Advisors, LLC More: the full row for Wealth Preservation Advisors, LLC 1 $5 <0.01% new 13F-HR Timeline